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Protein

Olfactory receptor 6C3

Gene

OR6C3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6C3
Alternative name(s):
HSA8
Gene namesi
Name:OR6C3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:15437. OR6C3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222ExtracellularSequence AnalysisAdd
BLAST
Transmembranei23 – 4321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini44 – 518CytoplasmicSequence Analysis
Transmembranei52 – 7221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini73 – 9624ExtracellularSequence AnalysisAdd
BLAST
Transmembranei97 – 11721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini118 – 13619CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei137 – 15721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini158 – 19437ExtracellularSequence AnalysisAdd
BLAST
Transmembranei195 – 21420Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini215 – 23420CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini256 – 26813ExtracellularSequence AnalysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini290 – 31122CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32581.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 6C3PRO_0000150625Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi94 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NZP0.
PRIDEiQ9NZP0.

PTM databases

PhosphoSiteiQ9NZP0.

Expressioni

Gene expression databases

CleanExiHS_OR6C3.
GenevestigatoriQ9NZP0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368989.

Structurei

3D structure databases

ProteinModelPortaliQ9NZP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41836.
GeneTreeiENSGT00760000118790.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ9NZP0.
KOiK04257.
OMAiEMNHTVI.
OrthoDBiEOG7KH9K8.
PhylomeDBiQ9NZP0.
TreeFamiTF336833.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NZP0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNHTMVTEFV LLGLSDDPDL QIVIFLFLFI TYILSVTGNL TIITLTFVDS
60 70 80 90 100
HLQTPMYFFL RNFSFLEISF TTVCIPRFLG AIITRNKTIS YNNCAAQLFF
110 120 130 140 150
FIFMGVTEFY ILTAMSYDRY VAICKPLHYT SIMNRKLCTL LVLCAWLSGF
160 170 180 190 200
LTIFPPLMLL LQLDYCASNV IDHFACDYFP LLQLSCSDTW LLEVIGFYFA
210 220 230 240 250
LVTLLFTLAL VILSYMYIIR TILRIPSASQ RKKAFSTCSS HMIVISISYG
260 270 280 290 300
SCIFMYANPS AKEKASLTKG IAILNTSVAP MLNPFIYTLR NQQVKQAFKN
310
VVHKVVFYAN Q
Length:311
Mass (Da):35,531
Last modified:January 10, 2006 - v2
Checksum:i1C5D41AA2738DA91
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti69 – 691S → L.
Corresponds to variant rs4318060 [ dbSNP | Ensembl ].
VAR_053218
Natural varianti133 – 1331M → T.
Corresponds to variant rs11835321 [ dbSNP | Ensembl ].
VAR_053219
Natural varianti234 – 2341A → S.
Corresponds to variant rs11832940 [ dbSNP | Ensembl ].
VAR_034245

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122684 Genomic DNA. No translation available.
AF179770 Genomic DNA. Translation: AAF40353.1.
CCDSiCCDS31819.1.
RefSeqiNP_473445.1. NM_054104.1.
UniGeneiHs.553653.

Genome annotation databases

EnsembliENST00000379667; ENSP00000368989; ENSG00000205329.
GeneIDi254786.
KEGGihsa:254786.
UCSCiuc010spj.2. human.

Polymorphism databases

DMDMi85541048.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122684 Genomic DNA. No translation available.
AF179770 Genomic DNA. Translation: AAF40353.1.
CCDSiCCDS31819.1.
RefSeqiNP_473445.1. NM_054104.1.
UniGeneiHs.553653.

3D structure databases

ProteinModelPortaliQ9NZP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368989.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9NZP0.

Polymorphism databases

DMDMi85541048.

Proteomic databases

PaxDbiQ9NZP0.
PRIDEiQ9NZP0.

Protocols and materials databases

DNASUi254786.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379667; ENSP00000368989; ENSG00000205329.
GeneIDi254786.
KEGGihsa:254786.
UCSCiuc010spj.2. human.

Organism-specific databases

CTDi254786.
GeneCardsiGC12P055725.
H-InvDBHIX0037270.
HGNCiHGNC:15437. OR6C3.
neXtProtiNX_Q9NZP0.
PharmGKBiPA32581.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41836.
GeneTreeiENSGT00760000118790.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ9NZP0.
KOiK04257.
OMAiEMNHTVI.
OrthoDBiEOG7KH9K8.
PhylomeDBiQ9NZP0.
TreeFamiTF336833.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR6C3.
GenomeRNAii254786.
NextBioi92393.
PROiQ9NZP0.

Gene expression databases

CleanExiHS_OR6C3.
GenevestigatoriQ9NZP0.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates."
    Rouquier S., Blancher A., Giorgi D.
    Proc. Natl. Acad. Sci. U.S.A. 97:2870-2874(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 121-282.

Entry informationi

Entry nameiOR6C3_HUMAN
AccessioniPrimary (citable) accession number: Q9NZP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: January 10, 2006
Last modified: January 7, 2015
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.