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Protein

Programmed cell death 1 ligand 1

Gene

CD274

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.2 Publications

GO - Biological processi

  • cell surface receptor signaling pathway Source: UniProtKB
  • immune response Source: UniProtKB
  • negative regulation of activated T cell proliferation Source: UniProtKB
  • negative regulation of interferon-gamma production Source: UniProtKB
  • negative regulation of interleukin-10 production Source: UniProtKB
  • negative regulation of tumor necrosis factor superfamily cytokine production Source: UniProtKB
  • positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process Source: UniProtKB
  • positive regulation of cell migration Source: Ensembl
  • positive regulation of interleukin-10 secretion Source: UniProtKB
  • positive regulation of T cell proliferation Source: UniProtKB
  • response to cytokine Source: AgBase
  • signal transduction Source: UniProtKB
  • T cell costimulation Source: UniProtKB
  • toxin transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107438-MONOMER.
ZFISH:ENSG00000120217-MONOMER.
ReactomeiR-HSA-389948. PD-1 signaling.
SIGNORiQ9NZQ7.

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death 1 ligand 1
Short name:
PD-L1
Short name:
PDCD1 ligand 1
Short name:
Programmed death ligand 1
Alternative name(s):
B7 homolog 1
Short name:
B7-H1
CD_antigen: CD274
Gene namesi
Name:CD274
Synonyms:B7H1, PDCD1L1, PDCD1LG1, PDL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:17635. CD274.

Subcellular locationi

Isoform 1 :
Isoform 2 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 238ExtracellularSequence analysisAdd BLAST220
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 290CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29126.
OpenTargetsiENSG00000120217.
PharmGKBiPA134915280.

Chemistry databases

ChEMBLiCHEMBL3580522.
GuidetoPHARMACOLOGYi2848.

Polymorphism and mutation databases

BioMutaiCD274.
DMDMi83287884.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001455319 – 290Programmed cell death 1 ligand 1Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi40 ↔ 114PROSITE-ProRule annotation1 Publication
Disulfide bondi155 ↔ 209PROSITE-ProRule annotation1 Publication
Glycosylationi192N-linked (GlcNAc...)1 Publication1
Glycosylationi200N-linked (GlcNAc...)Sequence analysis1
Glycosylationi219N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9NZQ7.
PaxDbiQ9NZQ7.
PeptideAtlasiQ9NZQ7.
PRIDEiQ9NZQ7.

PTM databases

iPTMnetiQ9NZQ7.
PhosphoSitePlusiQ9NZQ7.

Expressioni

Tissue specificityi

Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.2 Publications

Inductioni

Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. Up-regulated in B-cells activated by surface Ig cross-linking.2 Publications

Gene expression databases

BgeeiENSG00000120217.
CleanExiHS_CD274.
GenevisibleiQ9NZQ7. HS.

Organism-specific databases

HPAiCAB030018.

Interactioni

Subunit structurei

Interacts with PDCD1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CD80P336812EBI-4314282,EBI-1031024
PDCD1Q151162EBI-4314282,EBI-4314328

Protein-protein interaction databases

BioGridi118891. 47 interactors.
DIPiDIP-29731N.
IntActiQ9NZQ7. 2 interactors.
STRINGi9606.ENSP00000370989.

Structurei

Secondary structure

1290
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 31Combined sources5
Beta strandi36 – 41Combined sources6
Beta strandi45 – 47Combined sources3
Helixi50 – 52Combined sources3
Beta strandi53 – 59Combined sources7
Beta strandi62 – 68Combined sources7
Helixi74 – 76Combined sources3
Helixi79 – 81Combined sources3
Turni82 – 84Combined sources3
Beta strandi85 – 87Combined sources3
Helixi89 – 94Combined sources6
Beta strandi96 – 101Combined sources6
Helixi106 – 108Combined sources3
Beta strandi110 – 131Combined sources22
Beta strandi138 – 145Combined sources8
Turni146 – 149Combined sources4
Beta strandi150 – 161Combined sources12
Beta strandi164 – 169Combined sources6
Beta strandi177 – 183Combined sources7
Beta strandi185 – 187Combined sources3
Beta strandi191 – 200Combined sources10
Beta strandi206 – 213Combined sources8
Turni214 – 217Combined sources4
Beta strandi218 – 225Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BIKX-ray2.65A18-239[»]
3BISX-ray2.64A/B18-239[»]
3FN3X-ray2.70A/B19-238[»]
3SBWX-ray2.28C19-239[»]
4Z18X-ray1.95A/B19-239[»]
4ZQKX-ray2.45A18-132[»]
5C3TX-ray1.80A18-134[»]
5IUSX-ray2.89C/D18-239[»]
5J89X-ray2.20A/B/C/D2-134[»]
5J8OX-ray2.30A/B18-134[»]
ProteinModelPortaliQ9NZQ7.
SMRiQ9NZQ7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NZQ7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 127Ig-like V-typeAdd BLAST109
Domaini133 – 225Ig-like C2-typeAdd BLAST93

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIBU. Eukaryota.
ENOG4111V14. LUCA.
GeneTreeiENSGT00650000093373.
HOGENOMiHOG000130048.
HOVERGENiHBG082112.
InParanoidiQ9NZQ7.
KOiK06745.
OMAiAEVIWTS.
OrthoDBiEOG091G0F5W.
PhylomeDBiQ9NZQ7.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NZQ7-1) [UniParc]FASTAAdd to basket
Also known as: PD-L1I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRIFAVFIFM TYWHLLNAFT VTVPKDLYVV EYGSNMTIEC KFPVEKQLDL
60 70 80 90 100
AALIVYWEME DKNIIQFVHG EEDLKVQHSS YRQRARLLKD QLSLGNAALQ
110 120 130 140 150
ITDVKLQDAG VYRCMISYGG ADYKRITVKV NAPYNKINQR ILVVDPVTSE
160 170 180 190 200
HELTCQAEGY PKAEVIWTSS DHQVLSGKTT TTNSKREEKL FNVTSTLRIN
210 220 230 240 250
TTTNEIFYCT FRRLDPEENH TAELVIPELP LAHPPNERTH LVILGAILLC
260 270 280 290
LGVALTFIFR LRKGRMMDVK KCGIQDTNSK KQSDTHLEET
Length:290
Mass (Da):33,275
Last modified:October 1, 2000 - v1
Checksum:iFE957086E62A31A8
GO
Isoform 2 (identifier: Q9NZQ7-2) [UniParc]FASTAAdd to basket
Also known as: PD-L1II

The sequence of this isoform differs from the canonical sequence as follows:
     19-132: Missing.

Show »
Length:176
Mass (Da):20,246
Checksum:iB8BD0CFF9DEA722F
GO
Isoform 3 (identifier: Q9NZQ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-178: K → D
     179-290: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:178
Mass (Da):20,454
Checksum:iA306BF2018885F0B
GO

Sequence cautioni

The sequence BAA91966 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01373519 – 132Missing in isoform 2. 2 PublicationsAdd BLAST114
Alternative sequenceiVSP_013736178K → D in isoform 3. 2 Publications1
Alternative sequenceiVSP_013737179 – 290Missing in isoform 3. 2 PublicationsAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177937 mRNA. Translation: AAF25807.1.
AF233516 mRNA. Translation: AAG18508.1.
AY254342 mRNA. Translation: AAP13470.1.
AY291313 mRNA. Translation: AAP42144.1.
AY714881 mRNA. Translation: AAU09634.1.
DQ286582 mRNA. Translation: ABB90152.1.
AK001894 mRNA. Translation: BAA91966.1. Different initiation.
AK300470 mRNA. Translation: BAG62189.1.
AK314567 mRNA. Translation: BAG37149.1.
AL162253 Genomic DNA. Translation: CAI15983.1.
CH471071 Genomic DNA. Translation: EAW58763.1.
BC069381 mRNA. Translation: AAH69381.1.
BC074984 mRNA. Translation: AAH74984.1.
BC113734 mRNA. Translation: AAI13735.1.
BC113736 mRNA. Translation: AAI13737.1.
CCDSiCCDS59118.1. [Q9NZQ7-2]
CCDS6464.1. [Q9NZQ7-1]
RefSeqiNP_001254635.1. NM_001267706.1. [Q9NZQ7-2]
NP_054862.1. NM_014143.3. [Q9NZQ7-1]
UniGeneiHs.521989.

Genome annotation databases

EnsembliENST00000381573; ENSP00000370985; ENSG00000120217. [Q9NZQ7-2]
ENST00000381577; ENSP00000370989; ENSG00000120217. [Q9NZQ7-1]
GeneIDi29126.
KEGGihsa:29126.
UCSCiuc003zje.4. human. [Q9NZQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177937 mRNA. Translation: AAF25807.1.
AF233516 mRNA. Translation: AAG18508.1.
AY254342 mRNA. Translation: AAP13470.1.
AY291313 mRNA. Translation: AAP42144.1.
AY714881 mRNA. Translation: AAU09634.1.
DQ286582 mRNA. Translation: ABB90152.1.
AK001894 mRNA. Translation: BAA91966.1. Different initiation.
AK300470 mRNA. Translation: BAG62189.1.
AK314567 mRNA. Translation: BAG37149.1.
AL162253 Genomic DNA. Translation: CAI15983.1.
CH471071 Genomic DNA. Translation: EAW58763.1.
BC069381 mRNA. Translation: AAH69381.1.
BC074984 mRNA. Translation: AAH74984.1.
BC113734 mRNA. Translation: AAI13735.1.
BC113736 mRNA. Translation: AAI13737.1.
CCDSiCCDS59118.1. [Q9NZQ7-2]
CCDS6464.1. [Q9NZQ7-1]
RefSeqiNP_001254635.1. NM_001267706.1. [Q9NZQ7-2]
NP_054862.1. NM_014143.3. [Q9NZQ7-1]
UniGeneiHs.521989.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BIKX-ray2.65A18-239[»]
3BISX-ray2.64A/B18-239[»]
3FN3X-ray2.70A/B19-238[»]
3SBWX-ray2.28C19-239[»]
4Z18X-ray1.95A/B19-239[»]
4ZQKX-ray2.45A18-132[»]
5C3TX-ray1.80A18-134[»]
5IUSX-ray2.89C/D18-239[»]
5J89X-ray2.20A/B/C/D2-134[»]
5J8OX-ray2.30A/B18-134[»]
ProteinModelPortaliQ9NZQ7.
SMRiQ9NZQ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118891. 47 interactors.
DIPiDIP-29731N.
IntActiQ9NZQ7. 2 interactors.
STRINGi9606.ENSP00000370989.

Chemistry databases

ChEMBLiCHEMBL3580522.
GuidetoPHARMACOLOGYi2848.

PTM databases

iPTMnetiQ9NZQ7.
PhosphoSitePlusiQ9NZQ7.

Polymorphism and mutation databases

BioMutaiCD274.
DMDMi83287884.

Proteomic databases

MaxQBiQ9NZQ7.
PaxDbiQ9NZQ7.
PeptideAtlasiQ9NZQ7.
PRIDEiQ9NZQ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381573; ENSP00000370985; ENSG00000120217. [Q9NZQ7-2]
ENST00000381577; ENSP00000370989; ENSG00000120217. [Q9NZQ7-1]
GeneIDi29126.
KEGGihsa:29126.
UCSCiuc003zje.4. human. [Q9NZQ7-1]

Organism-specific databases

CTDi29126.
DisGeNETi29126.
GeneCardsiCD274.
HGNCiHGNC:17635. CD274.
HPAiCAB030018.
MIMi605402. gene.
neXtProtiNX_Q9NZQ7.
OpenTargetsiENSG00000120217.
PharmGKBiPA134915280.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIBU. Eukaryota.
ENOG4111V14. LUCA.
GeneTreeiENSGT00650000093373.
HOGENOMiHOG000130048.
HOVERGENiHBG082112.
InParanoidiQ9NZQ7.
KOiK06745.
OMAiAEVIWTS.
OrthoDBiEOG091G0F5W.
PhylomeDBiQ9NZQ7.
TreeFamiTF331083.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107438-MONOMER.
ZFISH:ENSG00000120217-MONOMER.
ReactomeiR-HSA-389948. PD-1 signaling.
SIGNORiQ9NZQ7.

Miscellaneous databases

EvolutionaryTraceiQ9NZQ7.
GeneWikiiPD-L1.
GenomeRNAii29126.
PROiQ9NZQ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120217.
CleanExiHS_CD274.
GenevisibleiQ9NZQ7. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPD1L1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZQ7
Secondary accession number(s): B2RBA2
, B4DU27, Q14CJ2, Q2V8D5, Q66RK1, Q6WEX4, Q9NUZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.