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Q9NZP2

- OR6C2_HUMAN

UniProt

Q9NZP2 - OR6C2_HUMAN

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Protein
Olfactory receptor 6C2
Gene
OR6C2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6C2
Alternative name(s):
HSA3
Gene namesi
Name:OR6C2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:15436. OR6C2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323Extracellular Reviewed prediction
Add
BLAST
Transmembranei24 – 4421Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini45 – 528Cytoplasmic Reviewed prediction
Transmembranei53 – 7321Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini74 – 9724Extracellular Reviewed prediction
Add
BLAST
Transmembranei98 – 11821Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini119 – 13719Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei138 – 15821Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini159 – 19537Extracellular Reviewed prediction
Add
BLAST
Transmembranei196 – 21520Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini216 – 23520Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei236 – 25621Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini257 – 26913Extracellular Reviewed prediction
Add
BLAST
Transmembranei270 – 29021Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini291 – 31222Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 6C2
PRO_0000150624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...) Reviewed prediction
Glycosylationi82 – 821N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi95 ↔ 187 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NZP2.
PRIDEiQ9NZP2.

Expressioni

Gene expression databases

CleanExiHS_OR6C2.
GenevestigatoriQ9NZP2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323606.

Structurei

3D structure databases

ProteinModelPortaliQ9NZP2.
SMRiQ9NZP2. Positions 24-296.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43260.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ9NZP2.
KOiK04257.
OMAiSYLYIVR.
OrthoDBiEOG7KH9K8.
PhylomeDBiQ9NZP2.
TreeFamiTF336833.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NZP2-1 [UniParc]FASTAAdd to Basket

« Hide

MKNHTVIRTF ILLGLTGDPH LQVLLFIFLF LTYMLSVTGN LTIITLTLVD    50
HHLKTPMYFF LRNFSFLEVS FTTVCIPRFL YNISMGDNTI TYNACASQIF 100
FVILFGATEF FLLAAMSYDR YVAICKPLHY VVIMNNRVCT LLVLCCWVAG 150
LMIIVPPLSL GLQLEFCDSN AIDHFSCDAG PLLKISCSDT WVIEQMVILM 200
AVFALIITLV CVILSYLYIV RTILKFPSVQ QRKKAFSTCS SHMIVVSIAY 250
GSCIFIYIKP SAKDEVAINK GVSVLTTSVA PLLNPFIYTL RNKQVKQAFS 300
DSIKRIAFLS KK 312
Length:312
Mass (Da):35,178
Last modified:January 10, 2006 - v2
Checksum:i8362872FB2D1CE23
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti181 – 1811P → A.
Corresponds to variant rs11171466 [ dbSNP | Ensembl ].
VAR_034243
Natural varianti209 – 2091L → P.1 Publication
Corresponds to variant rs11171467 [ dbSNP | Ensembl ].
VAR_034244

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC122685 Genomic DNA. No translation available.
AF179766 Genomic DNA. Translation: AAF40351.1.
CCDSiCCDS31824.1.
RefSeqiNP_473446.1. NM_054105.1.
UniGeneiHs.524483.

Genome annotation databases

EnsembliENST00000322678; ENSP00000323606; ENSG00000179695.
GeneIDi341416.
KEGGihsa:341416.
UCSCiuc001sgz.1. human.

Polymorphism databases

DMDMi85541047.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC122685 Genomic DNA. No translation available.
AF179766 Genomic DNA. Translation: AAF40351.1 .
CCDSi CCDS31824.1.
RefSeqi NP_473446.1. NM_054105.1.
UniGenei Hs.524483.

3D structure databases

ProteinModelPortali Q9NZP2.
SMRi Q9NZP2. Positions 24-296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000323606.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 85541047.

Proteomic databases

PaxDbi Q9NZP2.
PRIDEi Q9NZP2.

Protocols and materials databases

DNASUi 341416.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322678 ; ENSP00000323606 ; ENSG00000179695 .
GeneIDi 341416.
KEGGi hsa:341416.
UCSCi uc001sgz.1. human.

Organism-specific databases

CTDi 341416.
GeneCardsi GC12P055845.
H-InvDB HIX0201933.
HGNCi HGNC:15436. OR6C2.
neXtProti NX_Q9NZP2.
PharmGKBi PA32580.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43260.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q9NZP2.
KOi K04257.
OMAi SYLYIVR.
OrthoDBi EOG7KH9K8.
PhylomeDBi Q9NZP2.
TreeFami TF336833.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR6C2.
GenomeRNAii 341416.
NextBioi 98146.
PROi Q9NZP2.

Gene expression databases

CleanExi HS_OR6C2.
Genevestigatori Q9NZP2.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates."
    Rouquier S., Blancher A., Giorgi D.
    Proc. Natl. Acad. Sci. U.S.A. 97:2870-2874(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 122-283, VARIANT PRO-209.

Entry informationi

Entry nameiOR6C2_HUMAN
AccessioniPrimary (citable) accession number: Q9NZP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: January 10, 2006
Last modified: September 3, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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