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Q9NZP0

- OR6C3_HUMAN

UniProt

Q9NZP0 - OR6C3_HUMAN

Protein

Olfactory receptor 6C3

Gene

OR6C3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
    2. sensory perception of smell Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 6C3
    Alternative name(s):
    HSA8
    Gene namesi
    Name:OR6C3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:15437. OR6C3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32581.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Olfactory receptor 6C3PRO_0000150625Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi94 ↔ 186PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9NZP0.
    PRIDEiQ9NZP0.

    PTM databases

    PhosphoSiteiQ9NZP0.

    Expressioni

    Gene expression databases

    CleanExiHS_OR6C3.
    GenevestigatoriQ9NZP0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000368989.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NZP0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini44 – 518CytoplasmicSequence Analysis
    Topological domaini73 – 9624ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini118 – 13619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini158 – 19437ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini215 – 23420CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini256 – 26813ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini290 – 31122CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei97 – 11721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21420Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41836.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ9NZP0.
    KOiK04257.
    OMAiMNHTEIT.
    OrthoDBiEOG7KH9K8.
    PhylomeDBiQ9NZP0.
    TreeFamiTF336833.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NZP0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNHTMVTEFV LLGLSDDPDL QIVIFLFLFI TYILSVTGNL TIITLTFVDS    50
    HLQTPMYFFL RNFSFLEISF TTVCIPRFLG AIITRNKTIS YNNCAAQLFF 100
    FIFMGVTEFY ILTAMSYDRY VAICKPLHYT SIMNRKLCTL LVLCAWLSGF 150
    LTIFPPLMLL LQLDYCASNV IDHFACDYFP LLQLSCSDTW LLEVIGFYFA 200
    LVTLLFTLAL VILSYMYIIR TILRIPSASQ RKKAFSTCSS HMIVISISYG 250
    SCIFMYANPS AKEKASLTKG IAILNTSVAP MLNPFIYTLR NQQVKQAFKN 300
    VVHKVVFYAN Q 311
    Length:311
    Mass (Da):35,531
    Last modified:January 10, 2006 - v2
    Checksum:i1C5D41AA2738DA91
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti69 – 691S → L.
    Corresponds to variant rs4318060 [ dbSNP | Ensembl ].
    VAR_053218
    Natural varianti133 – 1331M → T.
    Corresponds to variant rs11835321 [ dbSNP | Ensembl ].
    VAR_053219
    Natural varianti234 – 2341A → S.
    Corresponds to variant rs11832940 [ dbSNP | Ensembl ].
    VAR_034245

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC122684 Genomic DNA. No translation available.
    AF179770 Genomic DNA. Translation: AAF40353.1.
    CCDSiCCDS31819.1.
    RefSeqiNP_473445.1. NM_054104.1.
    UniGeneiHs.553653.

    Genome annotation databases

    EnsembliENST00000379667; ENSP00000368989; ENSG00000205329.
    GeneIDi254786.
    KEGGihsa:254786.
    UCSCiuc010spj.2. human.

    Polymorphism databases

    DMDMi85541048.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC122684 Genomic DNA. No translation available.
    AF179770 Genomic DNA. Translation: AAF40353.1 .
    CCDSi CCDS31819.1.
    RefSeqi NP_473445.1. NM_054104.1.
    UniGenei Hs.553653.

    3D structure databases

    ProteinModelPortali Q9NZP0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000368989.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9NZP0.

    Polymorphism databases

    DMDMi 85541048.

    Proteomic databases

    PaxDbi Q9NZP0.
    PRIDEi Q9NZP0.

    Protocols and materials databases

    DNASUi 254786.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379667 ; ENSP00000368989 ; ENSG00000205329 .
    GeneIDi 254786.
    KEGGi hsa:254786.
    UCSCi uc010spj.2. human.

    Organism-specific databases

    CTDi 254786.
    GeneCardsi GC12P055725.
    H-InvDB HIX0037270.
    HGNCi HGNC:15437. OR6C3.
    neXtProti NX_Q9NZP0.
    PharmGKBi PA32581.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41836.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q9NZP0.
    KOi K04257.
    OMAi MNHTEIT.
    OrthoDBi EOG7KH9K8.
    PhylomeDBi Q9NZP0.
    TreeFami TF336833.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR6C3.
    NextBioi 92393.
    PROi Q9NZP0.

    Gene expression databases

    CleanExi HS_OR6C3.
    Genevestigatori Q9NZP0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates."
      Rouquier S., Blancher A., Giorgi D.
      Proc. Natl. Acad. Sci. U.S.A. 97:2870-2874(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 121-282.

    Entry informationi

    Entry nameiOR6C3_HUMAN
    AccessioniPrimary (citable) accession number: Q9NZP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3