Q9NZL9 (MAT2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Methionine adenosyltransferase 2 subunit beta

Alternative name(s):
Methionine adenosyltransferase II beta
Short name=MAT II beta
Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase

Gene names

Name:	MAT2B
Synonyms:	TGR
ORF Names:	MSTP045, Nbla02999, UNQ2435/PRO4995

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S-adenosylmethionine inhibition. Ref.1
Pathway	Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.
Subunit structure	Heterotetramer composed of 2 catalytic alpha subunits (alpha and alpha') (MAT2A) and 1 copy of beta subunit (MAT2B). Ref.1
Tissue specificity	Widely expressed. Ref.1 Ref.11
Miscellaneous	Its expression in hepatoma cell lines may lead to increase DNA synthesis and thereby participate in cell proliferation.
Sequence similarities	Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
Sequence caution	The sequence AAG39296.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	One-carbon metabolism
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	S-adenosylmethionine biosynthetic process Inferred from direct assay Ref.1. Source: UniProtKB extracellular polysaccharide biosynthetic process Inferred from electronic annotation. Source: InterPro methylation Traceable author statement. Source: Reactome one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW sulfur amino acid metabolic process Traceable author statement. Source: Reactome xenobiotic metabolic process Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome methionine adenosyltransferase complex Inferred from direct assay Ref.1. Source: UniProtKB mitochondrion Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay. Source: LIFEdb
Molecular_function	dTDP-4-dehydrorhamnose reductase activity Inferred from electronic annotation. Source: InterPro methionine adenosyltransferase regulator activity Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NZL9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NZL9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MVGREKELSIHFVPGSCRLVE → MPEMPEDMEQ

Isoform 3 (identifier: Q9NZL9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     241-259: DPSIKGTFHWSGNEQMTKY → VRRIPESCLSEGPLCLFHA
     260-334: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9NZL9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MVGREKELSIHFVPGSCRLVE → MPEMPEDMEQ
     279-295: Missing.

Isoform 5 (identifier: Q9NZL9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MVGREKELSIHFVPGSCRLV → MPEMPEDMEQ
     87-93: PHVIVHC → VLLTALS
     94-334: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.1

Chain

2 – 334

333

Methionine adenosyltransferase 2 subunit beta

PRO_0000287520

Natural variations

Alternative sequence

1 – 21

21

MVGRE…CRLVE → MPEMPEDMEQ in isoform 2 and isoform 4.

VSP_025534

Alternative sequence

1 – 20

20

MVGRE…SCRLV → MPEMPEDMEQ in isoform 5.

VSP_025535

Alternative sequence

87 – 93

7

PHVIVHC → VLLTALS in isoform 5.

VSP_025536

Alternative sequence

94 – 334

241

Missing in isoform 5.

VSP_025537

Alternative sequence

241 – 259

19

DPSIK…QMTKY → VRRIPESCLSEGPLCLFHA in isoform 3.

VSP_025538

Alternative sequence

260 – 334

75

Missing in isoform 3.

VSP_025539

Alternative sequence

279 – 295

17

Missing in isoform 4.

VSP_025540

Natural variant

293

1

A → T. Ref.9
Corresponds to variant rs17849948 [ dbSNP | Ensembl ].

VAR_032318

Experimental info

Sequence conflict

150

1

E → G in AAH93030. Ref.9

Sequence conflict

302

1

T → I in AAH66645. Ref.9

Secondary structure

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334

Helix Strand Turn

Details...

Beta strand

30 – 34

5

Turn

35 – 37

3

Helix

39 – 49

11

Turn

50 – 52

3

Beta strand

54 – 58

5

Turn

64 – 66

3

Beta strand

67 – 69

3

Helix

79 – 85

7

Beta strand

88 – 92

5

Helix

99 – 104

6

Helix

106 – 113

8

Helix

115 – 126

12

Beta strand

130 – 136

7

Helix

137 – 139

3

Beta strand

142 – 144

3

Helix

158 – 173

16

Beta strand

178 – 182

5

Beta strand

184 – 186

3

Helix

192 – 194

3

Helix

198 – 200

3

Helix

201 – 205

5

Beta strand

211 – 214

4

Beta strand

216 – 219

4

Helix

224 – 239

16

Beta strand

246 – 249

4

Helix

258 – 268

11

Beta strand

276 – 279

4

Beta strand

285 – 287

3

Helix

298 – 302

5

Helix

311 – 319

9

Helix

320 – 322

3

Turn

330 – 333

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 6AAA5381BAF3F65F	FASTA	334	37,552
	10 20 30 40 50 60 MVGREKELSI HFVPGSCRLV EEEVNIPNRR VLVTGATGLL GRAVHKEFQQ NNWHAVGCGF 70 80 90 100 110 120 RRARPKFEQV NLLDSNAVHH IIHDFQPHVI VHCAAERRPD VVENQPDAAS QLNVDASGNL 130 140 150 160 170 180 AKEAAAVGAF LIYISSDYVF DGTNPPYREE DIPAPLNLYG KTKLDGEKAV LENNLGAAVL 190 200 210 220 230 240 RIPILYGEVE KLEESAVTVM FDKVQFSNKS ANMDHWQQRF PTHVKDVATV CRQLAEKRML 250 260 270 280 290 300 DPSIKGTFHW SGNEQMTKYE MACAIADAFN LPSSHLRPIT DSPVLGAQRP RNAQLDCSKL 310 320 330 ETLGIGQRTP FRIGIKESLW PFLIDKRWRQ TVFH
	Isoform 2 [UniParc]. Checksum: 4B2197246063E711	FASTA	323	36,401
	10 20 30 40 50 60 MPEMPEDMEQ EEVNIPNRRV LVTGATGLLG RAVHKEFQQN NWHAVGCGFR RARPKFEQVN 70 80 90 100 110 120 LLDSNAVHHI IHDFQPHVIV HCAAERRPDV VENQPDAASQ LNVDASGNLA KEAAAVGAFL 130 140 150 160 170 180 IYISSDYVFD GTNPPYREED IPAPLNLYGK TKLDGEKAVL ENNLGAAVLR IPILYGEVEK 190 200 210 220 230 240 LEESAVTVMF DKVQFSNKSA NMDHWQQRFP THVKDVATVC RQLAEKRMLD PSIKGTFHWS 250 260 270 280 290 300 GNEQMTKYEM ACAIADAFNL PSSHLRPITD SPVLGAQRPR NAQLDCSKLE TLGIGQRTPF 310 320 RIGIKESLWP FLIDKRWRQT VFH
	Isoform 3 [UniParc]. Checksum: 7F4682A780B15E47	FASTA	259	28,954
	10 20 30 40 50 60 MVGREKELSI HFVPGSCRLV EEEVNIPNRR VLVTGATGLL GRAVHKEFQQ NNWHAVGCGF 70 80 90 100 110 120 RRARPKFEQV NLLDSNAVHH IIHDFQPHVI VHCAAERRPD VVENQPDAAS QLNVDASGNL 130 140 150 160 170 180 AKEAAAVGAF LIYISSDYVF DGTNPPYREE DIPAPLNLYG KTKLDGEKAV LENNLGAAVL 190 200 210 220 230 240 RIPILYGEVE KLEESAVTVM FDKVQFSNKS ANMDHWQQRF PTHVKDVATV CRQLAEKRML 250 VRRIPESCLS EGPLCLFHA
	Isoform 4 [UniParc]. Checksum: ECF509E5B6BE02EF	FASTA	306	34,583
	10 20 30 40 50 60 MPEMPEDMEQ EEVNIPNRRV LVTGATGLLG RAVHKEFQQN NWHAVGCGFR RARPKFEQVN 70 80 90 100 110 120 LLDSNAVHHI IHDFQPHVIV HCAAERRPDV VENQPDAASQ LNVDASGNLA KEAAAVGAFL 130 140 150 160 170 180 IYISSDYVFD GTNPPYREED IPAPLNLYGK TKLDGEKAVL ENNLGAAVLR IPILYGEVEK 190 200 210 220 230 240 LEESAVTVMF DKVQFSNKSA NMDHWQQRFP THVKDVATVC RQLAEKRMLD PSIKGTFHWS 250 260 270 280 290 300 GNEQMTKYEM ACAIADAFNL PSSHLRPDCS KLETLGIGQR TPFRIGIKES LWPFLIDKRW RQTVFH
	Isoform 5 [UniParc]. Checksum: F471368C041DE99A	FASTA	83	9,488
	10 20 30 40 50 60 MPEMPEDMEQ EEEVNIPNRR VLVTGATGLL GRAVHKEFQQ NNWHAVGCGF RRARPKFEQV 70 80 NLLDSNAVHH IIHDFQVLLT ALS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II)." LeGros H.L., Halim A.-B., Geller A.M., Kotb M. J. Biol. Chem. 275:2359-2366(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 2-20 AND 240-257, SUBUNIT, FUNCTION, TISSUE SPECIFICITY.
[2]	"Occurrence of a novel metabolic pathway converting dTDP-D-glucose in human cells." Sturla L., Zanardi D., Bisso A., Damonte G., Fasano M., De Flora A., Tonetti M. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"Alternative splicing of the MAT2B gene." Yang H., Magilnick N., Lu S.C. Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5).
[4]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma." Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A. Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Neuroblastoma.
[6]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Amygdala.
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-293. Tissue: Pancreas, Placenta and Skin.
[10]	Liu B., Liu Y.Q., Wang X.Y., Zhao B., Sheng H., Zhao X.W., Liu S., Xu Y.Y., Ye J., Song L., Gao Y., Zhang C.L., Zhang J., Wei Y.J., Cao H.Q., Zhao Y., Liu L.S., Ding J.F. , Gao R.L., Wu Q.Y., Qiang B.Q., Yuan J.G., Liew C.C., Zhao M.S., Hui R.T. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-334. Tissue: Heart.
[11]	"Regulation of the human MAT2B gene encoding the regulatory beta subunit of methionine adenosyltransferase, MAT II." LeGros L., Halim A.-B., Chamberlin M.E., Geller A., Kotb M. J. Biol. Chem. 276:24918-24924(2001) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[12]	"Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma." Martinez-Chantar M.L., Garcia-Trevijano E.R., Latasa M.U., Martin-Duce A., Fortes P., Caballeria J., Avila M.A., Mato J.M. Gastroenterology 124:940-948(2003) [PubMed] [Europe PMC] [Abstract] Cited for: EXPRESSION IN HEPATOMA.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[14]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[15]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF182814 mRNA. Translation: AAF28477.1.
AJ243721 mRNA. Translation: CAB56837.1.
DQ395260 mRNA. Translation: ABD59011.1.
DQ413183 mRNA. Translation: ABD85290.1.
AL136664 mRNA. Translation: CAB66599.1.
AB073390 mRNA. Translation: BAE45720.1.
AY358695 mRNA. Translation: AAQ89058.1.
AK312365 mRNA. Translation: BAG35283.1.
CH471062 Genomic DNA. Translation: EAW61517.1.
BC005218 mRNA. Translation: AAH05218.1.
BC066645 mRNA. Translation: AAH66645.1.
BC093030 mRNA. Translation: AAH93030.1.
AF113225 mRNA. Translation: AAG39296.1. Different initiation.

IPI

IPI00002324.
IPI00181717.
IPI00845294.
IPI00845444.
IPI00845510.

RefSeq

NP_037415.1. NM_013283.4.
NP_877725.1. NM_182796.2.

UniGene

Hs.54642.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2YDX	X-ray	2.80	A/B/C/D/E	28-334	[»]
2YDY	X-ray	2.25	A	28-334	[»]

ProteinModelPortal

Q9NZL9.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-2819994.

PTM databases

PhosphoSite

Q9NZL9.

Polymorphism databases

DMDM

74719662.

2D gel databases

REPRODUCTION-2DPAGE

IPI00002324.

Proteomic databases

PaxDb

Q9NZL9.

PRIDE

Q9NZL9.

Protocols and materials databases

DNASU

27430.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000280969; ENSP00000280969; ENSG00000038274.
ENST00000321757; ENSP00000325425; ENSG00000038274.
ENST00000518095; ENSP00000428046; ENSG00000038274.

GeneID

27430.

KEGG

hsa:27430.

UCSC

uc003lzj.3. human.
uc003lzk.3. human.
uc003lzl.1. human.

Organism-specific databases

CTD

27430.

GeneCards

GC05P162930.

HGNC

HGNC:6905. MAT2B.

HPA

HPA037721.
HPA037722.

MIM

605527. gene.

neXtProt

NX_Q9NZL9.

PharmGKB

PA30648.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG1091.

HOVERGEN

HBG105851.

InParanoid

Q9NZL9.

KO

K00789.

OMA

SPTYTKD.

PhylomeDB

Q9NZL9.

Enzyme and pathway databases

BRENDA

2.5.1.6. 2681.

Reactome

REACT_111217. Metabolism.

UniPathway

UPA00315; UER00080.

Gene expression databases

ArrayExpress

Q9NZL9.

Bgee

Q9NZL9.

Genevestigator

Q9NZL9.

Family and domain databases

Gene3D

3.40.50.720. 1 hit.

InterPro

IPR005913. dTDP_dehydrorham_reduct.
IPR016040. NAD(P)-bd_dom.
[Graphical view]

Pfam

PF04321. RmlD_sub_bind. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

MAT2B. human.

DrugBank

DB00134. L-Methionine.
DB00118. S-Adenosylmethionine.

EvolutionaryTrace

Q9NZL9.

GenomeRNAi

27430.

NextBio

50469.

SOURCE

Search...

Entry information

Entry name

MAT2B_HUMAN

Accession

Primary (citable) accession number: Q9NZL9
Secondary accession number(s): B2R5Y6 , Q1WAI7, Q27J92, Q3LIE8, Q567T7, Q6NYC7, Q9BS89, Q9H3E1, Q9UJ54

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	October 1, 2000
Last modified:	May 29, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.