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Q9NZQ7

- PD1L1_HUMAN

UniProt

Q9NZQ7 - PD1L1_HUMAN

Protein

Programmed cell death 1 ligand 1

Gene

CD274

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: UniProtKB
    2. immune response Source: UniProtKB
    3. negative regulation of T cell proliferation Source: Ensembl
    4. positive regulation of interleukin-10 secretion Source: UniProtKB
    5. positive regulation of T cell proliferation Source: UniProtKB
    6. signal transduction Source: UniProtKB
    7. T cell costimulation Source: UniProtKB

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_19324. PD-1 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Programmed cell death 1 ligand 1
    Short name:
    PD-L1
    Short name:
    PDCD1 ligand 1
    Short name:
    Programmed death ligand 1
    Alternative name(s):
    B7 homolog 1
    Short name:
    B7-H1
    CD_antigen: CD274
    Gene namesi
    Name:CD274
    Synonyms:B7H1, PDCD1L1, PDCD1LG1, PDL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:17635. CD274.

    Subcellular locationi

    GO - Cellular componenti

    1. endomembrane system Source: UniProtKB-SubCell
    2. external side of plasma membrane Source: Ensembl
    3. extracellular vesicular exosome Source: UniProtKB
    4. integral component of membrane Source: UniProtKB-KW
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134915280.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 290272Programmed cell death 1 ligand 1PRO_0000014553Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi40 ↔ 1141 PublicationPROSITE-ProRule annotation
    Disulfide bondi155 ↔ 2091 PublicationPROSITE-ProRule annotation
    Glycosylationi192 – 1921N-linked (GlcNAc...)1 Publication
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9NZQ7.
    PaxDbiQ9NZQ7.
    PRIDEiQ9NZQ7.

    PTM databases

    PhosphoSiteiQ9NZQ7.

    Expressioni

    Tissue specificityi

    Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.2 Publications

    Inductioni

    Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. Up-regulated in B-cells activated by surface Ig cross-linking.2 Publications

    Gene expression databases

    ArrayExpressiQ9NZQ7.
    BgeeiQ9NZQ7.
    CleanExiHS_CD274.
    GenevestigatoriQ9NZQ7.

    Organism-specific databases

    HPAiCAB030018.

    Interactioni

    Subunit structurei

    Interacts with PDCD1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CD80P336812EBI-4314282,EBI-1031024
    PDCD1Q151162EBI-4314282,EBI-4314328

    Protein-protein interaction databases

    BioGridi118891. 4 interactions.
    DIPiDIP-29731N.
    IntActiQ9NZQ7. 2 interactions.
    STRINGi9606.ENSP00000370989.

    Structurei

    Secondary structure

    1
    290
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi26 – 316
    Beta strandi36 – 416
    Turni50 – 523
    Beta strandi54 – 596
    Beta strandi62 – 687
    Beta strandi74 – 774
    Helixi79 – 813
    Beta strandi82 – 876
    Helixi89 – 924
    Turni93 – 953
    Beta strandi96 – 1038
    Helixi106 – 1083
    Beta strandi110 – 13223
    Beta strandi138 – 1458
    Turni146 – 1494
    Beta strandi150 – 16112
    Beta strandi164 – 1696
    Beta strandi178 – 1836
    Beta strandi185 – 1873
    Beta strandi191 – 20010
    Beta strandi206 – 2138
    Turni214 – 2174
    Beta strandi218 – 2258

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3BIKX-ray2.65A18-239[»]
    3BISX-ray2.64A/B18-239[»]
    3FN3X-ray2.70A/B19-238[»]
    3SBWX-ray2.28C19-239[»]
    ProteinModelPortaliQ9NZQ7.
    SMRiQ9NZQ7. Positions 19-230.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NZQ7.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 238220ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini260 – 29031CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 127109Ig-like V-typeAdd
    BLAST
    Domaini133 – 22593Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43849.
    HOGENOMiHOG000059625.
    HOVERGENiHBG082112.
    InParanoidiQ9NZQ7.
    KOiK06745.
    OMAiAEVIWTS.
    OrthoDBiEOG7T7GTP.
    PhylomeDBiQ9NZQ7.
    TreeFamiTF331083.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NZQ7-1) [UniParc]FASTAAdd to Basket

    Also known as: PD-L1I

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRIFAVFIFM TYWHLLNAFT VTVPKDLYVV EYGSNMTIEC KFPVEKQLDL    50
    AALIVYWEME DKNIIQFVHG EEDLKVQHSS YRQRARLLKD QLSLGNAALQ 100
    ITDVKLQDAG VYRCMISYGG ADYKRITVKV NAPYNKINQR ILVVDPVTSE 150
    HELTCQAEGY PKAEVIWTSS DHQVLSGKTT TTNSKREEKL FNVTSTLRIN 200
    TTTNEIFYCT FRRLDPEENH TAELVIPELP LAHPPNERTH LVILGAILLC 250
    LGVALTFIFR LRKGRMMDVK KCGIQDTNSK KQSDTHLEET 290
    Length:290
    Mass (Da):33,275
    Last modified:October 1, 2000 - v1
    Checksum:iFE957086E62A31A8
    GO
    Isoform 2 (identifier: Q9NZQ7-2) [UniParc]FASTAAdd to Basket

    Also known as: PD-L1II

    The sequence of this isoform differs from the canonical sequence as follows:
         19-132: Missing.

    Show »
    Length:176
    Mass (Da):20,246
    Checksum:iB8BD0CFF9DEA722F
    GO
    Isoform 3 (identifier: Q9NZQ7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         178-178: K → D
         179-290: Missing.

    Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:178
    Mass (Da):20,454
    Checksum:iA306BF2018885F0B
    GO

    Sequence cautioni

    The sequence BAA91966.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei19 – 132114Missing in isoform 2. 2 PublicationsVSP_013735Add
    BLAST
    Alternative sequencei178 – 1781K → D in isoform 3. 2 PublicationsVSP_013736
    Alternative sequencei179 – 290112Missing in isoform 3. 2 PublicationsVSP_013737Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF177937 mRNA. Translation: AAF25807.1.
    AF233516 mRNA. Translation: AAG18508.1.
    AY254342 mRNA. Translation: AAP13470.1.
    AY291313 mRNA. Translation: AAP42144.1.
    AY714881 mRNA. Translation: AAU09634.1.
    DQ286582 mRNA. Translation: ABB90152.1.
    AK001894 mRNA. Translation: BAA91966.1. Different initiation.
    AK300470 mRNA. Translation: BAG62189.1.
    AK314567 mRNA. Translation: BAG37149.1.
    AL162253 Genomic DNA. Translation: CAI15983.1.
    CH471071 Genomic DNA. Translation: EAW58763.1.
    BC069381 mRNA. Translation: AAH69381.1.
    BC074984 mRNA. Translation: AAH74984.1.
    BC113734 mRNA. Translation: AAI13735.1.
    BC113736 mRNA. Translation: AAI13737.1.
    CCDSiCCDS59118.1. [Q9NZQ7-2]
    CCDS6464.1. [Q9NZQ7-1]
    RefSeqiNP_001254635.1. NM_001267706.1. [Q9NZQ7-2]
    NP_054862.1. NM_014143.3. [Q9NZQ7-1]
    XP_006716822.1. XM_006716759.1. [Q9NZQ7-3]
    UniGeneiHs.521989.

    Genome annotation databases

    EnsembliENST00000381573; ENSP00000370985; ENSG00000120217. [Q9NZQ7-2]
    ENST00000381577; ENSP00000370989; ENSG00000120217. [Q9NZQ7-1]
    GeneIDi29126.
    KEGGihsa:29126.
    UCSCiuc003zje.3. human. [Q9NZQ7-1]
    uc011lmb.2. human. [Q9NZQ7-3]

    Polymorphism databases

    DMDMi83287884.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF177937 mRNA. Translation: AAF25807.1 .
    AF233516 mRNA. Translation: AAG18508.1 .
    AY254342 mRNA. Translation: AAP13470.1 .
    AY291313 mRNA. Translation: AAP42144.1 .
    AY714881 mRNA. Translation: AAU09634.1 .
    DQ286582 mRNA. Translation: ABB90152.1 .
    AK001894 mRNA. Translation: BAA91966.1 . Different initiation.
    AK300470 mRNA. Translation: BAG62189.1 .
    AK314567 mRNA. Translation: BAG37149.1 .
    AL162253 Genomic DNA. Translation: CAI15983.1 .
    CH471071 Genomic DNA. Translation: EAW58763.1 .
    BC069381 mRNA. Translation: AAH69381.1 .
    BC074984 mRNA. Translation: AAH74984.1 .
    BC113734 mRNA. Translation: AAI13735.1 .
    BC113736 mRNA. Translation: AAI13737.1 .
    CCDSi CCDS59118.1. [Q9NZQ7-2 ]
    CCDS6464.1. [Q9NZQ7-1 ]
    RefSeqi NP_001254635.1. NM_001267706.1. [Q9NZQ7-2 ]
    NP_054862.1. NM_014143.3. [Q9NZQ7-1 ]
    XP_006716822.1. XM_006716759.1. [Q9NZQ7-3 ]
    UniGenei Hs.521989.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3BIK X-ray 2.65 A 18-239 [» ]
    3BIS X-ray 2.64 A/B 18-239 [» ]
    3FN3 X-ray 2.70 A/B 19-238 [» ]
    3SBW X-ray 2.28 C 19-239 [» ]
    ProteinModelPortali Q9NZQ7.
    SMRi Q9NZQ7. Positions 19-230.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118891. 4 interactions.
    DIPi DIP-29731N.
    IntActi Q9NZQ7. 2 interactions.
    STRINGi 9606.ENSP00000370989.

    PTM databases

    PhosphoSitei Q9NZQ7.

    Polymorphism databases

    DMDMi 83287884.

    Proteomic databases

    MaxQBi Q9NZQ7.
    PaxDbi Q9NZQ7.
    PRIDEi Q9NZQ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381573 ; ENSP00000370985 ; ENSG00000120217 . [Q9NZQ7-2 ]
    ENST00000381577 ; ENSP00000370989 ; ENSG00000120217 . [Q9NZQ7-1 ]
    GeneIDi 29126.
    KEGGi hsa:29126.
    UCSCi uc003zje.3. human. [Q9NZQ7-1 ]
    uc011lmb.2. human. [Q9NZQ7-3 ]

    Organism-specific databases

    CTDi 29126.
    GeneCardsi GC09P005444.
    HGNCi HGNC:17635. CD274.
    HPAi CAB030018.
    MIMi 605402. gene.
    neXtProti NX_Q9NZQ7.
    PharmGKBi PA134915280.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43849.
    HOGENOMi HOG000059625.
    HOVERGENi HBG082112.
    InParanoidi Q9NZQ7.
    KOi K06745.
    OMAi AEVIWTS.
    OrthoDBi EOG7T7GTP.
    PhylomeDBi Q9NZQ7.
    TreeFami TF331083.

    Enzyme and pathway databases

    Reactomei REACT_19324. PD-1 signaling.

    Miscellaneous databases

    EvolutionaryTracei Q9NZQ7.
    GeneWikii PD-L1.
    GenomeRNAii 29126.
    NextBioi 52236.
    PROi Q9NZQ7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NZQ7.
    Bgeei Q9NZQ7.
    CleanExi HS_CD274.
    Genevestigatori Q9NZQ7.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion."
      Dong H., Zhu G., Tamada K., Chen L.
      Nat. Med. 5:1365-1369(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INDUCTION.
    2. "Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation."
      Freeman G.J., Long A.J., Iwai Y., Bourque K., Chernova T., Nishimura H., Fitz L.J., Malenkovich N., Okazaki T., Byrne M.C., Horton H.F., Fouser L., Carter L., Ling V., Bowman M.R., Carreno B.M., Collins M., Wood C.R., Honjo T.
      J. Exp. Med. 192:1027-1034(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH PDCD1, TISSUE SPECIFICITY, INDUCTION.
      Tissue: Placenta.
    3. "Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain."
      He X.-H., Xu L.-H., Liu Y.
      Acta Pharmacol. Sin. 26:462-468(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), SUBCELLULAR LOCATION.
    4. "Expression and significance of PD-L1 variant within tissues of human gastric carcinoma."
      Chi X.-Y., Zha Q.-B., Xu L.-H., Jia Q.-T., Li F.-Y., He X.-H.
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Gastric carcinoma.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Placenta.
    6. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-192.
      Tissue: Liver.
    10. "The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors."
      Lin D.Y., Tanaka Y., Iwasaki M., Gittis A.G., Su H.P., Mikami B., Okazaki T., Honjo T., Minato N., Garboczi D.N.
      Proc. Natl. Acad. Sci. U.S.A. 105:3011-3016(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.64 ANGSTROMS) OF 18-239 IN COMPLEX WITH MOUSE PDCD1, DISULFIDE BONDS.

    Entry informationi

    Entry nameiPD1L1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NZQ7
    Secondary accession number(s): B2RBA2
    , B4DU27, Q14CJ2, Q2V8D5, Q66RK1, Q6WEX4, Q9NUZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3