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Q9NZM4 (GSCR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glioma tumor suppressor candidate region gene 1 protein
Gene names
Name:GLTSCR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1560 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with BRD4. Ref.6

Tissue specificity

Expressed at moderate levels in heart, brain, placenta, skeletal muscle, and pancreas, and at lower levels in lung, liver and kidney. Ref.1

Sequence caution

The sequence AAF62874.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NCK1P163333EBI-1754943,EBI-389883

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NZM4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q9NZM4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-242: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15601560Glioma tumor suppressor candidate region gene 1 protein
PRO_0000083864

Regions

Compositional bias88 – 969Poly-Gly
Compositional bias935 – 9406Poly-Pro
Compositional bias1265 – 127612Poly-Ser
Compositional bias1333 – 13375Poly-Pro
Compositional bias1345 – 135511Poly-Pro

Amino acid modifications

Modified residue10571N6-acetyllysine Ref.5

Natural variations

Alternative sequence1 – 242242Missing in isoform 2.
VSP_035776
Natural variant6831P → S.
Corresponds to variant rs3745762 [ dbSNP | Ensembl ].
VAR_061663
Natural variant10441T → A.
Corresponds to variant rs13346368 [ dbSNP | Ensembl ].
VAR_059665

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: 32453B35C9219462

FASTA1,560158,490
        10         20         30         40         50         60 
MDDEDGRCLL DVICDPQALN DFLHGSEKLD SDDLLDNPGE AQSAFYEGPG LHVQEASGNH 

        70         80         90        100        110        120 
LNPEPNQPAP SVDLDFLEDD ILGSPATGGG GGGSGGADQP CDILQQSLQE ANITEQTLEA 

       130        140        150        160        170        180 
EAELDLGPFQ LPTLQPADGG AGPTGAGGAA AVAAGPQALF PGSTDLLGLQ GPPTVLTHQA 

       190        200        210        220        230        240 
LVPPQDVVNK ALSVQPFLQP VGLGNVTLQP IPGLQGLPNG SPGGATAATL GLAPIQVVGQ 

       250        260        270        280        290        300 
PVMALNTPTS QLLAKQVPVS GYLASAAGPS EPVTLASAGV SPQGAGLVIQ KNLSAAVATT 

       310        320        330        340        350        360 
LNGNSVFGGA GAASAPTGTP SGQPLAVAPG LGSSPLVPAP NVILHRTPTP IQPKPAGVLP 

       370        380        390        400        410        420 
PKLYQLTPKP FAPAGATLTI QGEPGALPQQ PKAPQNLTFM AAGKAGQNVV LSGFPAPALQ 

       430        440        450        460        470        480 
ANVFKQPPAT TTGAAPPQPP GALSKPMSVH LLNQGSSIVI PAQHMLPGQN QFLLPGAPAV 

       490        500        510        520        530        540 
QLPQQLSALP ANVGGQILAA AAPHTGGQLI ANPILTNQNL AGPLSLGPVL APHSGAHSAH 

       550        560        570        580        590        600 
ILSAAPIQVG QPALFQMPVS LAAGSLPTQS QPAPAGPAAT TVLQGVTLPP SAVAMLNTPD 

       610        620        630        640        650        660 
GLVQPATPAA ATGEAAPVLT VQPAPQAPPA VSTPLPLGLQ QPQAQQPPQA PTPQAAAPPQ 

       670        680        690        700        710        720 
ATTPQPSPGL ASSPEKIVLG QPPSATPTAI LTQDSLQMFL PQERSQQPLS AEGPHLSVPA 

       730        740        750        760        770        780 
SVIVSAPPPA QDPAPATPVA KGAGLGPQAP DSQASPAPAP QIPAAAPLKG PGPSSSPSLP 

       790        800        810        820        830        840 
HQAPLGDSPH LPSPHPTRPP SRPPSRPQSV SRPPSEPPLH PCPPPQAPPT LPGIFVIQNQ 

       850        860        870        880        890        900 
LGVPPPASNP APTAPGPPQP PLRPQSQPPE GPLPPAPHLP PSSTSSAVAS SSETSSRLPA 

       910        920        930        940        950        960 
PTPSDFQLQF PPSQGPHKSP TPPPTLHLVP EPAAPPPPPP RTFQMVTTPF PALPQPKALL 

       970        980        990       1000       1010       1020 
ERFHQVPSGI ILQNKAGGAP AAPQTSTSLG PLTSPAASVL VSGQAPSGTP TAPSHAPAPA 

      1030       1040       1050       1060       1070       1080 
PMAATGLPPL LPAENKAFAS NLPTLNVAKA ASSGPGKPSG LQYESKLSGL KKPPTLQPSK 

      1090       1100       1110       1120       1130       1140 
EACFLEHLHK HQGSVLHPDY KTAFPSFEDA LHRLLPYHVY QGALPSPSDY HKVDEEFETV 

      1150       1160       1170       1180       1190       1200 
STQLLKRTQA MLNKYRLLLL EESRRVSPSA EMVMIDRMFI QEEKTTLALD KQLAKEKPDE 

      1210       1220       1230       1240       1250       1260 
YVSSSRSLGL PIAASSEGHR LPGHGPLSSS APGASTQPPP HLPTKLVIRH GGAGGSPSVT 

      1270       1280       1290       1300       1310       1320 
WARASSSLSS SSSSSSAASS LDADEDGPMP SRNRPPIKTY EARSRIGLKL KIKQEAGLSK 

      1330       1340       1350       1360       1370       1380 
VVHNTALDPV HQPPPPPATL KVAEPPPRPP PPPPPTGQMN GTVDHPPPAA PERKPLGTAP 

      1390       1400       1410       1420       1430       1440 
HCPRLPLRKT YRENVGGPGA PEGTPAGRAR GGSPAPLPAK VDEATSGLIR ELAAVEDELY 

      1450       1460       1470       1480       1490       1500 
QRMLKGPPPE PAASAAQGTG DPDWEAPGLP PAKRRKSESP DVDQASFSSD SPQDDTLTEH 

      1510       1520       1530       1540       1550       1560 
LQSAIDSILN LQQAPGRTPA PSYPHAASAG TPASPPPLHR PEAYPPSSHN GGLGARTLTR 

« Hide

Isoform 2 [UniParc].

Checksum: 18A75F49F76AAE0C
Show »

FASTA1,318134,207

References

« Hide 'large scale' references
[1]"A transcript map of the chromosome 19q-Arm glioma tumor suppressor region."
Smith J.S., Tachibana I., Pohl U., Lee H.K., Thanarajasingam U., Portier B.P., Ueki K., Billings S., Ramaswamy S., Mohrenweiser H.W., Scheithauer B.W., Louis D.N., Jenkins R.B.
Genomics 64:44-50(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-500 (ISOFORM 1).
Tissue: Brain.
[5]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1057, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3."
Rahman S., Sowa M.E., Ottinger M., Smith J.A., Shi Y., Harper J.W., Howley P.M.
Mol. Cell. Biol. 31:2641-2652(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH BRD4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF182077 mRNA. Translation: AAF62874.1. Different initiation.
AC008985 Genomic DNA. No translation available.
AC010519 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57504.1.
BC032065 mRNA. No translation available.
RefSeqNP_056526.3. NM_015711.3.
XP_005258890.1. XM_005258833.2.
UniGeneHs.97244.

3D structure databases

ProteinModelPortalQ9NZM4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119022. 2 interactions.
IntActQ9NZM4. 9 interactions.
STRING9606.ENSP00000379946.

PTM databases

PhosphoSiteQ9NZM4.

Polymorphism databases

DMDM215273990.

Proteomic databases

PaxDbQ9NZM4.
PRIDEQ9NZM4.

Protocols and materials databases

DNASU29998.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000396720; ENSP00000379946; ENSG00000063169. [Q9NZM4-1]
GeneID29998.
KEGGhsa:29998.
UCSCuc002phh.4. human. [Q9NZM4-1]

Organism-specific databases

CTD29998.
GeneCardsGC19P048111.
H-InvDBHIX0018391.
HGNCHGNC:4332. GLTSCR1.
HPAHPA056211.
MIM605690. gene.
neXtProtNX_Q9NZM4.
PharmGKBPA28735.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG283687.
HOGENOMHOG000112824.
InParanoidQ9NZM4.
OMAPSPNDYH.
OrthoDBEOG7H1JKB.
PhylomeDBQ9NZM4.
TreeFamTF335495.

Gene expression databases

ArrayExpressQ9NZM4.
BgeeQ9NZM4.
CleanExHS_GLTSCR1.
GenevestigatorQ9NZM4.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi29998.
NextBio52804.
PROQ9NZM4.
SOURCESearch...

Entry information

Entry nameGSCR1_HUMAN
AccessionPrimary (citable) accession number: Q9NZM4
Secondary accession number(s): A8MW01
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 25, 2008
Last modified: April 16, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM