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Protein

Tropomodulin-4

Gene

TMOD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.

GO - Molecular functioni

GO - Biological processi

  • actin filament organization Source: GO_Central
  • muscle contraction Source: ProtInc
  • myofibril assembly Source: GO_Central
  • pointed-end actin filament capping Source: InterPro

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomodulin-4
Alternative name(s):
Skeletal muscle tropomodulin
Short name:
Sk-Tmod
Gene namesi
Name:TMOD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163157.14.
HGNCiHGNC:11874. TMOD4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi29765.
OpenTargetsiENSG00000163157.
PharmGKBiPA36575.

Polymorphism and mutation databases

BioMutaiTMOD4.
DMDMi23396885.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861361 – 345Tropomodulin-4Add BLAST345

Proteomic databases

PaxDbiQ9NZQ9.
PeptideAtlasiQ9NZQ9.
PRIDEiQ9NZQ9.

PTM databases

iPTMnetiQ9NZQ9.
PhosphoSitePlusiQ9NZQ9.

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000163157.
CleanExiHS_TMOD4.
ExpressionAtlasiQ9NZQ9. baseline.
GenevisibleiQ9NZQ9. HS.

Organism-specific databases

HPAiHPA028203.

Interactioni

Subunit structurei

Binds to the N-terminus of tropomyosin and to actin.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118898. 24 interactors.
IntActiQ9NZQ9. 4 interactors.
STRINGi9606.ENSP00000295314.

Structurei

3D structure databases

ProteinModelPortaliQ9NZQ9.
SMRiQ9NZQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tropomodulin family.Curated

Phylogenomic databases

eggNOGiKOG3735. Eukaryota.
ENOG410YAHM. LUCA.
GeneTreeiENSGT00760000119226.
HOGENOMiHOG000261624.
HOVERGENiHBG056172.
InParanoidiQ9NZQ9.
KOiK10370.
OMAiTNTYVRS.
OrthoDBiEOG091G0C3H.
PhylomeDBiQ9NZQ9.
TreeFamiTF315841.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR032675. LRR_dom_sf.
IPR004934. TMOD.
IPR030129. TMOD4.
PANTHERiPTHR10901. PTHR10901. 1 hit.
PTHR10901:SF9. PTHR10901:SF9. 1 hit.
PfamiView protein in Pfam
PF03250. Tropomodulin. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NZQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSYQKELEK YRDIDEDEIL RTLSPEELEQ LDCELQEMDP ENMLLPAGLR
60 70 80 90 100
QRDQTKKSPT GPLDREALLQ YLEQQALEVK ERDDLVPFTG EKKGKPYIQP
110 120 130 140 150
KREIPAEEQI TLEPELEEAL AHATDAEMCD IAAILDMYTL MSNKQYYDAL
160 170 180 190 200
CSGEICNTEG ISSVVQPDKY KPVPDEPPNP TNIEEILKRV RSNDKELEEV
210 220 230 240 250
NLNNIQDIPI PMLSELCEAM KANTYVRSFS LVATRSGDPI ANAVADMLRE
260 270 280 290 300
NRSLQSLNIE SNFISSTGLM AVLKAVRENA TLTELRVDNQ RQWPGDAVEM
310 320 330 340
EMATVLEQCP SIVRFGYHFT QQGPRARAAQ AMTRNNELRR QQKKR
Length:345
Mass (Da):39,335
Last modified:October 1, 2000 - v1
Checksum:i3ACE2692EF52E2CB
GO
Isoform 2 (identifier: Q9NZQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-163: Missing.

Note: No experimental confirmation available.
Show »
Length:276
Mass (Da):31,643
Checksum:i9A57028508E4F8D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti283T → I in AAF01277 (PubMed:10497209).Curated1
Sequence conflicti309C → R in AAH17810 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052400336N → S. Corresponds to variant dbSNP:rs11800088Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05686595 – 163Missing in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF165217 mRNA. Translation: AAF01277.1.
AF177173 mRNA. Translation: AAF31672.1.
AF321183 Genomic DNA. Translation: AAK06765.1.
AF393375 Genomic DNA. Translation: AAM73676.1.
AK300675 mRNA. Translation: BAH13325.1.
AL592424 Genomic DNA. Translation: CAI16383.1.
CH471121 Genomic DNA. Translation: EAW53465.1.
BC017810 mRNA. Translation: AAH17810.1.
CCDSiCCDS988.1. [Q9NZQ9-1]
RefSeqiNP_037485.2. NM_013353.2. [Q9NZQ9-1]
XP_011507751.1. XM_011509449.1. [Q9NZQ9-1]
XP_016856578.1. XM_017001089.1. [Q9NZQ9-1]
UniGeneiHs.709681.

Genome annotation databases

EnsembliENST00000295314; ENSP00000295314; ENSG00000163157. [Q9NZQ9-1]
GeneIDi29765.
KEGGihsa:29765.
UCSCiuc001exc.5. human. [Q9NZQ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTMOD4_HUMAN
AccessioniPrimary (citable) accession number: Q9NZQ9
Secondary accession number(s): B7Z6N9
, Q5JR83, Q8WVL3, Q9UKH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families