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Q9NZQ8

- TRPM5_HUMAN

UniProt

Q9NZQ8 - TRPM5_HUMAN

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Protein

Transient receptor potential cation channel subfamily M member 5

Gene

TRPM5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Voltage-modulated Ca2+-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na+, K+ and Cs+ ions equally well. Activated directly by increases in intracellular Ca2+, but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca2+. Also activated by a fast intracellular Ca2+ increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.1 Publication

GO - Molecular functioni

  1. calcium activated cation channel activity Source: Ensembl
  2. ion channel activity Source: ProtInc
  3. potassium channel activity Source: Ensembl
  4. sodium channel activity Source: Ensembl
  5. voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

  1. calcium ion transmembrane transport Source: Reactome
  2. ion transmembrane transport Source: Reactome
  3. sensory perception of taste Source: InterPro
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor, Voltage-gated channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_169333. TRP channels.

Protein family/group databases

TCDBi1.A.4.5.3. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 5
Alternative name(s):
Long transient receptor potential channel 5
Short name:
LTrpC-5
Short name:
LTrpC5
MLSN1- and TRP-related gene 1 protein
Gene namesi
Name:TRPM5Imported
Synonyms:LTRPC5Imported, MTR1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14323. TRPM5.

Subcellular locationi

Cell membrane Sequence Analysis; Multi-pass membrane protein By similaritySequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11651165Transient receptor potential cation channel subfamily M member 5PRO_0000328933Add
BLAST

Proteomic databases

PaxDbiQ9NZQ8.
PRIDEiQ9NZQ8.

PTM databases

PhosphoSiteiQ9NZQ8.

Expressioni

Tissue specificityi

Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression.1 Publication

Gene expression databases

BgeeiQ9NZQ8.
CleanExiHS_TRPM5.
ExpressionAtlasiQ9NZQ8. baseline and differential.
GenevestigatoriQ9NZQ8.

Organism-specific databases

HPAiHPA042115.
HPA043315.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000155858.

Structurei

3D structure databases

ProteinModelPortaliQ9NZQ8.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 646646CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini668 – 73366ExtracellularSequence AnalysisAdd
BLAST
Topological domaini755 – 81157CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini833 – 8353ExtracellularSequence Analysis
Topological domaini857 – 87216CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini894 – 95461ExtracellularSequence AnalysisAdd
BLAST
Topological domaini976 – 1165190CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei647 – 66721HelicalSequence AnalysisAdd
BLAST
Transmembranei734 – 75421HelicalSequence AnalysisAdd
BLAST
Transmembranei812 – 83221HelicalSequence AnalysisAdd
BLAST
Transmembranei836 – 85621HelicalSequence AnalysisAdd
BLAST
Transmembranei873 – 89321HelicalSequence AnalysisAdd
BLAST
Transmembranei955 – 97521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili553 – 58129Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253824.
GeneTreeiENSGT00760000119127.
HOVERGENiHBG108337.
InParanoidiQ9NZQ8.
KOiK04980.
OrthoDBiEOG725DH1.
PhylomeDBiQ9NZQ8.
TreeFamiTF314204.

Family and domain databases

InterProiIPR029577. TRPM5.
[Graphical view]
PANTHERiPTHR13800:SF5. PTHR13800:SF5. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 13 Publications (identifier: Q9NZQ8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQDVQGPRPG SPGDAEDRRE LGLHRGEVNF GGSGKKRGKF VRVPSGVAPS
60 70 80 90 100
VLFDLLLAEW HLPAPNLVVS LVGEEQPFAM KSWLRDVLRK GLVKAAQSTG
110 120 130 140 150
AWILTSALRV GLARHVGQAV RDHSLASTST KVRVVAVGMA SLGRVLHRRI
160 170 180 190 200
LEEAQEDFPV HYPEDDGGSQ GPLCSLDSNL SHFILVEPGP PGKGDGLTEL
210 220 230 240 250
RLRLEKHISE QRAGYGGTGS IEIPVLCLLV NGDPNTLERI SRAVEQAAPW
260 270 280 290 300
LILVGSGGIA DVLAALVNQP HLLVPKVAEK QFKEKFPSKH FSWEDIVRWT
310 320 330 340 350
KLLQNITSHQ HLLTVYDFEQ EGSEELDTVI LKALVKACKS HSQEPQDYLD
360 370 380 390 400
ELKLAVAWDR VDIAKSEIFN GDVEWKSCDL EEVMVDALVS NKPEFVRLFV
410 420 430 440 450
DNGADVADFL TYGRLQELYR SVSRKSLLFD LLQRKQEEAR LTLAGLGTQQ
460 470 480 490 500
AREPPAGPPA FSLHEVSRVL KDFLQDACRG FYQDGRPGDR RRAEKGPAKR
510 520 530 540 550
PTGQKWLLDL NQKSENPWRD LFLWAVLQNR HEMATYFWAM GQEGVAAALA
560 570 580 590 600
ACKILKEMSH LETEAEAARA TREAKYERLA LDLFSECYSN SEARAFALLV
610 620 630 640 650
RRNRCWSKTT CLHLATEADA KAFFAHDGVQ AFLTRIWWGD MAAGTPILRL
660 670 680 690 700
LGAFLCPALV YTNLITFSEE APLRTGLEDL QDLDSLDTEK SPLYGLQSRV
710 720 730 740 750
EELVEAPRAQ GDRGPRAVFL LTRWRKFWGA PVTVFLGNVV MYFAFLFLFT
760 770 780 790 800
YVLLVDFRPP PQGPSGPEVT LYFWVFTLVL EEIRQGFFTD EDTHLVKKFT
810 820 830 840 850
LYVGDNWNKC DMVAIFLFIV GVTCRMLPSA FEAGRTVLAM DFMVFTLRLI
860 870 880 890 900
HIFAIHKQLG PKIIVVERMM KDVFFFLFFL SVWLVAYGVT TQALLHPHDG
910 920 930 940 950
RLEWIFRRVL YRPYLQIFGQ IPLDEIDEAR VNCSTHPLLL EDSPSCPSLY
960 970 980 990 1000
ANWLVILLLV TFLLVTNVLL MNLLIAMFSY TFQVVQGNAD MFWKFQRYNL
1010 1020 1030 1040 1050
IVEYHERPAL APPFILLSHL SLTLRRVFKK EAEHKREHLE RDLPDPLDQK
1060 1070 1080 1090 1100
VVTWETVQKE NFLSKMEKRR RDSEGEVLRK TAHRVDFIAK YLGGLREQEK
1110 1120 1130 1140 1150
RIKCLESQIN YCSVLVSSVA DVLAQGGGPR SSQHCGEGSQ LVAADHRGGL
1160
DGWEQPGAGQ PPSDT
Length:1,165
Mass (Da):131,451
Last modified:October 1, 2000 - v1
Checksum:iC4AD5BAA866BE73B
GO
Isoform 21 Publication (identifier: Q9NZQ8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-155: Q → QVH

Show »
Length:1,167
Mass (Da):131,688
Checksum:i868C5AB7095124A1
GO
Isoform 31 Publication (identifier: Q9NZQ8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     870-872: MKD → KPV
     873-1165: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:872
Mass (Da):97,738
Checksum:i6C2D1E4D16392D00
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti235 – 2351N → S.
Corresponds to variant rs886277 [ dbSNP | Ensembl ].
VAR_052377
Natural varianti254 – 2541V → A.1 Publication
Corresponds to variant rs3986599 [ dbSNP | Ensembl ].
VAR_042578
Natural varianti335 – 3351V → L.
Corresponds to variant rs34350821 [ dbSNP | Ensembl ].
VAR_052378
Natural varianti456 – 4561A → T.
Corresponds to variant rs34551253 [ dbSNP | Ensembl ].
VAR_052379
Natural varianti578 – 5781R → Q.
Corresponds to variant rs4929982 [ dbSNP | Ensembl ].
VAR_059836

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei155 – 1551Q → QVH in isoform 2. 1 PublicationVSP_052741
Alternative sequencei870 – 8723MKD → KPV in isoform 3. 1 PublicationVSP_052742
Alternative sequencei873 – 1165293Missing in isoform 3. 1 PublicationVSP_052743Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF177473 mRNA. Translation: AAF26288.1.
AC124057 Genomic DNA. No translation available.
BC093787 mRNA. Translation: AAH93787.1.
BC093789 mRNA. Translation: AAH93789.1.
AJ270996 mRNA. Translation: CAB66342.1.
CCDSiCCDS31340.1. [Q9NZQ8-1]
RefSeqiNP_055370.1. NM_014555.3. [Q9NZQ8-1]
UniGeneiHs.272287.

Genome annotation databases

EnsembliENST00000155858; ENSP00000155858; ENSG00000070985. [Q9NZQ8-1]
ENST00000533881; ENSP00000434383; ENSG00000070985.
GeneIDi29850.
KEGGihsa:29850.
UCSCiuc001lwm.4. human. [Q9NZQ8-1]
uc009ydn.3. human. [Q9NZQ8-2]

Polymorphism databases

DMDMi74753086.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF177473 mRNA. Translation: AAF26288.1 .
AC124057 Genomic DNA. No translation available.
BC093787 mRNA. Translation: AAH93787.1 .
BC093789 mRNA. Translation: AAH93789.1 .
AJ270996 mRNA. Translation: CAB66342.1 .
CCDSi CCDS31340.1. [Q9NZQ8-1 ]
RefSeqi NP_055370.1. NM_014555.3. [Q9NZQ8-1 ]
UniGenei Hs.272287.

3D structure databases

ProteinModelPortali Q9NZQ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000155858.

Chemistry

ChEMBLi CHEMBL1628468.
GuidetoPHARMACOLOGYi 497.

Protein family/group databases

TCDBi 1.A.4.5.3. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

PhosphoSitei Q9NZQ8.

Polymorphism databases

DMDMi 74753086.

Proteomic databases

PaxDbi Q9NZQ8.
PRIDEi Q9NZQ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000155858 ; ENSP00000155858 ; ENSG00000070985 . [Q9NZQ8-1 ]
ENST00000533881 ; ENSP00000434383 ; ENSG00000070985 .
GeneIDi 29850.
KEGGi hsa:29850.
UCSCi uc001lwm.4. human. [Q9NZQ8-1 ]
uc009ydn.3. human. [Q9NZQ8-2 ]

Organism-specific databases

CTDi 29850.
GeneCardsi GC11M002425.
HGNCi HGNC:14323. TRPM5.
HPAi HPA042115.
HPA043315.
MIMi 604600. gene.
neXtProti NX_Q9NZQ8.
PharmGKBi PA37869.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253824.
GeneTreei ENSGT00760000119127.
HOVERGENi HBG108337.
InParanoidi Q9NZQ8.
KOi K04980.
OrthoDBi EOG725DH1.
PhylomeDBi Q9NZQ8.
TreeFami TF314204.

Enzyme and pathway databases

Reactomei REACT_169333. TRP channels.

Miscellaneous databases

GeneWikii TRPM5.
GenomeRNAii 29850.
NextBioi 52387.
PROi Q9NZQ8.
SOURCEi Search...

Gene expression databases

Bgeei Q9NZQ8.
CleanExi HS_TRPM5.
ExpressionAtlasi Q9NZQ8. baseline and differential.
Genevestigatori Q9NZQ8.

Family and domain databases

InterProi IPR029577. TRPM5.
[Graphical view ]
PANTHERi PTHR13800:SF5. PTHR13800:SF5. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression."
    Prawitt D., Enklaar T., Klemm G., Gaertner B., Spangenberg C., Winterpacht A., Higgins M., Pelletier J., Zabel B.
    Hum. Mol. Genet. 9:203-216(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING (ISOFORM 3), TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-254.
  4. "Comparative sequence analysis and characterization of the imprinting cluster on the human chromosome 11p15.5 and distal mouse chromosome 7."
    Paulsen M., El-Maarri O., Engemann S., Franck O., Stroedicke M., Davies K.R., Bowden L.M., Reinhardt R., Reik W., Harteneck C., Walter J.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-1165 (ISOFORM 2).
  5. "TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i."
    Prawitt D., Monteilh-Zoller M.K., Brixel L., Spangenberg C., Zabel B., Fleig A., Penner R.
    Proc. Natl. Acad. Sci. U.S.A. 100:15166-15171(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTRPM5_HUMAN
AccessioniPrimary (citable) accession number: Q9NZQ8
Secondary accession number(s): A6NHS0, Q52LU2, Q9NY34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3