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Protein

Olfactory receptor 5AC2

Gene

OR5AC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • odorant binding Source: GO_Central
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5AC2
Alternative name(s):
HSA1
Gene namesi
Name:OR5AC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:15431. OR5AC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence analysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence analysis
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 10124ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini123 – 13513CytoplasmicSequence analysisAdd
BLAST
Transmembranei136 – 15621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini157 – 19842ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23920CytoplasmicSequence analysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini261 – 27313ExtracellularSequence analysisAdd
BLAST
Transmembranei274 – 29421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini295 – 30915CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32457.

Polymorphism and mutation databases

BioMutaiOR5AC2.
DMDMi85541038.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 5AC2PRO_0000150574Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NZP5.
PeptideAtlasiQ9NZP5.
PRIDEiQ9NZP5.

Expressioni

Gene expression databases

CleanExiHS_OR5AC2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351466.

Structurei

3D structure databases

ProteinModelPortaliQ9NZP5.
SMRiQ9NZP5. Positions 33-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9AR. Eukaryota.
ENOG41113B9. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ9NZP5.
KOiK04257.
OMAiLAFSDAC.
OrthoDBiEOG754HQ1.
PhylomeDBiQ9NZP5.
TreeFamiTF352737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NZP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDISEGNKTL VTEFVLTGLT DRPWLHVLFF VVFLVVYLIT MVGNLGLIVL
60 70 80 90 100
IWNDPHLHMP MYLFLGGLAF SDACTSTSIT PRMLVNFLDK TAMISLAECI
110 120 130 140 150
TQFYFFASSA TTECFLLVMM AYDRYVAICN PLLYPVMMSN KLSAQLLSIS
160 170 180 190 200
YVIGFLHPLV HVSLLLRLTF CRFNIIHYFY CEILQLFKIS CNGPSINALM
210 220 230 240 250
IFIFGAFIQI PTLMTIIISY TRVLFDILKK KSEKGRSKAF STCGAHLLSV
260 270 280 290 300
SLYYGTLIFM YVRPASGLAE DQDKVYSLFY TIIIPLLNPF IYSLRNKKVM

HALRRVIRK
Length:309
Mass (Da):35,304
Last modified:January 10, 2006 - v2
Checksum:iBB9FD5CD01F0C5A9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti200 – 2001M → I.1 Publication
Corresponds to variant rs4518168 [ dbSNP | Ensembl ].
VAR_034214

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133439 Genomic DNA. No translation available.
AF179759 Genomic DNA. Translation: AAF40348.1.
CCDSiCCDS33796.1.
RefSeqiNP_473447.1. NM_054106.1.
UniGeneiHs.554715.

Genome annotation databases

EnsembliENST00000358642; ENSP00000351466; ENSG00000196578.
GeneIDi81050.
KEGGihsa:81050.
UCSCiuc011bgs.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133439 Genomic DNA. No translation available.
AF179759 Genomic DNA. Translation: AAF40348.1.
CCDSiCCDS33796.1.
RefSeqiNP_473447.1. NM_054106.1.
UniGeneiHs.554715.

3D structure databases

ProteinModelPortaliQ9NZP5.
SMRiQ9NZP5. Positions 33-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000351466.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR5AC2.
DMDMi85541038.

Proteomic databases

PaxDbiQ9NZP5.
PeptideAtlasiQ9NZP5.
PRIDEiQ9NZP5.

Protocols and materials databases

DNASUi81050.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358642; ENSP00000351466; ENSG00000196578.
GeneIDi81050.
KEGGihsa:81050.
UCSCiuc011bgs.2. human.

Organism-specific databases

CTDi81050.
GeneCardsiOR5AC2.
HGNCiHGNC:15431. OR5AC2.
neXtProtiNX_Q9NZP5.
PharmGKBiPA32457.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9AR. Eukaryota.
ENOG41113B9. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ9NZP5.
KOiK04257.
OMAiLAFSDAC.
OrthoDBiEOG754HQ1.
PhylomeDBiQ9NZP5.
TreeFamiTF352737.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5AC2.
GenomeRNAii81050.
PROiQ9NZP5.

Gene expression databases

CleanExiHS_OR5AC2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates."
    Rouquier S., Blancher A., Giorgi D.
    Proc. Natl. Acad. Sci. U.S.A. 97:2870-2874(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 126-287, VARIANT ILE-200.

Entry informationi

Entry nameiO5AC2_HUMAN
AccessioniPrimary (citable) accession number: Q9NZP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: January 10, 2006
Last modified: July 6, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.