Q9NZM5 (GSCR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glioma tumor suppressor candidate region gene 2 protein

Alternative name(s):
p60

Gene names

Name:

GLTSCR2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with HSV-1 early proteins ICP22 and ICP0.
Subcellular location	Nucleus › nucleolus Ref.3 Ref.6.
Tissue specificity	Expressed at high levels in heart and pancreas, moderate levels in placenta, liver, skeletal muscle, and kidney, and low levels in brain and lung. Ref.1
Sequence similarities	Belongs to the GLTSCR2 family.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleolus Inferred from direct assay. Source: HPA
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	Glioma tumor suppressor candidate region gene 2 protein		PRO_0000218960
Natural variations
	Natural variant	16	1	S → R. Corresponds to variant rs1042401 [ dbSNP | Ensembl ].		VAR_024456
	Natural variant	389	1	Q → R. Ref.1 Ref.2 Ref.4 Ref.5 Corresponds to variant rs1804994 [ dbSNP | Ensembl ].		VAR_011486
Experimental info
	Sequence conflict	9	1	G → R in AAG30413. Ref.3
	Sequence conflict	146 – 191	46	RRKEQ…TVERP → SGRSSYGRSWPSRASSPGGA QGPSPVAQPFCNKGPNPAPG HRIAA in AAG30413. Ref.3
	Sequence conflict	198 – 215	18	SDNPL…EFFLE → LNNPDKPVVWPGCLFPG in AAG30413. Ref.3
	Sequence conflict	235	1	A → S in AAH04229. Ref.2
	Sequence conflict	417	1	D → H in AAG30413. Ref.3
	Sequence conflict	433 – 477	45	PEGNI…FREIQ → VLTVSCRGAPCPVMTPSLLP VPPRGYGRHHGCPWAGPVGP MPRG Ref.5
	Sequence conflict	434 – 478	45	EGNIL…REIQL → RGQHSFETGSRAFRGGI in AAG30413. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9NZM5 [UniParc]. Last modified April 18, 2006. Version 2. Checksum: 7F1BA13D04BFB618	FASTA	478	54,389
	10 20 30 40 50 60 MAAGGSGVGG KRSSKSDADS GFLGLRPTSV DPALRRRRRG PRNKKRGWRR LAQEPLGLEV 70 80 90 100 110 120 DQFLEDVRLQ ERTSGGLLSE APNEKLFFVD TGSKEKGLTK KRTKVQKKSL LLKKPLRVDL 130 140 150 160 170 180 ILENTSKVPA PKDVLAHQVP NAKKLRRKEQ LWEKLAKQGE LPREVRRAQA RLLNPSATRA 190 200 210 220 230 240 KPGPQDTVER PFYDLWASDN PLDRPLVGQD EFFLEQTKKK GVKRPARLHT KPSQAPAVEV 250 260 270 280 290 300 APAGASYNPS FEDHQTLLSA AHEVELQRQK EAEKLERQLA LPATEQAATQ ESTFQELCEG 310 320 330 340 350 360 LLEESDGEGE PGQGEGPEAG DAEVCPTPAR LATTEKKTEQ QRRREKAVHR LRVQQAALRA 370 380 390 400 410 420 ARLRHQELFR LRGIKAQVAL RLAELARRQR RRQARREAEA DKPRRLGRLK YQAPDIDVQL 430 440 450 460 470 SSELTDSLRT LKPEGNILRD RFKSFQRRNM IEPRERAKFK RKYKVKLVEK RAFREIQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A transcript map of the chromosome 19q-Arm glioma tumor suppressor region." Smith J.S., Tachibana I., Pohl U., Lee H.K., Thanarajasingam U., Portier B.P., Ueki K., Billings S., Ramaswamy S., Mohrenweiser H.W., Scheithauer B.W., Louis D.N., Jenkins R.B. Genomics 64:44-50(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-389, TISSUE SPECIFICITY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-389. Tissue: Muscle.
[3]	"A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and is recruited to the nucleus after infection." Bruni R., Fineschi B., Ogle W.O., Roizman B. J. Virol. 73:3810-3817(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-478, SUBCELLULAR LOCATION.
[4]	The European IMAGE consortium Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-478, VARIANT ARG-389.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 218-477, VARIANT ARG-389. Tissue: Testis.
[6]	"Functional proteomic analysis of human nucleolus." Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J. Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF182076 mRNA. Translation: AAF62873.1. BC004229 mRNA. Translation: AAH04229.2. BC006311 mRNA. Translation: AAH06311.1. BC010095 mRNA. Translation: AAH10095.1. AF296124 mRNA. Translation: AAG30413.1. AL359335 mRNA. Translation: CAB94786.1. AL359336 mRNA. Translation: CAB94787.1. AL122063 mRNA. Translation: CAB59242.1.
IPI	IPI00024567.
RefSeq	NP_056525.2. NM_015710.4.
UniGene	Hs.421907.
3D structure databases
ProteinModelPortal	Q9NZM5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NZM5. 14 interactions.
MINT	MINT-1410423.
STRING	9606.ENSP00000246802.
PTM databases
PhosphoSite	Q9NZM5.
Polymorphism databases
DMDM	93141272.
2D gel databases
SWISS-2DPAGE	Q9NZM5.
Proteomic databases
PaxDb	Q9NZM5.
PRIDE	Q9NZM5.
Protocols and materials databases
DNASU	29997.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000246802; ENSP00000246802; ENSG00000105373.
GeneID	29997.
KEGG	hsa:29997.
UCSC	uc002phm.2. human.
Organism-specific databases
CTD	29997.
GeneCards	GC19P048248.
HGNC	HGNC:4333. GLTSCR2.
HPA	HPA018999.
MIM	605691. gene.
neXtProt	NX_Q9NZM5.
PharmGKB	PA28736.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG247933.
HOGENOM	HOG000070127.
HOVERGEN	HBG051849.
InParanoid	Q9NZM5.
KO	K14840.
OMA	ILAHQVP.
PhylomeDB	Q9NZM5.
Gene expression databases
Bgee	Q9NZM5.
CleanEx	HS_GLTSCR2.
Genevestigator	Q9NZM5.
GermOnline	ENSG00000105373. Homo sapiens.
Family and domain databases
InterPro	IPR011211. Gltscr2. IPR011687. P60-like. [Graphical view]
PANTHER	PTHR14211. PTHR14211. 1 hit.
Pfam	PF07767. Nop53. 1 hit. [Graphical view]
PIRSF	PIRSF017302. Gltscr2. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	GLTSCR2. human.
GenomeRNAi	29997.
NextBio	52800.
SOURCE	Search...

Entry information

Entry name

GSCR2_HUMAN

Accession

Primary (citable) accession number: Q9NZM5
Secondary accession number(s): Q9BTC6 , Q9HAX6, Q9NPP1, Q9NPR4, Q9UFI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	April 18, 2006
Last modified:	April 3, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.