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Q9NZK7

- PA2GE_HUMAN

UniProt

Q9NZK7 - PA2GE_HUMAN

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Protein

Group IIE secretory phospholipase A2

Gene

PLA2G2E

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Binds 1 calcium ion per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451Calcium; via carbonyl oxygenBy similarity
Metal bindingi47 – 471Calcium; via carbonyl oxygenBy similarity
Metal bindingi49 – 491Calcium; via carbonyl oxygenBy similarity
Active sitei65 – 651PROSITE-ProRule annotation
Metal bindingi66 – 661CalciumBy similarity
Active sitei109 – 1091PROSITE-ProRule annotation

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. phospholipase A2 activity Source: ProtInc

GO - Biological processi

  1. glycerophospholipid biosynthetic process Source: Reactome
  2. inflammatory response Source: ProtInc
  3. lipid catabolic process Source: UniProtKB-KW
  4. phosphatidic acid biosynthetic process Source: Reactome
  5. phosphatidylcholine acyl-chain remodeling Source: Reactome
  6. phosphatidylethanolamine acyl-chain remodeling Source: Reactome
  7. phosphatidylglycerol acyl-chain remodeling Source: Reactome
  8. phosphatidylinositol acyl-chain remodeling Source: Reactome
  9. phosphatidylserine acyl-chain remodeling Source: Reactome
  10. phospholipid metabolic process Source: Reactome
  11. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_120722. Acyl chain remodelling of PI.
REACT_120829. Acyl chain remodelling of PC.
REACT_120906. Synthesis of PA.
REACT_121324. Acyl chain remodelling of PG.
REACT_121369. Acyl chain remodelling of PE.
REACT_121384. Acyl chain remodelling of PS.

Names & Taxonomyi

Protein namesi
Recommended name:
Group IIE secretory phospholipase A2 (EC:3.1.1.4)
Short name:
GIIE sPLA2
Short name:
sPLA2-IIE
Alternative name(s):
Phosphatidylcholine 2-acylhydrolase 2E
Gene namesi
Name:PLA2G2E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:13414. PLA2G2E.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134889019.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 142123Group IIE secretory phospholipase A2PRO_0000022757Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 135By similarity
Disulfide bondi46 ↔ 62By similarity
Disulfide bondi61 ↔ 115By similarity
Disulfide bondi67 ↔ 142By similarity
Disulfide bondi68 ↔ 108By similarity
Disulfide bondi77 ↔ 101By similarity
Disulfide bondi95 ↔ 106By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9NZK7.
PRIDEiQ9NZK7.

Expressioni

Tissue specificityi

Restricted to the brain, heart, lung, and placenta.

Gene expression databases

CleanExiHS_PLA2G2E.
GenevestigatoriQ9NZK7.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000364257.

Structurei

3D structure databases

ProteinModelPortaliQ9NZK7.
SMRiQ9NZK7. Positions 20-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG310124.
GeneTreeiENSGT00760000119160.
HOGENOMiHOG000231749.
HOVERGENiHBG008137.
InParanoidiQ9NZK7.
KOiK01047.
OMAiFGVMIER.
OrthoDBiEOG7N63PF.
PhylomeDBiQ9NZK7.
TreeFamiTF319283.

Family and domain databases

Gene3Di1.20.90.10. 1 hit.
InterProiIPR001211. PLipase_A2.
IPR013090. PLipase_A2_AS.
IPR016090. PLipase_A2_dom.
[Graphical view]
PANTHERiPTHR11716. PTHR11716. 1 hit.
PfamiPF00068. Phospholip_A2_1. 1 hit.
[Graphical view]
PRINTSiPR00389. PHPHLIPASEA2.
SMARTiSM00085. PA2c. 1 hit.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00118. PA2_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NZK7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSPHVLVFL CLLVALVTGN LVQFGVMIEK MTGKSALQYN DYGCYCGIGG
60 70 80 90 100
SHWPVDQTDW CCHAHDCCYG RLEKLGCEPK LEKYLFSVSE RGIFCAGRTT
110 120 130 140
CQRLTCECDK RAALCFRRNL GTYNRKYAHY PNKLCTGPTP PC
Length:142
Mass (Da):15,989
Last modified:October 1, 2000 - v1
Checksum:i3C360EA710E141FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF189279 mRNA. Translation: AAF36541.1.
AL358253 Genomic DNA. Translation: CAH74016.1.
CCDSiCCDS200.1.
RefSeqiNP_055404.1. NM_014589.2.
UniGeneiHs.272372.

Genome annotation databases

EnsembliENST00000375116; ENSP00000364257; ENSG00000188784.
GeneIDi30814.
KEGGihsa:30814.
UCSCiuc001bct.1. human.

Polymorphism databases

DMDMi20139240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF189279 mRNA. Translation: AAF36541.1 .
AL358253 Genomic DNA. Translation: CAH74016.1 .
CCDSi CCDS200.1.
RefSeqi NP_055404.1. NM_014589.2.
UniGenei Hs.272372.

3D structure databases

ProteinModelPortali Q9NZK7.
SMRi Q9NZK7. Positions 20-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000364257.

Chemistry

BindingDBi Q9NZK7.
ChEMBLi CHEMBL2154.
DrugBanki DB00233. Aminosalicylic Acid.

Polymorphism databases

DMDMi 20139240.

Proteomic databases

PaxDbi Q9NZK7.
PRIDEi Q9NZK7.

Protocols and materials databases

DNASUi 30814.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375116 ; ENSP00000364257 ; ENSG00000188784 .
GeneIDi 30814.
KEGGi hsa:30814.
UCSCi uc001bct.1. human.

Organism-specific databases

CTDi 30814.
GeneCardsi GC01M020247.
HGNCi HGNC:13414. PLA2G2E.
neXtProti NX_Q9NZK7.
PharmGKBi PA134889019.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG310124.
GeneTreei ENSGT00760000119160.
HOGENOMi HOG000231749.
HOVERGENi HBG008137.
InParanoidi Q9NZK7.
KOi K01047.
OMAi FGVMIER.
OrthoDBi EOG7N63PF.
PhylomeDBi Q9NZK7.
TreeFami TF319283.

Enzyme and pathway databases

Reactomei REACT_120722. Acyl chain remodelling of PI.
REACT_120829. Acyl chain remodelling of PC.
REACT_120906. Synthesis of PA.
REACT_121324. Acyl chain remodelling of PG.
REACT_121369. Acyl chain remodelling of PE.
REACT_121384. Acyl chain remodelling of PS.

Miscellaneous databases

GenomeRNAii 30814.
NextBioi 52870.
PROi Q9NZK7.

Gene expression databases

CleanExi HS_PLA2G2E.
Genevestigatori Q9NZK7.

Family and domain databases

Gene3Di 1.20.90.10. 1 hit.
InterProi IPR001211. PLipase_A2.
IPR013090. PLipase_A2_AS.
IPR016090. PLipase_A2_dom.
[Graphical view ]
PANTHERi PTHR11716. PTHR11716. 1 hit.
Pfami PF00068. Phospholip_A2_1. 1 hit.
[Graphical view ]
PRINTSi PR00389. PHPHLIPASEA2.
SMARTi SM00085. PA2c. 1 hit.
[Graphical view ]
SUPFAMi SSF48619. SSF48619. 1 hit.
PROSITEi PS00118. PA2_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s."
    Suzuki N., Ishizaki J., Yokota Y., Higashino K., Ono T., Ikeda M., Fujii N., Kawamoto K., Hanasaki K.
    J. Biol. Chem. 275:5785-5793(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPA2GE_HUMAN
AccessioniPrimary (citable) accession number: Q9NZK7
Secondary accession number(s): Q5VXJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3