Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NZN8

- CNOT2_HUMAN

UniProt

Q9NZN8 - CNOT2_HUMAN

Protein

CCR4-NOT transcription complex subunit 2

Gene

CNOT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.4 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. RNA polymerase II transcription cofactor activity Source: UniProtKB
    3. RNA polymerase II transcription corepressor binding Source: UniProtKB

    GO - Biological processi

    1. gene expression Source: Reactome
    2. gene silencing by RNA Source: UniProtKB-KW
    3. mRNA metabolic process Source: Reactome
    4. negative regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
    5. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    6. nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: Reactome
    7. nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
    8. positive regulation of cytoplasmic mRNA processing body assembly Source: UniProtKB
    9. regulation of stem cell maintenance Source: UniProtKB
    10. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    11. regulation of translation Source: UniProtKB-KW
    12. RNA metabolic process Source: Reactome
    13. RNA phosphodiester bond hydrolysis, exonucleolytic Source: GOC
    14. transcription from RNA polymerase II promoter Source: GOC
    15. trophectodermal cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Repressor

    Keywords - Biological processi

    RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

    Enzyme and pathway databases

    ReactomeiREACT_20514. Deadenylation of mRNA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CCR4-NOT transcription complex subunit 2
    Alternative name(s):
    CCR4-associated factor 2
    Gene namesi
    Name:CNOT2
    Synonyms:CDC36, NOT2
    ORF Names:HSPC131, MSTP046
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:7878. CNOT2.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. CCR4-NOT complex Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. cytosol Source: Reactome
    4. membrane Source: UniProtKB
    5. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26673.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 540540CCR4-NOT transcription complex subunit 2PRO_0000198331Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei93 – 931Phosphothreonine1 Publication
    Modified residuei126 – 1261Phosphoserine2 Publications
    Modified residuei165 – 1651Phosphoserine4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NZN8.
    PaxDbiQ9NZN8.
    PRIDEiQ9NZN8.

    PTM databases

    PhosphoSiteiQ9NZN8.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.1 Publication

    Developmental stagei

    Expressed in embryonic stem (ES) cells.1 Publication

    Gene expression databases

    ArrayExpressiQ9NZN8.
    BgeeiQ9NZN8.
    CleanExiHS_CNOT2.
    GenevestigatoriQ9NZN8.

    Interactioni

    Subunit structurei

    Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3. Interacts with NCOR1, NCOR2. HDAC3 and GPS2.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CNOT1A5YKK63EBI-743033,EBI-1222758
    CNOT3O751752EBI-743033,EBI-743073
    CNOT8Q9UFF92EBI-743033,EBI-742299
    TNRC6CQ9HCJ03EBI-743033,EBI-6507625

    Protein-protein interaction databases

    BioGridi110910. 15 interactions.
    DIPiDIP-42656N.
    IntActiQ9NZN8. 21 interactions.
    MINTiMINT-1438957.
    STRINGi9606.ENSP00000229195.

    Structurei

    Secondary structure

    1
    540
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi357 – 36913
    Helixi371 – 3733
    Turni374 – 3785
    Beta strandi385 – 3873
    Helixi396 – 3983
    Turni419 – 4213
    Turni424 – 4263
    Turni428 – 4303
    Helixi436 – 4383
    Helixi441 – 4499
    Helixi453 – 46614
    Beta strandi470 – 4723
    Turni473 – 4764
    Beta strandi477 – 4815
    Beta strandi488 – 4903
    Beta strandi492 – 50312
    Turni504 – 5074
    Beta strandi508 – 51710
    Helixi518 – 5203
    Helixi535 – 5384

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4C0DX-ray3.20B344-540[»]
    4C0FX-ray2.40A/B/C/D429-540[»]
    ProteinModelPortaliQ9NZN8.
    SMRiQ9NZN8. Positions 350-540.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni437 – 540104Repressor domainAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CNOT2/3/5 family.Curated

    Phylogenomic databases

    eggNOGiCOG5601.
    HOGENOMiHOG000246523.
    HOVERGENiHBG051041.
    InParanoidiQ9NZN8.
    KOiK12605.
    OMAiTQDFSIH.
    PhylomeDBiQ9NZN8.
    TreeFamiTF313102.

    Family and domain databases

    InterProiIPR007282. NOT.
    [Graphical view]
    PfamiPF04153. NOT2_3_5. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NZN8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVRTDGHTLS EKRNYQVTNS MFGASRKKFV EGVDSDYHDE NMYYSQSSMF    50
    PHRSEKDMLA SPSTSGQLSQ FGASLYGQQS ALGLPMRGMS NNTPQLNRSL 100
    SQGTQLPSHV TPTTGVPTMS LHTPPSPSRG ILPMNPRNMM NHSQVGQGIG 150
    IPSRTNSMSS SGLGSPNRSS PSIICMPKQQ PSRQPFTVNS MSGFGMNRNQ 200
    AFGMNNSLSS NIFNGTDGSE NVTGLDLSDF PALADRNRRE GSGNPTPLIN 250
    PLAGRAPYVG MVTKPANEQS QDFSIHNEDF PALPGSSYKD PTSSNDDSKS 300
    NLNTSGKTTS STDGPKFPGD KSSTTQNNNQ QKKGIQVLPD GRVTNIPQGM 350
    VTDQFGMIGL LTFIRAAETD PGMVHLALGS DLTTLGLNLN SPENLYPKFA 400
    SPWASSPCRP QDIDFHVPSE YLTNIHIRDK LAAIKLGRYG EDLLFYLYYM 450
    NGGDVLQLLA AVELFNRDWR YHKEERVWIT RAPGMEPTMK TNTYERGTYY 500
    FFDCLNWRKV AKEFHLEYDK LEERPHLPST FNYNPAQQAF 540
    Length:540
    Mass (Da):59,738
    Last modified:October 1, 2000 - v1
    Checksum:i7183890F033E3B83
    GO
    Isoform 2 (identifier: Q9NZN8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-175: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:365
    Mass (Da):40,818
    Checksum:i27FC908ADA1A6201
    GO
    Isoform 3 (identifier: Q9NZN8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-349: Missing.

    Note: May be due to an intron retention. No experimental confirmation available.

    Show »
    Length:191
    Mass (Da):22,254
    Checksum:i803037A4A6F670CC
    GO
    Isoform 4 (identifier: Q9NZN8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         465-475: FNRDWRYHKEE → YVQSILITFVL
         476-540: Missing.

    Note: May be due to an intron retention. No experimental confirmation available.

    Show »
    Length:475
    Mass (Da):51,537
    Checksum:i5D5C630BB3E89F06
    GO
    Isoform 5 (identifier: Q9NZN8-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         229-278: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:490
    Mass (Da):54,306
    Checksum:i7C6A4CC0F0992C9C
    GO

    Sequence cautioni

    The sequence AAF29095.1 differs from that shown. Reason: Frameshift at position 474.
    The sequence AAQ13426.1 differs from that shown. Reason: Frameshift at positions 71, 76, 84, 98, 123, 370, 384 and 393.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti460 – 4601A → T.
    Corresponds to variant rs11178192 [ dbSNP | Ensembl ].
    VAR_048750

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 349349Missing in isoform 3. 1 PublicationVSP_009913Add
    BLAST
    Alternative sequencei1 – 175175Missing in isoform 2. 1 PublicationVSP_009912Add
    BLAST
    Alternative sequencei229 – 27850Missing in isoform 5. 1 PublicationVSP_009914Add
    BLAST
    Alternative sequencei465 – 47511FNRDWRYHKEE → YVQSILITFVL in isoform 4. 1 PublicationVSP_009915Add
    BLAST
    Alternative sequencei476 – 54065Missing in isoform 4. 1 PublicationVSP_009916Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF180473 mRNA. Translation: AAF29827.1.
    AF113226 mRNA. Translation: AAG39297.1.
    AF161480 mRNA. Translation: AAF29095.1. Frameshift.
    AK000662 mRNA. Translation: BAA91313.1.
    AL137674 mRNA. Translation: CAB70869.1.
    BX641116 mRNA. Translation: CAE46054.1.
    BC002597 mRNA. Translation: AAH02597.1.
    BC011826 mRNA. Translation: AAH11826.1.
    AF044215 mRNA. Translation: AAQ13426.1. Frameshift.
    CCDSiCCDS31857.1. [Q9NZN8-1]
    PIRiT46494.
    RefSeqiNP_001186231.1. NM_001199302.1. [Q9NZN8-1]
    NP_001186232.1. NM_001199303.1. [Q9NZN8-1]
    NP_055330.1. NM_014515.5. [Q9NZN8-1]
    UniGeneiHs.133350.
    Hs.730666.

    Genome annotation databases

    EnsembliENST00000229195; ENSP00000229195; ENSG00000111596. [Q9NZN8-1]
    ENST00000418359; ENSP00000412091; ENSG00000111596. [Q9NZN8-1]
    ENST00000551043; ENSP00000449260; ENSG00000111596. [Q9NZN8-1]
    ENST00000551483; ENSP00000448883; ENSG00000111596. [Q9NZN8-3]
    GeneIDi4848.
    KEGGihsa:4848.
    UCSCiuc001svv.3. human. [Q9NZN8-1]
    uc001svw.1. human. [Q9NZN8-2]

    Polymorphism databases

    DMDMi46396017.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF180473 mRNA. Translation: AAF29827.1 .
    AF113226 mRNA. Translation: AAG39297.1 .
    AF161480 mRNA. Translation: AAF29095.1 . Frameshift.
    AK000662 mRNA. Translation: BAA91313.1 .
    AL137674 mRNA. Translation: CAB70869.1 .
    BX641116 mRNA. Translation: CAE46054.1 .
    BC002597 mRNA. Translation: AAH02597.1 .
    BC011826 mRNA. Translation: AAH11826.1 .
    AF044215 mRNA. Translation: AAQ13426.1 . Frameshift.
    CCDSi CCDS31857.1. [Q9NZN8-1 ]
    PIRi T46494.
    RefSeqi NP_001186231.1. NM_001199302.1. [Q9NZN8-1 ]
    NP_001186232.1. NM_001199303.1. [Q9NZN8-1 ]
    NP_055330.1. NM_014515.5. [Q9NZN8-1 ]
    UniGenei Hs.133350.
    Hs.730666.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4C0D X-ray 3.20 B 344-540 [» ]
    4C0F X-ray 2.40 A/B/C/D 429-540 [» ]
    ProteinModelPortali Q9NZN8.
    SMRi Q9NZN8. Positions 350-540.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110910. 15 interactions.
    DIPi DIP-42656N.
    IntActi Q9NZN8. 21 interactions.
    MINTi MINT-1438957.
    STRINGi 9606.ENSP00000229195.

    PTM databases

    PhosphoSitei Q9NZN8.

    Polymorphism databases

    DMDMi 46396017.

    Proteomic databases

    MaxQBi Q9NZN8.
    PaxDbi Q9NZN8.
    PRIDEi Q9NZN8.

    Protocols and materials databases

    DNASUi 4848.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000229195 ; ENSP00000229195 ; ENSG00000111596 . [Q9NZN8-1 ]
    ENST00000418359 ; ENSP00000412091 ; ENSG00000111596 . [Q9NZN8-1 ]
    ENST00000551043 ; ENSP00000449260 ; ENSG00000111596 . [Q9NZN8-1 ]
    ENST00000551483 ; ENSP00000448883 ; ENSG00000111596 . [Q9NZN8-3 ]
    GeneIDi 4848.
    KEGGi hsa:4848.
    UCSCi uc001svv.3. human. [Q9NZN8-1 ]
    uc001svw.1. human. [Q9NZN8-2 ]

    Organism-specific databases

    CTDi 4848.
    GeneCardsi GC12P070636.
    HGNCi HGNC:7878. CNOT2.
    MIMi 604909. gene.
    neXtProti NX_Q9NZN8.
    PharmGKBi PA26673.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5601.
    HOGENOMi HOG000246523.
    HOVERGENi HBG051041.
    InParanoidi Q9NZN8.
    KOi K12605.
    OMAi TQDFSIH.
    PhylomeDBi Q9NZN8.
    TreeFami TF313102.

    Enzyme and pathway databases

    Reactomei REACT_20514. Deadenylation of mRNA.

    Miscellaneous databases

    ChiTaRSi CNOT2. human.
    GeneWikii CNOT2.
    GenomeRNAii 4848.
    NextBioi 18670.
    PROi Q9NZN8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NZN8.
    Bgeei Q9NZN8.
    CleanExi HS_CNOT2.
    Genevestigatori Q9NZN8.

    Family and domain databases

    InterProi IPR007282. NOT.
    [Graphical view ]
    Pfami PF04153. NOT2_3_5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits."
      Albert T.K., Lemaire M., van Berkum N.L., Gentz R., Collart M.A., Timmers H.T.M.
      Nucleic Acids Res. 28:809-817(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CNOT1, TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Heart.
    3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Umbilical cord blood.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
      Tissue: Fetal kidney and Testis.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lymph and Skin.
    7. "Separation and molecular cloning of a novel human cDNA fragment coding a protein without homologs."
      Bi A., Yu L., Zhang M., Fan Y., Zhang Q., Zhao Y., Gao J., Zhao S.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-377.
    8. "Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex."
      Zwartjes C.G., Jayne S., van den Berg D.L., Timmers H.T.
      J. Biol. Chem. 279:10848-10854(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DOMAIN.
    9. "Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex."
      Jayne S., Zwartjes C.G., van Schaik F.M., Timmers H.T.
      Biochem. J. 398:461-467(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NCOR1; NCOR2; HDAC3 AND GPS2.
    10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-93; SER-126 AND SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: IDENTIFICATION IN THE CCR4-NOT COMPLEX, COMPOSITION OF THE CCR4-NOT COMPLEX.
    14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death."
      Ito K., Inoue T., Yokoyama K., Morita M., Suzuki T., Yamamoto T.
      Genes Cells 16:368-379(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CNOT3, SUBCELLULAR LOCATION.
    18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation."
      Zheng X., Dumitru R., Lackford B.L., Freudenberg J.M., Singh A.P., Archer T.K., Jothi R., Hu G.
      Stem Cells 30:910-922(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiCNOT2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NZN8
    Secondary accession number(s): Q9H3E0
    , Q9NSX5, Q9NWR6, Q9P028
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3