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Q9NZK7

- PA2GE_HUMAN

UniProt

Q9NZK7 - PA2GE_HUMAN

Protein

Group IIE secretory phospholipase A2

Gene

PLA2G2E

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.

    Catalytic activityi

    Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion per subunit.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi45 – 451Calcium; via carbonyl oxygenBy similarity
    Metal bindingi47 – 471Calcium; via carbonyl oxygenBy similarity
    Metal bindingi49 – 491Calcium; via carbonyl oxygenBy similarity
    Active sitei65 – 651PROSITE-ProRule annotation
    Metal bindingi66 – 661CalciumBy similarity
    Active sitei109 – 1091PROSITE-ProRule annotation

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. phospholipase A2 activity Source: ProtInc

    GO - Biological processi

    1. glycerophospholipid biosynthetic process Source: Reactome
    2. inflammatory response Source: ProtInc
    3. lipid catabolic process Source: UniProtKB-KW
    4. phosphatidic acid biosynthetic process Source: Reactome
    5. phosphatidylcholine acyl-chain remodeling Source: Reactome
    6. phosphatidylethanolamine acyl-chain remodeling Source: Reactome
    7. phosphatidylglycerol acyl-chain remodeling Source: Reactome
    8. phosphatidylinositol acyl-chain remodeling Source: Reactome
    9. phosphatidylserine acyl-chain remodeling Source: Reactome
    10. phospholipid metabolic process Source: Reactome
    11. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_120722. Acyl chain remodelling of PI.
    REACT_120829. Acyl chain remodelling of PC.
    REACT_120906. Synthesis of PA.
    REACT_121324. Acyl chain remodelling of PG.
    REACT_121369. Acyl chain remodelling of PE.
    REACT_121384. Acyl chain remodelling of PS.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Group IIE secretory phospholipase A2 (EC:3.1.1.4)
    Short name:
    GIIE sPLA2
    Short name:
    sPLA2-IIE
    Alternative name(s):
    Phosphatidylcholine 2-acylhydrolase 2E
    Gene namesi
    Name:PLA2G2E
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:13414. PLA2G2E.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134889019.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 142123Group IIE secretory phospholipase A2PRO_0000022757Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi44 ↔ 135By similarity
    Disulfide bondi46 ↔ 62By similarity
    Disulfide bondi61 ↔ 115By similarity
    Disulfide bondi67 ↔ 142By similarity
    Disulfide bondi68 ↔ 108By similarity
    Disulfide bondi77 ↔ 101By similarity
    Disulfide bondi95 ↔ 106By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ9NZK7.
    PRIDEiQ9NZK7.

    Expressioni

    Tissue specificityi

    Restricted to the brain, heart, lung, and placenta.

    Gene expression databases

    CleanExiHS_PLA2G2E.
    GenevestigatoriQ9NZK7.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000364257.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NZK7.
    SMRiQ9NZK7. Positions 20-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phospholipase A2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG310124.
    HOGENOMiHOG000231749.
    HOVERGENiHBG008137.
    InParanoidiQ9NZK7.
    KOiK01047.
    OMAiFGVMIER.
    OrthoDBiEOG7N63PF.
    PhylomeDBiQ9NZK7.
    TreeFamiTF319283.

    Family and domain databases

    Gene3Di1.20.90.10. 1 hit.
    InterProiIPR001211. PLipase_A2.
    IPR013090. PLipase_A2_AS.
    IPR016090. PLipase_A2_dom.
    [Graphical view]
    PANTHERiPTHR11716. PTHR11716. 1 hit.
    PfamiPF00068. Phospholip_A2_1. 1 hit.
    [Graphical view]
    PRINTSiPR00389. PHPHLIPASEA2.
    SMARTiSM00085. PA2c. 1 hit.
    [Graphical view]
    SUPFAMiSSF48619. SSF48619. 1 hit.
    PROSITEiPS00118. PA2_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NZK7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSPHVLVFL CLLVALVTGN LVQFGVMIEK MTGKSALQYN DYGCYCGIGG    50
    SHWPVDQTDW CCHAHDCCYG RLEKLGCEPK LEKYLFSVSE RGIFCAGRTT 100
    CQRLTCECDK RAALCFRRNL GTYNRKYAHY PNKLCTGPTP PC 142
    Length:142
    Mass (Da):15,989
    Last modified:October 1, 2000 - v1
    Checksum:i3C360EA710E141FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF189279 mRNA. Translation: AAF36541.1.
    AL358253 Genomic DNA. Translation: CAH74016.1.
    CCDSiCCDS200.1.
    RefSeqiNP_055404.1. NM_014589.2.
    UniGeneiHs.272372.

    Genome annotation databases

    EnsembliENST00000375116; ENSP00000364257; ENSG00000188784.
    GeneIDi30814.
    KEGGihsa:30814.
    UCSCiuc001bct.1. human.

    Polymorphism databases

    DMDMi20139240.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF189279 mRNA. Translation: AAF36541.1 .
    AL358253 Genomic DNA. Translation: CAH74016.1 .
    CCDSi CCDS200.1.
    RefSeqi NP_055404.1. NM_014589.2.
    UniGenei Hs.272372.

    3D structure databases

    ProteinModelPortali Q9NZK7.
    SMRi Q9NZK7. Positions 20-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000364257.

    Chemistry

    BindingDBi Q9NZK7.
    ChEMBLi CHEMBL2154.

    Polymorphism databases

    DMDMi 20139240.

    Proteomic databases

    PaxDbi Q9NZK7.
    PRIDEi Q9NZK7.

    Protocols and materials databases

    DNASUi 30814.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375116 ; ENSP00000364257 ; ENSG00000188784 .
    GeneIDi 30814.
    KEGGi hsa:30814.
    UCSCi uc001bct.1. human.

    Organism-specific databases

    CTDi 30814.
    GeneCardsi GC01M020247.
    HGNCi HGNC:13414. PLA2G2E.
    neXtProti NX_Q9NZK7.
    PharmGKBi PA134889019.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG310124.
    HOGENOMi HOG000231749.
    HOVERGENi HBG008137.
    InParanoidi Q9NZK7.
    KOi K01047.
    OMAi FGVMIER.
    OrthoDBi EOG7N63PF.
    PhylomeDBi Q9NZK7.
    TreeFami TF319283.

    Enzyme and pathway databases

    Reactomei REACT_120722. Acyl chain remodelling of PI.
    REACT_120829. Acyl chain remodelling of PC.
    REACT_120906. Synthesis of PA.
    REACT_121324. Acyl chain remodelling of PG.
    REACT_121369. Acyl chain remodelling of PE.
    REACT_121384. Acyl chain remodelling of PS.

    Miscellaneous databases

    GenomeRNAii 30814.
    NextBioi 52870.
    PROi Q9NZK7.

    Gene expression databases

    CleanExi HS_PLA2G2E.
    Genevestigatori Q9NZK7.

    Family and domain databases

    Gene3Di 1.20.90.10. 1 hit.
    InterProi IPR001211. PLipase_A2.
    IPR013090. PLipase_A2_AS.
    IPR016090. PLipase_A2_dom.
    [Graphical view ]
    PANTHERi PTHR11716. PTHR11716. 1 hit.
    Pfami PF00068. Phospholip_A2_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00389. PHPHLIPASEA2.
    SMARTi SM00085. PA2c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48619. SSF48619. 1 hit.
    PROSITEi PS00118. PA2_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s."
      Suzuki N., Ishizaki J., Yokota Y., Higashino K., Ono T., Ikeda M., Fujii N., Kawamoto K., Hanasaki K.
      J. Biol. Chem. 275:5785-5793(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiPA2GE_HUMAN
    AccessioniPrimary (citable) accession number: Q9NZK7
    Secondary accession number(s): Q5VXJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3