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Protein

Intersectin-2

Gene

ITSN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi67 – 79PROSITE-ProRule annotationAdd BLAST13

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • Rho guanyl-nucleotide exchange factor activity Source: InterPro
  • SH3/SH2 adaptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, Endocytosis

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Intersectin-2
Alternative name(s):
SH3 domain-containing protein 1B
SH3P18
SH3P18-like WASP-associated protein
Gene namesi
Name:ITSN2
Synonyms:KIAA1256, SH3D1B, SWAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6184. ITSN2.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: CACAO
  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi50618.
OpenTargetsiENSG00000198399.
PharmGKBiPA29982.

Polymorphism and mutation databases

BioMutaiITSN2.
DMDMi294862505.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809611 – 1697Intersectin-2Add BLAST1697

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1
Modified residuei230PhosphoserineCombined sources1
Modified residuei553PhosphotyrosineBy similarity1
Modified residuei573PhosphothreonineCombined sources1
Modified residuei882PhosphothreonineBy similarity1
Modified residuei884PhosphoserineCombined sources1
Modified residuei889PhosphoserineCombined sources1
Modified residuei968PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NZM3.
MaxQBiQ9NZM3.
PaxDbiQ9NZM3.
PeptideAtlasiQ9NZM3.
PRIDEiQ9NZM3.

PTM databases

iPTMnetiQ9NZM3.
PhosphoSitePlusiQ9NZM3.

Expressioni

Tissue specificityi

Expressed in melanocytes (PubMed:23999003). Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver.1 Publication

Gene expression databases

BgeeiENSG00000198399.
CleanExiHS_ITSN2.
ExpressionAtlasiQ9NZM3. baseline and differential.
GenevisibleiQ9NZM3. HS.

Organism-specific databases

HPAiHPA036475.

Interactioni

Subunit structurei

Belongs to a complex that may contain multimers of ITSN1, ITSN2 and EPS15, and different partners according to the step in the endocytic process. Interacts with ADAM15. Interacts with FASLG. Interacts with ANKRD54 (By similarity). Interacts with FCHO2.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
K15-MQ9WNA92EBI-308689,EBI-7555439From a different organism.

GO - Molecular functioni

  • SH3/SH2 adaptor activity Source: ProtInc

Protein-protein interaction databases

BioGridi119098. 91 interactors.
IntActiQ9NZM3. 34 interactors.
MINTiMINT-1404321.
STRINGi9606.ENSP00000347244.

Structurei

Secondary structure

11697
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi762 – 766Combined sources5
Beta strandi772 – 774Combined sources3
Beta strandi783 – 786Combined sources4
Beta strandi793 – 801Combined sources9
Beta strandi804 – 809Combined sources6
Beta strandi812 – 815Combined sources4
Beta strandi818 – 821Combined sources4
Beta strandi901 – 907Combined sources7
Beta strandi924 – 931Combined sources8
Beta strandi934 – 939Combined sources6
Beta strandi942 – 947Combined sources6
Helixi948 – 950Combined sources3
Beta strandi951 – 954Combined sources4
Beta strandi983 – 987Combined sources5
Beta strandi995 – 999Combined sources5
Beta strandi1007 – 1010Combined sources4
Beta strandi1012 – 1014Combined sources3
Beta strandi1017 – 1020Combined sources4
Beta strandi1027 – 1029Combined sources3
Helixi1031 – 1033Combined sources3
Beta strandi1056 – 1060Combined sources5
Beta strandi1079 – 1085Combined sources7
Beta strandi1087 – 1095Combined sources9
Beta strandi1104 – 1108Combined sources5
Beta strandi1111 – 1114Combined sources4
Beta strandi1129 – 1136Combined sources8
Beta strandi1153 – 1156Combined sources4
Beta strandi1161 – 1166Combined sources6
Beta strandi1168 – 1171Combined sources4
Beta strandi1180 – 1183Combined sources4
Helixi1207 – 1234Combined sources28
Helixi1236 – 1242Combined sources7
Beta strandi1243 – 1245Combined sources3
Helixi1247 – 1254Combined sources8
Helixi1257 – 1272Combined sources16
Helixi1288 – 1294Combined sources7
Helixi1299 – 1321Combined sources23
Helixi1323 – 1333Combined sources11
Turni1336 – 1340Combined sources5
Helixi1343 – 1346Combined sources4
Helixi1349 – 1366Combined sources18
Helixi1375 – 1393Combined sources19
Beta strandi1569 – 1580Combined sources12
Beta strandi1592 – 1598Combined sources7
Beta strandi1601 – 1604Combined sources4
Beta strandi1615 – 1625Combined sources11
Turni1627 – 1629Combined sources3
Beta strandi1631 – 1638Combined sources8
Beta strandi1641 – 1644Combined sources4
Beta strandi1647 – 1654Combined sources8
Helixi1655 – 1665Combined sources11
Beta strandi1670 – 1673Combined sources4
Beta strandi1675 – 1679Combined sources5
Beta strandi1681 – 1690Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J3TNMR-A898-958[»]
1UDLNMR-A1103-1187[»]
1UE9NMR-A1056-1122[»]
1UFFNMR-A762-842[»]
1UHFNMR-A983-1038[»]
3GF9X-ray2.50A1130-1406[»]
3JZYX-ray1.56A1201-1692[»]
4IIOX-ray1.70A/B901-955[»]
ProteinModelPortaliQ9NZM3.
SMRiQ9NZM3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NZM3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 110EH 1PROSITE-ProRule annotationAdd BLAST89
Domaini54 – 89EF-handPROSITE-ProRule annotationAdd BLAST36
Domaini244 – 333EH 2PROSITE-ProRule annotationAdd BLAST90
Domaini757 – 818SH3 1PROSITE-ProRule annotationAdd BLAST62
Domaini898 – 956SH3 2PROSITE-ProRule annotationAdd BLAST59
Domaini981 – 1039SH3 3PROSITE-ProRule annotationAdd BLAST59
Domaini1053 – 1117SH3 4PROSITE-ProRule annotationAdd BLAST65
Domaini1127 – 1186SH3 5PROSITE-ProRule annotationAdd BLAST60
Domaini1209 – 1395DHPROSITE-ProRule annotationAdd BLAST187
Domaini1434 – 1544PHPROSITE-ProRule annotationAdd BLAST111
Domaini1556 – 1652C2PROSITE-ProRule annotationAdd BLAST97

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili361 – 756Sequence analysisAdd BLAST396

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 EF-hand domain.PROSITE-ProRule annotation
Contains 2 EH domains.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 5 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG1029. Eukaryota.
KOG4305. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00760000118985.
HOVERGENiHBG052159.
InParanoidiQ9NZM3.
KOiK20045.
OMAiRGGKQID.
OrthoDBiEOG091G0TXR.
PhylomeDBiQ9NZM3.
TreeFamiTF324293.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR027029. Intersectin-2.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR11216:SF29. PTHR11216:SF29. 5 hits.
PfamiPF00168. C2. 1 hit.
PF12763. EF-hand_4. 2 hits.
PF16652. PH_13. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF48065. SSF48065. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 5 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9NZM3-1) [UniParc]FASTAAdd to basket
Also known as: ITSN2-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAQFPTAMN GGPNMWAITS EERTKHDRQF DNLKPSGGYI TGDQARNFFL
60 70 80 90 100
QSGLPAPVLA EIWALSDLNK DGKMDQQEFS IAMKLIKLKL QGQQLPVVLP
110 120 130 140 150
PIMKQPPMFS PLISARFGMG SMPNLSIPQP LPPAAPITSL SSATSGTNLP
160 170 180 190 200
PLMMPTPLVP SVSTSSLPNG TASLIQPLPI PYSSSTLPHG SSYSLMMGGF
210 220 230 240 250
GGASIQKAQS LIDLGSSSST SSTASLSGNS PKTGTSEWAV PQPTRLKYRQ
260 270 280 290 300
KFNTLDKSMS GYLSGFQARN ALLQSNLSQT QLATIWTLAD VDGDGQLKAE
310 320 330 340 350
EFILAMHLTD MAKAGQPLPL TLPPELVPPS FRGGKQIDSI NGTLPSYQKM
360 370 380 390 400
QEEEPQKKLP VTFEDKRKAN YERGNMELEK RRQALMEQQQ REAERKAQKE
410 420 430 440 450
KEEWERKQRE LQEQEWKKQL ELEKRLEKQR ELERQREEER RKDIERREAA
460 470 480 490 500
KQELERQRRL EWERIRRQEL LNQKNREQEE IVRLNSKKKN LHLELEALNG
510 520 530 540 550
KHQQISGRLQ DVRLKKQTQK TELEVLDKQC DLEIMEIKQL QQELQEYQNK
560 570 580 590 600
LIYLVPEKQL LNERIKNMQF SNTPDSGVSL LHKKSLEKEE LCQRLKEQLD
610 620 630 640 650
ALEKETASKL SEMDSFNNQL KCGNMDDSVL QCLLSLLSCL NNLFLLLKEL
660 670 680 690 700
RETYNTQQLA LEQLYKIKRD KLKEIERKRL ELMQKKKLED EAARKAKQGK
710 720 730 740 750
ENLWKENLRK EEEEKQKRLQ EEKTQEKIQE EERKAEEKQR KDKDTLKAEE
760 770 780 790 800
KKRETASVLV NYRALYPFEA RNHDEMSFNS GDIIQVDEKT VGEPGWLYGS
810 820 830 840 850
FQGNFGWFPC NYVEKMPSSE NEKAVSPKKA LLPPTVSLSA TSTSSEPLSS
860 870 880 890 900
NQPASVTDYQ NVSFSNLTVN TSWQKKSAFT RTVSPGSVSP IHGQGQVVEN
910 920 930 940 950
LKAQALCSWT AKKDNHLNFS KHDIITVLEQ QENWWFGEVH GGRGWFPKSY
960 970 980 990 1000
VKIIPGSEVK REEPEALYAA VNKKPTSAAY SVGEEYIALY PYSSVEPGDL
1010 1020 1030 1040 1050
TFTEGEEILV TQKDGEWWTG SIGDRSGIFP SNYVKPKDQE SFGSASKSGA
1060 1070 1080 1090 1100
SNKKPEIAQV TSAYVASGSE QLSLAPGQLI LILKKNTSGW WQGELQARGK
1110 1120 1130 1140 1150
KRQKGWFPAS HVKLLGPSSE RATPAFHPVC QVIAMYDYAA NNEDELSFSK
1160 1170 1180 1190 1200
GQLINVMNKD DPDWWQGEIN GVTGLFPSNY VKMTTDSDPS QQWCADLQTL
1210 1220 1230 1240 1250
DTMQPIERKR QGYIHELIQT EERYMADLQL VVEVFQKRMA ESGFLTEGEM
1260 1270 1280 1290 1300
ALIFVNWKEL IMSNTKLLKA LRVRKKTGGE KMPVQMIGDI LAAELSHMQA
1310 1320 1330 1340 1350
YIRFCSCQLN GAALLQQKTD EDTDFKEFLK KLASDPRCKG MPLSSFLLKP
1360 1370 1380 1390 1400
MQRITRYPLL IRSILENTPE SHADHSSLKL ALERAEELCS QVNEGVREKE
1410 1420 1430 1440 1450
NSDRLEWIQA HVQCEGLAEQ LIFNSLTNCL GPRKLLHSGK LYKTKSNKEL
1460 1470 1480 1490 1500
HGFLFNDFLL LTYMVKQFAV SSGSEKLFSS KSNAQFKMYK TPIFLNEVLV
1510 1520 1530 1540 1550
KLPTDPSSDE PVFHISHIDR VYTLRTDNIN ERTAWVQKIK AASEQYIDTE
1560 1570 1580 1590 1600
KKKREKAYQA RSQKTSGIGR LMVHVIEATE LKACKPNGKS NPYCEISMGS
1610 1620 1630 1640 1650
QSYTTRTIQD TLNPKWNFNC QFFIKDLYQD VLCLTLFDRD QFSPDDFLGR
1660 1670 1680 1690
TEIPVAKIRT EQESKGPMTR RLLLHEVPTG EVWVRFDLQL FEQKTLL
Length:1,697
Mass (Da):193,461
Last modified:April 20, 2010 - v3
Checksum:i49C41AE1E32E1BD0
GO
Isoform 2 (identifier: Q9NZM3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     622-648: Missing.

Show »
Length:1,670
Mass (Da):190,496
Checksum:i91E65C08E5AB26F1
GO
Isoform 3 (identifier: Q9NZM3-3) [UniParc]FASTAAdd to basket
Also known as: ITSN2-S1

The sequence of this isoform differs from the canonical sequence as follows:
     1235-1249: FQKRMAESGFLTEGE → RRLLLASSRGICCLS
     1250-1697: Missing.

Show »
Length:1,249
Mass (Da):141,820
Checksum:i271797AF71A0EB28
GO
Isoform 4 (identifier: Q9NZM3-4) [UniParc]FASTAAdd to basket
Also known as: ITSN2-S2, SH3P18

The sequence of this isoform differs from the canonical sequence as follows:
     1193-1697: Missing.

Show »
Length:1,192
Mass (Da):135,144
Checksum:i2DA2049587CF4082
GO

Sequence cautioni

The sequence AAF59903 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF59904 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF63600 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA86570 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti679R → G in BAB13841 (PubMed:14702039).Curated1
Sequence conflicti823 – 828KAVSPK → FAAAST in AAD00899 (Ref. 6) Curated6
Sequence conflicti945 – 951WFPKSYV → EFAAAST in AAC50593 (PubMed:9630982).Curated7
Sequence conflicti1279 – 1285GEKMPVQ → VDAAANS in AAD00899 (Ref. 6) Curated7
Sequence conflicti1553K → Q in AAF63600 (Ref. 2) Curated1
Sequence conflicti1553K → Q in BAA86570 (PubMed:10574462).Curated1
Isoform 3 (identifier: Q9NZM3-3)
Sequence conflicti1235R → W in AAF59904 (PubMed:10922467).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024287254T → A.Corresponds to variant rs6744320dbSNPEnsembl.1
Natural variantiVAR_024288291V → I.1 PublicationCorresponds to variant rs7603997dbSNPEnsembl.1
Natural variantiVAR_0201931287I → T.Corresponds to variant rs3731625dbSNPEnsembl.1
Natural variantiVAR_0219371534A → T.Corresponds to variant rs2303291dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003892622 – 648Missing in isoform 2. 3 PublicationsAdd BLAST27
Alternative sequenceiVSP_0038951193 – 1697Missing in isoform 4. 1 PublicationAdd BLAST505
Alternative sequenceiVSP_0038931235 – 1249FQKRM…LTEGE → RRLLLASSRGICCLS in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0038941250 – 1697Missing in isoform 3. 1 PublicationAdd BLAST448

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182198 mRNA. Translation: AAF59903.1. Different initiation.
AF182199 mRNA. Translation: AAF59904.1. Different initiation.
AF248540 mRNA. Translation: AAF63600.1. Different initiation.
AB033082 mRNA. Translation: BAA86570.1. Different initiation.
AC008073 Genomic DNA. No translation available.
AC009228 Genomic DNA. No translation available.
AK021545 mRNA. Translation: BAB13841.1.
AK000302 mRNA. Translation: BAA91068.1.
AF001630 mRNA. Translation: AAD00899.1.
U61167 mRNA. Translation: AAC50593.1.
CCDSiCCDS1710.2. [Q9NZM3-1]
CCDS1711.2. [Q9NZM3-2]
CCDS46230.1. [Q9NZM3-3]
RefSeqiNP_006268.2. NM_006277.2. [Q9NZM3-1]
NP_062541.3. NM_019595.3. [Q9NZM3-2]
NP_671494.2. NM_147152.2. [Q9NZM3-3]
UniGeneiHs.432562.

Genome annotation databases

EnsembliENST00000355123; ENSP00000347244; ENSG00000198399. [Q9NZM3-1]
ENST00000361999; ENSP00000354561; ENSG00000198399. [Q9NZM3-2]
ENST00000406921; ENSP00000384499; ENSG00000198399. [Q9NZM3-3]
GeneIDi50618.
KEGGihsa:50618.
UCSCiuc002rfe.3. human. [Q9NZM3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182198 mRNA. Translation: AAF59903.1. Different initiation.
AF182199 mRNA. Translation: AAF59904.1. Different initiation.
AF248540 mRNA. Translation: AAF63600.1. Different initiation.
AB033082 mRNA. Translation: BAA86570.1. Different initiation.
AC008073 Genomic DNA. No translation available.
AC009228 Genomic DNA. No translation available.
AK021545 mRNA. Translation: BAB13841.1.
AK000302 mRNA. Translation: BAA91068.1.
AF001630 mRNA. Translation: AAD00899.1.
U61167 mRNA. Translation: AAC50593.1.
CCDSiCCDS1710.2. [Q9NZM3-1]
CCDS1711.2. [Q9NZM3-2]
CCDS46230.1. [Q9NZM3-3]
RefSeqiNP_006268.2. NM_006277.2. [Q9NZM3-1]
NP_062541.3. NM_019595.3. [Q9NZM3-2]
NP_671494.2. NM_147152.2. [Q9NZM3-3]
UniGeneiHs.432562.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J3TNMR-A898-958[»]
1UDLNMR-A1103-1187[»]
1UE9NMR-A1056-1122[»]
1UFFNMR-A762-842[»]
1UHFNMR-A983-1038[»]
3GF9X-ray2.50A1130-1406[»]
3JZYX-ray1.56A1201-1692[»]
4IIOX-ray1.70A/B901-955[»]
ProteinModelPortaliQ9NZM3.
SMRiQ9NZM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119098. 91 interactors.
IntActiQ9NZM3. 34 interactors.
MINTiMINT-1404321.
STRINGi9606.ENSP00000347244.

PTM databases

iPTMnetiQ9NZM3.
PhosphoSitePlusiQ9NZM3.

Polymorphism and mutation databases

BioMutaiITSN2.
DMDMi294862505.

Proteomic databases

EPDiQ9NZM3.
MaxQBiQ9NZM3.
PaxDbiQ9NZM3.
PeptideAtlasiQ9NZM3.
PRIDEiQ9NZM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355123; ENSP00000347244; ENSG00000198399. [Q9NZM3-1]
ENST00000361999; ENSP00000354561; ENSG00000198399. [Q9NZM3-2]
ENST00000406921; ENSP00000384499; ENSG00000198399. [Q9NZM3-3]
GeneIDi50618.
KEGGihsa:50618.
UCSCiuc002rfe.3. human. [Q9NZM3-1]

Organism-specific databases

CTDi50618.
DisGeNETi50618.
GeneCardsiITSN2.
H-InvDBHIX0001876.
HGNCiHGNC:6184. ITSN2.
HPAiHPA036475.
MIMi604464. gene.
neXtProtiNX_Q9NZM3.
OpenTargetsiENSG00000198399.
PharmGKBiPA29982.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1029. Eukaryota.
KOG4305. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00760000118985.
HOVERGENiHBG052159.
InParanoidiQ9NZM3.
KOiK20045.
OMAiRGGKQID.
OrthoDBiEOG091G0TXR.
PhylomeDBiQ9NZM3.
TreeFamiTF324293.

Enzyme and pathway databases

ReactomeiR-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

ChiTaRSiITSN2. human.
EvolutionaryTraceiQ9NZM3.
GeneWikiiITSN2.
GenomeRNAii50618.
PROiQ9NZM3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198399.
CleanExiHS_ITSN2.
ExpressionAtlasiQ9NZM3. baseline and differential.
GenevisibleiQ9NZM3. HS.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR027029. Intersectin-2.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR11216:SF29. PTHR11216:SF29. 5 hits.
PfamiPF00168. C2. 1 hit.
PF12763. EF-hand_4. 2 hits.
PF16652. PH_13. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF48065. SSF48065. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 5 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITSN2_HUMAN
AccessioniPrimary (citable) accession number: Q9NZM3
Secondary accession number(s): O95062
, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: April 20, 2010
Last modified: November 2, 2016
This is version 183 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Overexpression results in the inhibition of the transferrin uptake and the blockage of the clathrin-mediated endocytosis.

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated
Studies in clathrin-mediated endocytosis of ITGB1 and TFR used a siRNA mixture of ISTN1 and ISTN2 suggesting a partially overlapping role of the EH domain-containing proteins.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.