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Protein

Glioma tumor suppressor candidate region gene 2 protein

Gene

GLTSCR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Glioma tumor suppressor candidate region gene 2 protein
Alternative name(s):
p60
Gene namesi
Name:GLTSCR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:4333. GLTSCR2.

Subcellular locationi

GO - Cellular componenti

  • intracellular Source: UniProtKB
  • intracellular membrane-bounded organelle Source: HPA
  • nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28736.

Polymorphism and mutation databases

BioMutaiGLTSCR2.
DMDMi93141272.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 478477Glioma tumor suppressor candidate region gene 2 proteinPRO_0000218960Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei29 – 291PhosphoserineCombined sources
Modified residuei93 – 931PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NZM5.
MaxQBiQ9NZM5.
PaxDbiQ9NZM5.
PeptideAtlasiQ9NZM5.
PRIDEiQ9NZM5.

2D gel databases

SWISS-2DPAGEQ9NZM5.

PTM databases

iPTMnetiQ9NZM5.
PhosphoSiteiQ9NZM5.

Expressioni

Tissue specificityi

Expressed at high levels in heart and pancreas, moderate levels in placenta, liver, skeletal muscle, and kidney, and low levels in brain and lung.1 Publication

Gene expression databases

BgeeiQ9NZM5.
CleanExiHS_GLTSCR2.
ExpressionAtlasiQ9NZM5. baseline and differential.
GenevisibleiQ9NZM5. HS.

Organism-specific databases

HPAiHPA018999.
HPA049600.

Interactioni

Subunit structurei

Interacts with HSV-1 early proteins ICP22 and ICP0.

Protein-protein interaction databases

BioGridi119021. 99 interactions.
IntActiQ9NZM5. 19 interactions.
MINTiMINT-1410423.
STRINGi9606.ENSP00000246802.

Structurei

3D structure databases

ProteinModelPortaliQ9NZM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GLTSCR2 family.Curated

Phylogenomic databases

eggNOGiKOG2823. Eukaryota.
ENOG4111GSN. LUCA.
GeneTreeiENSGT00390000017267.
HOGENOMiHOG000070127.
HOVERGENiHBG051849.
InParanoidiQ9NZM5.
KOiK14840.
OMAiTQESAFQ.
OrthoDBiEOG7CVPZM.
PhylomeDBiQ9NZM5.
TreeFamiTF313004.

Family and domain databases

InterProiIPR011687. Nop53/GLTSCR2.
[Graphical view]
PANTHERiPTHR14211. PTHR14211. 1 hit.
PfamiPF07767. Nop53. 1 hit.
[Graphical view]
PIRSFiPIRSF017302. Gltscr2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NZM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGGSGVGG KRSSKSDADS GFLGLRPTSV DPALRRRRRG PRNKKRGWRR
60 70 80 90 100
LAQEPLGLEV DQFLEDVRLQ ERTSGGLLSE APNEKLFFVD TGSKEKGLTK
110 120 130 140 150
KRTKVQKKSL LLKKPLRVDL ILENTSKVPA PKDVLAHQVP NAKKLRRKEQ
160 170 180 190 200
LWEKLAKQGE LPREVRRAQA RLLNPSATRA KPGPQDTVER PFYDLWASDN
210 220 230 240 250
PLDRPLVGQD EFFLEQTKKK GVKRPARLHT KPSQAPAVEV APAGASYNPS
260 270 280 290 300
FEDHQTLLSA AHEVELQRQK EAEKLERQLA LPATEQAATQ ESTFQELCEG
310 320 330 340 350
LLEESDGEGE PGQGEGPEAG DAEVCPTPAR LATTEKKTEQ QRRREKAVHR
360 370 380 390 400
LRVQQAALRA ARLRHQELFR LRGIKAQVAL RLAELARRQR RRQARREAEA
410 420 430 440 450
DKPRRLGRLK YQAPDIDVQL SSELTDSLRT LKPEGNILRD RFKSFQRRNM
460 470
IEPRERAKFK RKYKVKLVEK RAFREIQL
Length:478
Mass (Da):54,389
Last modified:April 18, 2006 - v2
Checksum:i7F1BA13D04BFB618
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91G → R in AAG30413 (PubMed:10196275).Curated
Sequence conflicti146 – 19146RRKEQ…TVERP → SGRSSYGRSWPSRASSPGGA QGPSPVAQPFCNKGPNPAPG HRIAA in AAG30413 (PubMed:10196275).CuratedAdd
BLAST
Sequence conflicti198 – 21518SDNPL…EFFLE → LNNPDKPVVWPGCLFPG in AAG30413 (PubMed:10196275).CuratedAdd
BLAST
Sequence conflicti235 – 2351A → S in AAH04229 (PubMed:15489334).Curated
Sequence conflicti417 – 4171D → H in AAG30413 (PubMed:10196275).Curated
Sequence conflicti433 – 47745PEGNI…FREIQ → VLTVSCRGAPCPVMTPSLLP VPPRGYGRHHGCPWAGPVGP MPRG (PubMed:17974005).CuratedAdd
BLAST
Sequence conflicti434 – 47845EGNIL…REIQL → RGQHSFETGSRAFRGGI in AAG30413 (PubMed:10196275).CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161S → R.
Corresponds to variant rs1042401 [ dbSNP | Ensembl ].
VAR_024456
Natural varianti389 – 3891Q → R.4 Publications
Corresponds to variant rs1804994 [ dbSNP | Ensembl ].
VAR_011486

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182076 mRNA. Translation: AAF62873.1.
BC004229 mRNA. Translation: AAH04229.2.
BC006311 mRNA. Translation: AAH06311.1.
BC010095 mRNA. Translation: AAH10095.1.
AF296124 mRNA. Translation: AAG30413.1.
AL359335 mRNA. Translation: CAB94786.1.
AL359336 mRNA. Translation: CAB94787.1.
AL122063 mRNA. Translation: CAB59242.1.
CCDSiCCDS12705.1.
RefSeqiNP_056525.2. NM_015710.4.
UniGeneiHs.421907.

Genome annotation databases

EnsembliENST00000246802; ENSP00000246802; ENSG00000105373.
GeneIDi29997.
KEGGihsa:29997.
UCSCiuc002phm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182076 mRNA. Translation: AAF62873.1.
BC004229 mRNA. Translation: AAH04229.2.
BC006311 mRNA. Translation: AAH06311.1.
BC010095 mRNA. Translation: AAH10095.1.
AF296124 mRNA. Translation: AAG30413.1.
AL359335 mRNA. Translation: CAB94786.1.
AL359336 mRNA. Translation: CAB94787.1.
AL122063 mRNA. Translation: CAB59242.1.
CCDSiCCDS12705.1.
RefSeqiNP_056525.2. NM_015710.4.
UniGeneiHs.421907.

3D structure databases

ProteinModelPortaliQ9NZM5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119021. 99 interactions.
IntActiQ9NZM5. 19 interactions.
MINTiMINT-1410423.
STRINGi9606.ENSP00000246802.

PTM databases

iPTMnetiQ9NZM5.
PhosphoSiteiQ9NZM5.

Polymorphism and mutation databases

BioMutaiGLTSCR2.
DMDMi93141272.

2D gel databases

SWISS-2DPAGEQ9NZM5.

Proteomic databases

EPDiQ9NZM5.
MaxQBiQ9NZM5.
PaxDbiQ9NZM5.
PeptideAtlasiQ9NZM5.
PRIDEiQ9NZM5.

Protocols and materials databases

DNASUi29997.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246802; ENSP00000246802; ENSG00000105373.
GeneIDi29997.
KEGGihsa:29997.
UCSCiuc002phm.3. human.

Organism-specific databases

CTDi29997.
GeneCardsiGLTSCR2.
HGNCiHGNC:4333. GLTSCR2.
HPAiHPA018999.
HPA049600.
MIMi605691. gene.
neXtProtiNX_Q9NZM5.
PharmGKBiPA28736.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2823. Eukaryota.
ENOG4111GSN. LUCA.
GeneTreeiENSGT00390000017267.
HOGENOMiHOG000070127.
HOVERGENiHBG051849.
InParanoidiQ9NZM5.
KOiK14840.
OMAiTQESAFQ.
OrthoDBiEOG7CVPZM.
PhylomeDBiQ9NZM5.
TreeFamiTF313004.

Miscellaneous databases

ChiTaRSiGLTSCR2. human.
GeneWikiiGLTSCR2.
GenomeRNAii29997.
PROiQ9NZM5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NZM5.
CleanExiHS_GLTSCR2.
ExpressionAtlasiQ9NZM5. baseline and differential.
GenevisibleiQ9NZM5. HS.

Family and domain databases

InterProiIPR011687. Nop53/GLTSCR2.
[Graphical view]
PANTHERiPTHR14211. PTHR14211. 1 hit.
PfamiPF07767. Nop53. 1 hit.
[Graphical view]
PIRSFiPIRSF017302. Gltscr2. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-389, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-389.
    Tissue: Muscle.
  3. "A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and is recruited to the nucleus after infection."
    Bruni R., Fineschi B., Ogle W.O., Roizman B.
    J. Virol. 73:3810-3817(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-478, SUBCELLULAR LOCATION.
  4. The European IMAGE consortium
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-478, VARIANT ARG-389.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 218-477, VARIANT ARG-389.
    Tissue: Testis.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29 AND SER-93, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiGSCR2_HUMAN
AccessioniPrimary (citable) accession number: Q9NZM5
Secondary accession number(s): Q9BTC6
, Q9HAX6, Q9NPP1, Q9NPR4, Q9UFI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: April 18, 2006
Last modified: July 6, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.