Unreviewed, UniProtKB/TrEMBL Q9NZL2 (Q9NZL2_HUMAN)

Names and origin

Protein names

Submitted name:
    Aspartyl protease EMBL AAF35835.1
Submitted name:
    Beta-site APP-cleaving enzyme 2, isoform CRA_a EMBL EAX09611.1

Gene names

Name:	BACE2 EMBL AAF35835.1
ORF Names:	hCG_401240 EMBL EAX09611.1

Organism

Homo sapiens (Human) EMBL AAF35835.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the peptidase A1 family. RuleBase RU000454V1

Ontologies

Keywords
Molecular function	Aspartyl protease RuleBase RU000454V1 Hydrolase Protease
Gene Ontology (GO)
Biological process	membrane protein ectodomain proteolysis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of amyloid precursor protein biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	aspartic-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9NZL2-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 717E0920126A0142	FASTA	468	50,325
	10 20 30 40 50 60 MGALARALLL PLLAQWLLRA APELAPAPFT LPLRVAAATN RVVAPTPGPG TPAERHADGL 70 80 90 100 110 120 ALALEPALAS PAGAANFLAM VDNLQGDSGR GYYLEMLIGT PPQKLQILVD TGSSNFAVAG 130 140 150 160 170 180 TPHSYIDTYF DTERSSTYRS KGFDVTVKYT QGSWTGFVGE DLVTIPKGFN TSFLVNIATI 190 200 210 220 230 240 FESENFFLPG IKWNGILGLA YATLAKPSSS LETFFDSLVT QANIPNVFSM QMCGAGLPVA 250 260 270 280 290 300 GSGTNGGSLV LGGIEPSLYK GDIWYTPIKE EWYYQIEILK LEIGGQSLNL DCREYNADKA 310 320 330 340 350 360 IVDSGTTLLR LPQKVFDAVV EAVARASLLY IQPMMGAGLN YECYRFGISP STNALVIGAT 370 380 390 400 410 420 VMEGFYVIFD RAQKRVGFAA SPCAEIAGAA VSEISGPFST EDVASNCVPA QSLSEPILWI 430 440 450 460 VSYALMSVCG AILLVLIVLL LLPFRCQRRP RDPEVVNDES SLVRHRWK

References

[1]	"A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase." Solans A., Estivill X., de La Luna S. Cytogenet. Cell Genet. 89:177-184(2000) [PubMed: 10965118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF188276 mRNA. Translation: AAF35835.1. CH471079 Genomic DNA. Translation: EAX09611.1.
IPI	IPI00024561.
RefSeq	NP_620476.1.
UniGene	Hs.529408
3D structure databases
HSSP	HSSP built from PDB template 1FKN based on UniProtKB P56817.
SMR	Q9NZL2. Positions 78-410.
ModBase	Search...
Proteomic databases
PRIDE	Q9NZL2.
Genome annotation databases
Ensembl	ENSG00000182240. Homo sapiens. [Contig view]
GeneID	25825.
Organism-specific databases
HGNC	HGNC:934. BACE2.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9NZL2.
Enzyme and pathway databases
BRENDA	3.4.23.45. 247.
Gene expression databases
ArrayExpress	Q9NZL2.
Bgee	Q9NZL2.
Family and domain databases
InterPro	IPR009119. Pept_A1_BACE. IPR009121. Pept_A1_BACE2. IPR001461. Peptidase_A1. IPR001969. Peptidase_aspartic_AS. IPR009007. Peptidase_aspartic_catalytic. [Graphical view]
Gene3D	G3DSA:2.40.70.10. Pept_Aspartc_cat. 1 hit.
PANTHER	PTHR13683. Peptidase_A1. 1 hit.
Pfam	PF00026. Asp. 1 hit. [Graphical view]
PRINTS	PR01817. BACE2. PR01815. BACEFAMILY. PR00792. PEPSIN.
PROSITE	PS00141. ASP_PROTEASE. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	47099.

Entry information

Entry name

Q9NZL2_HUMAN

Accession

Primary (citable) accession number: Q9NZL2

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)