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Protein

Mitochondrial carrier homolog 1

Gene

MTCH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potential mitochondrial transporter. May play a role in apoptosis.1 Publication

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • apoptotic process Source: UniProtKB-KW
  • neuronal ion channel clustering Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
  • regulation of signal transduction Source: UniProtKB
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137409-MONOMER.

Protein family/group databases

TCDBi2.A.29.25.1. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carrier homolog 1
Alternative name(s):
Presenilin-associated protein
Gene namesi
Name:MTCH1
Synonyms:PSAP
ORF Names:CGI-64, UNQ1871/PRO4314
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:17586. MTCH1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: UniProtKB
  • membrane Source: GO_Central
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23787.
OpenTargetsiENSG00000137409.
PharmGKBiPA134958992.

Polymorphism and mutation databases

DMDMi74753085.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002323851 – 389Mitochondrial carrier homolog 1Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ9NZJ7.
MaxQBiQ9NZJ7.
PaxDbiQ9NZJ7.
PeptideAtlasiQ9NZJ7.
PRIDEiQ9NZJ7.

PTM databases

iPTMnetiQ9NZJ7.
PhosphoSitePlusiQ9NZJ7.
SwissPalmiQ9NZJ7.

Expressioni

Tissue specificityi

Widely expressed with a predominant expression in brain.1 Publication

Gene expression databases

BgeeiENSG00000137409.
CleanExiHS_MTCH1.
HS_PSAP.
ExpressionAtlasiQ9NZJ7. baseline and differential.
GenevisibleiQ9NZJ7. HS.

Organism-specific databases

HPAiHPA015971.

Interactioni

Subunit structurei

Interacts with PSEN1.2 Publications

Protein-protein interaction databases

BioGridi117286. 58 interactors.
IntActiQ9NZJ7. 10 interactors.
STRINGi9606.ENSP00000362718.

Structurei

3D structure databases

ProteinModelPortaliQ9NZJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati81 – 176Solcar 1Add BLAST96
Repeati192 – 280Solcar 2Add BLAST89

Sequence similaritiesi

Contains 2 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2745. Eukaryota.
ENOG410XSXF. LUCA.
GeneTreeiENSGT00390000000020.
HOVERGENiHBG058632.
InParanoidiQ9NZJ7.
KOiK17885.
OMAiVGREVKY.
PhylomeDBiQ9NZJ7.
TreeFamiTF313721.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NZJ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGASDPEVAP WARGGAAGMA GAGAGAGARG GAAAGVEARA RDPPPAHRAH
60 70 80 90 100
PRHPRPAAQP SARRMDGGSG GLGSGDNAPT TEALFVALGA GVTALSHPLL
110 120 130 140 150
YVKLLIQVGH EPMPPTLGTN VLGRKVLYLP SFFTYAKYIV QVDGKIGLFR
160 170 180 190 200
GLSPRLMSNA LSTVTRGSMK KVFPPDEIEQ VSNKDDMKTS LKKVVKETSY
210 220 230 240 250
EMMMQCVSRM LAHPLHVISM RCMVQFVGRE AKYSGVLSSI GKIFKEEGLL
260 270 280 290 300
GFFVGLIPHL LGDVVFLWGC NLLAHFINAY LVDDSVSDTP GGLGNDQNPG
310 320 330 340 350
SQFSQALAIR SYTKFVMGIA VSMLTYPFLL VGDLMAVNNC GLQAGLPPYS
360 370 380
PVFKSWIHCW KYLSVQGQLF RGSSLLFRRV SSGSCFALE
Length:389
Mass (Da):41,544
Last modified:October 1, 2000 - v1
Checksum:i13C37758C4D22F4F
GO
Isoform 2 (identifier: Q9NZJ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-302: Missing.

Show »
Length:372
Mass (Da):39,920
Checksum:iC579F8F4CD688A2F
GO
Isoform 3 (identifier: Q9NZJ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-201: Missing.
     286-302: Missing.

Note: No experimental confirmation available.
Show »
Length:171
Mass (Da):19,058
Checksum:iFAD41D7FE484D975
GO

Sequence cautioni

The sequence AAF07936 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0178811 – 201Missing in isoform 3. 1 PublicationAdd BLAST201
Alternative sequenceiVSP_017882286 – 302Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176006 mRNA. Translation: AAD52644.3.
AF192559 mRNA. Translation: AAF12793.3.
AY358519 mRNA. Translation: AAQ88883.1.
AK315067 mRNA. Translation: BAG37540.1.
AL122034 Genomic DNA. Translation: CAI23305.1.
AL122034 Genomic DNA. Translation: CAI23306.1.
CH471081 Genomic DNA. Translation: EAX03927.1.
CH471081 Genomic DNA. Translation: EAX03928.1.
BC000702 mRNA. Translation: AAH00702.2.
BC006507 mRNA. Translation: AAH06507.1.
BC009962 mRNA. Translation: AAH09962.2.
BC110914 mRNA. Translation: AAI10915.1.
BC153873 mRNA. Translation: AAI53874.1.
AF189289 mRNA. Translation: AAF07936.1. Different initiation.
CCDSiCCDS4828.1. [Q9NZJ7-2]
CCDS64411.1. [Q9NZJ7-1]
RefSeqiNP_001258570.1. NM_001271641.1. [Q9NZJ7-1]
NP_055156.1. NM_014341.2. [Q9NZJ7-2]
UniGeneiHs.485262.
Hs.689540.

Genome annotation databases

EnsembliENST00000373616; ENSP00000362718; ENSG00000137409. [Q9NZJ7-2]
ENST00000373627; ENSP00000362730; ENSG00000137409. [Q9NZJ7-1]
GeneIDi23787.
KEGGihsa:23787.
UCSCiuc003onc.3. human. [Q9NZJ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176006 mRNA. Translation: AAD52644.3.
AF192559 mRNA. Translation: AAF12793.3.
AY358519 mRNA. Translation: AAQ88883.1.
AK315067 mRNA. Translation: BAG37540.1.
AL122034 Genomic DNA. Translation: CAI23305.1.
AL122034 Genomic DNA. Translation: CAI23306.1.
CH471081 Genomic DNA. Translation: EAX03927.1.
CH471081 Genomic DNA. Translation: EAX03928.1.
BC000702 mRNA. Translation: AAH00702.2.
BC006507 mRNA. Translation: AAH06507.1.
BC009962 mRNA. Translation: AAH09962.2.
BC110914 mRNA. Translation: AAI10915.1.
BC153873 mRNA. Translation: AAI53874.1.
AF189289 mRNA. Translation: AAF07936.1. Different initiation.
CCDSiCCDS4828.1. [Q9NZJ7-2]
CCDS64411.1. [Q9NZJ7-1]
RefSeqiNP_001258570.1. NM_001271641.1. [Q9NZJ7-1]
NP_055156.1. NM_014341.2. [Q9NZJ7-2]
UniGeneiHs.485262.
Hs.689540.

3D structure databases

ProteinModelPortaliQ9NZJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117286. 58 interactors.
IntActiQ9NZJ7. 10 interactors.
STRINGi9606.ENSP00000362718.

Protein family/group databases

TCDBi2.A.29.25.1. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiQ9NZJ7.
PhosphoSitePlusiQ9NZJ7.
SwissPalmiQ9NZJ7.

Polymorphism and mutation databases

DMDMi74753085.

Proteomic databases

EPDiQ9NZJ7.
MaxQBiQ9NZJ7.
PaxDbiQ9NZJ7.
PeptideAtlasiQ9NZJ7.
PRIDEiQ9NZJ7.

Protocols and materials databases

DNASUi23787.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373616; ENSP00000362718; ENSG00000137409. [Q9NZJ7-2]
ENST00000373627; ENSP00000362730; ENSG00000137409. [Q9NZJ7-1]
GeneIDi23787.
KEGGihsa:23787.
UCSCiuc003onc.3. human. [Q9NZJ7-1]

Organism-specific databases

CTDi23787.
DisGeNETi23787.
GeneCardsiMTCH1.
HGNCiHGNC:17586. MTCH1.
HPAiHPA015971.
MIMi610449. gene.
neXtProtiNX_Q9NZJ7.
OpenTargetsiENSG00000137409.
PharmGKBiPA134958992.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2745. Eukaryota.
ENOG410XSXF. LUCA.
GeneTreeiENSGT00390000000020.
HOVERGENiHBG058632.
InParanoidiQ9NZJ7.
KOiK17885.
OMAiVGREVKY.
PhylomeDBiQ9NZJ7.
TreeFamiTF313721.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137409-MONOMER.

Miscellaneous databases

ChiTaRSiMTCH1. human.
GeneWikiiMTCH1.
GenomeRNAii23787.
PROiQ9NZJ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137409.
CleanExiHS_MTCH1.
HS_PSAP.
ExpressionAtlasiQ9NZJ7. baseline and differential.
GenevisibleiQ9NZJ7. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTCH1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZJ7
Secondary accession number(s): A8KAX5
, B2RCE3, Q6PK60, Q6UX45, Q7L465, Q9BW23, Q9NZR6, Q9UJZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.