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Q9NZN8

- CNOT2_HUMAN

UniProt

Q9NZN8 - CNOT2_HUMAN

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Protein

CCR4-NOT transcription complex subunit 2

Gene

CNOT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.4 Publications

GO - Molecular functioni

  1. RNA polymerase II transcription cofactor activity Source: UniProtKB
  2. RNA polymerase II transcription corepressor binding Source: UniProtKB

GO - Biological processi

  1. gene expression Source: Reactome
  2. gene silencing by RNA Source: UniProtKB-KW
  3. mRNA metabolic process Source: Reactome
  4. negative regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
  5. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  6. nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: Reactome
  7. nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
  8. positive regulation of cytoplasmic mRNA processing body assembly Source: UniProtKB
  9. regulation of stem cell maintenance Source: UniProtKB
  10. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  11. regulation of translation Source: UniProtKB-KW
  12. RNA metabolic process Source: Reactome
  13. RNA phosphodiester bond hydrolysis, exonucleolytic Source: GOC
  14. transcription from RNA polymerase II promoter Source: GOC
  15. trophectodermal cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

ReactomeiREACT_20514. Deadenylation of mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 2
Alternative name(s):
CCR4-associated factor 2
Gene namesi
Name:CNOT2
Synonyms:CDC36, NOT2
ORF Names:HSPC131, MSTP046
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:7878. CNOT2.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. CCR4-NOT complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. cytosol Source: Reactome
  4. membrane Source: UniProtKB
  5. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26673.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540CCR4-NOT transcription complex subunit 2PRO_0000198331Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei93 – 931Phosphothreonine1 Publication
Modified residuei126 – 1261Phosphoserine2 Publications
Modified residuei165 – 1651Phosphoserine4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NZN8.
PaxDbiQ9NZN8.
PRIDEiQ9NZN8.

PTM databases

PhosphoSiteiQ9NZN8.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.1 Publication

Developmental stagei

Expressed in embryonic stem (ES) cells.1 Publication

Gene expression databases

BgeeiQ9NZN8.
CleanExiHS_CNOT2.
ExpressionAtlasiQ9NZN8. baseline and differential.
GenevestigatoriQ9NZN8.

Interactioni

Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3. Interacts with NCOR1, NCOR2. HDAC3 and GPS2.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CNOT1A5YKK63EBI-743033,EBI-1222758
CNOT3O751752EBI-743033,EBI-743073
CNOT8Q9UFF92EBI-743033,EBI-742299
TNRC6CQ9HCJ03EBI-743033,EBI-6507625

Protein-protein interaction databases

BioGridi110910. 20 interactions.
DIPiDIP-42656N.
IntActiQ9NZN8. 21 interactions.
MINTiMINT-1438957.
STRINGi9606.ENSP00000229195.

Structurei

Secondary structure

1
540
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi357 – 36913Combined sources
Helixi371 – 3733Combined sources
Turni374 – 3785Combined sources
Beta strandi385 – 3873Combined sources
Helixi396 – 3983Combined sources
Turni419 – 4213Combined sources
Turni424 – 4263Combined sources
Turni428 – 4303Combined sources
Helixi436 – 4383Combined sources
Helixi441 – 4499Combined sources
Helixi453 – 46614Combined sources
Beta strandi470 – 4723Combined sources
Turni473 – 4764Combined sources
Beta strandi477 – 4815Combined sources
Beta strandi488 – 4903Combined sources
Beta strandi492 – 50312Combined sources
Turni504 – 5074Combined sources
Beta strandi508 – 51710Combined sources
Helixi518 – 5203Combined sources
Helixi535 – 5384Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C0DX-ray3.20B344-540[»]
4C0FX-ray2.40A/B/C/D429-540[»]
ProteinModelPortaliQ9NZN8.
SMRiQ9NZN8. Positions 350-540.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni437 – 540104Repressor domainAdd
BLAST

Sequence similaritiesi

Belongs to the CNOT2/3/5 family.Curated

Phylogenomic databases

eggNOGiCOG5601.
GeneTreeiENSGT00390000001285.
HOGENOMiHOG000246523.
HOVERGENiHBG051041.
InParanoidiQ9NZN8.
KOiK12605.
OMAiTQDFSIH.
PhylomeDBiQ9NZN8.
TreeFamiTF313102.

Family and domain databases

InterProiIPR007282. NOT.
[Graphical view]
PfamiPF04153. NOT2_3_5. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NZN8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRTDGHTLS EKRNYQVTNS MFGASRKKFV EGVDSDYHDE NMYYSQSSMF
60 70 80 90 100
PHRSEKDMLA SPSTSGQLSQ FGASLYGQQS ALGLPMRGMS NNTPQLNRSL
110 120 130 140 150
SQGTQLPSHV TPTTGVPTMS LHTPPSPSRG ILPMNPRNMM NHSQVGQGIG
160 170 180 190 200
IPSRTNSMSS SGLGSPNRSS PSIICMPKQQ PSRQPFTVNS MSGFGMNRNQ
210 220 230 240 250
AFGMNNSLSS NIFNGTDGSE NVTGLDLSDF PALADRNRRE GSGNPTPLIN
260 270 280 290 300
PLAGRAPYVG MVTKPANEQS QDFSIHNEDF PALPGSSYKD PTSSNDDSKS
310 320 330 340 350
NLNTSGKTTS STDGPKFPGD KSSTTQNNNQ QKKGIQVLPD GRVTNIPQGM
360 370 380 390 400
VTDQFGMIGL LTFIRAAETD PGMVHLALGS DLTTLGLNLN SPENLYPKFA
410 420 430 440 450
SPWASSPCRP QDIDFHVPSE YLTNIHIRDK LAAIKLGRYG EDLLFYLYYM
460 470 480 490 500
NGGDVLQLLA AVELFNRDWR YHKEERVWIT RAPGMEPTMK TNTYERGTYY
510 520 530 540
FFDCLNWRKV AKEFHLEYDK LEERPHLPST FNYNPAQQAF
Length:540
Mass (Da):59,738
Last modified:October 1, 2000 - v1
Checksum:i7183890F033E3B83
GO
Isoform 2 (identifier: Q9NZN8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.

Note: No experimental confirmation available.

Show »
Length:365
Mass (Da):40,818
Checksum:i27FC908ADA1A6201
GO
Isoform 3 (identifier: Q9NZN8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-349: Missing.

Note: May be due to an intron retention. No experimental confirmation available.

Show »
Length:191
Mass (Da):22,254
Checksum:i803037A4A6F670CC
GO
Isoform 4 (identifier: Q9NZN8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-475: FNRDWRYHKEE → YVQSILITFVL
     476-540: Missing.

Note: May be due to an intron retention. No experimental confirmation available.

Show »
Length:475
Mass (Da):51,537
Checksum:i5D5C630BB3E89F06
GO
Isoform 5 (identifier: Q9NZN8-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-278: Missing.

Note: No experimental confirmation available.

Show »
Length:490
Mass (Da):54,306
Checksum:i7C6A4CC0F0992C9C
GO

Sequence cautioni

The sequence AAF29095.1 differs from that shown. Reason: Frameshift at position 474. Curated
The sequence AAQ13426.1 differs from that shown. Reason: Frameshift at positions 71, 76, 84, 98, 123, 370, 384 and 393. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti460 – 4601A → T.
Corresponds to variant rs11178192 [ dbSNP | Ensembl ].
VAR_048750

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 349349Missing in isoform 3. 1 PublicationVSP_009913Add
BLAST
Alternative sequencei1 – 175175Missing in isoform 2. 1 PublicationVSP_009912Add
BLAST
Alternative sequencei229 – 27850Missing in isoform 5. 1 PublicationVSP_009914Add
BLAST
Alternative sequencei465 – 47511FNRDWRYHKEE → YVQSILITFVL in isoform 4. 1 PublicationVSP_009915Add
BLAST
Alternative sequencei476 – 54065Missing in isoform 4. 1 PublicationVSP_009916Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180473 mRNA. Translation: AAF29827.1.
AF113226 mRNA. Translation: AAG39297.1.
AF161480 mRNA. Translation: AAF29095.1. Frameshift.
AK000662 mRNA. Translation: BAA91313.1.
AL137674 mRNA. Translation: CAB70869.1.
BX641116 mRNA. Translation: CAE46054.1.
BC002597 mRNA. Translation: AAH02597.1.
BC011826 mRNA. Translation: AAH11826.1.
AF044215 mRNA. Translation: AAQ13426.1. Frameshift.
CCDSiCCDS31857.1. [Q9NZN8-1]
PIRiT46494.
RefSeqiNP_001186231.1. NM_001199302.1. [Q9NZN8-1]
NP_001186232.1. NM_001199303.1. [Q9NZN8-1]
NP_055330.1. NM_014515.5. [Q9NZN8-1]
UniGeneiHs.133350.
Hs.730666.

Genome annotation databases

EnsembliENST00000229195; ENSP00000229195; ENSG00000111596. [Q9NZN8-1]
ENST00000418359; ENSP00000412091; ENSG00000111596. [Q9NZN8-1]
ENST00000551043; ENSP00000449260; ENSG00000111596. [Q9NZN8-1]
ENST00000551483; ENSP00000448883; ENSG00000111596. [Q9NZN8-3]
GeneIDi4848.
KEGGihsa:4848.
UCSCiuc001svv.3. human. [Q9NZN8-1]
uc001svw.1. human. [Q9NZN8-2]

Polymorphism databases

DMDMi46396017.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180473 mRNA. Translation: AAF29827.1 .
AF113226 mRNA. Translation: AAG39297.1 .
AF161480 mRNA. Translation: AAF29095.1 . Frameshift.
AK000662 mRNA. Translation: BAA91313.1 .
AL137674 mRNA. Translation: CAB70869.1 .
BX641116 mRNA. Translation: CAE46054.1 .
BC002597 mRNA. Translation: AAH02597.1 .
BC011826 mRNA. Translation: AAH11826.1 .
AF044215 mRNA. Translation: AAQ13426.1 . Frameshift.
CCDSi CCDS31857.1. [Q9NZN8-1 ]
PIRi T46494.
RefSeqi NP_001186231.1. NM_001199302.1. [Q9NZN8-1 ]
NP_001186232.1. NM_001199303.1. [Q9NZN8-1 ]
NP_055330.1. NM_014515.5. [Q9NZN8-1 ]
UniGenei Hs.133350.
Hs.730666.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4C0D X-ray 3.20 B 344-540 [» ]
4C0F X-ray 2.40 A/B/C/D 429-540 [» ]
ProteinModelPortali Q9NZN8.
SMRi Q9NZN8. Positions 350-540.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110910. 20 interactions.
DIPi DIP-42656N.
IntActi Q9NZN8. 21 interactions.
MINTi MINT-1438957.
STRINGi 9606.ENSP00000229195.

PTM databases

PhosphoSitei Q9NZN8.

Polymorphism databases

DMDMi 46396017.

Proteomic databases

MaxQBi Q9NZN8.
PaxDbi Q9NZN8.
PRIDEi Q9NZN8.

Protocols and materials databases

DNASUi 4848.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000229195 ; ENSP00000229195 ; ENSG00000111596 . [Q9NZN8-1 ]
ENST00000418359 ; ENSP00000412091 ; ENSG00000111596 . [Q9NZN8-1 ]
ENST00000551043 ; ENSP00000449260 ; ENSG00000111596 . [Q9NZN8-1 ]
ENST00000551483 ; ENSP00000448883 ; ENSG00000111596 . [Q9NZN8-3 ]
GeneIDi 4848.
KEGGi hsa:4848.
UCSCi uc001svv.3. human. [Q9NZN8-1 ]
uc001svw.1. human. [Q9NZN8-2 ]

Organism-specific databases

CTDi 4848.
GeneCardsi GC12P070636.
HGNCi HGNC:7878. CNOT2.
MIMi 604909. gene.
neXtProti NX_Q9NZN8.
PharmGKBi PA26673.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5601.
GeneTreei ENSGT00390000001285.
HOGENOMi HOG000246523.
HOVERGENi HBG051041.
InParanoidi Q9NZN8.
KOi K12605.
OMAi TQDFSIH.
PhylomeDBi Q9NZN8.
TreeFami TF313102.

Enzyme and pathway databases

Reactomei REACT_20514. Deadenylation of mRNA.

Miscellaneous databases

ChiTaRSi CNOT2. human.
GeneWikii CNOT2.
GenomeRNAii 4848.
NextBioi 18670.
PROi Q9NZN8.
SOURCEi Search...

Gene expression databases

Bgeei Q9NZN8.
CleanExi HS_CNOT2.
ExpressionAtlasi Q9NZN8. baseline and differential.
Genevestigatori Q9NZN8.

Family and domain databases

InterProi IPR007282. NOT.
[Graphical view ]
Pfami PF04153. NOT2_3_5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits."
    Albert T.K., Lemaire M., van Berkum N.L., Gentz R., Collart M.A., Timmers H.T.M.
    Nucleic Acids Res. 28:809-817(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CNOT1, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Heart.
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    Tissue: Fetal kidney and Testis.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lymph and Skin.
  7. "Separation and molecular cloning of a novel human cDNA fragment coding a protein without homologs."
    Bi A., Yu L., Zhang M., Fan Y., Zhang Q., Zhao Y., Gao J., Zhao S.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-377.
  8. "Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex."
    Zwartjes C.G., Jayne S., van den Berg D.L., Timmers H.T.
    J. Biol. Chem. 279:10848-10854(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN.
  9. "Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex."
    Jayne S., Zwartjes C.G., van Schaik F.M., Timmers H.T.
    Biochem. J. 398:461-467(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NCOR1; NCOR2; HDAC3 AND GPS2.
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-93; SER-126 AND SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: IDENTIFICATION IN THE CCR4-NOT COMPLEX, COMPOSITION OF THE CCR4-NOT COMPLEX.
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death."
    Ito K., Inoue T., Yokoyama K., Morita M., Suzuki T., Yamamoto T.
    Genes Cells 16:368-379(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CNOT3, SUBCELLULAR LOCATION.
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation."
    Zheng X., Dumitru R., Lackford B.L., Freudenberg J.M., Singh A.P., Archer T.K., Jothi R., Hu G.
    Stem Cells 30:910-922(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCNOT2_HUMAN
AccessioniPrimary (citable) accession number: Q9NZN8
Secondary accession number(s): Q9H3E0
, Q9NSX5, Q9NWR6, Q9P028
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3