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Q9NZQ7

- PD1L1_HUMAN

UniProt

Q9NZQ7 - PD1L1_HUMAN

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Protein
Programmed cell death 1 ligand 1
Gene
CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.2 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. T cell costimulation Source: UniProtKB
  2. cell surface receptor signaling pathway Source: UniProtKB
  3. immune response Source: UniProtKB
  4. negative regulation of T cell proliferation Source: Ensembl
  5. positive regulation of T cell proliferation Source: UniProtKB
  6. positive regulation of interleukin-10 secretion Source: UniProtKB
  7. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_19324. PD-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death 1 ligand 1
Short name:
PD-L1
Short name:
PDCD1 ligand 1
Short name:
Programmed death ligand 1
Alternative name(s):
B7 homolog 1
Short name:
B7-H1
CD_antigen: CD274
Gene namesi
Name:CD274
Synonyms:B7H1, PDCD1L1, PDCD1LG1, PDL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:17635. CD274.

Subcellular locationi

Isoform 1 : Cell membrane; Single-pass type I membrane protein 1 Publication
Isoform 2 : Endomembrane system; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 238220Extracellular Reviewed prediction
Add
BLAST
Transmembranei239 – 25921Helical; Reviewed prediction
Add
BLAST
Topological domaini260 – 29031Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endomembrane system Source: UniProtKB-SubCell
  2. external side of plasma membrane Source: Ensembl
  3. extracellular vesicular exosome Source: UniProtKB
  4. integral component of membrane Source: UniProtKB-KW
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134915280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 290272Programmed cell death 1 ligand 1
PRO_0000014553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi40 ↔ 1141 Publication
Disulfide bondi155 ↔ 2091 Publication
Glycosylationi192 – 1921N-linked (GlcNAc...)1 Publication
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi219 – 2191N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9NZQ7.
PaxDbiQ9NZQ7.
PRIDEiQ9NZQ7.

PTM databases

PhosphoSiteiQ9NZQ7.

Expressioni

Tissue specificityi

Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.2 Publications

Inductioni

Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. Up-regulated in B-cells activated by surface Ig cross-linking.2 Publications

Gene expression databases

ArrayExpressiQ9NZQ7.
BgeeiQ9NZQ7.
CleanExiHS_CD274.
GenevestigatoriQ9NZQ7.

Organism-specific databases

HPAiCAB030018.

Interactioni

Subunit structurei

Interacts with PDCD1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CD80P336812EBI-4314282,EBI-1031024
PDCD1Q151162EBI-4314282,EBI-4314328

Protein-protein interaction databases

BioGridi118891. 4 interactions.
DIPiDIP-29731N.
IntActiQ9NZQ7. 2 interactions.
STRINGi9606.ENSP00000370989.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 316
Beta strandi36 – 416
Turni50 – 523
Beta strandi54 – 596
Beta strandi62 – 687
Beta strandi74 – 774
Helixi79 – 813
Beta strandi82 – 876
Helixi89 – 924
Turni93 – 953
Beta strandi96 – 1038
Helixi106 – 1083
Beta strandi110 – 13223
Beta strandi138 – 1458
Turni146 – 1494
Beta strandi150 – 16112
Beta strandi164 – 1696
Beta strandi178 – 1836
Beta strandi185 – 1873
Beta strandi191 – 20010
Beta strandi206 – 2138
Turni214 – 2174
Beta strandi218 – 2258

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BIKX-ray2.65A18-239[»]
3BISX-ray2.64A/B18-239[»]
3FN3X-ray2.70A/B19-238[»]
3SBWX-ray2.28C19-239[»]
ProteinModelPortaliQ9NZQ7.
SMRiQ9NZQ7. Positions 19-230.

Miscellaneous databases

EvolutionaryTraceiQ9NZQ7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 127109Ig-like V-type
Add
BLAST
Domaini133 – 22593Ig-like C2-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43849.
HOGENOMiHOG000059625.
HOVERGENiHBG082112.
InParanoidiQ9NZQ7.
KOiK06745.
OMAiAEVIWTS.
OrthoDBiEOG7T7GTP.
PhylomeDBiQ9NZQ7.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NZQ7-1) [UniParc]FASTAAdd to Basket

Also known as: PD-L1I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRIFAVFIFM TYWHLLNAFT VTVPKDLYVV EYGSNMTIEC KFPVEKQLDL    50
AALIVYWEME DKNIIQFVHG EEDLKVQHSS YRQRARLLKD QLSLGNAALQ 100
ITDVKLQDAG VYRCMISYGG ADYKRITVKV NAPYNKINQR ILVVDPVTSE 150
HELTCQAEGY PKAEVIWTSS DHQVLSGKTT TTNSKREEKL FNVTSTLRIN 200
TTTNEIFYCT FRRLDPEENH TAELVIPELP LAHPPNERTH LVILGAILLC 250
LGVALTFIFR LRKGRMMDVK KCGIQDTNSK KQSDTHLEET 290
Length:290
Mass (Da):33,275
Last modified:October 1, 2000 - v1
Checksum:iFE957086E62A31A8
GO
Isoform 2 (identifier: Q9NZQ7-2) [UniParc]FASTAAdd to Basket

Also known as: PD-L1II

The sequence of this isoform differs from the canonical sequence as follows:
     19-132: Missing.

Show »
Length:176
Mass (Da):20,246
Checksum:iB8BD0CFF9DEA722F
GO
Isoform 3 (identifier: Q9NZQ7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-178: K → D
     179-290: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:178
Mass (Da):20,454
Checksum:iA306BF2018885F0B
GO

Sequence cautioni

The sequence BAA91966.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei19 – 132114Missing in isoform 2.
VSP_013735Add
BLAST
Alternative sequencei178 – 1781K → D in isoform 3.
VSP_013736
Alternative sequencei179 – 290112Missing in isoform 3.
VSP_013737Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF177937 mRNA. Translation: AAF25807.1.
AF233516 mRNA. Translation: AAG18508.1.
AY254342 mRNA. Translation: AAP13470.1.
AY291313 mRNA. Translation: AAP42144.1.
AY714881 mRNA. Translation: AAU09634.1.
DQ286582 mRNA. Translation: ABB90152.1.
AK001894 mRNA. Translation: BAA91966.1. Different initiation.
AK300470 mRNA. Translation: BAG62189.1.
AK314567 mRNA. Translation: BAG37149.1.
AL162253 Genomic DNA. Translation: CAI15983.1.
CH471071 Genomic DNA. Translation: EAW58763.1.
BC069381 mRNA. Translation: AAH69381.1.
BC074984 mRNA. Translation: AAH74984.1.
BC113734 mRNA. Translation: AAI13735.1.
BC113736 mRNA. Translation: AAI13737.1.
CCDSiCCDS59118.1. [Q9NZQ7-2]
CCDS6464.1. [Q9NZQ7-1]
RefSeqiNP_001254635.1. NM_001267706.1. [Q9NZQ7-2]
NP_054862.1. NM_014143.3. [Q9NZQ7-1]
XP_006716822.1. XM_006716759.1. [Q9NZQ7-3]
UniGeneiHs.521989.

Genome annotation databases

EnsembliENST00000381573; ENSP00000370985; ENSG00000120217. [Q9NZQ7-2]
ENST00000381577; ENSP00000370989; ENSG00000120217. [Q9NZQ7-1]
GeneIDi29126.
KEGGihsa:29126.
UCSCiuc003zje.3. human. [Q9NZQ7-1]
uc011lmb.2. human. [Q9NZQ7-3]

Polymorphism databases

DMDMi83287884.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF177937 mRNA. Translation: AAF25807.1 .
AF233516 mRNA. Translation: AAG18508.1 .
AY254342 mRNA. Translation: AAP13470.1 .
AY291313 mRNA. Translation: AAP42144.1 .
AY714881 mRNA. Translation: AAU09634.1 .
DQ286582 mRNA. Translation: ABB90152.1 .
AK001894 mRNA. Translation: BAA91966.1 . Different initiation.
AK300470 mRNA. Translation: BAG62189.1 .
AK314567 mRNA. Translation: BAG37149.1 .
AL162253 Genomic DNA. Translation: CAI15983.1 .
CH471071 Genomic DNA. Translation: EAW58763.1 .
BC069381 mRNA. Translation: AAH69381.1 .
BC074984 mRNA. Translation: AAH74984.1 .
BC113734 mRNA. Translation: AAI13735.1 .
BC113736 mRNA. Translation: AAI13737.1 .
CCDSi CCDS59118.1. [Q9NZQ7-2 ]
CCDS6464.1. [Q9NZQ7-1 ]
RefSeqi NP_001254635.1. NM_001267706.1. [Q9NZQ7-2 ]
NP_054862.1. NM_014143.3. [Q9NZQ7-1 ]
XP_006716822.1. XM_006716759.1. [Q9NZQ7-3 ]
UniGenei Hs.521989.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3BIK X-ray 2.65 A 18-239 [» ]
3BIS X-ray 2.64 A/B 18-239 [» ]
3FN3 X-ray 2.70 A/B 19-238 [» ]
3SBW X-ray 2.28 C 19-239 [» ]
ProteinModelPortali Q9NZQ7.
SMRi Q9NZQ7. Positions 19-230.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118891. 4 interactions.
DIPi DIP-29731N.
IntActi Q9NZQ7. 2 interactions.
STRINGi 9606.ENSP00000370989.

PTM databases

PhosphoSitei Q9NZQ7.

Polymorphism databases

DMDMi 83287884.

Proteomic databases

MaxQBi Q9NZQ7.
PaxDbi Q9NZQ7.
PRIDEi Q9NZQ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381573 ; ENSP00000370985 ; ENSG00000120217 . [Q9NZQ7-2 ]
ENST00000381577 ; ENSP00000370989 ; ENSG00000120217 . [Q9NZQ7-1 ]
GeneIDi 29126.
KEGGi hsa:29126.
UCSCi uc003zje.3. human. [Q9NZQ7-1 ]
uc011lmb.2. human. [Q9NZQ7-3 ]

Organism-specific databases

CTDi 29126.
GeneCardsi GC09P005444.
HGNCi HGNC:17635. CD274.
HPAi CAB030018.
MIMi 605402. gene.
neXtProti NX_Q9NZQ7.
PharmGKBi PA134915280.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43849.
HOGENOMi HOG000059625.
HOVERGENi HBG082112.
InParanoidi Q9NZQ7.
KOi K06745.
OMAi AEVIWTS.
OrthoDBi EOG7T7GTP.
PhylomeDBi Q9NZQ7.
TreeFami TF331083.

Enzyme and pathway databases

Reactomei REACT_19324. PD-1 signaling.

Miscellaneous databases

EvolutionaryTracei Q9NZQ7.
GeneWikii PD-L1.
GenomeRNAii 29126.
NextBioi 52236.
PROi Q9NZQ7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NZQ7.
Bgeei Q9NZQ7.
CleanExi HS_CD274.
Genevestigatori Q9NZQ7.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion."
    Dong H., Zhu G., Tamada K., Chen L.
    Nat. Med. 5:1365-1369(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INDUCTION.
  2. "Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation."
    Freeman G.J., Long A.J., Iwai Y., Bourque K., Chernova T., Nishimura H., Fitz L.J., Malenkovich N., Okazaki T., Byrne M.C., Horton H.F., Fouser L., Carter L., Ling V., Bowman M.R., Carreno B.M., Collins M., Wood C.R., Honjo T.
    J. Exp. Med. 192:1027-1034(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH PDCD1, TISSUE SPECIFICITY, INDUCTION.
    Tissue: Placenta.
  3. "Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain."
    He X.-H., Xu L.-H., Liu Y.
    Acta Pharmacol. Sin. 26:462-468(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), SUBCELLULAR LOCATION.
  4. "Expression and significance of PD-L1 variant within tissues of human gastric carcinoma."
    Chi X.-Y., Zha Q.-B., Xu L.-H., Jia Q.-T., Li F.-Y., He X.-H.
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Gastric carcinoma.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Placenta.
  6. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-192.
    Tissue: Liver.
  10. "The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors."
    Lin D.Y., Tanaka Y., Iwasaki M., Gittis A.G., Su H.P., Mikami B., Okazaki T., Honjo T., Minato N., Garboczi D.N.
    Proc. Natl. Acad. Sci. U.S.A. 105:3011-3016(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.64 ANGSTROMS) OF 18-239 IN COMPLEX WITH MOUSE PDCD1, DISULFIDE BONDS.

Entry informationi

Entry nameiPD1L1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZQ7
Secondary accession number(s): B2RBA2
, B4DU27, Q14CJ2, Q2V8D5, Q66RK1, Q6WEX4, Q9NUZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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