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Q9NZN8 (CNOT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CCR4-NOT transcription complex subunit 2
Alternative name(s):
CCR4-associated factor 2
Gene names
Name:CNOT2
Synonyms:CDC36, NOT2
ORF Names:HSPC131, MSTP046
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity. Ref.8 Ref.9 Ref.17 Ref.19

Subunit structure

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3. Interacts with NCOR1, NCOR2. HDAC3 and GPS2. Ref.1 Ref.9 Ref.13 Ref.17

Subcellular location

Cytoplasm. Nucleus Probable Ref.17.

Tissue specificity

Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Ref.1

Developmental stage

Expressed in embryonic stem (ES) cells. Ref.19

Sequence similarities

Belongs to the CNOT2/3/5 family.

Sequence caution

The sequence AAF29095.1 differs from that shown. Reason: Frameshift at position 474.

The sequence AAQ13426.1 differs from that shown. Reason: Frameshift at positions 71, 76, 84, 98, 123, 370, 384 and 393.

Ontologies

Keywords
   Biological processRNA-mediated gene silencing
Transcription
Transcription regulation
Translation regulation
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   Molecular functionDevelopmental protein
Repressor
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA metabolic process

Traceable author statement. Source: Reactome

RNA phosphodiester bond hydrolysis, exonucleolytic

Inferred from mutant phenotype Ref.17. Source: GOC

gene expression

Traceable author statement. Source: Reactome

gene silencing by RNA

Inferred from electronic annotation. Source: UniProtKB-KW

mRNA metabolic process

Traceable author statement. Source: Reactome

negative regulation of intracellular estrogen receptor signaling pathway

Inferred from mutant phenotype PubMed 16778766. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay Ref.8Ref.9. Source: UniProtKB

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Traceable author statement. Source: Reactome

nuclear-transcribed mRNA poly(A) tail shortening

Traceable author statement. Source: Reactome

positive regulation of cytoplasmic mRNA processing body assembly

Inferred from mutant phenotype Ref.17. Source: UniProtKB

regulation of stem cell maintenance

Inferred from mutant phenotype Ref.19. Source: UniProtKB

regulation of transcription from RNA polymerase II promoter

Non-traceable author statement Ref.1. Source: UniProtKB

regulation of translation

Inferred from electronic annotation. Source: UniProtKB-KW

transcription from RNA polymerase II promoter

Traceable author statement Ref.1. Source: GOC

trophectodermal cell differentiation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentCCR4-NOT complex

Inferred from direct assay Ref.13. Source: UniProtKB

cytoplasm

Inferred from direct assay Ref.17. Source: UniProtKB

cytosol

Traceable author statement. Source: Reactome

nucleus

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular_functionRNA polymerase II transcription cofactor activity

Traceable author statement Ref.1. Source: UniProtKB

RNA polymerase II transcription corepressor binding

Inferred from direct assay Ref.9. Source: UniProtKB

protein binding

Inferred from physical interaction Ref.1PubMed 16189514PubMed 16778766PubMed 21981923. Source: IntAct

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NZN8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NZN8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9NZN8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-349: Missing.
Note: May be due to an intron retention. No experimental confirmation available.
Isoform 4 (identifier: Q9NZN8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     465-475: FNRDWRYHKEE → YVQSILITFVL
     476-540: Missing.
Note: May be due to an intron retention. No experimental confirmation available.
Isoform 5 (identifier: Q9NZN8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     229-278: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 540540CCR4-NOT transcription complex subunit 2
PRO_0000198331

Regions

Region437 – 540104Repressor domain

Amino acid modifications

Modified residue931Phosphothreonine Ref.11
Modified residue1261Phosphoserine Ref.11 Ref.14
Modified residue1651Phosphoserine Ref.10 Ref.11 Ref.15 Ref.18

Natural variations

Alternative sequence1 – 349349Missing in isoform 3.
VSP_009913
Alternative sequence1 – 175175Missing in isoform 2.
VSP_009912
Alternative sequence229 – 27850Missing in isoform 5.
VSP_009914
Alternative sequence465 – 47511FNRDWRYHKEE → YVQSILITFVL in isoform 4.
VSP_009915
Alternative sequence476 – 54065Missing in isoform 4.
VSP_009916
Natural variant4601A → T.
Corresponds to variant rs11178192 [ dbSNP | Ensembl ].
VAR_048750

Secondary structure

................................... 540
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 7183890F033E3B83

FASTA54059,738
        10         20         30         40         50         60 
MVRTDGHTLS EKRNYQVTNS MFGASRKKFV EGVDSDYHDE NMYYSQSSMF PHRSEKDMLA 

        70         80         90        100        110        120 
SPSTSGQLSQ FGASLYGQQS ALGLPMRGMS NNTPQLNRSL SQGTQLPSHV TPTTGVPTMS 

       130        140        150        160        170        180 
LHTPPSPSRG ILPMNPRNMM NHSQVGQGIG IPSRTNSMSS SGLGSPNRSS PSIICMPKQQ 

       190        200        210        220        230        240 
PSRQPFTVNS MSGFGMNRNQ AFGMNNSLSS NIFNGTDGSE NVTGLDLSDF PALADRNRRE 

       250        260        270        280        290        300 
GSGNPTPLIN PLAGRAPYVG MVTKPANEQS QDFSIHNEDF PALPGSSYKD PTSSNDDSKS 

       310        320        330        340        350        360 
NLNTSGKTTS STDGPKFPGD KSSTTQNNNQ QKKGIQVLPD GRVTNIPQGM VTDQFGMIGL 

       370        380        390        400        410        420 
LTFIRAAETD PGMVHLALGS DLTTLGLNLN SPENLYPKFA SPWASSPCRP QDIDFHVPSE 

       430        440        450        460        470        480 
YLTNIHIRDK LAAIKLGRYG EDLLFYLYYM NGGDVLQLLA AVELFNRDWR YHKEERVWIT 

       490        500        510        520        530        540 
RAPGMEPTMK TNTYERGTYY FFDCLNWRKV AKEFHLEYDK LEERPHLPST FNYNPAQQAF 

« Hide

Isoform 2 [UniParc].

Checksum: 27FC908ADA1A6201
Show »

FASTA36540,818
Isoform 3 [UniParc].

Checksum: 803037A4A6F670CC
Show »

FASTA19122,254
Isoform 4 [UniParc].

Checksum: 5D5C630BB3E89F06
Show »

FASTA47551,537
Isoform 5 [UniParc].

Checksum: 7C6A4CC0F0992C9C
Show »

FASTA49054,306

References

« Hide 'large scale' references
[1]"Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits."
Albert T.K., Lemaire M., van Berkum N.L., Gentz R., Collart M.A., Timmers H.T.M.
Nucleic Acids Res. 28:809-817(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CNOT1, TISSUE SPECIFICITY.
[2]Liu B., Liu Y.Q., Wang X.Y., Zhao B., Sheng H., Zhao X.W., Liu S., Xu Y.Y., Ye J., Song L., Gao Y., Zhang C.L., Zhang J., Wei Y.J., Cao H.Q., Zhao Y., Liu L.S., Ding J.F. expand/collapse author list , Gao R.L., Wu Q.Y., Qiang B.Q., Yuan J.G., Liew C.C., Zhao M.S., Hui R.T.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Heart.
[3]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Umbilical cord blood.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
Tissue: Fetal kidney and Testis.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lymph and Skin.
[7]"Separation and molecular cloning of a novel human cDNA fragment coding a protein without homologs."
Bi A., Yu L., Zhang M., Fan Y., Zhang Q., Zhao Y., Gao J., Zhao S.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-377.
[8]"Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex."
Zwartjes C.G., Jayne S., van den Berg D.L., Timmers H.T.
J. Biol. Chem. 279:10848-10854(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DOMAIN.
[9]"Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex."
Jayne S., Zwartjes C.G., van Schaik F.M., Timmers H.T.
Biochem. J. 398:461-467(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH NCOR1; NCOR2; HDAC3 AND GPS2.
[10]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-93; SER-126 AND SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Human Ccr4-Not complexes contain variable deadenylase subunits."
Lau N.C., Kolkman A., van Schaik F.M., Mulder K.W., Pijnappel W.W., Heck A.J., Timmers H.T.
Biochem. J. 422:443-453(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE CCR4-NOT COMPLEX, COMPOSITION OF THE CCR4-NOT COMPLEX.
[14]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[15]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[16]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]"CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death."
Ito K., Inoue T., Yokoyama K., Morita M., Suzuki T., Yamamoto T.
Genes Cells 16:368-379(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CNOT3, SUBCELLULAR LOCATION.
[18]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[19]"Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation."
Zheng X., Dumitru R., Lackford B.L., Freudenberg J.M., Singh A.P., Archer T.K., Jothi R., Hu G.
Stem Cells 30:910-922(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF180473 mRNA. Translation: AAF29827.1.
AF113226 mRNA. Translation: AAG39297.1.
AF161480 mRNA. Translation: AAF29095.1. Frameshift.
AK000662 mRNA. Translation: BAA91313.1.
AL137674 mRNA. Translation: CAB70869.1.
BX641116 mRNA. Translation: CAE46054.1.
BC002597 mRNA. Translation: AAH02597.1.
BC011826 mRNA. Translation: AAH11826.1.
AF044215 mRNA. Translation: AAQ13426.1. Frameshift.
CCDSCCDS31857.1. [Q9NZN8-1]
PIRT46494.
RefSeqNP_001186231.1. NM_001199302.1. [Q9NZN8-1]
NP_001186232.1. NM_001199303.1. [Q9NZN8-1]
NP_055330.1. NM_014515.5. [Q9NZN8-1]
UniGeneHs.133350.
Hs.730666.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4C0DX-ray3.20B344-540[»]
4C0FX-ray2.40A/B/C/D429-540[»]
ProteinModelPortalQ9NZN8.
SMRQ9NZN8. Positions 350-540.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110910. 14 interactions.
DIPDIP-42656N.
IntActQ9NZN8. 21 interactions.
MINTMINT-1438957.
STRING9606.ENSP00000229195.

PTM databases

PhosphoSiteQ9NZN8.

Polymorphism databases

DMDM46396017.

Proteomic databases

MaxQBQ9NZN8.
PaxDbQ9NZN8.
PRIDEQ9NZN8.

Protocols and materials databases

DNASU4848.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000229195; ENSP00000229195; ENSG00000111596. [Q9NZN8-1]
ENST00000418359; ENSP00000412091; ENSG00000111596. [Q9NZN8-1]
ENST00000551043; ENSP00000449260; ENSG00000111596. [Q9NZN8-1]
ENST00000551483; ENSP00000448883; ENSG00000111596. [Q9NZN8-3]
GeneID4848.
KEGGhsa:4848.
UCSCuc001svv.3. human. [Q9NZN8-1]
uc001svw.1. human. [Q9NZN8-2]

Organism-specific databases

CTD4848.
GeneCardsGC12P070636.
HGNCHGNC:7878. CNOT2.
MIM604909. gene.
neXtProtNX_Q9NZN8.
PharmGKBPA26673.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5601.
HOGENOMHOG000246523.
HOVERGENHBG051041.
InParanoidQ9NZN8.
KOK12605.
OMATQDFSIH.
PhylomeDBQ9NZN8.
TreeFamTF313102.

Enzyme and pathway databases

ReactomeREACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9NZN8.
BgeeQ9NZN8.
CleanExHS_CNOT2.
GenevestigatorQ9NZN8.

Family and domain databases

InterProIPR007282. NOT.
[Graphical view]
PfamPF04153. NOT2_3_5. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCNOT2. human.
GeneWikiCNOT2.
GenomeRNAi4848.
NextBio18670.
PROQ9NZN8.
SOURCESearch...

Entry information

Entry nameCNOT2_HUMAN
AccessionPrimary (citable) accession number: Q9NZN8
Secondary accession number(s): Q9H3E0 expand/collapse secondary AC list , Q9NSX5, Q9NWR6, Q9P028
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM