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Protein

Group IIE secretory phospholipase A2

Gene

PLA2G2E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+Note: Binds 1 Ca2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Calcium; via carbonyl oxygenBy similarity1
Metal bindingi47Calcium; via carbonyl oxygenBy similarity1
Metal bindingi49Calcium; via carbonyl oxygenBy similarity1
Active sitei65PROSITE-ProRule annotation1
Metal bindingi66CalciumBy similarity1
Active sitei109PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-1482788. Acyl chain remodelling of PC.
R-HSA-1482801. Acyl chain remodelling of PS.
R-HSA-1482839. Acyl chain remodelling of PE.
R-HSA-1482922. Acyl chain remodelling of PI.
R-HSA-1482925. Acyl chain remodelling of PG.
R-HSA-1483166. Synthesis of PA.

Chemistry databases

SwissLipidsiSLP:000001082.

Names & Taxonomyi

Protein namesi
Recommended name:
Group IIE secretory phospholipase A2 (EC:3.1.1.4)
Short name:
GIIE sPLA2
Short name:
sPLA2-IIE
Alternative name(s):
Phosphatidylcholine 2-acylhydrolase 2E
Gene namesi
Name:PLA2G2E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:13414. PLA2G2E.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi30814.
OpenTargetsiENSG00000188784.
PharmGKBiPA134889019.

Chemistry databases

ChEMBLiCHEMBL2154.
DrugBankiDB07958. (2-CARBAMOYLMETHYL-5-PROPYL-OCTAHYDRO-INDOL-7-YL)ACETIC ACID.
DB07500. (2E)-1-[2-hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one.
DB07950. 1H-INDOL-3-YLACETIC ACID.
DB06987. 2-(4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ETHANAMIDE.
DB08447. 3-{3-[(DIMETHYLAMINO)METHYL]-1H-INDOL-7-YL}PROPAN-1-OL.
DB00233. Aminosalicylic Acid.
DB04077. Glycerol.
DB02758. Indolylpropionic Acid.
DB04725. Licofelone.
DB02448. N-Tridecanoic Acid.
DB04743. Nimesulide.
DB03585. Oxyphenbutazone.
DB02795. P-Anisic Acid.
GuidetoPHARMACOLOGYi1419.

Polymorphism and mutation databases

DMDMi20139240.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002275720 – 142Group IIE secretory phospholipase A2Add BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 135By similarity
Disulfide bondi46 ↔ 62By similarity
Disulfide bondi61 ↔ 115By similarity
Disulfide bondi67 ↔ 142By similarity
Disulfide bondi68 ↔ 108By similarity
Disulfide bondi77 ↔ 101By similarity
Disulfide bondi95 ↔ 106By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9NZK7.
PeptideAtlasiQ9NZK7.
PRIDEiQ9NZK7.

PTM databases

iPTMnetiQ9NZK7.
PhosphoSitePlusiQ9NZK7.

Expressioni

Tissue specificityi

Restricted to the brain, heart, lung, and placenta.

Gene expression databases

BgeeiENSG00000188784.
CleanExiHS_PLA2G2E.
GenevisibleiQ9NZK7. HS.

Organism-specific databases

HPAiHPA064085.

Interactioni

Protein-protein interaction databases

IntActiQ9NZK7. 1 interactor.
STRINGi9606.ENSP00000364257.

Chemistry databases

BindingDBiQ9NZK7.

Structurei

3D structure databases

ProteinModelPortaliQ9NZK7.
SMRiQ9NZK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4087. Eukaryota.
ENOG411283D. LUCA.
GeneTreeiENSGT00760000119160.
HOGENOMiHOG000231749.
HOVERGENiHBG008137.
InParanoidiQ9NZK7.
KOiK01047.
OMAiLQYNDYG.
OrthoDBiEOG091G0UZ3.
PhylomeDBiQ9NZK7.
TreeFamiTF319283.

Family and domain databases

CDDicd00125. PLA2c. 1 hit.
Gene3Di1.20.90.10. 1 hit.
InterProiView protein in InterPro
IPR001211. PLipase_A2.
IPR016090. PLipase_A2_dom.
IPR033113. PLipase_A2_His_AS.
PANTHERiPTHR11716. PTHR11716. 1 hit.
PfamiView protein in Pfam
PF00068. Phospholip_A2_1. 1 hit.
PRINTSiPR00389. PHPHLIPASEA2.
SMARTiView protein in SMART
SM00085. PA2c. 1 hit.
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiView protein in PROSITE
PS00118. PA2_HIS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NZK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSPHVLVFL CLLVALVTGN LVQFGVMIEK MTGKSALQYN DYGCYCGIGG
60 70 80 90 100
SHWPVDQTDW CCHAHDCCYG RLEKLGCEPK LEKYLFSVSE RGIFCAGRTT
110 120 130 140
CQRLTCECDK RAALCFRRNL GTYNRKYAHY PNKLCTGPTP PC
Length:142
Mass (Da):15,989
Last modified:October 1, 2000 - v1
Checksum:i3C360EA710E141FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189279 mRNA. Translation: AAF36541.1.
AL358253 Genomic DNA. No translation available.
CCDSiCCDS200.1.
RefSeqiNP_055404.1. NM_014589.2.
UniGeneiHs.272372.

Genome annotation databases

EnsembliENST00000375116; ENSP00000364257; ENSG00000188784.
GeneIDi30814.
KEGGihsa:30814.
UCSCiuc001bct.2. human.

Similar proteinsi

Entry informationi

Entry nameiPA2GE_HUMAN
AccessioniPrimary (citable) accession number: Q9NZK7
Secondary accession number(s): Q5VXJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families