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Q9NZP0 (OR6C3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 6C3
Alternative name(s):
HSA8
Gene names
Name:OR6C3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Olfactory receptor 6C3
PRO_0000150625

Regions

Topological domain1 – 2222Extracellular Potential
Transmembrane23 – 4321Helical; Name=1; Potential
Topological domain44 – 518Cytoplasmic Potential
Transmembrane52 – 7221Helical; Name=2; Potential
Topological domain73 – 9624Extracellular Potential
Transmembrane97 – 11721Helical; Name=3; Potential
Topological domain118 – 13619Cytoplasmic Potential
Transmembrane137 – 15721Helical; Name=4; Potential
Topological domain158 – 19437Extracellular Potential
Transmembrane195 – 21420Helical; Name=5; Potential
Topological domain215 – 23420Cytoplasmic Potential
Transmembrane235 – 25521Helical; Name=6; Potential
Topological domain256 – 26813Extracellular Potential
Transmembrane269 – 28921Helical; Name=7; Potential
Topological domain290 – 31122Cytoplasmic Potential

Amino acid modifications

Glycosylation21N-linked (GlcNAc...) Potential
Disulfide bond94 ↔ 186 By similarity

Natural variations

Natural variant691S → L.
Corresponds to variant rs4318060 [ dbSNP | Ensembl ].
VAR_053218
Natural variant1331M → T.
Corresponds to variant rs11835321 [ dbSNP | Ensembl ].
VAR_053219
Natural variant2341A → S.
Corresponds to variant rs11832940 [ dbSNP | Ensembl ].
VAR_034245

Sequences

Sequence LengthMass (Da)Tools
Q9NZP0 [UniParc].

Last modified January 10, 2006. Version 2.
Checksum: 1C5D41AA2738DA91

FASTA31135,531
        10         20         30         40         50         60 
MNHTMVTEFV LLGLSDDPDL QIVIFLFLFI TYILSVTGNL TIITLTFVDS HLQTPMYFFL 

        70         80         90        100        110        120 
RNFSFLEISF TTVCIPRFLG AIITRNKTIS YNNCAAQLFF FIFMGVTEFY ILTAMSYDRY 

       130        140        150        160        170        180 
VAICKPLHYT SIMNRKLCTL LVLCAWLSGF LTIFPPLMLL LQLDYCASNV IDHFACDYFP 

       190        200        210        220        230        240 
LLQLSCSDTW LLEVIGFYFA LVTLLFTLAL VILSYMYIIR TILRIPSASQ RKKAFSTCSS 

       250        260        270        280        290        300 
HMIVISISYG SCIFMYANPS AKEKASLTKG IAILNTSVAP MLNPFIYTLR NQQVKQAFKN 

       310 
VVHKVVFYAN Q 

« Hide

References

« Hide 'large scale' references
[1]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates."
Rouquier S., Blancher A., Giorgi D.
Proc. Natl. Acad. Sci. U.S.A. 97:2870-2874(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 121-282.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC122684 Genomic DNA. No translation available.
AF179770 Genomic DNA. Translation: AAF40353.1.
RefSeqNP_473445.1. NM_054104.1.
UniGeneHs.553653.

3D structure databases

ProteinModelPortalQ9NZP0.
SMRQ9NZP0. Positions 106-137, 276-303.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000368989.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9NZP0.

Polymorphism databases

DMDM85541048.

Proteomic databases

PaxDbQ9NZP0.
PRIDEQ9NZP0.

Protocols and materials databases

DNASU254786.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000379667; ENSP00000368989; ENSG00000205329.
GeneID254786.
KEGGhsa:254786.
UCSCuc010spj.2. human.

Organism-specific databases

CTD254786.
GeneCardsGC12P055725.
H-InvDBHIX0037270.
HGNCHGNC:15437. OR6C3.
neXtProtNX_Q9NZP0.
PharmGKBPA32581.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41836.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ9NZP0.
KOK04257.
OMAMNHTEIT.
OrthoDBEOG7KH9K8.
PhylomeDBQ9NZP0.
TreeFamTF336833.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR6C3.
GenevestigatorQ9NZP0.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR6C3.
NextBio92393.
PROQ9NZP0.

Entry information

Entry nameOR6C3_HUMAN
AccessionPrimary (citable) accession number: Q9NZP0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: January 10, 2006
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries