Q9NZM6 (PK2L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Polycystic kidney disease 2-like 2 protein

Alternative name(s):
Polycystin-2L2
Polycystin-L2

Gene names

Name:

PKD2L2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	624 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May function as a subunit of a cation channel and play a role in fertilization.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	According to Ref.1, expressed only in testis. According to Ref.2, expressed also in brain and kidney. Isoform 2 is found only in transformed lymphoblasts. Isoform 3 is found in all tissues tested.
Sequence similarities	Belongs to the polycystin family.
Sequence caution	The sequence AAD46478.1 differs from that shown. Reason: Frameshift at position 595.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Transmembrane Transmembrane helix
Molecular function	Ion channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of mechanical stimulus Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	integral to membrane Traceable author statement Ref.1. Source: UniProtKB
Molecular_function	calcium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q9NZM6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NZM6-2)

Also known as: PKD2L2b;

The sequence of this isoform differs from the canonical sequence as follows:
     11-44: Missing.
     45-45: L → V

Isoform 3 (identifier: Q9NZM6-3)

Also known as: PKD2L2a;

The sequence of this isoform differs from the canonical sequence as follows:
     45-57: LTFGMVNPHMYYL → CYVISIFGHFCAW
     58-624: Missing.

Isoform 4 (identifier: Q9NZM6-4)

Also known as: PKD2L2c;

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: ASKHKLHYRKEV → YVISIFGHFCAW
     24-624: Missing.

Isoform 5 (identifier: Q9NZM6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     595-624: ELFLYAVELEKELHYINLKLNQVVRKVSAL → DGTTTKYKMRFSECLTKRI

Note: No experimental confirmation available.

Isoform 6 (identifier: Q9NZM6-6)

The sequence of this isoform differs from the canonical sequence as follows:
     383-483: Missing.

Note: No experimental confirmation available.

Isoform 7 (identifier: Q9NZM6-7)

The sequence of this isoform differs from the canonical sequence as follows:
     326-347: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 624	624	Polycystic kidney disease 2-like 2 protein		PRO_0000164361
Regions
	Topological domain	1 – 31	31	Cytoplasmic Potential
	Transmembrane	32 – 52	21	Helical; Potential
	Topological domain	53 – 276	224	Extracellular Potential
	Transmembrane	277 – 297	21	Helical; Potential
	Topological domain	298 – 314	17	Cytoplasmic Potential
	Transmembrane	315 – 335	21	Helical; Potential
	Topological domain	336 – 360	25	Extracellular Potential
	Transmembrane	361 – 381	21	Helical; Potential
	Topological domain	382 – 406	25	Cytoplasmic Potential
	Transmembrane	407 – 427	21	Helical; Potential
	Topological domain	428 – 469	42	Extracellular Potential
	Transmembrane	470 – 490	21	Helical; Potential
	Topological domain	491 – 624	134	Cytoplasmic Potential
	Coiled coil	556 – 576	21	Potential
	Motif	126 – 138	13	Polycystin motif
Amino acid modifications
	Glycosylation	115	1	N-linked (GlcNAc...) Potential
	Glycosylation	138	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	11 – 44	34	Missing in isoform 2.		VSP_004732
	Alternative sequence	12 – 23	12	ASKHK…YRKEV → YVISIFGHFCAW in isoform 4.		VSP_004733
	Alternative sequence	24 – 624	601	Missing in isoform 4.		VSP_004734
	Alternative sequence	45 – 57	13	LTFGM…HMYYL → CYVISIFGHFCAW in isoform 3.		VSP_004736
	Alternative sequence	45	1	L → V in isoform 2.		VSP_004735
	Alternative sequence	58 – 624	567	Missing in isoform 3.		VSP_004737
	Alternative sequence	326 – 347	22	Missing in isoform 7.		VSP_045581
	Alternative sequence	383 – 483	101	Missing in isoform 6.		VSP_045582
	Alternative sequence	595 – 624	30	ELFLY…KVSAL → DGTTTKYKMRFSECLTKRI in isoform 5.		VSP_035775
	Natural variant	404	1	V → I. Ref.3 Corresponds to variant rs1880458 [ dbSNP | Ensembl ].		VAR_047542
	Natural variant	507	1	L → P. Ref.1 Ref.2 Ref.3 Ref.6 Corresponds to variant rs12187140 [ dbSNP | Ensembl ].		VAR_047543
Experimental info
	Sequence conflict	205 – 206	2	Missing in BAG63344. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 2. Checksum: 7D9FFA04542A47A4	FASTA	624	73,790
	10 20 30 40 50 60 MAEASRWHRG GASKHKLHYR KEVEITTTLQ ELLLYFIFLI NLCILTFGMV NPHMYYLNKV 70 80 90 100 110 120 MSSLFLDTSV PGEERTNFKS IRSITDFWKF MEGPLLEGLY WDSWYNNQQL YNLKNSSRIY 130 140 150 160 170 180 YENILLGVPR VRQLKVRNNT CKVYSSFQSL MSECYGKYTS ANEDLSNFGL QINTEWRYST 190 200 210 220 230 240 SNTNSPWHWG FLGVYRNGGY IFTLSKSKSE TKNKFIDLRL NSWITRGTRV IFIDFSLYNA 250 260 270 280 290 300 NVNLFCIIRL VAEFPATGGI LTSWQFYSVK LLRYVSYYDY FIASCEITFC IFLFVFTTQE 310 320 330 340 350 360 VKKIKEFKSA YFKSIWNWLE LLLLLLCFVA VSFNTYYNVQ IFLLLGQLLK STEKYSDFYF 370 380 390 400 410 420 LACWHIYYNN IIAITIFFAW IKIFKFISFN KTMSQLSSTL SRCVKDIVGF AIMFFIIFFA 430 440 450 460 470 480 YAQLGFLVFG SQVDDFSTFQ NSIFAQFRIV LGDFNFAGIQ QANPILGPIY FITFIFFVFF 490 500 510 520 530 540 VLLNMFLAII NDTYSEVKAD YSIGRRLDFE LGKMIKQSYK NVLEKFRLKK AQKDEDKKTK 550 560 570 580 590 600 GSGDLAEQAR REGFDENEIQ NAEQMKKWKE RLEKKYYSME IQDDYQPVTQ EEFRELFLYA 610 620 VELEKELHYI NLKLNQVVRK VSAL
	Isoform 2 (PKD2L2b) [UniParc]. Checksum: BDDE4D9C3C3D7C5F	FASTA	590	69,746
	10 20 30 40 50 60 MAEASRWHRG VTFGMVNPHM YYLNKVMSSL FLDTSVPGEE RTNFKSIRSI TDFWKFMEGP 70 80 90 100 110 120 LLEGLYWDSW YNNQQLYNLK NSSRIYYENI LLGVPRVRQL KVRNNTCKVY SSFQSLMSEC 130 140 150 160 170 180 YGKYTSANED LSNFGLQINT EWRYSTSNTN SPWHWGFLGV YRNGGYIFTL SKSKSETKNK 190 200 210 220 230 240 FIDLRLNSWI TRGTRVIFID FSLYNANVNL FCIIRLVAEF PATGGILTSW QFYSVKLLRY 250 260 270 280 290 300 VSYYDYFIAS CEITFCIFLF VFTTQEVKKI KEFKSAYFKS IWNWLELLLL LLCFVAVSFN 310 320 330 340 350 360 TYYNVQIFLL LGQLLKSTEK YSDFYFLACW HIYYNNIIAI TIFFAWIKIF KFISFNKTMS 370 380 390 400 410 420 QLSSTLSRCV KDIVGFAIMF FIIFFAYAQL GFLVFGSQVD DFSTFQNSIF AQFRIVLGDF 430 440 450 460 470 480 NFAGIQQANP ILGPIYFITF IFFVFFVLLN MFLAIINDTY SEVKADYSIG RRLDFELGKM 490 500 510 520 530 540 IKQSYKNVLE KFRLKKAQKD EDKKTKGSGD LAEQARREGF DENEIQNAEQ MKKWKERLEK 550 560 570 580 590 KYYSMEIQDD YQPVTQEEFR ELFLYAVELE KELHYINLKL NQVVRKVSAL
	Isoform 3 (PKD2L2a) [UniParc]. Checksum: 4539353342C77CAA	FASTA	57	6,759
	10 20 30 40 50 MAEASRWHRG GASKHKLHYR KEVEITTTLQ ELLLYFIFLI NLCICYVISI FGHFCAW
	Isoform 4 (PKD2L2c) [UniParc]. Checksum: 0C7B55E80C496CC0	FASTA	23	2,682
	10 20 MAEASRWHRG GYVISIFGHF CAW
	Isoform 5 [UniParc]. Checksum: 198CD4B1F9EC9804	FASTA	613	72,496
	10 20 30 40 50 60 MAEASRWHRG GASKHKLHYR KEVEITTTLQ ELLLYFIFLI NLCILTFGMV NPHMYYLNKV 70 80 90 100 110 120 MSSLFLDTSV PGEERTNFKS IRSITDFWKF MEGPLLEGLY WDSWYNNQQL YNLKNSSRIY 130 140 150 160 170 180 YENILLGVPR VRQLKVRNNT CKVYSSFQSL MSECYGKYTS ANEDLSNFGL QINTEWRYST 190 200 210 220 230 240 SNTNSPWHWG FLGVYRNGGY IFTLSKSKSE TKNKFIDLRL NSWITRGTRV IFIDFSLYNA 250 260 270 280 290 300 NVNLFCIIRL VAEFPATGGI LTSWQFYSVK LLRYVSYYDY FIASCEITFC IFLFVFTTQE 310 320 330 340 350 360 VKKIKEFKSA YFKSIWNWLE LLLLLLCFVA VSFNTYYNVQ IFLLLGQLLK STEKYSDFYF 370 380 390 400 410 420 LACWHIYYNN IIAITIFFAW IKIFKFISFN KTMSQLSSTL SRCVKDIVGF AIMFFIIFFA 430 440 450 460 470 480 YAQLGFLVFG SQVDDFSTFQ NSIFAQFRIV LGDFNFAGIQ QANPILGPIY FITFIFFVFF 490 500 510 520 530 540 VLLNMFLAII NDTYSEVKAD YSIGRRLDFE LGKMIKQSYK NVLEKFRLKK AQKDEDKKTK 550 560 570 580 590 600 GSGDLAEQAR REGFDENEIQ NAEQMKKWKE RLEKKYYSME IQDDYQPVTQ EEFRDGTTTK 610 YKMRFSECLT KRI
	Isoform 6 [UniParc]. Checksum: 9D1CAFED503A7EF6	FASTA	523	62,216
	10 20 30 40 50 60 MAEASRWHRG GASKHKLHYR KEVEITTTLQ ELLLYFIFLI NLCILTFGMV NPHMYYLNKV 70 80 90 100 110 120 MSSLFLDTSV PGEERTNFKS IRSITDFWKF MEGPLLEGLY WDSWYNNQQL YNLKNSSRIY 130 140 150 160 170 180 YENILLGVPR VRQLKVRNNT CKVYSSFQSL MSECYGKYTS ANEDLSNFGL QINTEWRYST 190 200 210 220 230 240 SNTNSPWHWG FLGVYRNGGY IFTLSKSKSE TKNKFIDLRL NSWITRGTRV IFIDFSLYNA 250 260 270 280 290 300 NVNLFCIIRL VAEFPATGGI LTSWQFYSVK LLRYVSYYDY FIASCEITFC IFLFVFTTQE 310 320 330 340 350 360 VKKIKEFKSA YFKSIWNWLE LLLLLLCFVA VSFNTYYNVQ IFLLLGQLLK STEKYSDFYF 370 380 390 400 410 420 LACWHIYYNN IIAITIFFAW IKNMFLAIIN DTYSEVKADY SIGRRLDFEL GKMIKQSYKN 430 440 450 460 470 480 VLEKFRLKKA QKDEDKKTKG SGDLAEQARR EGFDENEIQN AEQMKKWKER LEKKYYSMEI 490 500 510 520 QDDYQPVTQE EFRELFLYAV ELEKELHYIN LKLNQVVRKV SAL
	Isoform 7 [UniParc]. Checksum: C409FD9113F83EB1	FASTA	602	71,255
	10 20 30 40 50 60 MAEASRWHRG GASKHKLHYR KEVEITTTLQ ELLLYFIFLI NLCILTFGMV NPHMYYLNKV 70 80 90 100 110 120 MSSLFLDTSV PGEERTNFKS IRSITDFWKF MEGPLLEGLY WDSWYNNQQL YNLKNSSRIY 130 140 150 160 170 180 YENILLGVPR VRQLKVRNNT CKVYSSFQSL MSECYGKYTS ANEDLSNFGL QINTEWRYST 190 200 210 220 230 240 SNTNSPWHWG FLGVYRNGGY IFTLSKSKSE TKNKFIDLRL NSWITRGTRV IFIDFSLYNA 250 260 270 280 290 300 NVNLFCIIRL VAEFPATGGI LTSWQFYSVK LLRYVSYYDY FIASCEITFC IFLFVFTTQE 310 320 330 340 350 360 VKKIKEFKSA YFKSIWNWLE LLLLLLLKST EKYSDFYFLA CWHIYYNNII AITIFFAWIK 370 380 390 400 410 420 IFKFISFNKT MSQLSSTLSR CVKDIVGFAI MFFIIFFAYA QLGFLVFGSQ VDDFSTFQNS 430 440 450 460 470 480 IFAQFRIVLG DFNFAGIQQA NPILGPIYFI TFIFFVFFVL LNMFLAIIND TYSEVKADYS 490 500 510 520 530 540 IGRRLDFELG KMIKQSYKNV LEKFRLKKAQ KDEDKKTKGS GDLAEQARRE GFDENEIQNA 550 560 570 580 590 600 EQMKKWKERL EKKYYSMEIQ DDYQPVTQEE FRELFLYAVE LEKELHYINL KLNQVVRKVS AL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2)." Veldhuisen B., Spruit L., Dauwerse H.G., Breuning M.H., Peters D.J.M. Eur. J. Hum. Genet. 7:860-872(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), VARIANT PRO-507. Tissue: Testis.
[2]	"Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization." Guo L., Schreiber T.H., Weremowicz S., Morton C.C., Lee C., Zhou J. Genomics 64:241-251(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANT PRO-507.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7), VARIANTS ILE-404 AND PRO-507. Tissue: Testis.
[4]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), VARIANT PRO-507. Tissue: Testis.
[7]	"Polycystin channels and kidney disease." Stayner C., Zhou J. Trends Pharmacol. Sci. 22:543-546(2001) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF118125 mRNA. Translation: AAD46478.1. Frameshift. AF182034 mRNA. Translation: AAF65622.1. AC106753 Genomic DNA. No translation available. AK301924 mRNA. Translation: BAG63344.1. AC106791 Genomic DNA. No translation available. CH471062 Genomic DNA. Translation: EAW62174.1. BC044581 mRNA. Translation: AAH44581.1.
IPI	IPI00021443. IPI00070729. IPI00216678. IPI00216679. IPI00216680. IPI00384675. IPI00910627.
RefSeq	NP_001245377.1. NM_001258448.1. NP_001245378.1. NM_001258449.1. NP_055201.2. NM_014386.3.
UniGene	Hs.716884.
3D structure databases
ProteinModelPortal	Q9NZM6.
SMR	Q9NZM6. Positions 410-493.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000290431.
PTM databases
PhosphoSite	Q9NZM6.
Polymorphism databases
DMDM	23821937.
Proteomic databases
PaxDb	Q9NZM6.
PRIDE	Q9NZM6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000290431; ENSP00000290431; ENSG00000078795. ENST00000350250; ENSP00000344177; ENSG00000078795. ENST00000414094; ENSP00000388060; ENSG00000078795. ENST00000502810; ENSP00000425513; ENSG00000078795. ENST00000508638; ENSP00000423382; ENSG00000078795. ENST00000508883; ENSP00000424725; ENSG00000078795.
GeneID	27039.
KEGG	hsa:27039.
UCSC	uc003lbw.1. human. uc003lbx.3. human. uc003lby.3. human.
Organism-specific databases
CTD	27039.
GeneCards	GC05P137225.
H-InvDB	HIX0024797.
HGNC	HGNC:9012. PKD2L2.
HPA	HPA041903. HPA043634.
MIM	604669. gene.
neXtProt	NX_Q9NZM6.
PharmGKB	PA33345.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG325704.
HOGENOM	HOG000230858.
HOVERGEN	HBG014945.
InParanoid	Q9NZM6.
KO	K04991.
OMA	KFMEGPL.
PhylomeDB	Q9NZM6.
Gene expression databases
ArrayExpress	Q9NZM6.
Bgee	Q9NZM6.
CleanEx	HS_PKD2L2.
Genevestigator	Q9NZM6.
GermOnline	ENSG00000078795. Homo sapiens.
Family and domain databases
InterPro	IPR013122. PKD1_2_channel. IPR003915. PKD_2. [Graphical view]
Pfam	PF08016. PKD_channel. 1 hit. [Graphical view]
PRINTS	PR01433. POLYCYSTIN2.
ProtoNet	Search...
Other
GenomeRNAi	27039.
NextBio	49604.
SOURCE	Search...

Entry information

Entry name

PK2L2_HUMAN

Accession

Primary (citable) accession number: Q9NZM6
Secondary accession number(s): A6NK98 , B4DXD2, E9PC91, E9PDG4, Q86YB4, Q9UNJ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	January 11, 2011
Last modified:	May 29, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.