Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9NZR2 (LRP1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low-density lipoprotein receptor-related protein 1B

Short name=LRP-1B
Alternative name(s):
Low-density lipoprotein receptor-related protein-deleted in tumor
Short name=LRP-DIT
Gene names
Name:LRP1B
Synonyms:LRPDIT
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length4599 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.

Subunit structure

Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by internalization and degradation of the ligands.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain. Ref.3

Miscellaneous

The gene is preferentially inactivated in one histological type of lung cancer (non-small cell lung cancer (NSCLC)). May thus play an important role in tumorigenesis of NSCLCs.

Sequence similarities

Belongs to the LDLR family.

Contains 14 EGF-like domains.

Contains 32 LDL-receptor class A domains.

Contains 36 LDL-receptor class B repeats.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 45994579Low-density lipoprotein receptor-related protein 1B
PRO_0000017319

Regions

Topological domain25 – 44444420Extracellular Potential
Transmembrane4445 – 446723Helical; Potential
Topological domain4468 – 4599132Cytoplasmic Potential
Domain31 – 7040LDL-receptor class A 1
Domain76 – 11439LDL-receptor class A 2
Domain116 – 15439EGF-like 1
Domain155 – 19440EGF-like 2; calcium-binding Potential
Repeat245 – 29450LDL-receptor class B 1
Repeat295 – 33743LDL-receptor class B 2
Repeat338 – 38144LDL-receptor class B 3
Repeat382 – 42544LDL-receptor class B 4
Repeat568 – 61043LDL-receptor class B 5
Repeat611 – 65646LDL-receptor class B 6
Repeat657 – 70650LDL-receptor class B 7
Repeat707 – 75044LDL-receptor class B 8
Domain794 – 83441EGF-like 3
Domain844 – 88239LDL-receptor class A 3
Domain885 – 92339LDL-receptor class A 4
Domain926 – 96338LDL-receptor class A 5
Domain966 – 100338LDL-receptor class A 6
Domain1005 – 104339LDL-receptor class A 7
Domain1052 – 108938LDL-receptor class A 8
Domain1094 – 113239LDL-receptor class A 9
Domain1135 – 117440LDL-receptor class A 10
Repeat1300 – 134647LDL-receptor class B 9
Repeat1347 – 138943LDL-receptor class B 10
Repeat1390 – 143647LDL-receptor class B 11
Repeat1437 – 148044LDL-receptor class B 12
Repeat1481 – 152242LDL-receptor class B 13
Repeat1618 – 166043LDL-receptor class B 14
Repeat1661 – 170444LDL-receptor class B 15
Repeat1705 – 174440LDL-receptor class B 16
Repeat1745 – 178743LDL-receptor class B 17
Repeat1788 – 183043LDL-receptor class B 18
Domain1834 – 187542EGF-like 4
Repeat1922 – 196443LDL-receptor class B 19
Repeat1965 – 200743LDL-receptor class B 20
Repeat2008 – 205144LDL-receptor class B 21
Repeat2052 – 209544LDL-receptor class B 22
Domain2143 – 218341EGF-like 5
Repeat2239 – 228042LDL-receptor class B 23
Repeat2281 – 232949LDL-receptor class B 24
Repeat2330 – 237445LDL-receptor class B 25
Repeat2375 – 241642LDL-receptor class B 26
Repeat2417 – 245943LDL-receptor class B 27
Domain2509 – 254840LDL-receptor class A 11
Domain2551 – 258737LDL-receptor class A 12
Domain2590 – 262637LDL-receptor class A 13
Domain2629 – 267547LDL-receptor class A 14
Domain2681 – 271737LDL-receptor class A 15
Domain2719 – 275739LDL-receptor class A 16
Domain2760 – 280041LDL-receptor class A 17
Domain2804 – 284138LDL-receptor class A 18
Domain2844 – 288542LDL-receptor class A 19
Domain2890 – 292637LDL-receptor class A 20
Domain2926 – 296742EGF-like 6
Domain2968 – 300841EGF-like 7
Repeat3055 – 309844LDL-receptor class B 28
Repeat3099 – 314143LDL-receptor class B 29
Repeat3142 – 318544LDL-receptor class B 30
Repeat3186 – 322439LDL-receptor class B 31
Repeat3225 – 326844LDL-receptor class B 32
Domain3316 – 335338LDL-receptor class A 21
Domain3356 – 339237LDL-receptor class A 22
Domain3395 – 343238LDL-receptor class A 23
Domain3435 – 347238LDL-receptor class A 24
Domain3475 – 351137LDL-receptor class A 25
Domain3514 – 355037LDL-receptor class A 26
Domain3552 – 358837LDL-receptor class A 27
Domain3593 – 362937LDL-receptor class A 28
Domain3631 – 366838LDL-receptor class A 29
Domain3673 – 371139LDL-receptor class A 30
Domain3714 – 375239LDL-receptor class A 31
Domain3761 – 379737LDL-receptor class A 32
Domain3801 – 384343EGF-like 8
Domain3844 – 388138EGF-like 9
Repeat3933 – 398048LDL-receptor class B 33
Repeat3981 – 403858LDL-receptor class B 34
Repeat4039 – 408244LDL-receptor class B 35
Repeat4083 – 412745LDL-receptor class B 36
Domain4213 – 424634EGF-like 10
Domain4249 – 428537EGF-like 11
Domain4285 – 432137EGF-like 12
Domain4321 – 435737EGF-like 13
Domain4390 – 442738EGF-like 14
Motif4492 – 44954Endocytosis signal Potential
Motif4559 – 45624Endocytosis signal Potential

Amino acid modifications

Glycosylation1341N-linked (GlcNAc...) Potential
Glycosylation1901N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation3131N-linked (GlcNAc...) Potential
Glycosylation3601N-linked (GlcNAc...) Potential
Glycosylation4431N-linked (GlcNAc...) Potential
Glycosylation7251N-linked (GlcNAc...) Potential
Glycosylation7581N-linked (GlcNAc...) Potential
Glycosylation8291N-linked (GlcNAc...) Potential
Glycosylation8831N-linked (GlcNAc...) Potential
Glycosylation9191N-linked (GlcNAc...) Potential
Glycosylation10411N-linked (GlcNAc...) Potential
Glycosylation10891N-linked (GlcNAc...) Potential
Glycosylation11451N-linked (GlcNAc...) Potential
Glycosylation12091N-linked (GlcNAc...) Potential
Glycosylation12981N-linked (GlcNAc...) Potential
Glycosylation15021N-linked (GlcNAc...) Potential
Glycosylation15491N-linked (GlcNAc...) Potential
Glycosylation16361N-linked (GlcNAc...) Potential
Glycosylation17541N-linked (GlcNAc...) Potential
Glycosylation18161N-linked (GlcNAc...) Potential
Glycosylation19211N-linked (GlcNAc...) Potential
Glycosylation19831N-linked (GlcNAc...) Potential
Glycosylation21051N-linked (GlcNAc...) Potential
Glycosylation24581N-linked (GlcNAc...) Potential
Glycosylation24881N-linked (GlcNAc...) Potential
Glycosylation25071N-linked (GlcNAc...) Potential
Glycosylation25491N-linked (GlcNAc...) Potential
Glycosylation26261N-linked (GlcNAc...) Potential
Glycosylation26471N-linked (GlcNAc...) Potential
Glycosylation28021N-linked (GlcNAc...) Potential
Glycosylation28921N-linked (GlcNAc...) Potential
Glycosylation30341N-linked (GlcNAc...) Potential
Glycosylation30661N-linked (GlcNAc...) Potential
Glycosylation30761N-linked (GlcNAc...) Potential
Glycosylation31641N-linked (GlcNAc...) Potential
Glycosylation33101N-linked (GlcNAc...) Potential
Glycosylation33161N-linked (GlcNAc...) Potential
Glycosylation36821N-linked (GlcNAc...) Potential
Glycosylation38771N-linked (GlcNAc...) Potential
Glycosylation38941N-linked (GlcNAc...) Potential
Glycosylation39061N-linked (GlcNAc...) Potential
Glycosylation40171N-linked (GlcNAc...) Potential
Glycosylation42041N-linked (GlcNAc...) Potential
Glycosylation43811N-linked (GlcNAc...) Potential
Glycosylation44201N-linked (GlcNAc...) Potential
Disulfide bond32 ↔ 45 By similarity
Disulfide bond39 ↔ 58 By similarity
Disulfide bond52 ↔ 69 By similarity
Disulfide bond77 ↔ 90 By similarity
Disulfide bond84 ↔ 103 By similarity
Disulfide bond97 ↔ 113 By similarity
Disulfide bond120 ↔ 129 By similarity
Disulfide bond125 ↔ 138 By similarity
Disulfide bond140 ↔ 153 By similarity
Disulfide bond159 ↔ 169 By similarity
Disulfide bond165 ↔ 178 By similarity
Disulfide bond180 ↔ 193 By similarity
Disulfide bond798 ↔ 809 By similarity
Disulfide bond805 ↔ 818 By similarity
Disulfide bond820 ↔ 833 By similarity
Disulfide bond845 ↔ 857 By similarity
Disulfide bond852 ↔ 870 By similarity
Disulfide bond864 ↔ 881 By similarity
Disulfide bond886 ↔ 898 By similarity
Disulfide bond893 ↔ 911 By similarity
Disulfide bond905 ↔ 922 By similarity
Disulfide bond927 ↔ 939 By similarity
Disulfide bond934 ↔ 952 By similarity
Disulfide bond946 ↔ 962 By similarity
Disulfide bond967 ↔ 980 By similarity
Disulfide bond975 ↔ 993 By similarity
Disulfide bond987 ↔ 1002 By similarity
Disulfide bond1006 ↔ 1018 By similarity
Disulfide bond1013 ↔ 1031 By similarity
Disulfide bond1025 ↔ 1042 By similarity
Disulfide bond1053 ↔ 1066 By similarity
Disulfide bond1060 ↔ 1079 By similarity
Disulfide bond1073 ↔ 1088 By similarity
Disulfide bond1095 ↔ 1109 By similarity
Disulfide bond1103 ↔ 1122 By similarity
Disulfide bond1116 ↔ 1131 By similarity
Disulfide bond1136 ↔ 1150 By similarity
Disulfide bond1143 ↔ 1163 By similarity
Disulfide bond1157 ↔ 1173 By similarity
Disulfide bond1838 ↔ 1849 By similarity
Disulfide bond1845 ↔ 1859 By similarity
Disulfide bond1861 ↔ 1874 By similarity
Disulfide bond2147 ↔ 2158 By similarity
Disulfide bond2154 ↔ 2168 By similarity
Disulfide bond2170 ↔ 2182 By similarity
Disulfide bond2510 ↔ 2523 By similarity
Disulfide bond2518 ↔ 2536 By similarity
Disulfide bond2530 ↔ 2547 By similarity
Disulfide bond2552 ↔ 2564 By similarity
Disulfide bond2559 ↔ 2577 By similarity
Disulfide bond2571 ↔ 2586 By similarity
Disulfide bond2591 ↔ 2603 By similarity
Disulfide bond2598 ↔ 2616 By similarity
Disulfide bond2610 ↔ 2625 By similarity
Disulfide bond2630 ↔ 2652 By similarity
Disulfide bond2646 ↔ 2665 By similarity
Disulfide bond2659 ↔ 2674 By similarity
Disulfide bond2682 ↔ 2694 By similarity
Disulfide bond2689 ↔ 2707 By similarity
Disulfide bond2701 ↔ 2716 By similarity
Disulfide bond2720 ↔ 2732 By similarity
Disulfide bond2727 ↔ 2745 By similarity
Disulfide bond2739 ↔ 2756 By similarity
Disulfide bond2761 ↔ 2774 By similarity
Disulfide bond2768 ↔ 2787 By similarity
Disulfide bond2781 ↔ 2799 By similarity
Disulfide bond2805 ↔ 2817 By similarity
Disulfide bond2812 ↔ 2830 By similarity
Disulfide bond2824 ↔ 2840 By similarity
Disulfide bond2845 ↔ 2857 By similarity
Disulfide bond2852 ↔ 2871 By similarity
Disulfide bond2865 ↔ 2884 By similarity
Disulfide bond2891 ↔ 2903 By similarity
Disulfide bond2898 ↔ 2916 By similarity
Disulfide bond2910 ↔ 2925 By similarity
Disulfide bond2930 ↔ 2942 By similarity
Disulfide bond2938 ↔ 2951 By similarity
Disulfide bond2953 ↔ 2966 By similarity
Disulfide bond2972 ↔ 2982 By similarity
Disulfide bond2978 ↔ 2991 By similarity
Disulfide bond2993 ↔ 3007 By similarity
Disulfide bond3317 ↔ 3329 By similarity
Disulfide bond3324 ↔ 3342 By similarity
Disulfide bond3336 ↔ 3352 By similarity
Disulfide bond3357 ↔ 3369 By similarity
Disulfide bond3364 ↔ 3382 By similarity
Disulfide bond3376 ↔ 3391 By similarity
Disulfide bond3396 ↔ 3409 By similarity
Disulfide bond3403 ↔ 3422 By similarity
Disulfide bond3416 ↔ 3431 By similarity
Disulfide bond3436 ↔ 3449 By similarity
Disulfide bond3443 ↔ 3462 By similarity
Disulfide bond3456 ↔ 3471 By similarity
Disulfide bond3476 ↔ 3488 By similarity
Disulfide bond3483 ↔ 3501 By similarity
Disulfide bond3495 ↔ 3510 By similarity
Disulfide bond3515 ↔ 3527 By similarity
Disulfide bond3522 ↔ 3540 By similarity
Disulfide bond3534 ↔ 3549 By similarity
Disulfide bond3553 ↔ 3565 By similarity
Disulfide bond3560 ↔ 3578 By similarity
Disulfide bond3572 ↔ 3587 By similarity
Disulfide bond3594 ↔ 3606 By similarity
Disulfide bond3601 ↔ 3619 By similarity
Disulfide bond3613 ↔ 3628 By similarity
Disulfide bond3632 ↔ 3645 By similarity
Disulfide bond3639 ↔ 3658 By similarity
Disulfide bond3652 ↔ 3667 By similarity
Disulfide bond3674 ↔ 3686 By similarity
Disulfide bond3681 ↔ 3699 By similarity
Disulfide bond3693 ↔ 3710 By similarity
Disulfide bond3715 ↔ 3729 By similarity
Disulfide bond3723 ↔ 3742 By similarity
Disulfide bond3736 ↔ 3751 By similarity
Disulfide bond3762 ↔ 3774 By similarity
Disulfide bond3769 ↔ 3787 By similarity
Disulfide bond3781 ↔ 3796 By similarity
Disulfide bond3805 ↔ 3818 By similarity
Disulfide bond3812 ↔ 3827 By similarity
Disulfide bond3829 ↔ 3842 By similarity
Disulfide bond3848 ↔ 3858 By similarity
Disulfide bond3854 ↔ 3867 By similarity
Disulfide bond3869 ↔ 3880 By similarity
Disulfide bond4217 ↔ 4227 By similarity
Disulfide bond4221 ↔ 4237 By similarity
Disulfide bond4253 ↔ 4263 By similarity
Disulfide bond4257 ↔ 4273 By similarity
Disulfide bond4275 ↔ 4284 By similarity
Disulfide bond4289 ↔ 4299 By similarity
Disulfide bond4293 ↔ 4309 By similarity
Disulfide bond4311 ↔ 4320 By similarity
Disulfide bond4325 ↔ 4335 By similarity
Disulfide bond4329 ↔ 4345 By similarity
Disulfide bond4347 ↔ 4356 By similarity
Disulfide bond4394 ↔ 4404 By similarity
Disulfide bond4398 ↔ 4415 By similarity
Disulfide bond4417 ↔ 4426 By similarity

Natural variations

Natural variant481Q → R.
Corresponds to variant rs12990449 [ dbSNP | Ensembl ].
VAR_049759
Natural variant31401Q → R.
Corresponds to variant rs34488772 [ dbSNP | Ensembl ].
VAR_049760
Natural variant31571R → C in NSCLC cells. Ref.1
VAR_018328
Natural variant34581E → K.
Corresponds to variant rs1878740 [ dbSNP | Ensembl ].
VAR_049761
Natural variant37341Q → K.
Corresponds to variant rs35546150 [ dbSNP | Ensembl ].
VAR_049762
Natural variant42641V → L.
Corresponds to variant rs17386226 [ dbSNP | Ensembl ].
VAR_049763

Experimental info

Sequence conflict5161C → Y in AAL38107. Ref.2
Sequence conflict12571P → S in AAL38108. Ref.2
Sequence conflict15711E → G in AAL38108. Ref.2
Sequence conflict2654 – 26552LP → CQ in AAL38108. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9NZR2 [UniParc].

Last modified January 4, 2005. Version 2.
Checksum: 98B70555F46CAE66

FASTA4,599515,498
        10         20         30         40         50         60 
MSEFLLALLT LSGLLPIARV LTVGADRDQQ LCDPGEFLCH DHVTCVSQSW LCDGDPDCPD 

        70         80         90        100        110        120 
DSDESLDTCP EEVEIKCPLN HIACLGTNKC VHLSQLCNGV LDCPDGYDEG VHCQELLSNC 

       130        140        150        160        170        180 
QQLNCQYKCT MVRNSTRCYC EDGFEITEDG RSCKDQDECA VYGTCSQTCR NTHGSYTCSC 

       190        200        210        220        230        240 
VEGYLMQPDN RSCKAKIEPT DRPPILLIAN FETIEVFYLN GSKMATLSSV NGNEIHTLDF 

       250        260        270        280        290        300 
IYNEDMICWI ESRESSNQLK CIQITKAGGL TDEWTINILQ SFHNVQQMAI DWLTRNLYFV 

       310        320        330        340        350        360 
DHVGDRIFVC NSNGSVCVTL IDLELHNPKA IAVDPIAGKL FFTDYGNVAK VERCDMDGMN 

       370        380        390        400        410        420 
RTRIIDSKTE QPAALALDLV NKLVYWVDLY LDYVGVVDYQ GKNRHTVIQG RQVRHLYGIT 

       430        440        450        460        470        480 
VFEDYLYATN SDNYNIVRIN RFNGTDIHSL IKIENAWGIR IYQKRTQPTV RSHACEVDPY 

       490        500        510        520        530        540 
GMPGGCSHIC LLSSSYKTRT CRCRTGFNLG SDGRSCKRPK NELFLFYGKG RPGIVRGMDL 

       550        560        570        580        590        600 
NTKIADEYMI PIENLVNPRA LDFHAETNYI YFADTTSFLI GRQKIDGTER ETILKDDLDN 

       610        620        630        640        650        660 
VEGIAVDWIG NNLYWTNDGH RKTINVARLE KASQSRKTLL EGEMSHPRGI VVDPVNGWMY 

       670        680        690        700        710        720 
WTDWEEDEID DSVGRIEKAW MDGFNRQIFV TSKMLWPNGL TLDFHTNTLY WCDAYYDHIE 

       730        740        750        760        770        780 
KVFLNGTHRK IVYSGRELNH PFGLSHHGNY VFWTDYMNGS IFQLDLITSE VTLLRHERPP 

       790        800        810        820        830        840 
LFGLQIYDPR KQQGDNMCRV NNGGCSTLCL AIPGGRVCAC ADNQLLDENG TTCTFNPGEA 

       850        860        870        880        890        900 
LPHICKAGEF RCKNRHCIQA RWKCDGDDDC LDGSDEDSVN CFNHSCPDDQ FKCQNNRCIP 

       910        920        930        940        950        960 
KRWLCDGAND CGSNEDESNQ TCTARTCQVD QFSCGNGRCI PRAWLCDRED DCGDQTDEMA 

       970        980        990       1000       1010       1020 
SCEFPTCEPL TQFVCKSGRC ISSKWHCDSD DDCGDGSDEV GCVHSCFDNQ FRCSSGRCIP 

      1030       1040       1050       1060       1070       1080 
GHWACDGDND CGDFSDEAQI NCTKEEIHSP AGCNGNEFQC HPDGNCVPDL WRCDGEKDCE 

      1090       1100       1110       1120       1130       1140 
DGSDEKGCNG TIRLCDHKTK FSCWSTGRCI NKAWVCDGDI DCEDQSDEDD CDSFLCGPPK 

      1150       1160       1170       1180       1190       1200 
HPCANDTSVC LQPEKLCNGK KDCPDGSDEG YLCDECSLNN GGCSNHCSVV PGRGIVCSCP 

      1210       1220       1230       1240       1250       1260 
EGLQLNKDNK TCEIVDYCSN HLKCSQVCEQ HKHTVKCSCY EGWKLDVDGE SCTSVDPFEA 

      1270       1280       1290       1300       1310       1320 
FIIFSIRHEI RRIDLHKRDY SLLVPGLRNT IALDFHFNQS LLYWTDVVED RIYRGKLSES 

      1330       1340       1350       1360       1370       1380 
GGVSAIEVVV EHGLATPEGL TVDWIAGNIY WIDSNLDQIE VAKLDGSLRT TLIAGAMEHP 

      1390       1400       1410       1420       1430       1440 
RAIALDPRYG ILFWTDWDAN FPRIESASMS GAGRKTIYKD MKTGAWPNGL TVDHFEKRIV 

      1450       1460       1470       1480       1490       1500 
WTDARSDAIY SALYDGTNMI EIIRGHEYLS HPFAVSLYGS EVYWTDWRTN TLSKANKWTG 

      1510       1520       1530       1540       1550       1560 
QNVSVIQKTS AQPFDLQIYH PSRQPQAPNP CAANDGKGPC SHMCLINHNR SAACACPHLM 

      1570       1580       1590       1600       1610       1620 
KLSSDKKTCY EMKKFLLYAR RSEIRGVDID NPYFNFITAF TVPDIDDVTV IDFDASEERL 

      1630       1640       1650       1660       1670       1680 
YWTDIKTQTI KRAFINGTGL ETVISRDIQS IRGLAVDWVS RNLYWISSEF DETQINVARL 

      1690       1700       1710       1720       1730       1740 
DGSLKTSIIH GIDKPQCLAA HPVRGKLYWT DGNTINMANM DGSNSKILFQ NQKEPVGLSI 

      1750       1760       1770       1780       1790       1800 
DYVENKLYWI SSGNGTINRC NLDGGNLEVI ESMKEELTKA TALTIMDKKL WWADQNLAQL 

      1810       1820       1830       1840       1850       1860 
GTCSKRDGRN PTILRNKTSG VVHMKVYDKE AQQGSNSCQL NNGGCSQLCL PTSETTRTCM 

      1870       1880       1890       1900       1910       1920 
CTVGYYLQKN RMSCQGIESF LMYSVHEGIR GIPLEPSDKM DALMPISGTS FAVGIDFHAE 

      1930       1940       1950       1960       1970       1980 
NDTIYWTDMG FNKISRAKRD QTWKEDIITN GLGRVEGIAV DWIAGNIYWT DHGFNLIEVA 

      1990       2000       2010       2020       2030       2040 
RLNGSFRYVI ISQGLDQPRS IAVHPEKGLL FWTEWGQMPC IGKARLDGSE KVVLVSMGIA 

      2050       2060       2070       2080       2090       2100 
WPNGISIDYE ENKLYWCDAR TDKIERIDLE TGGNREMVLS GSNVDMFSVA VFGAYIYWSD 

      2110       2120       2130       2140       2150       2160 
RAHANGSVRR GHKNDATETI TMRTGLGVNL KEVKIFNRVR EKGTNVCARD NGGCKQLCLY 

      2170       2180       2190       2200       2210       2220 
RGNSRRTCAC AHGYLAEDGV TCLRHEGYLL YSGRTILKSI HLSDETNLNS PIRPYENPRY 

      2230       2240       2250       2260       2270       2280 
FKNVIALAFD YNQRRKGTNR IFYSDAHFGN IQLIKDNWED RQVIVENVGS VEGLAYHRAW 

      2290       2300       2310       2320       2330       2340 
DTLYWTSSTT SSITRHTVDQ TRPGAFDREA VITMSEDDHP HVLALDECQN LMFWTNWNEQ 

      2350       2360       2370       2380       2390       2400 
HPSIMRSTLT GKNAQVVVST DILTPNGLTI DYRAEKLYFS DGSLGKIERC EYDGSQRHVI 

      2410       2420       2430       2440       2450       2460 
VKSGPGTFLS LAVYDNYIFW SDWGRRAILR SNKYTGGDTK ILRSDIPHQP MGIIAVANDT 

      2470       2480       2490       2500       2510       2520 
NSCELSPCAL LNGGCHDLCL LTPNGRVNCS CRGDRILLED NRCVTKNSSC NAYSEFECGN 

      2530       2540       2550       2560       2570       2580 
GECIDYQLTC DGIPHCKDKS DEKLLYCENR SCRRGFKPCY NRRCIPHGKL CDGENDCGDN 

      2590       2600       2610       2620       2630       2640 
SDELDCKVST CATVEFRCAD GTCIPRSARC NQNIDCADAS DEKNCNNTDC THFYKLGVKT 

      2650       2660       2670       2680       2690       2700 
TGFIRCNSTS LCVLPTWICD GSNDCGDYSD ELKCPVQNKH KCEENYFSCP SGRCILNTWI 

      2710       2720       2730       2740       2750       2760 
CDGQKDCEDG RDEFHCDSSC SWNQFACSAQ KCISKHWICD GEDDCGDGLD ESDSICGAIT 

      2770       2780       2790       2800       2810       2820 
CAADMFSCQG SRACVPRHWL CDGERDCPDG SDELSTAGCA PNNTCDENAF MCHNKVCIPK 

      2830       2840       2850       2860       2870       2880 
QFVCDHDDDC GDGSDESPQC GYRQCGTEEF SCADGRCLLN TQWQCDGDFD CPDHSDEAPL 

      2890       2900       2910       2920       2930       2940 
NPKCKSAEQS CNSSFFMCKN GRCIPSGGLC DNKDDCGDGS DERNCHINEC LSKKVSGCSQ 

      2950       2960       2970       2980       2990       3000 
DCQDLPVSYK CKCWPGFQLK DDGKTCVDID ECSSGFPCSQ QCINTYGTYK CLCTDGYEIQ 

      3010       3020       3030       3040       3050       3060 
PDNPNGCKSL SDEEPFLILA DHHEIRKIST DGSNYTLLKQ GLNNVIAIDF DYREEFIYWI 

      3070       3080       3090       3100       3110       3120 
DSSRPNGSRI NRMCLNGSDI KVVHNTAVPN ALAVDWIGKN LYWSDTEKRI IEVSKLNGLY 

      3130       3140       3150       3160       3170       3180 
PTILVSKRLK FPRDLSLDPQ AGYLYWIDCC EYPHIGRVGM DGTNQSVVIE TKISRPMALT 

      3190       3200       3210       3220       3230       3240 
IDYVNRRLYW ADENHIEFSN MDGSHRHKVP NQDIPGVIAL TLFEDYIYWT DGKTKSLSRA 

      3250       3260       3270       3280       3290       3300 
HKTSGADRLS LIYSWHAITD IQVYHSYRQP DVSKHLCMIN NGGCSHLCLL APGKTHTCAC 

      3310       3320       3330       3340       3350       3360 
PTNFYLAADN RTCLSNCTAS QFRCKTDKCI PFWWKCDTVD DCGDGSDEPD DCPEFRCQPG 

      3370       3380       3390       3400       3410       3420 
RFQCGTGLCA LPAFICDGEN DCGDNSDELN CDTHVCLSGQ FKCTKNQKCI PVNLRCNGQD 

      3430       3440       3450       3460       3470       3480 
DCGDEEDERD CPENSCSPDY FQCKTTKHCI SKLWVCDEDP DCADASDEAN CDKKTCGPHE 

      3490       3500       3510       3520       3530       3540 
FQCKNNNCIP DHWRCDSQND CSDNSDEENC KPQTCTLKDF LCANGDCVSS RFWCDGDFDC 

      3550       3560       3570       3580       3590       3600 
ADGSDERNCE TSCSKDQFRC SNGQCIPAKW KCDGHEDCKY GEDEKSCEPA SPTCSSREYI 

      3610       3620       3630       3640       3650       3660 
CASDGCISAS LKCNGEYDCA DGSDEMDCVT ECKEDQFRCK NKAHCIPIRW LCDGIHDCVD 

      3670       3680       3690       3700       3710       3720 
GSDEENCERG GNICRADEFL CNNSLCKLHF WVCDGEDDCG DNSDEAPDMC VKFLCPSTRP 

      3730       3740       3750       3760       3770       3780 
HRCRNNRICL QSEQMCNGID ECGDNSDEDH CGGKLTYKAR PCKKDEFACS NKKCIPMDLQ 

      3790       3800       3810       3820       3830       3840 
CDRLDDCGDG SDEQGCRIAP TEYTCEDNVN PCGDDAYCNQ IKTSVFCRCK PGFQRNMKNR 

      3850       3860       3870       3880       3890       3900 
QCEDLNECLV FGTCSHQCIN VEGSYKCVCD QNFQERNNTC IAEGSEDQVL YIANDTDILG 

      3910       3920       3930       3940       3950       3960 
FIYPFNYSGD HQQISHIEHN SRITGMDVYY QRDMIIWSTQ FNPGGIFYKR IHGREKRQAN 

      3970       3980       3990       4000       4010       4020 
SGLICPEFKR PRDIAVDWVA GNIYWTDHSR MHWFSYYTTH WTSLRYSINV GQLNGPNCTR 

      4030       4040       4050       4060       4070       4080 
LLTNMAGEPY AIAVNPKRGM MYWTVVGDHS HIEEAAMDGT LRRILVQKNL QRPTGLAVDY 

      4090       4100       4110       4120       4130       4140 
FSERIYWADF ELSIIGSVLY DGSNSVVSVS SKQGLLHPHR IDIFEDYIYG AGPKNGVFRV 

      4150       4160       4170       4180       4190       4200 
QKFGHGSVEY LALNIDKTKG VLISHRYKQL DLPNPCLDLA CEFLCLLNPS GATCVCPEGK 

      4210       4220       4230       4240       4250       4260 
YLINGTCNDD SLLDDSCKLT CENGGRCILN EKGDLRCHCW PSYSGERCEV NHCSNYCQNG 

      4270       4280       4290       4300       4310       4320 
GTCVPSVLGR PTCSCALGFT GPNCGKTVCE DFCQNGGTCI VTAGNQPYCH CQPEYTGDRC 

      4330       4340       4350       4360       4370       4380 
QYYVCHHYCV NSESCTIGDD GSVECVCPTR YEGPKCEVDK CVRCHGGHCI INKDSEDIFC 

      4390       4400       4410       4420       4430       4440 
NCTNGKIASS CQLCDGYCYN GGTCQLDPET NVPVCLCSTN WSGTQCERPA PKSSKSDHIS 

      4450       4460       4470       4480       4490       4500 
TRSIAIIVPL VLLVTLITTL VIGLVLCKRK RRTKTIRRQP IINGGINVEI GNPSYNMYEV 

      4510       4520       4530       4540       4550       4560 
DHDHNDGGLL DPGFMIDPTK ARYIGGGPSA FKLPHTAPPI YLNSDLKGPL TAGPTNYSNP 

      4570       4580       4590 
VYAKLYMDGQ NCRNSLGSVD ERKELLPKKI EIGIRETVA 

« Hide

References

[1]"LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines."
Liu C.-X., Musco S., Lisitsina N.M., Forgacs E., Minna J.D., Lisitsyn N.A.
Cancer Res. 60:1961-1967(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT CYS-3157.
Tissue: Lung cancer.
[2]"Genomic organization of a new candidate tumor suppressor gene, LRP1B."
Liu C.-X., Musco S., Lisitsina N.M., Yaklichkin S.Y., Lisitsyn N.A.
Genomics 69:271-274(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-2655 AND 2677-4213.
[3]"The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein."
Liu C.-X., Li Y., Obermoeller-McCormick L.M., Schwartz A.L., Bu G.
J. Biol. Chem. 276:28889-28896(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH LRPAP1; PLAU; PLAT AND SERPINE1, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF176832 mRNA. Translation: AAF70379.1.
AF283343 Genomic DNA. No translation available.
AF283342 expand/collapse EMBL AC list , AF283327, AF283328, AF283329, AF283330, AF283331, AF283332, AF283333, AF283334, AF283335, AF283336, AF283337, AF283338, AF283339, AF283340, AF283341 Genomic DNA. Translation: AAL38107.1.
AF283374 expand/collapse EMBL AC list , AF283344, AF283345, AF283346, AF283347, AF283348, AF283349, AF283350, AF283351, AF283352, AF283353, AF283354, AF283355, AF283356, AF283357, AF283358, AF283359, AF283360, AF283361, AF283362, AF283363, AF283364, AF283366, AF283367, AF283368, AF283369, AF283370, AF283371, AF283372, AF283373 Genomic DNA. Translation: AAL38108.1.
AF283408 expand/collapse EMBL AC list , AF283376, AF283377, AF283378, AF283379, AF283380, AF283381, AF283382, AF283383, AF283384, AF283385, AF283386, AF283387, AF283388, AF283389, AF283390, AF283391, AF283392, AF283393, AF283394, AF283395, AF283396, AF283397, AF283398, AF283399, AF283400, AF283401, AF283402, AF283403, AF283404, AF283405, AF283406, AF283407 Genomic DNA. Translation: AAL38109.1.
RefSeqNP_061027.2. NM_018557.2.
UniGeneHs.656461.

3D structure databases

ProteinModelPortalQ9NZR2.
SMRQ9NZR2. Positions 29-4209, 4217-4357.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119750. 2 interactions.
IntActQ9NZR2. 3 interactions.
STRING9606.ENSP00000374135.

PTM databases

PhosphoSiteQ9NZR2.

Polymorphism databases

DMDM57015418.

Proteomic databases

PaxDbQ9NZR2.
PRIDEQ9NZR2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000389484; ENSP00000374135; ENSG00000168702.
GeneID53353.
KEGGhsa:53353.
UCSCuc002tvj.1. human.

Organism-specific databases

CTD53353.
GeneCardsGC02M141020.
H-InvDBHIX0017207.
HGNCHGNC:6693. LRP1B.
MIM608766. gene.
neXtProtNX_Q9NZR2.
PharmGKBPA30451.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG235850.
HOGENOMHOG000230574.
HOVERGENHBG006292.
InParanoidQ9NZR2.
OMAGSNSCQL.
OrthoDBEOG790FZT.
PhylomeDBQ9NZR2.
TreeFamTF315253.

Gene expression databases

ArrayExpressQ9NZR2.
BgeeQ9NZR2.
CleanExHS_LRP1B.
GenevestigatorQ9NZR2.

Family and domain databases

Gene3D2.120.10.30. 8 hits.
4.10.400.10. 31 hits.
InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamPF12662. cEGF. 1 hit.
PF00008. EGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00057. Ldl_recept_a. 30 hits.
PF00058. Ldl_recept_b. 12 hits.
[Graphical view]
PRINTSPR00261. LDLRECEPTOR.
SMARTSM00181. EGF. 16 hits.
SM00179. EGF_CA. 4 hits.
SM00192. LDLa. 32 hits.
SM00135. LY. 37 hits.
[Graphical view]
SUPFAMSSF57184. SSF57184. 6 hits.
SSF57424. SSF57424. 32 hits.
PROSITEPS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 5 hits.
PS01186. EGF_2. 9 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 3 hits.
PS01209. LDLRA_1. 27 hits.
PS50068. LDLRA_2. 32 hits.
PS51120. LDLRB. 37 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLRP1B. human.
GeneWikiLRP1B.
GenomeRNAi53353.
NextBio56010.
PROQ9NZR2.
SOURCESearch...

Entry information

Entry nameLRP1B_HUMAN
AccessionPrimary (citable) accession number: Q9NZR2
Secondary accession number(s): Q8WY29, Q8WY30, Q8WY31
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 4, 2005
Last modified: March 19, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM