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Q9NZN5

- ARHGC_HUMAN

UniProt

Q9NZN5 - ARHGC_HUMAN

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Protein

Rho guanine nucleotide exchange factor 12

Gene
ARHGEF12, KIAA0382, LARG
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei308 – 3092Breakpoint for translocation to form KMT2A/MLL1-ARHGEF12 oncogene

GO - Molecular functioni

  1. G-protein coupled receptor binding Source: MGI
  2. GTPase activator activity Source: UniProtKB-KW
  3. protein binding Source: UniProtKB
  4. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. apoptotic signaling pathway Source: Reactome
  2. axon guidance Source: Reactome
  3. G-protein coupled receptor signaling pathway Source: MGI
  4. neurotrophin TRK receptor signaling pathway Source: Reactome
  5. positive regulation of apoptotic process Source: Reactome
  6. regulation of small GTPase mediated signal transduction Source: Reactome
  7. small GTPase mediated signal transduction Source: Reactome
  8. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.
REACT_13638. NRAGE signals death through JNK.
REACT_18407. G alpha (12/13) signalling events.
REACT_19277. Sema4D induced cell migration and growth-cone collapse.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 12
Alternative name(s):
Leukemia-associated RhoGEF
Gene namesi
Synonyms:KIAA0382, LARG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14193. ARHGEF12.

Subcellular locationi

Cytoplasm Inferred. Membrane Inferred
Note: Translocated to the membrane upon stimulation Inferred.

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: Reactome
  3. extracellular vesicular exosome Source: UniProt
  4. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with KMT2A/MLL1.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA24969.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 15441543Rho guanine nucleotide exchange factor 12PRO_0000080930Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei341 – 3411Phosphoserine1 Publication
Modified residuei637 – 6371Phosphoserine1 Publication
Modified residuei736 – 7361Phosphothreonine1 Publication
Modified residuei1327 – 13271Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9NZN5.
PaxDbiQ9NZN5.
PRIDEiQ9NZN5.

PTM databases

PhosphoSiteiQ9NZN5.

Expressioni

Tissue specificityi

Ubiquitously expressed. Isoform 2 is found in jejunum and testis.

Gene expression databases

ArrayExpressiQ9NZN5.
BgeeiQ9NZN5.
CleanExiHS_ARHGEF12.
GenevestigatoriQ9NZN5.

Organism-specific databases

HPAiCAB025581.
HPA018911.

Interactioni

Subunit structurei

Interacts with GNA12 and GNA13, probably through the RGS-like domain. Interacts with RHOA, PLXNB1 and PLXNB2. Interacts through its PDZ domain with IGF1R beta subunit. Interacts with GCSAM.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IGF1RP080697EBI-821440,EBI-475981
Lpar1P617933EBI-821440,EBI-7512335From a different organism.
RHOAP615862EBI-821440,EBI-446668

Protein-protein interaction databases

BioGridi116945. 13 interactions.
DIPiDIP-37887N.
IntActiQ9NZN5. 10 interactions.
MINTiMINT-1774807.
STRINGi9606.ENSP00000380942.

Structurei

Secondary structure

1
1544
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi70 – 767
Beta strandi85 – 873
Beta strandi89 – 913
Beta strandi93 – 964
Helixi102 – 1065
Beta strandi112 – 1198
Turni122 – 1243
Helixi127 – 1359
Beta strandi137 – 1459
Helixi769 – 7724
Helixi775 – 7784
Helixi783 – 81230
Helixi814 – 8207
Helixi825 – 8328
Helixi835 – 85319
Beta strandi857 – 8604
Helixi865 – 8728
Helixi875 – 88915
Helixi891 – 90414
Helixi906 – 91712
Helixi919 – 9213
Helixi926 – 9294
Helixi932 – 94918
Helixi954 – 99340
Beta strandi1001 – 10033
Helixi1005 – 10073
Helixi1008 – 10114
Helixi1015 – 10173
Beta strandi1020 – 103314
Beta strandi1038 – 105316
Beta strandi1056 – 10583
Beta strandi1078 – 10814
Helixi1082 – 10843
Beta strandi1085 – 10895
Beta strandi1091 – 10933
Beta strandi1096 – 11027
Beta strandi1107 – 11137
Helixi1117 – 113721

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TXDX-ray2.13A766-1138[»]
1X86X-ray3.22A/C/E/G766-1138[»]
2OMJNMR-A67-151[»]
2OS6NMR-A67-151[»]
ProteinModelPortaliQ9NZN5.
SMRiQ9NZN5. Positions 67-151, 766-1138.

Miscellaneous databases

EvolutionaryTraceiQ9NZN5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 15180PDZAdd
BLAST
Domaini367 – 558192RGSLAdd
BLAST
Domaini787 – 977191DHAdd
BLAST
Domaini1019 – 1132114PHAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili194 – 26269 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.
Contains 1 PH domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5422.
HOGENOMiHOG000034046.
HOVERGENiHBG050571.
InParanoidiQ9NZN5.
KOiK07532.
OMAiMTPEMPT.
OrthoDBiEOG7GJ6CF.
PhylomeDBiQ9NZN5.
TreeFamiTF106495.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001478. PDZ.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR016137. Regulat_G_prot_signal_superfam.
IPR015212. RGS-like_dom.
IPR015721. RhoGEF-like.
[Graphical view]
PANTHERiPTHR22825. PTHR22825. 1 hit.
PfamiPF00595. PDZ. 1 hit.
PF09128. RGS-like. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NZN5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERIA SHDFDPTDSS     50
SKKTKSSSEE SRSEIYGLVQ RCVIIQKDDN GFGLTVSGDN PVFVQSVKED 100
GAAMRAGVQT GDRIIKVNGT LVTHSNHLEV VKLIKSGSYV ALTVQGRPPG 150
SPQIPLADSE VEPSVIGHMS PIMTSPHSPG ASGNMERITS PVLMGEENNV 200
VHNQKVEILR KMLQKEQERL QLLQEDYNRT PAQRLLKEIQ EAKKHIPQLQ 250
EQLSKATGSA QDGAVVTPSR PLGDTLTVSE AETDPGDVLG RTDCSSGDAS 300
RPSSDNADSP KSGPKERIYL EENPEKSETI QDTDTQSLVG SPSTRIAPHI 350
IGAEDDDFGT EHEQINGQCS CFQSIELLKS RPAHLAVFLH HVVSQFDPAT 400
LLCYLYSDLY KHTNSKETRR IFLEFHQFFL DRSAHLKVSV PDEMSADLEK 450
RRPELIPEDL HRHYIQTMQE RVHPEVQRHL EDFRQKRSMG LTLAESELTK 500
LDAERDKDRL TLEKERTCAE QIVAKIEEVL MTAQAVEEDK SSTMQYVILM 550
YMKHLGVKVK EPRNLEHKRG RIGFLPKIKQ SMKKDKEGEE KGKRRGFPSI 600
LGPPRRPSRH DNSAIGRAME LQKARHPKHL STPSSVSPEP QDSAKLRQSG 650
LANEGTDAGY LPANSMSSVA SGASFSQEGG KENDTGSKQV GETSAPGDTL 700
DGTPRTLNTV FDFPPPPLDQ VQEEECEVER VTEHGTPKPF RKFDSVAFGE 750
SQSEDEQFEN DLETDPPNWQ QLVSREVLLG LKPCEIKRQE VINELFYTER 800
AHVRTLKVLD QVFYQRVSRE GILSPSELRK IFSNLEDILQ LHIGLNEQMK 850
AVRKRNETSV IDQIGEDLLT WFSGPGEEKL KHAAATFCSN QPFALEMIKS 900
RQKKDSRFQT FVQDAESNPL CRRLQLKDII PTQMQRLTKY PLLLDNIAKY 950
TEWPTEREKV KKAADHCRQI LNYVNQAVKE AENKQRLEDY QRRLDTSSLK 1000
LSEYPNVEEL RNLDLTKRKM IHEGPLVWKV NRDKTIDLYT LLLEDILVLL 1050
QKQDDRLVLR CHSKILASTA DSKHTFSPVI KLSTVLVRQV ATDNKALFVI 1100
SMSDNGAQIY ELVAQTVSEK TVWQDLICRM AASVKEQSTK PIPLPQSTPG 1150
EGDNDEEDPS KLKEEQHGIS VTGLQSPDRD LGLESTLISS KPQSHSLSTS 1200
GKSEVRDLFV AERQFAKEQH TDGTLKEVGE DYQIAIPDSH LPVSEERWAL 1250
DALRNLGLLK QLLVQQLGLT EKSVQEDWQH FPRYRTASQG PQTDSVIQNS 1300
ENIKAYHSGE GHMPFRTGTG DIATCYSPRT STESFAPRDS VGLAPQDSQA 1350
SNILVMDHMI MTPEMPTMEP EGGLDDSGEH FFDAREAHSD ENPSEGDGAV 1400
NKEEKDVNLR ISGNYLILDG YDPVQESSTD EEVASSLTLQ PMTGIPAVES 1450
THQQQHSPQN THSDGAISPF TPEFLVQQRW GAMEYSCFEI QSPSSCADSQ 1500
SQIMEYIHKI EADLEHLKKV EESYTILCQR LAGSALTDKH SDKS 1544
Length:1,544
Mass (Da):173,232
Last modified:October 1, 2000 - v1
Checksum:i0B7E319CF7C7A224
GO
Isoform 2 (identifier: Q9NZN5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-66: Missing.

Note: Contains a phosphoserine at position 41.

Show »
Length:1,525
Mass (Da):171,115
Checksum:i47FF1323DE2DFF55
GO

Sequence cautioni

The sequence AAH63117.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti973 – 9731Y → F.1 Publication
Corresponds to variant rs2305013 [ dbSNP | Ensembl ].
VAR_020191

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei48 – 6619Missing in isoform 2. VSP_008131Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF180681 mRNA. Translation: AAF36817.1.
AB002380 mRNA. Translation: BAA20836.2.
BC063117 mRNA. Translation: AAH63117.1. Sequence problems.
CCDSiCCDS41727.1. [Q9NZN5-1]
CCDS55794.1. [Q9NZN5-2]
RefSeqiNP_001185594.1. NM_001198665.1. [Q9NZN5-2]
NP_056128.1. NM_015313.2. [Q9NZN5-1]
UniGeneiHs.24598.

Genome annotation databases

EnsembliENST00000356641; ENSP00000349056; ENSG00000196914. [Q9NZN5-2]
ENST00000397843; ENSP00000380942; ENSG00000196914. [Q9NZN5-1]
GeneIDi23365.
KEGGihsa:23365.
UCSCiuc001pxl.2. human. [Q9NZN5-1]
uc009zat.3. human. [Q9NZN5-2]

Polymorphism databases

DMDMi34395525.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF180681 mRNA. Translation: AAF36817.1 .
AB002380 mRNA. Translation: BAA20836.2 .
BC063117 mRNA. Translation: AAH63117.1 . Sequence problems.
CCDSi CCDS41727.1. [Q9NZN5-1 ]
CCDS55794.1. [Q9NZN5-2 ]
RefSeqi NP_001185594.1. NM_001198665.1. [Q9NZN5-2 ]
NP_056128.1. NM_015313.2. [Q9NZN5-1 ]
UniGenei Hs.24598.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1TXD X-ray 2.13 A 766-1138 [» ]
1X86 X-ray 3.22 A/C/E/G 766-1138 [» ]
2OMJ NMR - A 67-151 [» ]
2OS6 NMR - A 67-151 [» ]
ProteinModelPortali Q9NZN5.
SMRi Q9NZN5. Positions 67-151, 766-1138.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116945. 13 interactions.
DIPi DIP-37887N.
IntActi Q9NZN5. 10 interactions.
MINTi MINT-1774807.
STRINGi 9606.ENSP00000380942.

PTM databases

PhosphoSitei Q9NZN5.

Polymorphism databases

DMDMi 34395525.

Proteomic databases

MaxQBi Q9NZN5.
PaxDbi Q9NZN5.
PRIDEi Q9NZN5.

Protocols and materials databases

DNASUi 23365.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356641 ; ENSP00000349056 ; ENSG00000196914 . [Q9NZN5-2 ]
ENST00000397843 ; ENSP00000380942 ; ENSG00000196914 . [Q9NZN5-1 ]
GeneIDi 23365.
KEGGi hsa:23365.
UCSCi uc001pxl.2. human. [Q9NZN5-1 ]
uc009zat.3. human. [Q9NZN5-2 ]

Organism-specific databases

CTDi 23365.
GeneCardsi GC11P120207.
H-InvDB HIX0010202.
HIX0036240.
HGNCi HGNC:14193. ARHGEF12.
HPAi CAB025581.
HPA018911.
MIMi 604763. gene.
neXtProti NX_Q9NZN5.
PharmGKBi PA24969.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5422.
HOGENOMi HOG000034046.
HOVERGENi HBG050571.
InParanoidi Q9NZN5.
KOi K07532.
OMAi MTPEMPT.
OrthoDBi EOG7GJ6CF.
PhylomeDBi Q9NZN5.
TreeFami TF106495.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.
REACT_13638. NRAGE signals death through JNK.
REACT_18407. G alpha (12/13) signalling events.
REACT_19277. Sema4D induced cell migration and growth-cone collapse.

Miscellaneous databases

ChiTaRSi ARHGEF12. human.
EvolutionaryTracei Q9NZN5.
GeneWikii ARHGEF12.
GenomeRNAii 23365.
NextBioi 45421.
PROi Q9NZN5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NZN5.
Bgeei Q9NZN5.
CleanExi HS_ARHGEF12.
Genevestigatori Q9NZN5.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001478. PDZ.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR016137. Regulat_G_prot_signal_superfam.
IPR015212. RGS-like_dom.
IPR015721. RhoGEF-like.
[Graphical view ]
PANTHERi PTHR22825. PTHR22825. 1 hit.
Pfami PF00595. PDZ. 1 hit.
PF09128. RGS-like. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEi PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia."
    Kourlas P.J., Strout M.P., Becknell B., Veronese M.L., Croce C.M., Theil K.S., Krahe R., Ruutu T., Knuutila S., Bloomfield C.D., Caligiuri M.A.
    Proc. Natl. Acad. Sci. U.S.A. 97:2145-2150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), CHROMOSOMAL TRANSLOCATION.
    Tissue: Prostate.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-584 (ISOFORM 2).
    Tissue: Thyroid.
  3. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 102-1544, VARIANT PHE-973.
    Tissue: Brain.
  4. Ohara O., Nagase T., Kikuno R., Nomura N.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho."
    Fukuhara S., Chikumi H., Gutkind J.S.
    FEBS Lett. 485:183-188(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RHOA; GNA12 AND GNA13.
  6. "Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF."
    Taya S., Inagaki N., Sengiku H., Makino H., Iwamatsu A., Urakawa I., Nagao K., Kataoka S., Kaibuchi K.
    J. Cell Biol. 155:809-820(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IGF1R.
  7. Cited for: INTERACTION WITH PLXNB1 AND PLXNB2.
  8. "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF."
    Perrot V., Vazquez-Prado J., Gutkind J.S.
    J. Biol. Chem. 277:43115-43120(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PLXNB1 AND PLXNB2.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-736, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway."
    Jiang X., Lu X., McNamara G., Liu X., Cubedo E., Sarosiek K.A., Sanchez-Garcia I., Helfman D.M., Lossos I.S.
    Blood 116:5217-5227(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GCSAM.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-637, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor."
    Kristelly R., Gao G., Tesmer J.J.
    J. Biol. Chem. 279:47352-47362(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.13 ANGSTROMS) OF 766-1138 IN COMPLEX WITH RHOA, SUBUNIT.
  19. "Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factor."
    Liu J., Zhang J., Yang Y., Huang H., Shen W., Hu Q., Wang X., Wu J., Shi Y.
    Protein Sci. 17:1003-1014(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 67-151 IN COMPLEX WITH PLXNB1, SUBUNIT.

Entry informationi

Entry nameiARHGC_HUMAN
AccessioniPrimary (citable) accession number: Q9NZN5
Secondary accession number(s): O15086, Q6P526
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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