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Q9NZR2

- LRP1B_HUMAN

UniProt

Q9NZR2 - LRP1B_HUMAN

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Protein
Low-density lipoprotein receptor-related protein 1B
Gene
LRP1B, LRPDIT
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. low-density lipoprotein receptor activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. protein transport Source: ProtInc
  2. receptor-mediated endocytosis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 1B
Short name:
LRP-1B
Alternative name(s):
Low-density lipoprotein receptor-related protein-deleted in tumor
Short name:
LRP-DIT
Gene namesi
Name:LRP1B
Synonyms:LRPDIT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:6693. LRP1B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 44444420Extracellular Reviewed prediction
Add
BLAST
Transmembranei4445 – 446723Helical; Reviewed prediction
Add
BLAST
Topological domaini4468 – 4599132Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30451.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 45994579Low-density lipoprotein receptor-related protein 1B
PRO_0000017319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 45 By similarity
Disulfide bondi39 ↔ 58 By similarity
Disulfide bondi52 ↔ 69 By similarity
Disulfide bondi77 ↔ 90 By similarity
Disulfide bondi84 ↔ 103 By similarity
Disulfide bondi97 ↔ 113 By similarity
Disulfide bondi120 ↔ 129 By similarity
Disulfide bondi125 ↔ 138 By similarity
Glycosylationi134 – 1341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi140 ↔ 153 By similarity
Disulfide bondi159 ↔ 169 By similarity
Disulfide bondi165 ↔ 178 By similarity
Disulfide bondi180 ↔ 193 By similarity
Glycosylationi190 – 1901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi220 – 2201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi313 – 3131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi360 – 3601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi443 – 4431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi725 – 7251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi758 – 7581N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi798 ↔ 809 By similarity
Disulfide bondi805 ↔ 818 By similarity
Disulfide bondi820 ↔ 833 By similarity
Glycosylationi829 – 8291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi845 ↔ 857 By similarity
Disulfide bondi852 ↔ 870 By similarity
Disulfide bondi864 ↔ 881 By similarity
Glycosylationi883 – 8831N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi886 ↔ 898 By similarity
Disulfide bondi893 ↔ 911 By similarity
Disulfide bondi905 ↔ 922 By similarity
Glycosylationi919 – 9191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi927 ↔ 939 By similarity
Disulfide bondi934 ↔ 952 By similarity
Disulfide bondi946 ↔ 962 By similarity
Disulfide bondi967 ↔ 980 By similarity
Disulfide bondi975 ↔ 993 By similarity
Disulfide bondi987 ↔ 1002 By similarity
Disulfide bondi1006 ↔ 1018 By similarity
Disulfide bondi1013 ↔ 1031 By similarity
Disulfide bondi1025 ↔ 1042 By similarity
Glycosylationi1041 – 10411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1053 ↔ 1066 By similarity
Disulfide bondi1060 ↔ 1079 By similarity
Disulfide bondi1073 ↔ 1088 By similarity
Glycosylationi1089 – 10891N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1095 ↔ 1109 By similarity
Disulfide bondi1103 ↔ 1122 By similarity
Disulfide bondi1116 ↔ 1131 By similarity
Disulfide bondi1136 ↔ 1150 By similarity
Disulfide bondi1143 ↔ 1163 By similarity
Glycosylationi1145 – 11451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1157 ↔ 1173 By similarity
Glycosylationi1209 – 12091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1298 – 12981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1502 – 15021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1549 – 15491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1636 – 16361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1754 – 17541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1816 – 18161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1838 ↔ 1849 By similarity
Disulfide bondi1845 ↔ 1859 By similarity
Disulfide bondi1861 ↔ 1874 By similarity
Glycosylationi1921 – 19211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1983 – 19831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2105 – 21051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2147 ↔ 2158 By similarity
Disulfide bondi2154 ↔ 2168 By similarity
Disulfide bondi2170 ↔ 2182 By similarity
Glycosylationi2458 – 24581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2488 – 24881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2507 – 25071N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2510 ↔ 2523 By similarity
Disulfide bondi2518 ↔ 2536 By similarity
Disulfide bondi2530 ↔ 2547 By similarity
Glycosylationi2549 – 25491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2552 ↔ 2564 By similarity
Disulfide bondi2559 ↔ 2577 By similarity
Disulfide bondi2571 ↔ 2586 By similarity
Disulfide bondi2591 ↔ 2603 By similarity
Disulfide bondi2598 ↔ 2616 By similarity
Disulfide bondi2610 ↔ 2625 By similarity
Glycosylationi2626 – 26261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2630 ↔ 2652 By similarity
Disulfide bondi2646 ↔ 2665 By similarity
Glycosylationi2647 – 26471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2659 ↔ 2674 By similarity
Disulfide bondi2682 ↔ 2694 By similarity
Disulfide bondi2689 ↔ 2707 By similarity
Disulfide bondi2701 ↔ 2716 By similarity
Disulfide bondi2720 ↔ 2732 By similarity
Disulfide bondi2727 ↔ 2745 By similarity
Disulfide bondi2739 ↔ 2756 By similarity
Disulfide bondi2761 ↔ 2774 By similarity
Disulfide bondi2768 ↔ 2787 By similarity
Disulfide bondi2781 ↔ 2799 By similarity
Glycosylationi2802 – 28021N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2805 ↔ 2817 By similarity
Disulfide bondi2812 ↔ 2830 By similarity
Disulfide bondi2824 ↔ 2840 By similarity
Disulfide bondi2845 ↔ 2857 By similarity
Disulfide bondi2852 ↔ 2871 By similarity
Disulfide bondi2865 ↔ 2884 By similarity
Disulfide bondi2891 ↔ 2903 By similarity
Glycosylationi2892 – 28921N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2898 ↔ 2916 By similarity
Disulfide bondi2910 ↔ 2925 By similarity
Disulfide bondi2930 ↔ 2942 By similarity
Disulfide bondi2938 ↔ 2951 By similarity
Disulfide bondi2953 ↔ 2966 By similarity
Disulfide bondi2972 ↔ 2982 By similarity
Disulfide bondi2978 ↔ 2991 By similarity
Disulfide bondi2993 ↔ 3007 By similarity
Glycosylationi3034 – 30341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3066 – 30661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3076 – 30761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3164 – 31641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3310 – 33101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3316 – 33161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3317 ↔ 3329 By similarity
Disulfide bondi3324 ↔ 3342 By similarity
Disulfide bondi3336 ↔ 3352 By similarity
Disulfide bondi3357 ↔ 3369 By similarity
Disulfide bondi3364 ↔ 3382 By similarity
Disulfide bondi3376 ↔ 3391 By similarity
Disulfide bondi3396 ↔ 3409 By similarity
Disulfide bondi3403 ↔ 3422 By similarity
Disulfide bondi3416 ↔ 3431 By similarity
Disulfide bondi3436 ↔ 3449 By similarity
Disulfide bondi3443 ↔ 3462 By similarity
Disulfide bondi3456 ↔ 3471 By similarity
Disulfide bondi3476 ↔ 3488 By similarity
Disulfide bondi3483 ↔ 3501 By similarity
Disulfide bondi3495 ↔ 3510 By similarity
Disulfide bondi3515 ↔ 3527 By similarity
Disulfide bondi3522 ↔ 3540 By similarity
Disulfide bondi3534 ↔ 3549 By similarity
Disulfide bondi3553 ↔ 3565 By similarity
Disulfide bondi3560 ↔ 3578 By similarity
Disulfide bondi3572 ↔ 3587 By similarity
Disulfide bondi3594 ↔ 3606 By similarity
Disulfide bondi3601 ↔ 3619 By similarity
Disulfide bondi3613 ↔ 3628 By similarity
Disulfide bondi3632 ↔ 3645 By similarity
Disulfide bondi3639 ↔ 3658 By similarity
Disulfide bondi3652 ↔ 3667 By similarity
Disulfide bondi3674 ↔ 3686 By similarity
Disulfide bondi3681 ↔ 3699 By similarity
Glycosylationi3682 – 36821N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3693 ↔ 3710 By similarity
Disulfide bondi3715 ↔ 3729 By similarity
Disulfide bondi3723 ↔ 3742 By similarity
Disulfide bondi3736 ↔ 3751 By similarity
Disulfide bondi3762 ↔ 3774 By similarity
Disulfide bondi3769 ↔ 3787 By similarity
Disulfide bondi3781 ↔ 3796 By similarity
Disulfide bondi3805 ↔ 3818 By similarity
Disulfide bondi3812 ↔ 3827 By similarity
Disulfide bondi3829 ↔ 3842 By similarity
Disulfide bondi3848 ↔ 3858 By similarity
Disulfide bondi3854 ↔ 3867 By similarity
Disulfide bondi3869 ↔ 3880 By similarity
Glycosylationi3877 – 38771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3894 – 38941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3906 – 39061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4017 – 40171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4204 – 42041N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4217 ↔ 4227 By similarity
Disulfide bondi4221 ↔ 4237 By similarity
Disulfide bondi4253 ↔ 4263 By similarity
Disulfide bondi4257 ↔ 4273 By similarity
Disulfide bondi4275 ↔ 4284 By similarity
Disulfide bondi4289 ↔ 4299 By similarity
Disulfide bondi4293 ↔ 4309 By similarity
Disulfide bondi4311 ↔ 4320 By similarity
Disulfide bondi4325 ↔ 4335 By similarity
Disulfide bondi4329 ↔ 4345 By similarity
Disulfide bondi4347 ↔ 4356 By similarity
Glycosylationi4381 – 43811N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4394 ↔ 4404 By similarity
Disulfide bondi4398 ↔ 4415 By similarity
Disulfide bondi4417 ↔ 4426 By similarity
Glycosylationi4420 – 44201N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9NZR2.
PaxDbiQ9NZR2.
PRIDEiQ9NZR2.

PTM databases

PhosphoSiteiQ9NZR2.

Expressioni

Tissue specificityi

Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain.1 Publication

Gene expression databases

ArrayExpressiQ9NZR2.
BgeeiQ9NZR2.
CleanExiHS_LRP1B.
GenevestigatoriQ9NZR2.

Interactioni

Subunit structurei

Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by internalization and degradation of the ligands.

Protein-protein interaction databases

BioGridi119750. 2 interactions.
IntActiQ9NZR2. 3 interactions.
STRINGi9606.ENSP00000374135.

Structurei

3D structure databases

ProteinModelPortaliQ9NZR2.
SMRiQ9NZR2. Positions 32-109, 125-3744, 3765-4441.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 7040LDL-receptor class A 1
Add
BLAST
Domaini76 – 11439LDL-receptor class A 2
Add
BLAST
Domaini116 – 15439EGF-like 1
Add
BLAST
Domaini155 – 19440EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Repeati295 – 33743LDL-receptor class B 1
Add
BLAST
Repeati338 – 38144LDL-receptor class B 2
Add
BLAST
Repeati382 – 42544LDL-receptor class B 3
Add
BLAST
Domaini471 – 51747EGF-like 3
Add
BLAST
Repeati568 – 61043LDL-receptor class B 4
Add
BLAST
Repeati611 – 65646LDL-receptor class B 5
Add
BLAST
Repeati657 – 70650LDL-receptor class B 6
Add
BLAST
Repeati707 – 75044LDL-receptor class B 7
Add
BLAST
Domaini794 – 83441EGF-like 4
Add
BLAST
Domaini844 – 88239LDL-receptor class A 3
Add
BLAST
Domaini885 – 92339LDL-receptor class A 4
Add
BLAST
Domaini926 – 96338LDL-receptor class A 5
Add
BLAST
Domaini966 – 100338LDL-receptor class A 6
Add
BLAST
Domaini1005 – 104339LDL-receptor class A 7
Add
BLAST
Domaini1052 – 108938LDL-receptor class A 8
Add
BLAST
Domaini1094 – 113239LDL-receptor class A 9
Add
BLAST
Domaini1135 – 117440LDL-receptor class A 10
Add
BLAST
Domaini1174 – 121340EGF-like 5
Add
BLAST
Domaini1214 – 125340EGF-like 6
Add
BLAST
Repeati1300 – 134647LDL-receptor class B 8
Add
BLAST
Repeati1347 – 138943LDL-receptor class B 9
Add
BLAST
Repeati1390 – 143647LDL-receptor class B 10
Add
BLAST
Repeati1437 – 148044LDL-receptor class B 11
Add
BLAST
Repeati1481 – 152242LDL-receptor class B 12
Add
BLAST
Domaini1527 – 157044EGF-like 7
Add
BLAST
Repeati1618 – 166043LDL-receptor class B 13
Add
BLAST
Repeati1661 – 170444LDL-receptor class B 14
Add
BLAST
Repeati1705 – 174440LDL-receptor class B 15
Add
BLAST
Repeati1745 – 178743LDL-receptor class B 16
Add
BLAST
Domaini1834 – 187542EGF-like 8
Add
BLAST
Repeati1922 – 196443LDL-receptor class B 17
Add
BLAST
Repeati1965 – 200743LDL-receptor class B 28
Add
BLAST
Repeati2008 – 205144LDL-receptor class B 19
Add
BLAST
Repeati2052 – 209544LDL-receptor class B 20
Add
BLAST
Domaini2143 – 218341EGF-like 9
Add
BLAST
Repeati2239 – 228042LDL-receptor class B 21
Add
BLAST
Repeati2281 – 232949LDL-receptor class B 22
Add
BLAST
Repeati2330 – 237445LDL-receptor class B 23
Add
BLAST
Repeati2375 – 241642LDL-receptor class B 24
Add
BLAST
Repeati2417 – 245943LDL-receptor class B 25
Add
BLAST
Domaini2464 – 250441EGF-like 10
Add
BLAST
Domaini2509 – 254840LDL-receptor class A 11
Add
BLAST
Domaini2551 – 258737LDL-receptor class A 12
Add
BLAST
Domaini2590 – 262637LDL-receptor class A 13
Add
BLAST
Domaini2629 – 267547LDL-receptor class A 14
Add
BLAST
Domaini2681 – 271737LDL-receptor class A 15
Add
BLAST
Domaini2719 – 275739LDL-receptor class A 16
Add
BLAST
Domaini2760 – 280041LDL-receptor class A 17
Add
BLAST
Domaini2804 – 284138LDL-receptor class A 18
Add
BLAST
Domaini2844 – 288542LDL-receptor class A 19
Add
BLAST
Domaini2890 – 292637LDL-receptor class A 20
Add
BLAST
Domaini2927 – 296741EGF-like 11
Add
BLAST
Domaini2968 – 300841EGF-like 12; calcium-binding Reviewed prediction
Add
BLAST
Repeati3055 – 309844LDL-receptor class B 26
Add
BLAST
Repeati3099 – 314143LDL-receptor class B 27
Add
BLAST
Repeati3142 – 318544LDL-receptor class B 28
Add
BLAST
Repeati3186 – 322439LDL-receptor class B 29
Add
BLAST
Repeati3225 – 326844LDL-receptor class B 30
Add
BLAST
Domaini3273 – 331442EGF-like 13
Add
BLAST
Domaini3316 – 335338LDL-receptor class A 21
Add
BLAST
Domaini3356 – 339237LDL-receptor class A 22
Add
BLAST
Domaini3395 – 343238LDL-receptor class A 23
Add
BLAST
Domaini3435 – 347238LDL-receptor class A 24
Add
BLAST
Domaini3475 – 351137LDL-receptor class A 25
Add
BLAST
Domaini3514 – 355037LDL-receptor class A 26
Add
BLAST
Domaini3552 – 358837LDL-receptor class A 27
Add
BLAST
Domaini3593 – 362937LDL-receptor class A 28
Add
BLAST
Domaini3631 – 366838LDL-receptor class A 29
Add
BLAST
Domaini3673 – 371139LDL-receptor class A 30
Add
BLAST
Domaini3714 – 375239LDL-receptor class A 31
Add
BLAST
Domaini3761 – 379737LDL-receptor class A 32
Add
BLAST
Domaini3801 – 384343EGF-like 14
Add
BLAST
Domaini3844 – 388138EGF-like 15
Add
BLAST
Repeati3933 – 398048LDL-receptor class B 31
Add
BLAST
Repeati3981 – 403858LDL-receptor class B 32
Add
BLAST
Repeati4039 – 408244LDL-receptor class B 33
Add
BLAST
Repeati4083 – 412745LDL-receptor class B 34
Add
BLAST
Domaini4171 – 420838EGF-like 16
Add
BLAST
Domaini4213 – 424937EGF-like 17
Add
BLAST
Domaini4249 – 428537EGF-like 18
Add
BLAST
Domaini4285 – 432137EGF-like 19
Add
BLAST
Domaini4321 – 435737EGF-like 20
Add
BLAST
Domaini4357 – 439236EGF-like 21
Add
BLAST
Domaini4390 – 442738EGF-like 22
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi4492 – 44954Endocytosis signal Reviewed prediction
Motifi4559 – 45624Endocytosis signal Reviewed prediction

Sequence similaritiesi

Belongs to the LDLR family.
Contains 22 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG235850.
HOGENOMiHOG000230574.
HOVERGENiHBG006292.
InParanoidiQ9NZR2.
OMAiGSNSCQL.
OrthoDBiEOG790FZT.
PhylomeDBiQ9NZR2.
TreeFamiTF315253.

Family and domain databases

Gene3Di2.120.10.30. 8 hits.
4.10.400.10. 31 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF00008. EGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00057. Ldl_recept_a. 30 hits.
PF00058. Ldl_recept_b. 12 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00181. EGF. 16 hits.
SM00179. EGF_CA. 4 hits.
SM00192. LDLa. 32 hits.
SM00135. LY. 37 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 6 hits.
SSF57424. SSF57424. 32 hits.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 5 hits.
PS01186. EGF_2. 9 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 3 hits.
PS01209. LDLRA_1. 27 hits.
PS50068. LDLRA_2. 32 hits.
PS51120. LDLRB. 37 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NZR2-1 [UniParc]FASTAAdd to Basket

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MSEFLLALLT LSGLLPIARV LTVGADRDQQ LCDPGEFLCH DHVTCVSQSW     50
LCDGDPDCPD DSDESLDTCP EEVEIKCPLN HIACLGTNKC VHLSQLCNGV 100
LDCPDGYDEG VHCQELLSNC QQLNCQYKCT MVRNSTRCYC EDGFEITEDG 150
RSCKDQDECA VYGTCSQTCR NTHGSYTCSC VEGYLMQPDN RSCKAKIEPT 200
DRPPILLIAN FETIEVFYLN GSKMATLSSV NGNEIHTLDF IYNEDMICWI 250
ESRESSNQLK CIQITKAGGL TDEWTINILQ SFHNVQQMAI DWLTRNLYFV 300
DHVGDRIFVC NSNGSVCVTL IDLELHNPKA IAVDPIAGKL FFTDYGNVAK 350
VERCDMDGMN RTRIIDSKTE QPAALALDLV NKLVYWVDLY LDYVGVVDYQ 400
GKNRHTVIQG RQVRHLYGIT VFEDYLYATN SDNYNIVRIN RFNGTDIHSL 450
IKIENAWGIR IYQKRTQPTV RSHACEVDPY GMPGGCSHIC LLSSSYKTRT 500
CRCRTGFNLG SDGRSCKRPK NELFLFYGKG RPGIVRGMDL NTKIADEYMI 550
PIENLVNPRA LDFHAETNYI YFADTTSFLI GRQKIDGTER ETILKDDLDN 600
VEGIAVDWIG NNLYWTNDGH RKTINVARLE KASQSRKTLL EGEMSHPRGI 650
VVDPVNGWMY WTDWEEDEID DSVGRIEKAW MDGFNRQIFV TSKMLWPNGL 700
TLDFHTNTLY WCDAYYDHIE KVFLNGTHRK IVYSGRELNH PFGLSHHGNY 750
VFWTDYMNGS IFQLDLITSE VTLLRHERPP LFGLQIYDPR KQQGDNMCRV 800
NNGGCSTLCL AIPGGRVCAC ADNQLLDENG TTCTFNPGEA LPHICKAGEF 850
RCKNRHCIQA RWKCDGDDDC LDGSDEDSVN CFNHSCPDDQ FKCQNNRCIP 900
KRWLCDGAND CGSNEDESNQ TCTARTCQVD QFSCGNGRCI PRAWLCDRED 950
DCGDQTDEMA SCEFPTCEPL TQFVCKSGRC ISSKWHCDSD DDCGDGSDEV 1000
GCVHSCFDNQ FRCSSGRCIP GHWACDGDND CGDFSDEAQI NCTKEEIHSP 1050
AGCNGNEFQC HPDGNCVPDL WRCDGEKDCE DGSDEKGCNG TIRLCDHKTK 1100
FSCWSTGRCI NKAWVCDGDI DCEDQSDEDD CDSFLCGPPK HPCANDTSVC 1150
LQPEKLCNGK KDCPDGSDEG YLCDECSLNN GGCSNHCSVV PGRGIVCSCP 1200
EGLQLNKDNK TCEIVDYCSN HLKCSQVCEQ HKHTVKCSCY EGWKLDVDGE 1250
SCTSVDPFEA FIIFSIRHEI RRIDLHKRDY SLLVPGLRNT IALDFHFNQS 1300
LLYWTDVVED RIYRGKLSES GGVSAIEVVV EHGLATPEGL TVDWIAGNIY 1350
WIDSNLDQIE VAKLDGSLRT TLIAGAMEHP RAIALDPRYG ILFWTDWDAN 1400
FPRIESASMS GAGRKTIYKD MKTGAWPNGL TVDHFEKRIV WTDARSDAIY 1450
SALYDGTNMI EIIRGHEYLS HPFAVSLYGS EVYWTDWRTN TLSKANKWTG 1500
QNVSVIQKTS AQPFDLQIYH PSRQPQAPNP CAANDGKGPC SHMCLINHNR 1550
SAACACPHLM KLSSDKKTCY EMKKFLLYAR RSEIRGVDID NPYFNFITAF 1600
TVPDIDDVTV IDFDASEERL YWTDIKTQTI KRAFINGTGL ETVISRDIQS 1650
IRGLAVDWVS RNLYWISSEF DETQINVARL DGSLKTSIIH GIDKPQCLAA 1700
HPVRGKLYWT DGNTINMANM DGSNSKILFQ NQKEPVGLSI DYVENKLYWI 1750
SSGNGTINRC NLDGGNLEVI ESMKEELTKA TALTIMDKKL WWADQNLAQL 1800
GTCSKRDGRN PTILRNKTSG VVHMKVYDKE AQQGSNSCQL NNGGCSQLCL 1850
PTSETTRTCM CTVGYYLQKN RMSCQGIESF LMYSVHEGIR GIPLEPSDKM 1900
DALMPISGTS FAVGIDFHAE NDTIYWTDMG FNKISRAKRD QTWKEDIITN 1950
GLGRVEGIAV DWIAGNIYWT DHGFNLIEVA RLNGSFRYVI ISQGLDQPRS 2000
IAVHPEKGLL FWTEWGQMPC IGKARLDGSE KVVLVSMGIA WPNGISIDYE 2050
ENKLYWCDAR TDKIERIDLE TGGNREMVLS GSNVDMFSVA VFGAYIYWSD 2100
RAHANGSVRR GHKNDATETI TMRTGLGVNL KEVKIFNRVR EKGTNVCARD 2150
NGGCKQLCLY RGNSRRTCAC AHGYLAEDGV TCLRHEGYLL YSGRTILKSI 2200
HLSDETNLNS PIRPYENPRY FKNVIALAFD YNQRRKGTNR IFYSDAHFGN 2250
IQLIKDNWED RQVIVENVGS VEGLAYHRAW DTLYWTSSTT SSITRHTVDQ 2300
TRPGAFDREA VITMSEDDHP HVLALDECQN LMFWTNWNEQ HPSIMRSTLT 2350
GKNAQVVVST DILTPNGLTI DYRAEKLYFS DGSLGKIERC EYDGSQRHVI 2400
VKSGPGTFLS LAVYDNYIFW SDWGRRAILR SNKYTGGDTK ILRSDIPHQP 2450
MGIIAVANDT NSCELSPCAL LNGGCHDLCL LTPNGRVNCS CRGDRILLED 2500
NRCVTKNSSC NAYSEFECGN GECIDYQLTC DGIPHCKDKS DEKLLYCENR 2550
SCRRGFKPCY NRRCIPHGKL CDGENDCGDN SDELDCKVST CATVEFRCAD 2600
GTCIPRSARC NQNIDCADAS DEKNCNNTDC THFYKLGVKT TGFIRCNSTS 2650
LCVLPTWICD GSNDCGDYSD ELKCPVQNKH KCEENYFSCP SGRCILNTWI 2700
CDGQKDCEDG RDEFHCDSSC SWNQFACSAQ KCISKHWICD GEDDCGDGLD 2750
ESDSICGAIT CAADMFSCQG SRACVPRHWL CDGERDCPDG SDELSTAGCA 2800
PNNTCDENAF MCHNKVCIPK QFVCDHDDDC GDGSDESPQC GYRQCGTEEF 2850
SCADGRCLLN TQWQCDGDFD CPDHSDEAPL NPKCKSAEQS CNSSFFMCKN 2900
GRCIPSGGLC DNKDDCGDGS DERNCHINEC LSKKVSGCSQ DCQDLPVSYK 2950
CKCWPGFQLK DDGKTCVDID ECSSGFPCSQ QCINTYGTYK CLCTDGYEIQ 3000
PDNPNGCKSL SDEEPFLILA DHHEIRKIST DGSNYTLLKQ GLNNVIAIDF 3050
DYREEFIYWI DSSRPNGSRI NRMCLNGSDI KVVHNTAVPN ALAVDWIGKN 3100
LYWSDTEKRI IEVSKLNGLY PTILVSKRLK FPRDLSLDPQ AGYLYWIDCC 3150
EYPHIGRVGM DGTNQSVVIE TKISRPMALT IDYVNRRLYW ADENHIEFSN 3200
MDGSHRHKVP NQDIPGVIAL TLFEDYIYWT DGKTKSLSRA HKTSGADRLS 3250
LIYSWHAITD IQVYHSYRQP DVSKHLCMIN NGGCSHLCLL APGKTHTCAC 3300
PTNFYLAADN RTCLSNCTAS QFRCKTDKCI PFWWKCDTVD DCGDGSDEPD 3350
DCPEFRCQPG RFQCGTGLCA LPAFICDGEN DCGDNSDELN CDTHVCLSGQ 3400
FKCTKNQKCI PVNLRCNGQD DCGDEEDERD CPENSCSPDY FQCKTTKHCI 3450
SKLWVCDEDP DCADASDEAN CDKKTCGPHE FQCKNNNCIP DHWRCDSQND 3500
CSDNSDEENC KPQTCTLKDF LCANGDCVSS RFWCDGDFDC ADGSDERNCE 3550
TSCSKDQFRC SNGQCIPAKW KCDGHEDCKY GEDEKSCEPA SPTCSSREYI 3600
CASDGCISAS LKCNGEYDCA DGSDEMDCVT ECKEDQFRCK NKAHCIPIRW 3650
LCDGIHDCVD GSDEENCERG GNICRADEFL CNNSLCKLHF WVCDGEDDCG 3700
DNSDEAPDMC VKFLCPSTRP HRCRNNRICL QSEQMCNGID ECGDNSDEDH 3750
CGGKLTYKAR PCKKDEFACS NKKCIPMDLQ CDRLDDCGDG SDEQGCRIAP 3800
TEYTCEDNVN PCGDDAYCNQ IKTSVFCRCK PGFQRNMKNR QCEDLNECLV 3850
FGTCSHQCIN VEGSYKCVCD QNFQERNNTC IAEGSEDQVL YIANDTDILG 3900
FIYPFNYSGD HQQISHIEHN SRITGMDVYY QRDMIIWSTQ FNPGGIFYKR 3950
IHGREKRQAN SGLICPEFKR PRDIAVDWVA GNIYWTDHSR MHWFSYYTTH 4000
WTSLRYSINV GQLNGPNCTR LLTNMAGEPY AIAVNPKRGM MYWTVVGDHS 4050
HIEEAAMDGT LRRILVQKNL QRPTGLAVDY FSERIYWADF ELSIIGSVLY 4100
DGSNSVVSVS SKQGLLHPHR IDIFEDYIYG AGPKNGVFRV QKFGHGSVEY 4150
LALNIDKTKG VLISHRYKQL DLPNPCLDLA CEFLCLLNPS GATCVCPEGK 4200
YLINGTCNDD SLLDDSCKLT CENGGRCILN EKGDLRCHCW PSYSGERCEV 4250
NHCSNYCQNG GTCVPSVLGR PTCSCALGFT GPNCGKTVCE DFCQNGGTCI 4300
VTAGNQPYCH CQPEYTGDRC QYYVCHHYCV NSESCTIGDD GSVECVCPTR 4350
YEGPKCEVDK CVRCHGGHCI INKDSEDIFC NCTNGKIASS CQLCDGYCYN 4400
GGTCQLDPET NVPVCLCSTN WSGTQCERPA PKSSKSDHIS TRSIAIIVPL 4450
VLLVTLITTL VIGLVLCKRK RRTKTIRRQP IINGGINVEI GNPSYNMYEV 4500
DHDHNDGGLL DPGFMIDPTK ARYIGGGPSA FKLPHTAPPI YLNSDLKGPL 4550
TAGPTNYSNP VYAKLYMDGQ NCRNSLGSVD ERKELLPKKI EIGIRETVA 4599
Length:4,599
Mass (Da):515,498
Last modified:January 4, 2005 - v2
Checksum:i98B70555F46CAE66
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481Q → R.
Corresponds to variant rs12990449 [ dbSNP | Ensembl ].
VAR_049759
Natural varianti3140 – 31401Q → R.
Corresponds to variant rs34488772 [ dbSNP | Ensembl ].
VAR_049760
Natural varianti3157 – 31571R → C in NSCLC cells. 1 Publication
VAR_018328
Natural varianti3458 – 34581E → K.
Corresponds to variant rs1878740 [ dbSNP | Ensembl ].
VAR_049761
Natural varianti3734 – 37341Q → K.
Corresponds to variant rs35546150 [ dbSNP | Ensembl ].
VAR_049762
Natural varianti4264 – 42641V → L.
Corresponds to variant rs17386226 [ dbSNP | Ensembl ].
VAR_049763

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti516 – 5161C → Y in AAL38107. 1 Publication
Sequence conflicti1257 – 12571P → S in AAL38108. 1 Publication
Sequence conflicti1571 – 15711E → G in AAL38108. 1 Publication
Sequence conflicti2654 – 26552LP → CQ in AAL38108. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF176832 mRNA. Translation: AAF70379.1.
AF283343 Genomic DNA. No translation available.
AF283342
, AF283327, AF283328, AF283329, AF283330, AF283331, AF283332, AF283333, AF283334, AF283335, AF283336, AF283337, AF283338, AF283339, AF283340, AF283341 Genomic DNA. Translation: AAL38107.1.
AF283374
, AF283344, AF283345, AF283346, AF283347, AF283348, AF283349, AF283350, AF283351, AF283352, AF283353, AF283354, AF283355, AF283356, AF283357, AF283358, AF283359, AF283360, AF283361, AF283362, AF283363, AF283364, AF283366, AF283367, AF283368, AF283369, AF283370, AF283371, AF283372, AF283373 Genomic DNA. Translation: AAL38108.1.
AF283408
, AF283376, AF283377, AF283378, AF283379, AF283380, AF283381, AF283382, AF283383, AF283384, AF283385, AF283386, AF283387, AF283388, AF283389, AF283390, AF283391, AF283392, AF283393, AF283394, AF283395, AF283396, AF283397, AF283398, AF283399, AF283400, AF283401, AF283402, AF283403, AF283404, AF283405, AF283406, AF283407 Genomic DNA. Translation: AAL38109.1.
CCDSiCCDS2182.1.
RefSeqiNP_061027.2. NM_018557.2.
UniGeneiHs.656461.

Genome annotation databases

EnsembliENST00000389484; ENSP00000374135; ENSG00000168702.
GeneIDi53353.
KEGGihsa:53353.
UCSCiuc002tvj.1. human.

Polymorphism databases

DMDMi57015418.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF176832 mRNA. Translation: AAF70379.1 .
AF283343 Genomic DNA. No translation available.
AF283342
, AF283327 , AF283328 , AF283329 , AF283330 , AF283331 , AF283332 , AF283333 , AF283334 , AF283335 , AF283336 , AF283337 , AF283338 , AF283339 , AF283340 , AF283341 Genomic DNA. Translation: AAL38107.1 .
AF283374
, AF283344 , AF283345 , AF283346 , AF283347 , AF283348 , AF283349 , AF283350 , AF283351 , AF283352 , AF283353 , AF283354 , AF283355 , AF283356 , AF283357 , AF283358 , AF283359 , AF283360 , AF283361 , AF283362 , AF283363 , AF283364 , AF283366 , AF283367 , AF283368 , AF283369 , AF283370 , AF283371 , AF283372 , AF283373 Genomic DNA. Translation: AAL38108.1 .
AF283408
, AF283376 , AF283377 , AF283378 , AF283379 , AF283380 , AF283381 , AF283382 , AF283383 , AF283384 , AF283385 , AF283386 , AF283387 , AF283388 , AF283389 , AF283390 , AF283391 , AF283392 , AF283393 , AF283394 , AF283395 , AF283396 , AF283397 , AF283398 , AF283399 , AF283400 , AF283401 , AF283402 , AF283403 , AF283404 , AF283405 , AF283406 , AF283407 Genomic DNA. Translation: AAL38109.1 .
CCDSi CCDS2182.1.
RefSeqi NP_061027.2. NM_018557.2.
UniGenei Hs.656461.

3D structure databases

ProteinModelPortali Q9NZR2.
SMRi Q9NZR2. Positions 32-109, 125-3744, 3765-4441.
ModBasei Search...

Protein-protein interaction databases

BioGridi 119750. 2 interactions.
IntActi Q9NZR2. 3 interactions.
STRINGi 9606.ENSP00000374135.

PTM databases

PhosphoSitei Q9NZR2.

Polymorphism databases

DMDMi 57015418.

Proteomic databases

MaxQBi Q9NZR2.
PaxDbi Q9NZR2.
PRIDEi Q9NZR2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000389484 ; ENSP00000374135 ; ENSG00000168702 .
GeneIDi 53353.
KEGGi hsa:53353.
UCSCi uc002tvj.1. human.

Organism-specific databases

CTDi 53353.
GeneCardsi GC02M141020.
H-InvDBi HIX0017207.
HGNCi HGNC:6693. LRP1B.
MIMi 608766. gene.
neXtProti NX_Q9NZR2.
PharmGKBi PA30451.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG235850.
HOGENOMi HOG000230574.
HOVERGENi HBG006292.
InParanoidi Q9NZR2.
OMAi GSNSCQL.
OrthoDBi EOG790FZT.
PhylomeDBi Q9NZR2.
TreeFami TF315253.

Miscellaneous databases

ChiTaRSi LRP1B. human.
GeneWikii LRP1B.
GenomeRNAii 53353.
NextBioi 56010.
PROi Q9NZR2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NZR2.
Bgeei Q9NZR2.
CleanExi HS_LRP1B.
Genevestigatori Q9NZR2.

Family and domain databases

Gene3Di 2.120.10.30. 8 hits.
4.10.400.10. 31 hits.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view ]
Pfami PF12662. cEGF. 1 hit.
PF00008. EGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00057. Ldl_recept_a. 30 hits.
PF00058. Ldl_recept_b. 12 hits.
[Graphical view ]
PRINTSi PR00261. LDLRECEPTOR.
SMARTi SM00181. EGF. 16 hits.
SM00179. EGF_CA. 4 hits.
SM00192. LDLa. 32 hits.
SM00135. LY. 37 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 6 hits.
SSF57424. SSF57424. 32 hits.
PROSITEi PS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 5 hits.
PS01186. EGF_2. 9 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 3 hits.
PS01209. LDLRA_1. 27 hits.
PS50068. LDLRA_2. 32 hits.
PS51120. LDLRB. 37 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines."
    Liu C.-X., Musco S., Lisitsina N.M., Forgacs E., Minna J.D., Lisitsyn N.A.
    Cancer Res. 60:1961-1967(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT CYS-3157.
    Tissue: Lung cancer.
  2. "Genomic organization of a new candidate tumor suppressor gene, LRP1B."
    Liu C.-X., Musco S., Lisitsina N.M., Yaklichkin S.Y., Lisitsyn N.A.
    Genomics 69:271-274(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-2655 AND 2677-4213.
  3. "The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein."
    Liu C.-X., Li Y., Obermoeller-McCormick L.M., Schwartz A.L., Bu G.
    J. Biol. Chem. 276:28889-28896(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LRPAP1; PLAU; PLAT AND SERPINE1, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLRP1B_HUMAN
AccessioniPrimary (citable) accession number: Q9NZR2
Secondary accession number(s): Q8WY29, Q8WY30, Q8WY31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 4, 2005
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene is preferentially inactivated in one histological type of lung cancer (non-small cell lung cancer (NSCLC)). May thus play an important role in tumorigenesis of NSCLCs.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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