Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear pore-associated protein 1

Gene

NPAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in spermatogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Protein family/group databases

TCDBi1.I.1.1.3. the eukaryotic nuclear pore complex (e-npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore-associated protein 1
Gene namesi
Name:NPAP1
Synonyms:C15orf2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000185823.3.
HGNCiHGNC:1190. NPAP1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23742.
GeneReviewsiNPAP1.
OpenTargetsiENSG00000185823.
PharmGKBiPA25519.

Polymorphism and mutation databases

BioMutaiNPAP1.
DMDMi147744554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002439291 – 1156Nuclear pore-associated protein 1Add BLAST1156

Proteomic databases

PaxDbiQ9NZP6.
PRIDEiQ9NZP6.

PTM databases

iPTMnetiQ9NZP6.
PhosphoSitePlusiQ9NZP6.

Expressioni

Tissue specificityi

Testis-specific in adults. In fetal brain expressed only from the paternal allele.3 Publications

Gene expression databases

BgeeiENSG00000185823.
CleanExiHS_C15orf2.
GenevisibleiQ9NZP6. HS.

Organism-specific databases

HPAiHPA018828.
HPA019562.

Interactioni

Subunit structurei

Associates with the nuclear pore complex (NPC).1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000333735.

Structurei

3D structure databases

ProteinModelPortaliQ9NZP6.
SMRiQ9NZP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi285 – 536Pro-richAdd BLAST252

Phylogenomic databases

eggNOGiENOG410IWUR. Eukaryota.
ENOG411141I. LUCA.
GeneTreeiENSGT00500000045111.
HOGENOMiHOG000111850.
InParanoidiQ9NZP6.
OMAiFYTSSTH.
OrthoDBiEOG091G015E.
PhylomeDBiQ9NZP6.
TreeFamiTF340538.

Family and domain databases

InterProiView protein in InterPro
IPR026054. Nucleoporin.
PANTHERiPTHR23193. PTHR23193. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NZP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNLLSKFRP GCRRRPLPGP GRGAPAPLSR DASPPGRAHS VPTPRPFRGL
60 70 80 90 100
FRRNARRRPS AASIFVAPKR PCPLPRAAAA PLGVLPAVGW GLAIRKTPML
110 120 130 140 150
PARNPPRFGH PSSVRIPPPS RMFTLLLPSP REPAVKARKP IPATLLEETE
160 170 180 190 200
VWAQEGPRRV KKDEDPVQIE GEDDEKRTPL SSGEASSTSR SQGTQGDVAS
210 220 230 240 250
FRCSPGPLEG NVYHKFSENS MSEKAQASPA SSCLEGPAMP STHSQAGCAR
260 270 280 290 300
HLGKPDPDAT APPEPAVGCS LLQQKLAAEV LNEEPPPSSL GLPIPLMSGK
310 320 330 340 350
RMPDEKPFCI PPRSAAPPRA ARNRPCKRKM SIPLLLPLPP SLPLLWDRGE
360 370 380 390 400
LPPPAKLPCL SVEGDLHTLE KSPEYKRNSR ILEDKTETMT NSSITQPAPS
410 420 430 440 450
FSQPVQTTDS LPLTTYTSQV SAPLPIPDLA DLATGPLILP IPPLSTTPKM
460 470 480 490 500
DEKIAFTIPN SPLALPADLV PILGDQSNEK GGSYNSVVGA APLTSDPPTP
510 520 530 540 550
PSSTPSFKPP VTRESPISMC VDSPPPLSFL TLLPVPSTGT SVITSKPMNS
560 570 580 590 600
TSVISTVTTN ASAHLTSQTA VDPEVVNMDT TAPSQVVIFT SSLSSRVSSL
610 620 630 640 650
PNSQIHCSAE QRHPGKTSVY TSPLPFIFHN TTPSFNQLFG KEATPQPKFE
660 670 680 690 700
APDGQPQKAS LPSACVFLSL PIIPPPDTST LVNSASTASS SKPPIETNAM
710 720 730 740 750
HTTPPSKAVI LQSASVSKKY LPFYLGLPGS GNTQPSGNTA SVQGSTSLPA
760 770 780 790 800
QSVRAPATAS NHPLNPGATP QPKFGAPDGP QQKTSLPSAH DFLSLPIMVP
810 820 830 840 850
PDTSTLVSSA SAASLSKPAI DTSDMNTTPP SKTVILQSTF VSRKEEYIRF
860 870 880 890 900
YMGLPGSGNT LHSDSIASAQ VSTSFPAQAD RRPTTTSSHP LNTGSISHST
910 920 930 940 950
LGATDGQQKS DSSFILGNPA TPAPVIGLTS PSVQPLSGSI IPPGFAELTS
960 970 980 990 1000
PYTALGTPVN AEPVEGHNAS AFPNGTAKTS GFRIATGMPG TGDSTLLVGN
1010 1020 1030 1040 1050
TIPGPQVIMG PGTPMDGGSI GFSMSAPGPS STSGELNIGQ GQSGTPSTTS
1060 1070 1080 1090 1100
VFPFGQAAWD PTGHSMAAAP QGASNIPVFG YTSAAAYIPG LDPPTQNSCS
1110 1120 1130 1140 1150
GMGGDGTRSI VGGPCVPAFQ QCILQHTWTE RKFYTSSTHY YGQETYVRRH

VCFQLP
Length:1,156
Mass (Da):120,954
Last modified:May 15, 2007 - v2
Checksum:iEB8ABE1B1C932CE6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05087834P → Q. Corresponds to variant dbSNP:rs35022251Ensembl.1
Natural variantiVAR_03568237R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs772577429Ensembl.1
Natural variantiVAR_035683114V → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs778802437Ensembl.1
Natural variantiVAR_050879152W → R. Corresponds to variant dbSNP:rs35870568Ensembl.1
Natural variantiVAR_026872212V → A. Corresponds to variant dbSNP:rs3784246Ensembl.1
Natural variantiVAR_026873253G → R1 PublicationCorresponds to variant dbSNP:rs1563102Ensembl.1
Natural variantiVAR_026874282N → S. Corresponds to variant dbSNP:rs7165533Ensembl.1
Natural variantiVAR_050880343P → A. Corresponds to variant dbSNP:rs36025315Ensembl.1
Natural variantiVAR_026875406Q → E. Corresponds to variant dbSNP:rs3742950Ensembl.1
Natural variantiVAR_050881757A → T. Corresponds to variant dbSNP:rs36032407Ensembl.1
Natural variantiVAR_050882929T → P. Corresponds to variant dbSNP:rs34413216Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179681 Genomic DNA. Translation: AAF72107.1.
AC100720 Genomic DNA. No translation available.
CCDSiCCDS10015.1.
RefSeqiNP_061831.2. NM_018958.2.
UniGeneiHs.649663.

Genome annotation databases

EnsembliENST00000329468; ENSP00000333735; ENSG00000185823.
GeneIDi23742.
KEGGihsa:23742.
UCSCiuc001ywo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNPAP1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 15, 2007
Last modified: September 27, 2017
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot