Q9NZP0 (OR6C3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 6C3

Alternative name(s):
HSA8

Gene names

Name:

OR6C3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement Ref.2. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Non-traceable author statement Ref.2. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Olfactory receptor 6C3		PRO_0000150625
Regions
	Topological domain	1 – 22	22	Extracellular Potential
	Transmembrane	23 – 43	21	Helical; Name=1; Potential
	Topological domain	44 – 51	8	Cytoplasmic Potential
	Transmembrane	52 – 72	21	Helical; Name=2; Potential
	Topological domain	73 – 96	24	Extracellular Potential
	Transmembrane	97 – 117	21	Helical; Name=3; Potential
	Topological domain	118 – 136	19	Cytoplasmic Potential
	Transmembrane	137 – 157	21	Helical; Name=4; Potential
	Topological domain	158 – 194	37	Extracellular Potential
	Transmembrane	195 – 214	20	Helical; Name=5; Potential
	Topological domain	215 – 234	20	Cytoplasmic Potential
	Transmembrane	235 – 255	21	Helical; Name=6; Potential
	Topological domain	256 – 268	13	Extracellular Potential
	Transmembrane	269 – 289	21	Helical; Name=7; Potential
	Topological domain	290 – 311	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	2	1	N-linked (GlcNAc...) Potential
	Disulfide bond	94 ↔ 186		By similarity
Natural variations
	Natural variant	69	1	S → L. Corresponds to variant rs4318060 [ dbSNP | Ensembl ].		VAR_053218
	Natural variant	133	1	M → T. Corresponds to variant rs11835321 [ dbSNP | Ensembl ].		VAR_053219
	Natural variant	234	1	A → S. Corresponds to variant rs11832940 [ dbSNP | Ensembl ].		VAR_034245

Sequences

	Sequence		Length	Mass (Da)
	Q9NZP0 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: 1C5D41AA2738DA91	FASTA	311	35,531
	10 20 30 40 50 60 MNHTMVTEFV LLGLSDDPDL QIVIFLFLFI TYILSVTGNL TIITLTFVDS HLQTPMYFFL 70 80 90 100 110 120 RNFSFLEISF TTVCIPRFLG AIITRNKTIS YNNCAAQLFF FIFMGVTEFY ILTAMSYDRY 130 140 150 160 170 180 VAICKPLHYT SIMNRKLCTL LVLCAWLSGF LTIFPPLMLL LQLDYCASNV IDHFACDYFP 190 200 210 220 230 240 LLQLSCSDTW LLEVIGFYFA LVTLLFTLAL VILSYMYIIR TILRIPSASQ RKKAFSTCSS 250 260 270 280 290 300 HMIVISISYG SCIFMYANPS AKEKASLTKG IAILNTSVAP MLNPFIYTLR NQQVKQAFKN 310 VVHKVVFYAN Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates." Rouquier S., Blancher A., Giorgi D. Proc. Natl. Acad. Sci. U.S.A. 97:2870-2874(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 121-282.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC122684 Genomic DNA. No translation available. AF179770 Genomic DNA. Translation: AAF40353.1.
IPI	IPI00437594.
RefSeq	NP_473445.1. NM_054104.1.
UniGene	Hs.553653.
3D structure databases
ProteinModelPortal	Q9NZP0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000368989.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9NZP0.
Polymorphism databases
DMDM	85541048.
Proteomic databases
PaxDb	Q9NZP0.
PRIDE	Q9NZP0.
Protocols and materials databases
DNASU	254786.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000379667; ENSP00000368989; ENSG00000205329.
GeneID	254786.
KEGG	hsa:254786.
UCSC	uc010spj.2. human.
Organism-specific databases
CTD	254786.
GeneCards	GC12P055725.
H-InvDB	HIX0037270.
HGNC	HGNC:15437. OR6C3.
neXtProt	NX_Q9NZP0.
PharmGKB	PA32581.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41836.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	Q9NZP0.
KO	K04257.
OMA	HKVVFST.
OrthoDB	EOG451DR7.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR6C3.
Genevestigator	Q9NZP0.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	92393.

Entry information

Entry name

OR6C3_HUMAN

Accession

Primary (citable) accession number: Q9NZP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	January 10, 2006
Last modified:	May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.