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Protein

Tropomodulin-2

Gene

TMOD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomodulin-2
Alternative name(s):
Neuronal tropomodulin
Short name:
N-Tmod
Gene namesi
Name:TMOD2
Synonyms:NTMOD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000128872.9
HGNCiHGNC:11872 TMOD2
MIMi602928 gene
neXtProtiNX_Q9NZR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi29767
OpenTargetsiENSG00000128872
PharmGKBiPA36573

Polymorphism and mutation databases

BioMutaiTMOD2
DMDMi23396886

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861311 – 351Tropomodulin-2Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NZR1
MaxQBiQ9NZR1
PaxDbiQ9NZR1
PeptideAtlasiQ9NZR1
PRIDEiQ9NZR1

2D gel databases

UCD-2DPAGEiQ9NZR1

PTM databases

iPTMnetiQ9NZR1
PhosphoSitePlusiQ9NZR1

Expressioni

Tissue specificityi

Neuronal-tissue specific.1 Publication

Gene expression databases

BgeeiENSG00000128872
CleanExiHS_TMOD2
ExpressionAtlasiQ9NZR1 baseline and differential
GenevisibleiQ9NZR1 HS

Organism-specific databases

HPAiHPA041365

Interactioni

Subunit structurei

Binds to the N-terminus of tropomyosin and to actin.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi11890030 interactors.
STRINGi9606.ENSP00000249700

Structurei

3D structure databases

ProteinModelPortaliQ9NZR1
SMRiQ9NZR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tropomodulin family.Curated

Phylogenomic databases

eggNOGiKOG3735 Eukaryota
ENOG410YAHM LUCA
GeneTreeiENSGT00760000119226
HOGENOMiHOG000261624
HOVERGENiHBG056172
InParanoidiQ9NZR1
KOiK10370
OMAiTHVKTFS
OrthoDBiEOG091G0C3H
PhylomeDBiQ9NZR1
TreeFamiTF315841

Family and domain databases

Gene3Di3.80.10.101 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR004934 TMOD
IPR030130 TMOD2
PANTHERiPTHR10901 PTHR10901, 1 hit
PTHR10901:SF15 PTHR10901:SF15, 1 hit
PfamiView protein in Pfam
PF03250 Tropomodulin, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NZR1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPFQKELE KYKNIDEDEL LGKLSEEELK QLENVLDDLD PESAMLPAGF
60 70 80 90 100
RQKDQTQKAA TGPFDREHLL MYLEKEALEQ KDREDFVPFT GEKKGRVFIP
110 120 130 140 150
KEKPIETRKE EKVTLDPELE EALASASDTE LYDLAAVLGV HNLLNNPKFD
160 170 180 190 200
EETANNKGGK GPVRNVVKGE KVKPVFEEPP NPTNVEISLQ QMKANDPSLQ
210 220 230 240 250
EVNLNNIKNI PIPTLREFAK ALETNTHVKK FSLAATRSND PVAIAFADML
260 270 280 290 300
KVNKTLTSLN IESNFITGTG ILALVEALKE NDTLTEIKID NQRQQLGTAV
310 320 330 340 350
EMEIAQMLEE NSRILKFGYQ FTKQGPRTRV AAAITKNNDL VRKKRVEADR

R
Length:351
Mass (Da):39,595
Last modified:October 1, 2000 - v1
Checksum:i547004595FCD6385
GO
Isoform 2 (identifier: Q9NZR1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-244: Missing.

Show »
Length:315
Mass (Da):35,648
Checksum:iEA9F902EA74B4ADD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti284L → M in BAG57227 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05239963P → A. Corresponds to variant dbSNP:rs34791185Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041506209 – 244Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177169 mRNA Translation: AAF31668.1
AK293823 mRNA Translation: BAG57227.1
AC026770 Genomic DNA No translation available.
AC090971 Genomic DNA No translation available.
BC064961 mRNA Translation: AAH64961.1
CCDSiCCDS10144.1 [Q9NZR1-1]
CCDS45260.1 [Q9NZR1-2]
RefSeqiNP_001136357.1, NM_001142885.1 [Q9NZR1-2]
NP_055363.1, NM_014548.3 [Q9NZR1-1]
UniGeneiHs.513734

Genome annotation databases

EnsembliENST00000249700; ENSP00000249700; ENSG00000128872 [Q9NZR1-1]
ENST00000435126; ENSP00000404590; ENSG00000128872 [Q9NZR1-2]
GeneIDi29767
KEGGihsa:29767
UCSCiuc002abk.4 human [Q9NZR1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTMOD2_HUMAN
AccessioniPrimary (citable) accession number: Q9NZR1
Secondary accession number(s): B4DEW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: February 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome