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Q9NZJ7

- MTCH1_HUMAN

UniProt

Q9NZJ7 - MTCH1_HUMAN

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Protein

Mitochondrial carrier homolog 1

Gene

MTCH1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Potential mitochondrial transporter. May play a role in apoptosis.1 Publication

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  2. neuronal ion channel clustering Source: UniProtKB
  3. positive regulation of apoptotic process Source: UniProtKB
  4. regulation of signal transduction Source: UniProtKB
  5. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Transport

Protein family/group databases

TCDBi2.A.29.25.1. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carrier homolog 1
Alternative name(s):
Presenilin-associated protein
Gene namesi
Name:MTCH1
Synonyms:PSAP
ORF Names:CGI-64, UNQ1871/PRO4314
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:17586. MTCH1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intracellular Source: UniProtKB
  3. mitochondrial inner membrane Source: UniProtKB-KW
  4. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134958992.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Mitochondrial carrier homolog 1PRO_0000232385Add
BLAST

Proteomic databases

MaxQBiQ9NZJ7.
PaxDbiQ9NZJ7.
PRIDEiQ9NZJ7.

PTM databases

PhosphoSiteiQ9NZJ7.

Expressioni

Tissue specificityi

Widely expressed with a predominant expression in brain.1 Publication

Gene expression databases

BgeeiQ9NZJ7.
CleanExiHS_MTCH1.
HS_PSAP.
ExpressionAtlasiQ9NZJ7. baseline and differential.
GenevestigatoriQ9NZJ7.

Organism-specific databases

HPAiHPA015971.

Interactioni

Subunit structurei

Interacts with PSEN1.2 Publications

Protein-protein interaction databases

BioGridi117286. 10 interactions.
IntActiQ9NZJ7. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9NZJ7.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei248 – 26821HelicalSequence AnalysisAdd
BLAST
Transmembranei315 – 33521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati81 – 17696Solcar 1Add
BLAST
Repeati192 – 28089Solcar 2Add
BLAST

Sequence similaritiesi

Contains 2 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311439.
GeneTreeiENSGT00390000000020.
HOVERGENiHBG058632.
InParanoidiQ9NZJ7.
KOiK17885.
OMAiFTYARHI.
OrthoDBiEOG7966H6.
PhylomeDBiQ9NZJ7.
TreeFamiTF313721.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NZJ7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGASDPEVAP WARGGAAGMA GAGAGAGARG GAAAGVEARA RDPPPAHRAH
60 70 80 90 100
PRHPRPAAQP SARRMDGGSG GLGSGDNAPT TEALFVALGA GVTALSHPLL
110 120 130 140 150
YVKLLIQVGH EPMPPTLGTN VLGRKVLYLP SFFTYAKYIV QVDGKIGLFR
160 170 180 190 200
GLSPRLMSNA LSTVTRGSMK KVFPPDEIEQ VSNKDDMKTS LKKVVKETSY
210 220 230 240 250
EMMMQCVSRM LAHPLHVISM RCMVQFVGRE AKYSGVLSSI GKIFKEEGLL
260 270 280 290 300
GFFVGLIPHL LGDVVFLWGC NLLAHFINAY LVDDSVSDTP GGLGNDQNPG
310 320 330 340 350
SQFSQALAIR SYTKFVMGIA VSMLTYPFLL VGDLMAVNNC GLQAGLPPYS
360 370 380
PVFKSWIHCW KYLSVQGQLF RGSSLLFRRV SSGSCFALE
Length:389
Mass (Da):41,544
Last modified:October 1, 2000 - v1
Checksum:i13C37758C4D22F4F
GO
Isoform 2 (identifier: Q9NZJ7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-302: Missing.

Show »
Length:372
Mass (Da):39,920
Checksum:iC579F8F4CD688A2F
GO
Isoform 3 (identifier: Q9NZJ7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-201: Missing.
     286-302: Missing.

Note: No experimental confirmation available.

Show »
Length:171
Mass (Da):19,058
Checksum:iFAD41D7FE484D975
GO

Sequence cautioni

The sequence AAF07936.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 201201Missing in isoform 3. 1 PublicationVSP_017881Add
BLAST
Alternative sequencei286 – 30217Missing in isoform 2 and isoform 3. 4 PublicationsVSP_017882Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF176006 mRNA. Translation: AAD52644.3.
AF192559 mRNA. Translation: AAF12793.3.
AY358519 mRNA. Translation: AAQ88883.1.
AK315067 mRNA. Translation: BAG37540.1.
AL122034 Genomic DNA. Translation: CAI23305.1.
AL122034 Genomic DNA. Translation: CAI23306.1.
CH471081 Genomic DNA. Translation: EAX03927.1.
CH471081 Genomic DNA. Translation: EAX03928.1.
BC000702 mRNA. Translation: AAH00702.2.
BC006507 mRNA. Translation: AAH06507.1.
BC009962 mRNA. Translation: AAH09962.2.
BC110914 mRNA. Translation: AAI10915.1.
BC153873 mRNA. Translation: AAI53874.1.
AF189289 mRNA. Translation: AAF07936.1. Different initiation.
CCDSiCCDS4828.1. [Q9NZJ7-2]
CCDS64411.1. [Q9NZJ7-1]
RefSeqiNP_001258570.1. NM_001271641.1. [Q9NZJ7-1]
NP_055156.1. NM_014341.2. [Q9NZJ7-2]
UniGeneiHs.485262.

Genome annotation databases

EnsembliENST00000373616; ENSP00000362718; ENSG00000137409. [Q9NZJ7-2]
ENST00000373627; ENSP00000362730; ENSG00000137409. [Q9NZJ7-1]
GeneIDi23787.
KEGGihsa:23787.
UCSCiuc003onc.2. human. [Q9NZJ7-2]
uc003ond.2. human. [Q9NZJ7-1]

Polymorphism databases

DMDMi74753085.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF176006 mRNA. Translation: AAD52644.3 .
AF192559 mRNA. Translation: AAF12793.3 .
AY358519 mRNA. Translation: AAQ88883.1 .
AK315067 mRNA. Translation: BAG37540.1 .
AL122034 Genomic DNA. Translation: CAI23305.1 .
AL122034 Genomic DNA. Translation: CAI23306.1 .
CH471081 Genomic DNA. Translation: EAX03927.1 .
CH471081 Genomic DNA. Translation: EAX03928.1 .
BC000702 mRNA. Translation: AAH00702.2 .
BC006507 mRNA. Translation: AAH06507.1 .
BC009962 mRNA. Translation: AAH09962.2 .
BC110914 mRNA. Translation: AAI10915.1 .
BC153873 mRNA. Translation: AAI53874.1 .
AF189289 mRNA. Translation: AAF07936.1 . Different initiation.
CCDSi CCDS4828.1. [Q9NZJ7-2 ]
CCDS64411.1. [Q9NZJ7-1 ]
RefSeqi NP_001258570.1. NM_001271641.1. [Q9NZJ7-1 ]
NP_055156.1. NM_014341.2. [Q9NZJ7-2 ]
UniGenei Hs.485262.

3D structure databases

ProteinModelPortali Q9NZJ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117286. 10 interactions.
IntActi Q9NZJ7. 3 interactions.

Protein family/group databases

TCDBi 2.A.29.25.1. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSitei Q9NZJ7.

Polymorphism databases

DMDMi 74753085.

Proteomic databases

MaxQBi Q9NZJ7.
PaxDbi Q9NZJ7.
PRIDEi Q9NZJ7.

Protocols and materials databases

DNASUi 23787.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373616 ; ENSP00000362718 ; ENSG00000137409 . [Q9NZJ7-2 ]
ENST00000373627 ; ENSP00000362730 ; ENSG00000137409 . [Q9NZJ7-1 ]
GeneIDi 23787.
KEGGi hsa:23787.
UCSCi uc003onc.2. human. [Q9NZJ7-2 ]
uc003ond.2. human. [Q9NZJ7-1 ]

Organism-specific databases

CTDi 23787.
GeneCardsi GC06M036982.
HGNCi HGNC:17586. MTCH1.
HPAi HPA015971.
MIMi 610449. gene.
neXtProti NX_Q9NZJ7.
PharmGKBi PA134958992.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG311439.
GeneTreei ENSGT00390000000020.
HOVERGENi HBG058632.
InParanoidi Q9NZJ7.
KOi K17885.
OMAi FTYARHI.
OrthoDBi EOG7966H6.
PhylomeDBi Q9NZJ7.
TreeFami TF313721.

Miscellaneous databases

ChiTaRSi MTCH1. human.
GeneWikii MTCH1.
GenomeRNAii 23787.
NextBioi 46793.
PROi Q9NZJ7.
SOURCEi Search...

Gene expression databases

Bgeei Q9NZJ7.
CleanExi HS_MTCH1.
HS_PSAP.
ExpressionAtlasi Q9NZJ7. baseline and differential.
Genevestigatori Q9NZJ7.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 1 hit.
[Graphical view ]
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of an evolutionary conserved mitochondrial carrier family from various organisms."
    Jang J.S., Hahn Y., Park C., Chung J.H.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Kidney, Muscle and Pancreas.
  7. "Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1."
    Xu X., Shi Y.-C., Wu X., Gambetti P., Sui D., Cui M.-Z.
    J. Biol. Chem. 274:32543-32546(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-389, TISSUE SPECIFICITY, INTERACTION WITH PSEN1.
    Tissue: Brain.
  8. "The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein."
    Xu X., Shi Y.-C., Gao W., Mao G., Zhao G., Agrawal S., Chisolm G.M., Sui D., Cui M.-Z.
    J. Biol. Chem. 277:48913-48922(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PSEN1.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMTCH1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZJ7
Secondary accession number(s): A8KAX5
, B2RCE3, Q6PK60, Q6UX45, Q7L465, Q9BW23, Q9NZR6, Q9UJZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3