Q9NZQ3 (SPN90_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NCK-interacting protein with SH3 domain

Alternative name(s):
54 kDa VacA-interacting protein
54 kDa vimentin-interacting protein
Short name=VIP54
90 kDa SH3 protein interacting with Nck
AF3p21
Dia-interacting protein 1
Short name=DIP-1
Diaphanous protein-interacting protein
SH3 adapter protein SPIN90
WASP-interacting SH3-domain protein
Short name=WISH
Wiskott-Aldrich syndrome protein-interacting protein

Gene names

Name:	NCKIPSD
Synonyms:	AF3P21, SPIN90

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	722 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo By similarity. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 By similarity. May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. Ref.13
Subunit structure	Associates with the intermediate filaments, vimentin and desmin. Binds the first and third SH3 domains of NCK. Binds the proline-rich domains of N-WASP through its SH3 domain By similarity. Similarly, binds diaphanous protein homolog 1 (DRF1). Binds the SH3 domains of GRB2 through its proline-rich domains. Interacts with Helicobacter pylori toxin vacA. Isoform 4 interacts with FHOD1. Interacts with FASLG. Interacts with TMIGD2. Ref.2 Ref.6 Ref.11 Ref.13
Subcellular location	Nucleus. Note: Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes.
Tissue specificity	Highest expression in heart, brain, skeletal muscle, kidney and liver. Lower levels in placenta, lung, small intestine and leukocytes. Weak expression in colon, thymus and spleen. Ref.2
Involvement in disease	A chromosomal aberration involving NCKIPSD/AF3p21 is found in therapy-related leukemia. Translocation t(3;11)(p21;q23) with MLL.
Sequence similarities	Contains 1 SH3 domain.
Sequence caution	The sequence BAG57476.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Disease	Proto-oncogene
Domain	SH3 domain SH3-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	NLS-bearing substrate import into nucleus Traceable author statement Ref.1. Source: ProtInc cytoskeleton organization Non-traceable author statement Ref.2. Source: UniProtKB signal transduction Traceable author statement Ref.1. Source: ProtInc
Cellular_component	intermediate filament Non-traceable author statement Ref.2. Source: UniProtKB nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytoskeletal protein binding Non-traceable author statement Ref.2. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NZQ3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NZQ3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     656-722: LRMEYLSLMH...EFLVLGEAPS → GPFGAGQRPW...IDSAFGGRSV

Isoform 3 (identifier: Q9NZQ3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     165-171: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9NZQ3-4)

Also known as: WISH-B;

The sequence of this isoform differs from the canonical sequence as follows:
     165-171: Missing.
     656-658: LRM → GVH
     659-722: Missing.

Isoform 5 (identifier: Q9NZQ3-5)

The sequence of this isoform differs from the canonical sequence as follows:
     567-596: AADQNVIMAALSKHANVKIFSEKLLLLLNR → GGVGPGWAVAEHMVALRLSTLSIPMSFLSC
     597-722: Missing.

Note: Found in a brain affected by Alzheimer disease. May be due to intron retention. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 722	722	NCK-interacting protein with SH3 domain		PRO_0000072130
Regions
	Domain	1 – 58	58	SH3
	Motif	175 – 192	18	Nuclear localization signal Potential
	Compositional bias	171 – 275	105	Pro-rich
	Compositional bias	197 – 240	44	Ser/Thr-rich
	Compositional bias	442 – 487	46	Leu-rich
	Compositional bias	534 – 601	68	Leu-rich
Sites
	Site	57 – 58	2	Breakpoint for translocation to form MLL-AF3P21 oncogene
Natural variations
	Alternative sequence	165 – 171	7	Missing in isoform 3 and isoform 4.		VSP_039422
	Alternative sequence	567 – 596	30	AADQN…LLLNR → GGVGPGWAVAEHMVALRLST LSIPMSFLSC in isoform 5.		VSP_039423
	Alternative sequence	597 – 722	126	Missing in isoform 5.		VSP_039424
	Alternative sequence	656 – 722	67	LRMEY…GEAPS → GPFGAGQRPWPGVPRLLEPG STPSREPHPVERSGVPALTS SWASGCPRPLHPALQLVIDS AFGGRSV in isoform 2.		VSP_003971
	Alternative sequence	656 – 658	3	LRM → GVH in isoform 4.		VSP_039425
	Alternative sequence	659 – 722	64	Missing in isoform 4.		VSP_039426
	Natural variant	324	1	T → S. Corresponds to variant rs6785620 [ dbSNP | Ensembl ].		VAR_051378
	Natural variant	660	1	Y → S. Ref.8 Corresponds to variant rs17855516 [ dbSNP | Ensembl ].		VAR_063400

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 7683046B94647332	FASTA	722	78,960
	10 20 30 40 50 60 MYRALYAFRS AEPNALAFAA GETFLVLERS SAHWWLAARA RSGETGYVPP AYLRRLQGLE 70 80 90 100 110 120 QDVLQAIDRA IEAVHNTAMR DGGKYSLEQR GVLQKLIHHR KETLSRRGPS ASSVAVMTSS 130 140 150 160 170 180 TSDHHLDAAA ARQPNGVCRA GFERQHSLPS SEHLGADGGL YQIPLPSSQI PPQPRRAAPT 190 200 210 220 230 240 TPPPPVKRRD REALMASGSG GHNTMPSGGN SVSSGSSVSS TSLDTLYTSS SPSEPGSSCS 250 260 270 280 290 300 PTPPPVPRRG THTTVSQVQP PPSKASAPEP PAEEEVATGT TSASDDLEAL GTLSLGTTEE 310 320 330 340 350 360 KAAAEAAVPR TIGAELMELV RRNTGLSHEL CRVAIGIIVG HIQASVPASS PVMEQVLLSL 370 380 390 400 410 420 VEGKDLSMAL PSGQVCHDQQ RLEVIFADLA RRKDDAQQRS WALYEDEGVI RCYLEELLHI 430 440 450 460 470 480 LTDADPEVCK KMCKRNEFES VLALVAYYQM EHRASLRLLL LKCFGAMCSL DAAIISTLVS 490 500 510 520 530 540 SVLPVELARD MQTDTQDHQK LCYSALILAM VFSMGEAVPY AHYEHLGTPF AQFLLNIVED 550 560 570 580 590 600 GLPLDTTEQL PDLCVNLLLA LNLHLPAADQ NVIMAALSKH ANVKIFSEKL LLLLNRGDDP 610 620 630 640 650 660 VRIFKHEPQP PHSVLKFLQD VFGSPATAAI FYHTDMMALI DITVRHIADL SPGDKLRMEY 670 680 690 700 710 720 LSLMHAIVRT TPYLQHRHRL PDLQAILRRI LNEEETSPQC QMDRMIVREM CKEFLVLGEA PS
	Isoform 2 [UniParc]. Checksum: BFC8DE473D3C2A4B	FASTA	722	77,931
	10 20 30 40 50 60 MYRALYAFRS AEPNALAFAA GETFLVLERS SAHWWLAARA RSGETGYVPP AYLRRLQGLE 70 80 90 100 110 120 QDVLQAIDRA IEAVHNTAMR DGGKYSLEQR GVLQKLIHHR KETLSRRGPS ASSVAVMTSS 130 140 150 160 170 180 TSDHHLDAAA ARQPNGVCRA GFERQHSLPS SEHLGADGGL YQIPLPSSQI PPQPRRAAPT 190 200 210 220 230 240 TPPPPVKRRD REALMASGSG GHNTMPSGGN SVSSGSSVSS TSLDTLYTSS SPSEPGSSCS 250 260 270 280 290 300 PTPPPVPRRG THTTVSQVQP PPSKASAPEP PAEEEVATGT TSASDDLEAL GTLSLGTTEE 310 320 330 340 350 360 KAAAEAAVPR TIGAELMELV RRNTGLSHEL CRVAIGIIVG HIQASVPASS PVMEQVLLSL 370 380 390 400 410 420 VEGKDLSMAL PSGQVCHDQQ RLEVIFADLA RRKDDAQQRS WALYEDEGVI RCYLEELLHI 430 440 450 460 470 480 LTDADPEVCK KMCKRNEFES VLALVAYYQM EHRASLRLLL LKCFGAMCSL DAAIISTLVS 490 500 510 520 530 540 SVLPVELARD MQTDTQDHQK LCYSALILAM VFSMGEAVPY AHYEHLGTPF AQFLLNIVED 550 560 570 580 590 600 GLPLDTTEQL PDLCVNLLLA LNLHLPAADQ NVIMAALSKH ANVKIFSEKL LLLLNRGDDP 610 620 630 640 650 660 VRIFKHEPQP PHSVLKFLQD VFGSPATAAI FYHTDMMALI DITVRHIADL SPGDKGPFGA 670 680 690 700 710 720 GQRPWPGVPR LLEPGSTPSR EPHPVERSGV PALTSSWASG CPRPLHPALQ LVIDSAFGGR SV
	Isoform 3 [UniParc]. Checksum: 73B743E6BA30F469	FASTA	715	78,237
	10 20 30 40 50 60 MYRALYAFRS AEPNALAFAA GETFLVLERS SAHWWLAARA RSGETGYVPP AYLRRLQGLE 70 80 90 100 110 120 QDVLQAIDRA IEAVHNTAMR DGGKYSLEQR GVLQKLIHHR KETLSRRGPS ASSVAVMTSS 130 140 150 160 170 180 TSDHHLDAAA ARQPNGVCRA GFERQHSLPS SEHLGADGGL YQIPPQPRRA APTTPPPPVK 190 200 210 220 230 240 RRDREALMAS GSGGHNTMPS GGNSVSSGSS VSSTSLDTLY TSSSPSEPGS SCSPTPPPVP 250 260 270 280 290 300 RRGTHTTVSQ VQPPPSKASA PEPPAEEEVA TGTTSASDDL EALGTLSLGT TEEKAAAEAA 310 320 330 340 350 360 VPRTIGAELM ELVRRNTGLS HELCRVAIGI IVGHIQASVP ASSPVMEQVL LSLVEGKDLS 370 380 390 400 410 420 MALPSGQVCH DQQRLEVIFA DLARRKDDAQ QRSWALYEDE GVIRCYLEEL LHILTDADPE 430 440 450 460 470 480 VCKKMCKRNE FESVLALVAY YQMEHRASLR LLLLKCFGAM CSLDAAIIST LVSSVLPVEL 490 500 510 520 530 540 ARDMQTDTQD HQKLCYSALI LAMVFSMGEA VPYAHYEHLG TPFAQFLLNI VEDGLPLDTT 550 560 570 580 590 600 EQLPDLCVNL LLALNLHLPA ADQNVIMAAL SKHANVKIFS EKLLLLLNRG DDPVRIFKHE 610 620 630 640 650 660 PQPPHSVLKF LQDVFGSPAT AAIFYHTDMM ALIDITVRHI ADLSPGDKLR MEYLSLMHAI 670 680 690 700 710 VRTTPYLQHR HRLPDLQAIL RRILNEEETS PQCQMDRMIV REMCKEFLVL GEAPS
	Isoform 4 (WISH-B) [UniParc]. Checksum: 98E450E7A59047A6	FASTA	651	70,540
	10 20 30 40 50 60 MYRALYAFRS AEPNALAFAA GETFLVLERS SAHWWLAARA RSGETGYVPP AYLRRLQGLE 70 80 90 100 110 120 QDVLQAIDRA IEAVHNTAMR DGGKYSLEQR GVLQKLIHHR KETLSRRGPS ASSVAVMTSS 130 140 150 160 170 180 TSDHHLDAAA ARQPNGVCRA GFERQHSLPS SEHLGADGGL YQIPPQPRRA APTTPPPPVK 190 200 210 220 230 240 RRDREALMAS GSGGHNTMPS GGNSVSSGSS VSSTSLDTLY TSSSPSEPGS SCSPTPPPVP 250 260 270 280 290 300 RRGTHTTVSQ VQPPPSKASA PEPPAEEEVA TGTTSASDDL EALGTLSLGT TEEKAAAEAA 310 320 330 340 350 360 VPRTIGAELM ELVRRNTGLS HELCRVAIGI IVGHIQASVP ASSPVMEQVL LSLVEGKDLS 370 380 390 400 410 420 MALPSGQVCH DQQRLEVIFA DLARRKDDAQ QRSWALYEDE GVIRCYLEEL LHILTDADPE 430 440 450 460 470 480 VCKKMCKRNE FESVLALVAY YQMEHRASLR LLLLKCFGAM CSLDAAIIST LVSSVLPVEL 490 500 510 520 530 540 ARDMQTDTQD HQKLCYSALI LAMVFSMGEA VPYAHYEHLG TPFAQFLLNI VEDGLPLDTT 550 560 570 580 590 600 EQLPDLCVNL LLALNLHLPA ADQNVIMAAL SKHANVKIFS EKLLLLLNRG DDPVRIFKHE 610 620 630 640 650 PQPPHSVLKF LQDVFGSPAT AAIFYHTDMM ALIDITVRHI ADLSPGDKGV H
	Isoform 5 [UniParc]. Checksum: 59BFFD741EE788F2	FASTA	596	64,196
	10 20 30 40 50 60 MYRALYAFRS AEPNALAFAA GETFLVLERS SAHWWLAARA RSGETGYVPP AYLRRLQGLE 70 80 90 100 110 120 QDVLQAIDRA IEAVHNTAMR DGGKYSLEQR GVLQKLIHHR KETLSRRGPS ASSVAVMTSS 130 140 150 160 170 180 TSDHHLDAAA ARQPNGVCRA GFERQHSLPS SEHLGADGGL YQIPLPSSQI PPQPRRAAPT 190 200 210 220 230 240 TPPPPVKRRD REALMASGSG GHNTMPSGGN SVSSGSSVSS TSLDTLYTSS SPSEPGSSCS 250 260 270 280 290 300 PTPPPVPRRG THTTVSQVQP PPSKASAPEP PAEEEVATGT TSASDDLEAL GTLSLGTTEE 310 320 330 340 350 360 KAAAEAAVPR TIGAELMELV RRNTGLSHEL CRVAIGIIVG HIQASVPASS PVMEQVLLSL 370 380 390 400 410 420 VEGKDLSMAL PSGQVCHDQQ RLEVIFADLA RRKDDAQQRS WALYEDEGVI RCYLEELLHI 430 440 450 460 470 480 LTDADPEVCK KMCKRNEFES VLALVAYYQM EHRASLRLLL LKCFGAMCSL DAAIISTLVS 490 500 510 520 530 540 SVLPVELARD MQTDTQDHQK LCYSALILAM VFSMGEAVPY AHYEHLGTPF AQFLLNIVED 550 560 570 580 590 GLPLDTTEQL PDLCVNLLLA LNLHLPGGVG PGWAVAEHMV ALRLSTLSIP MSFLSC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11)(p21;q23)." Sano K., Hayakawa A., Piao J.-H., Kosaka Y., Nakamura H. Blood 95:1066-1068(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHROMOSOMAL TRANSLOCATION WITH MLL. Tissue: Leukemia.
[2]	"The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein." de Bernard M., Moschioni M., Napolitani G., Rappuoli R., Montecucco C. EMBO J. 19:48-56(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH VACA, TISSUE SPECIFICITY. Tissue: Cervix carcinoma.
[3]	"Genomic organization, tissue expression and cellular localization of AF3p21, a fusion partner of MLL in therapy-related leukemia." Hayakawa A., Matsuda Y., Daibata M., Nakamura H., Sano K. Genes Chromosomes Cancer 30:364-374(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). Tissue: Cervix carcinoma.
[4]	"SPIN90 (SH3 protein interacting with Nck, 90 kDa), an adapter protein that is developmentally regulated during cardiac myocyte differentiation." Lim C.S., Park E.S., Kim D.J., Song Y.H., Eom S.H., Chun J.-S., Kim J.H., Kim J.-K., Park D., Song W.K. J. Biol. Chem. 276:12871-12878(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Heart.
[5]	"mDia-interacting protein acts downstream of rho-mDia and modifies src activation and stress fiber formation." Satoh S., Tominaga T. J. Biol. Chem. 276:39290-39294(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1 AND 2). Tissue: Brain and Placenta.
[6]	"Identification of FHOD1-binding proteins and mechanisms of FHOD1-regulated actin dynamics." Westendorf J.J., Koka S. J. Cell. Biochem. 92:29-41(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), INTERACTION WITH FHOD1. Tissue: Bone marrow.
[7]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT SER-660. Tissue: Placenta and Skin.
[9]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 448-722 (ISOFORM 5). Tissue: Brain cortex.
[10]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Platelet.
[11]	"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening." Voss M., Lettau M., Janssen O. BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FASLG.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis." Rahimi N., Rezazadeh K., Mahoney J.E., Hartsough E., Meyer R.D. Mol. Biol. Cell 23:1646-1656(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN ANGIOGENESIS, INTERACTION WITH TMIGD2.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF178432 mRNA. Translation: AAF35985.1. AJ242655 mRNA. Translation: CAB65089.2. AF303581 mRNA. Translation: AAK09094.1. AB069981 Genomic DNA. Translation: BAB63204.1. AB069982 Genomic DNA. Translation: BAB63205.1. AY453794 mRNA. Translation: AAR83735.1. AC141002 Genomic DNA. No translation available. BC016052 mRNA. Translation: AAH16052.1. BC026280 mRNA. Translation: AAH26280.1. AK294151 mRNA. Translation: BAG57476.1. Different initiation.
IPI	IPI00009319. IPI00218563. IPI00555978. IPI00969137. IPI00969157.
RefSeq	NP_057537.1. NM_016453.2. NP_909119.1. NM_184231.1.
UniGene	Hs.655006.
3D structure databases
HSSP	HSSP built from PDB template 1NYF based on UniProtKB P06241.
ProteinModelPortal	Q9NZQ3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NZQ3. 10 interactions.
MINT	MINT-1438080.
STRING	9606.ENSP00000294129.
PTM databases
PhosphoSite	Q9NZQ3.
Polymorphism databases
DMDM	17433253.
Proteomic databases
PaxDb	Q9NZQ3.
PRIDE	Q9NZQ3.
Protocols and materials databases
DNASU	51517.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000294129; ENSP00000294129; ENSG00000213672. ENST00000341520; ENSP00000342621; ENSG00000213672. ENST00000416649; ENSP00000389059; ENSG00000213672.
GeneID	51517.
KEGG	hsa:51517.
UCSC	uc003cum.3. human. uc003cun.3. human.
Organism-specific databases
CTD	51517.
GeneCards	GC03M048701.
HGNC	HGNC:15486. NCKIPSD.
HPA	CAB019267.
MIM	606671. gene.
neXtProt	NX_Q9NZQ3.
PharmGKB	PA134872724.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG283973.
HOGENOM	HOG000008184.
HOVERGEN	HBG061630.
OMA	ERQHSLP.
OrthoDB	EOG4GMTWT.
Gene expression databases
ArrayExpress	Q9NZQ3.
Bgee	Q9NZQ3.
CleanEx	HS_NCKIPSD.
Genevestigator	Q9NZQ3.
GermOnline	ENSG00000008300. Homo sapiens.
Family and domain databases
InterPro	IPR018556. DUF2013. IPR001452. SH3_domain. [Graphical view]
Pfam	PF09431. DUF2013. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
SMART	SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NCKIPSD. human.
GenomeRNAi	51517.
NextBio	55214.
SOURCE	Search...

Entry information

Entry name

SPN90_HUMAN

Accession

Primary (citable) accession number: Q9NZQ3
Secondary accession number(s): B4DFL5 , Q6GU34, Q6SPF3, Q8TC10, Q9UGM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.