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Q9NZQ8

- TRPM5_HUMAN

UniProt

Q9NZQ8 - TRPM5_HUMAN

Protein

Transient receptor potential cation channel subfamily M member 5

Gene

TRPM5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Voltage-modulated Ca2+-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na+, K+ and Cs+ ions equally well. Activated directly by increases in intracellular Ca2+, but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca2+. Also activated by a fast intracellular Ca2+ increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.1 Publication

    GO - Molecular functioni

    1. calcium activated cation channel activity Source: Ensembl
    2. ion channel activity Source: ProtInc
    3. potassium channel activity Source: Ensembl
    4. sodium channel activity Source: Ensembl
    5. voltage-gated ion channel activity Source: UniProtKB-KW

    GO - Biological processi

    1. calcium ion transmembrane transport Source: Reactome
    2. ion transmembrane transport Source: Reactome
    3. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_169333. TRP channels.

    Protein family/group databases

    TCDBi1.A.4.5.3. the transient receptor potential ca(2+) channel (trp-cc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transient receptor potential cation channel subfamily M member 5
    Alternative name(s):
    Long transient receptor potential channel 5
    Short name:
    LTrpC-5
    Short name:
    LTrpC5
    MLSN1- and TRP-related gene 1 protein
    Gene namesi
    Name:TRPM5Imported
    Synonyms:LTRPC5Imported, MTR1Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14323. TRPM5.

    Subcellular locationi

    Cell membrane Sequence Analysis; Multi-pass membrane protein By similaritySequence Analysis

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37869.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11651165Transient receptor potential cation channel subfamily M member 5PRO_0000328933Add
    BLAST

    Proteomic databases

    PaxDbiQ9NZQ8.
    PRIDEiQ9NZQ8.

    PTM databases

    PhosphoSiteiQ9NZQ8.

    Expressioni

    Tissue specificityi

    Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression.1 Publication

    Gene expression databases

    ArrayExpressiQ9NZQ8.
    BgeeiQ9NZQ8.
    CleanExiHS_TRPM5.
    GenevestigatoriQ9NZQ8.

    Organism-specific databases

    HPAiHPA042115.
    HPA043315.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000155858.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NZQ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 646646CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini668 – 73366ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini755 – 81157CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini833 – 8353ExtracellularSequence Analysis
    Topological domaini857 – 87216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini894 – 95461ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini976 – 1165190CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei647 – 66721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei734 – 75421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei812 – 83221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei836 – 85621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei873 – 89321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei955 – 97521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili553 – 58129Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253824.
    HOVERGENiHBG108337.
    InParanoidiQ9NZQ8.
    KOiK04980.
    OrthoDBiEOG725DH1.
    PhylomeDBiQ9NZQ8.
    TreeFamiTF314204.

    Family and domain databases

    InterProiIPR029577. TRPM5.
    [Graphical view]
    PANTHERiPTHR13800:SF5. PTHR13800:SF5. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 13 Publications (identifier: Q9NZQ8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQDVQGPRPG SPGDAEDRRE LGLHRGEVNF GGSGKKRGKF VRVPSGVAPS     50
    VLFDLLLAEW HLPAPNLVVS LVGEEQPFAM KSWLRDVLRK GLVKAAQSTG 100
    AWILTSALRV GLARHVGQAV RDHSLASTST KVRVVAVGMA SLGRVLHRRI 150
    LEEAQEDFPV HYPEDDGGSQ GPLCSLDSNL SHFILVEPGP PGKGDGLTEL 200
    RLRLEKHISE QRAGYGGTGS IEIPVLCLLV NGDPNTLERI SRAVEQAAPW 250
    LILVGSGGIA DVLAALVNQP HLLVPKVAEK QFKEKFPSKH FSWEDIVRWT 300
    KLLQNITSHQ HLLTVYDFEQ EGSEELDTVI LKALVKACKS HSQEPQDYLD 350
    ELKLAVAWDR VDIAKSEIFN GDVEWKSCDL EEVMVDALVS NKPEFVRLFV 400
    DNGADVADFL TYGRLQELYR SVSRKSLLFD LLQRKQEEAR LTLAGLGTQQ 450
    AREPPAGPPA FSLHEVSRVL KDFLQDACRG FYQDGRPGDR RRAEKGPAKR 500
    PTGQKWLLDL NQKSENPWRD LFLWAVLQNR HEMATYFWAM GQEGVAAALA 550
    ACKILKEMSH LETEAEAARA TREAKYERLA LDLFSECYSN SEARAFALLV 600
    RRNRCWSKTT CLHLATEADA KAFFAHDGVQ AFLTRIWWGD MAAGTPILRL 650
    LGAFLCPALV YTNLITFSEE APLRTGLEDL QDLDSLDTEK SPLYGLQSRV 700
    EELVEAPRAQ GDRGPRAVFL LTRWRKFWGA PVTVFLGNVV MYFAFLFLFT 750
    YVLLVDFRPP PQGPSGPEVT LYFWVFTLVL EEIRQGFFTD EDTHLVKKFT 800
    LYVGDNWNKC DMVAIFLFIV GVTCRMLPSA FEAGRTVLAM DFMVFTLRLI 850
    HIFAIHKQLG PKIIVVERMM KDVFFFLFFL SVWLVAYGVT TQALLHPHDG 900
    RLEWIFRRVL YRPYLQIFGQ IPLDEIDEAR VNCSTHPLLL EDSPSCPSLY 950
    ANWLVILLLV TFLLVTNVLL MNLLIAMFSY TFQVVQGNAD MFWKFQRYNL 1000
    IVEYHERPAL APPFILLSHL SLTLRRVFKK EAEHKREHLE RDLPDPLDQK 1050
    VVTWETVQKE NFLSKMEKRR RDSEGEVLRK TAHRVDFIAK YLGGLREQEK 1100
    RIKCLESQIN YCSVLVSSVA DVLAQGGGPR SSQHCGEGSQ LVAADHRGGL 1150
    DGWEQPGAGQ PPSDT 1165
    Length:1,165
    Mass (Da):131,451
    Last modified:October 1, 2000 - v1
    Checksum:iC4AD5BAA866BE73B
    GO
    Isoform 21 Publication (identifier: Q9NZQ8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         155-155: Q → QVH

    Show »
    Length:1,167
    Mass (Da):131,688
    Checksum:i868C5AB7095124A1
    GO
    Isoform 31 Publication (identifier: Q9NZQ8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         870-872: MKD → KPV
         873-1165: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:872
    Mass (Da):97,738
    Checksum:i6C2D1E4D16392D00
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti235 – 2351N → S.
    Corresponds to variant rs886277 [ dbSNP | Ensembl ].
    VAR_052377
    Natural varianti254 – 2541V → A.1 Publication
    Corresponds to variant rs3986599 [ dbSNP | Ensembl ].
    VAR_042578
    Natural varianti335 – 3351V → L.
    Corresponds to variant rs34350821 [ dbSNP | Ensembl ].
    VAR_052378
    Natural varianti456 – 4561A → T.
    Corresponds to variant rs34551253 [ dbSNP | Ensembl ].
    VAR_052379
    Natural varianti578 – 5781R → Q.
    Corresponds to variant rs4929982 [ dbSNP | Ensembl ].
    VAR_059836

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei155 – 1551Q → QVH in isoform 2. 1 PublicationVSP_052741
    Alternative sequencei870 – 8723MKD → KPV in isoform 3. 1 PublicationVSP_052742
    Alternative sequencei873 – 1165293Missing in isoform 3. 1 PublicationVSP_052743Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF177473 mRNA. Translation: AAF26288.1.
    AC124057 Genomic DNA. No translation available.
    BC093787 mRNA. Translation: AAH93787.1.
    BC093789 mRNA. Translation: AAH93789.1.
    AJ270996 mRNA. Translation: CAB66342.1.
    CCDSiCCDS31340.1. [Q9NZQ8-1]
    RefSeqiNP_055370.1. NM_014555.3. [Q9NZQ8-1]
    UniGeneiHs.272287.

    Genome annotation databases

    EnsembliENST00000155858; ENSP00000155858; ENSG00000070985. [Q9NZQ8-1]
    ENST00000533881; ENSP00000434383; ENSG00000070985.
    GeneIDi29850.
    KEGGihsa:29850.
    UCSCiuc001lwm.4. human. [Q9NZQ8-1]
    uc009ydn.3. human. [Q9NZQ8-2]

    Polymorphism databases

    DMDMi74753086.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF177473 mRNA. Translation: AAF26288.1 .
    AC124057 Genomic DNA. No translation available.
    BC093787 mRNA. Translation: AAH93787.1 .
    BC093789 mRNA. Translation: AAH93789.1 .
    AJ270996 mRNA. Translation: CAB66342.1 .
    CCDSi CCDS31340.1. [Q9NZQ8-1 ]
    RefSeqi NP_055370.1. NM_014555.3. [Q9NZQ8-1 ]
    UniGenei Hs.272287.

    3D structure databases

    ProteinModelPortali Q9NZQ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000155858.

    Chemistry

    ChEMBLi CHEMBL1628468.
    GuidetoPHARMACOLOGYi 497.

    Protein family/group databases

    TCDBi 1.A.4.5.3. the transient receptor potential ca(2+) channel (trp-cc) family.

    PTM databases

    PhosphoSitei Q9NZQ8.

    Polymorphism databases

    DMDMi 74753086.

    Proteomic databases

    PaxDbi Q9NZQ8.
    PRIDEi Q9NZQ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000155858 ; ENSP00000155858 ; ENSG00000070985 . [Q9NZQ8-1 ]
    ENST00000533881 ; ENSP00000434383 ; ENSG00000070985 .
    GeneIDi 29850.
    KEGGi hsa:29850.
    UCSCi uc001lwm.4. human. [Q9NZQ8-1 ]
    uc009ydn.3. human. [Q9NZQ8-2 ]

    Organism-specific databases

    CTDi 29850.
    GeneCardsi GC11M002425.
    HGNCi HGNC:14323. TRPM5.
    HPAi HPA042115.
    HPA043315.
    MIMi 604600. gene.
    neXtProti NX_Q9NZQ8.
    PharmGKBi PA37869.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253824.
    HOVERGENi HBG108337.
    InParanoidi Q9NZQ8.
    KOi K04980.
    OrthoDBi EOG725DH1.
    PhylomeDBi Q9NZQ8.
    TreeFami TF314204.

    Enzyme and pathway databases

    Reactomei REACT_169333. TRP channels.

    Miscellaneous databases

    GeneWikii TRPM5.
    GenomeRNAii 29850.
    NextBioi 52387.
    PROi Q9NZQ8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NZQ8.
    Bgeei Q9NZQ8.
    CleanExi HS_TRPM5.
    Genevestigatori Q9NZQ8.

    Family and domain databases

    InterProi IPR029577. TRPM5.
    [Graphical view ]
    PANTHERi PTHR13800:SF5. PTHR13800:SF5. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression."
      Prawitt D., Enklaar T., Klemm G., Gaertner B., Spangenberg C., Winterpacht A., Higgins M., Pelletier J., Zabel B.
      Hum. Mol. Genet. 9:203-216(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING (ISOFORM 3), TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-254.
    4. "Comparative sequence analysis and characterization of the imprinting cluster on the human chromosome 11p15.5 and distal mouse chromosome 7."
      Paulsen M., El-Maarri O., Engemann S., Franck O., Stroedicke M., Davies K.R., Bowden L.M., Reinhardt R., Reik W., Harteneck C., Walter J.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-1165 (ISOFORM 2).
    5. "TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i."
      Prawitt D., Monteilh-Zoller M.K., Brixel L., Spangenberg C., Zabel B., Fleig A., Penner R.
      Proc. Natl. Acad. Sci. U.S.A. 100:15166-15171(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiTRPM5_HUMAN
    AccessioniPrimary (citable) accession number: Q9NZQ8
    Secondary accession number(s): A6NHS0, Q52LU2, Q9NY34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3