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Protein

Glioma tumor suppressor candidate region gene 1 protein

Gene

GLTSCR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000063169-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glioma tumor suppressor candidate region gene 1 protein
Gene namesi
Name:GLTSCR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:4332. GLTSCR1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi29998.
OpenTargetsiENSG00000063169.
PharmGKBiPA28735.

Polymorphism and mutation databases

BioMutaiGLTSCR1.
DMDMi215273990.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000838641 – 1560Glioma tumor suppressor candidate region gene 1 proteinAdd BLAST1560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei919PhosphoserineCombined sources1
Modified residuei921PhosphothreonineCombined sources1
Modified residuei1057N6-acetyllysineCombined sources1
Modified residuei1413PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NZM4.
MaxQBiQ9NZM4.
PaxDbiQ9NZM4.
PeptideAtlasiQ9NZM4.
PRIDEiQ9NZM4.

PTM databases

iPTMnetiQ9NZM4.
PhosphoSitePlusiQ9NZM4.

Expressioni

Tissue specificityi

Expressed at moderate levels in heart, brain, placenta, skeletal muscle, and pancreas, and at lower levels in lung, liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000063169.
CleanExiHS_GLTSCR1.
ExpressionAtlasiQ9NZM4. baseline and differential.
GenevisibleiQ9NZM4. HS.

Organism-specific databases

HPAiHPA056211.

Interactioni

Subunit structurei

Interacts with BRD4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163333EBI-1754943,EBI-389883

Protein-protein interaction databases

BioGridi119022. 10 interactors.
IntActiQ9NZM4. 11 interactors.
STRINGi9606.ENSP00000379946.

Structurei

3D structure databases

ProteinModelPortaliQ9NZM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi88 – 96Poly-Gly9
Compositional biasi935 – 940Poly-Pro6
Compositional biasi1265 – 1276Poly-SerAdd BLAST12
Compositional biasi1333 – 1337Poly-Pro5
Compositional biasi1345 – 1355Poly-ProAdd BLAST11

Phylogenomic databases

eggNOGiENOG410IIYC. Eukaryota.
ENOG41126SK. LUCA.
GeneTreeiENSGT00530000063935.
HOGENOMiHOG000112824.
InParanoidiQ9NZM4.
OMAiPVMALNT.
OrthoDBiEOG091G18DF.
PhylomeDBiQ9NZM4.
TreeFamiTF335495.

Family and domain databases

InterProiIPR015671. GSCR1_dom.
[Graphical view]
PfamiPF15249. GLTSCR1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NZM4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDEDGRCLL DVICDPQALN DFLHGSEKLD SDDLLDNPGE AQSAFYEGPG
60 70 80 90 100
LHVQEASGNH LNPEPNQPAP SVDLDFLEDD ILGSPATGGG GGGSGGADQP
110 120 130 140 150
CDILQQSLQE ANITEQTLEA EAELDLGPFQ LPTLQPADGG AGPTGAGGAA
160 170 180 190 200
AVAAGPQALF PGSTDLLGLQ GPPTVLTHQA LVPPQDVVNK ALSVQPFLQP
210 220 230 240 250
VGLGNVTLQP IPGLQGLPNG SPGGATAATL GLAPIQVVGQ PVMALNTPTS
260 270 280 290 300
QLLAKQVPVS GYLASAAGPS EPVTLASAGV SPQGAGLVIQ KNLSAAVATT
310 320 330 340 350
LNGNSVFGGA GAASAPTGTP SGQPLAVAPG LGSSPLVPAP NVILHRTPTP
360 370 380 390 400
IQPKPAGVLP PKLYQLTPKP FAPAGATLTI QGEPGALPQQ PKAPQNLTFM
410 420 430 440 450
AAGKAGQNVV LSGFPAPALQ ANVFKQPPAT TTGAAPPQPP GALSKPMSVH
460 470 480 490 500
LLNQGSSIVI PAQHMLPGQN QFLLPGAPAV QLPQQLSALP ANVGGQILAA
510 520 530 540 550
AAPHTGGQLI ANPILTNQNL AGPLSLGPVL APHSGAHSAH ILSAAPIQVG
560 570 580 590 600
QPALFQMPVS LAAGSLPTQS QPAPAGPAAT TVLQGVTLPP SAVAMLNTPD
610 620 630 640 650
GLVQPATPAA ATGEAAPVLT VQPAPQAPPA VSTPLPLGLQ QPQAQQPPQA
660 670 680 690 700
PTPQAAAPPQ ATTPQPSPGL ASSPEKIVLG QPPSATPTAI LTQDSLQMFL
710 720 730 740 750
PQERSQQPLS AEGPHLSVPA SVIVSAPPPA QDPAPATPVA KGAGLGPQAP
760 770 780 790 800
DSQASPAPAP QIPAAAPLKG PGPSSSPSLP HQAPLGDSPH LPSPHPTRPP
810 820 830 840 850
SRPPSRPQSV SRPPSEPPLH PCPPPQAPPT LPGIFVIQNQ LGVPPPASNP
860 870 880 890 900
APTAPGPPQP PLRPQSQPPE GPLPPAPHLP PSSTSSAVAS SSETSSRLPA
910 920 930 940 950
PTPSDFQLQF PPSQGPHKSP TPPPTLHLVP EPAAPPPPPP RTFQMVTTPF
960 970 980 990 1000
PALPQPKALL ERFHQVPSGI ILQNKAGGAP AAPQTSTSLG PLTSPAASVL
1010 1020 1030 1040 1050
VSGQAPSGTP TAPSHAPAPA PMAATGLPPL LPAENKAFAS NLPTLNVAKA
1060 1070 1080 1090 1100
ASSGPGKPSG LQYESKLSGL KKPPTLQPSK EACFLEHLHK HQGSVLHPDY
1110 1120 1130 1140 1150
KTAFPSFEDA LHRLLPYHVY QGALPSPSDY HKVDEEFETV STQLLKRTQA
1160 1170 1180 1190 1200
MLNKYRLLLL EESRRVSPSA EMVMIDRMFI QEEKTTLALD KQLAKEKPDE
1210 1220 1230 1240 1250
YVSSSRSLGL PIAASSEGHR LPGHGPLSSS APGASTQPPP HLPTKLVIRH
1260 1270 1280 1290 1300
GGAGGSPSVT WARASSSLSS SSSSSSAASS LDADEDGPMP SRNRPPIKTY
1310 1320 1330 1340 1350
EARSRIGLKL KIKQEAGLSK VVHNTALDPV HQPPPPPATL KVAEPPPRPP
1360 1370 1380 1390 1400
PPPPPTGQMN GTVDHPPPAA PERKPLGTAP HCPRLPLRKT YRENVGGPGA
1410 1420 1430 1440 1450
PEGTPAGRAR GGSPAPLPAK VDEATSGLIR ELAAVEDELY QRMLKGPPPE
1460 1470 1480 1490 1500
PAASAAQGTG DPDWEAPGLP PAKRRKSESP DVDQASFSSD SPQDDTLTEH
1510 1520 1530 1540 1550
LQSAIDSILN LQQAPGRTPA PSYPHAASAG TPASPPPLHR PEAYPPSSHN
1560
GGLGARTLTR
Note: No experimental confirmation available.
Length:1,560
Mass (Da):158,490
Last modified:November 25, 2008 - v2
Checksum:i32453B35C9219462
GO
Isoform 2 (identifier: Q9NZM4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-242: Missing.

Note: No experimental confirmation available.
Show »
Length:1,318
Mass (Da):134,207
Checksum:i18A75F49F76AAE0C
GO

Sequence cautioni

The sequence AAF62874 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061663683P → S.Corresponds to variant rs3745762dbSNPEnsembl.1
Natural variantiVAR_0596651044T → A.Corresponds to variant rs13346368dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0357761 – 242Missing in isoform 2. 1 PublicationAdd BLAST242

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182077 mRNA. Translation: AAF62874.1. Different initiation.
AC008985 Genomic DNA. No translation available.
AC010519 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57504.1.
BC032065 mRNA. No translation available.
CCDSiCCDS46134.1. [Q9NZM4-1]
RefSeqiNP_056526.3. NM_015711.3. [Q9NZM4-1]
XP_005258890.1. XM_005258833.4. [Q9NZM4-1]
UniGeneiHs.97244.

Genome annotation databases

EnsembliENST00000396720; ENSP00000379946; ENSG00000063169. [Q9NZM4-1]
GeneIDi29998.
KEGGihsa:29998.
UCSCiuc002phh.4. human. [Q9NZM4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182077 mRNA. Translation: AAF62874.1. Different initiation.
AC008985 Genomic DNA. No translation available.
AC010519 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57504.1.
BC032065 mRNA. No translation available.
CCDSiCCDS46134.1. [Q9NZM4-1]
RefSeqiNP_056526.3. NM_015711.3. [Q9NZM4-1]
XP_005258890.1. XM_005258833.4. [Q9NZM4-1]
UniGeneiHs.97244.

3D structure databases

ProteinModelPortaliQ9NZM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119022. 10 interactors.
IntActiQ9NZM4. 11 interactors.
STRINGi9606.ENSP00000379946.

PTM databases

iPTMnetiQ9NZM4.
PhosphoSitePlusiQ9NZM4.

Polymorphism and mutation databases

BioMutaiGLTSCR1.
DMDMi215273990.

Proteomic databases

EPDiQ9NZM4.
MaxQBiQ9NZM4.
PaxDbiQ9NZM4.
PeptideAtlasiQ9NZM4.
PRIDEiQ9NZM4.

Protocols and materials databases

DNASUi29998.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396720; ENSP00000379946; ENSG00000063169. [Q9NZM4-1]
GeneIDi29998.
KEGGihsa:29998.
UCSCiuc002phh.4. human. [Q9NZM4-1]

Organism-specific databases

CTDi29998.
DisGeNETi29998.
GeneCardsiGLTSCR1.
H-InvDBHIX0018391.
HGNCiHGNC:4332. GLTSCR1.
HPAiHPA056211.
MIMi605690. gene.
neXtProtiNX_Q9NZM4.
OpenTargetsiENSG00000063169.
PharmGKBiPA28735.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIYC. Eukaryota.
ENOG41126SK. LUCA.
GeneTreeiENSGT00530000063935.
HOGENOMiHOG000112824.
InParanoidiQ9NZM4.
OMAiPVMALNT.
OrthoDBiEOG091G18DF.
PhylomeDBiQ9NZM4.
TreeFamiTF335495.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000063169-MONOMER.

Miscellaneous databases

ChiTaRSiGLTSCR1. human.
GenomeRNAii29998.
PROiQ9NZM4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000063169.
CleanExiHS_GLTSCR1.
ExpressionAtlasiQ9NZM4. baseline and differential.
GenevisibleiQ9NZM4. HS.

Family and domain databases

InterProiIPR015671. GSCR1_dom.
[Graphical view]
PfamiPF15249. GLTSCR1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSCR1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZM4
Secondary accession number(s): A8MW01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.