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Protein

Group IIE secretory phospholipase A2

Gene

PLA2G2E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+Note: Binds 1 Ca2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Calcium; via carbonyl oxygenBy similarity1
Metal bindingi47Calcium; via carbonyl oxygenBy similarity1
Metal bindingi49Calcium; via carbonyl oxygenBy similarity1
Active sitei65PROSITE-ProRule annotation1
Metal bindingi66CalciumBy similarity1
Active sitei109PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482922 Acyl chain remodelling of PI
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA

Chemistry databases

SwissLipidsiSLP:000001082

Names & Taxonomyi

Protein namesi
Recommended name:
Group IIE secretory phospholipase A2 (EC:3.1.1.4)
Short name:
GIIE sPLA2
Short name:
sPLA2-IIE
Alternative name(s):
Phosphatidylcholine 2-acylhydrolase 2E
Gene namesi
Name:PLA2G2E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188784.4
HGNCiHGNC:13414 PLA2G2E
neXtProtiNX_Q9NZK7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi30814
OpenTargetsiENSG00000188784
PharmGKBiPA134889019

Chemistry databases

ChEMBLiCHEMBL2154
DrugBankiDB07958 (2-CARBAMOYLMETHYL-5-PROPYL-OCTAHYDRO-INDOL-7-YL)ACETIC ACID
DB07500 (2E)-1-[2-hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
DB07950 1H-INDOL-3-YLACETIC ACID
DB06987 2-(4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ETHANAMIDE
DB08447 3-{3-[(DIMETHYLAMINO)METHYL]-1H-INDOL-7-YL}PROPAN-1-OL
DB00233 Aminosalicylic Acid
DB04077 Glycerol
DB02758 Indolylpropionic Acid
DB04725 Licofelone
DB02448 N-Tridecanoic Acid
DB04743 Nimesulide
DB03585 Oxyphenbutazone
DB02795 P-Anisic Acid
GuidetoPHARMACOLOGYi1419

Polymorphism and mutation databases

DMDMi20139240

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002275720 – 142Group IIE secretory phospholipase A2Add BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 135By similarity
Disulfide bondi46 ↔ 62By similarity
Disulfide bondi61 ↔ 115By similarity
Disulfide bondi67 ↔ 142By similarity
Disulfide bondi68 ↔ 108By similarity
Disulfide bondi77 ↔ 101By similarity
Disulfide bondi95 ↔ 106By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9NZK7
PeptideAtlasiQ9NZK7
PRIDEiQ9NZK7

PTM databases

iPTMnetiQ9NZK7
PhosphoSitePlusiQ9NZK7

Expressioni

Tissue specificityi

Restricted to the brain, heart, lung, and placenta.

Gene expression databases

BgeeiENSG00000188784
CleanExiHS_PLA2G2E
GenevisibleiQ9NZK7 HS

Organism-specific databases

HPAiHPA064085

Interactioni

Protein-protein interaction databases

IntActiQ9NZK7, 1 interactor
STRINGi9606.ENSP00000364257

Chemistry databases

BindingDBiQ9NZK7

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi23 – 32Combined sources10
Helixi36 – 38Combined sources3
Turni39 – 41Combined sources3
Turni43 – 45Combined sources3
Beta strandi46 – 48Combined sources3
Helixi57 – 74Combined sources18
Turni79 – 81Combined sources3
Beta strandi85 – 88Combined sources4
Beta strandi93 – 96Combined sources4
Helixi100 – 118Combined sources19
Helixi120 – 122Combined sources3
Helixi125 – 127Combined sources3
Helixi132 – 134Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WZMX-ray2.00A22-142[»]
5WZOX-ray1.90A20-142[»]
5WZSX-ray2.30A20-142[»]
5WZTX-ray2.40A20-142[»]
5WZUX-ray2.20A20-142[»]
5WZVX-ray2.20A20-142[»]
5WZWX-ray1.95A20-142[»]
ProteinModelPortaliQ9NZK7
SMRiQ9NZK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4087 Eukaryota
ENOG411283D LUCA
GeneTreeiENSGT00760000119160
HOGENOMiHOG000231749
HOVERGENiHBG008137
InParanoidiQ9NZK7
KOiK01047
OMAiLQYNDYG
OrthoDBiEOG091G0UZ3
PhylomeDBiQ9NZK7
TreeFamiTF319283

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00118 PA2_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NZK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSPHVLVFL CLLVALVTGN LVQFGVMIEK MTGKSALQYN DYGCYCGIGG
60 70 80 90 100
SHWPVDQTDW CCHAHDCCYG RLEKLGCEPK LEKYLFSVSE RGIFCAGRTT
110 120 130 140
CQRLTCECDK RAALCFRRNL GTYNRKYAHY PNKLCTGPTP PC
Length:142
Mass (Da):15,989
Last modified:October 1, 2000 - v1
Checksum:i3C360EA710E141FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189279 mRNA Translation: AAF36541.1
AL358253 Genomic DNA No translation available.
CCDSiCCDS200.1
RefSeqiNP_055404.1, NM_014589.2
UniGeneiHs.272372

Genome annotation databases

EnsembliENST00000375116; ENSP00000364257; ENSG00000188784
GeneIDi30814
KEGGihsa:30814
UCSCiuc001bct.2 human

Similar proteinsi

Entry informationi

Entry nameiPA2GE_HUMAN
AccessioniPrimary (citable) accession number: Q9NZK7
Secondary accession number(s): Q5VXJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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