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Q9NZJ7

- MTCH1_HUMAN

UniProt

Q9NZJ7 - MTCH1_HUMAN

Protein

Mitochondrial carrier homolog 1

Gene

MTCH1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Potential mitochondrial transporter. May play a role in apoptosis.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    2. neuronal ion channel clustering Source: UniProtKB
    3. positive regulation of apoptotic process Source: UniProtKB
    4. regulation of signal transduction Source: UniProtKB
    5. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, Transport

    Protein family/group databases

    TCDBi2.A.29.25.1. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial carrier homolog 1
    Alternative name(s):
    Presenilin-associated protein
    Gene namesi
    Name:MTCH1
    Synonyms:PSAP
    ORF Names:CGI-64, UNQ1871/PRO4314
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:17586. MTCH1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. intracellular Source: UniProtKB
    3. mitochondrial inner membrane Source: UniProtKB-SubCell
    4. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134958992.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389Mitochondrial carrier homolog 1PRO_0000232385Add
    BLAST

    Proteomic databases

    MaxQBiQ9NZJ7.
    PaxDbiQ9NZJ7.
    PRIDEiQ9NZJ7.

    PTM databases

    PhosphoSiteiQ9NZJ7.

    Expressioni

    Tissue specificityi

    Widely expressed with a predominant expression in brain.1 Publication

    Gene expression databases

    ArrayExpressiQ9NZJ7.
    BgeeiQ9NZJ7.
    CleanExiHS_MTCH1.
    HS_PSAP.
    GenevestigatoriQ9NZJ7.

    Organism-specific databases

    HPAiHPA015971.

    Interactioni

    Subunit structurei

    Interacts with PSEN1.2 Publications

    Protein-protein interaction databases

    BioGridi117286. 7 interactions.
    IntActiQ9NZJ7. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NZJ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei248 – 26821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei315 – 33521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati81 – 17696Solcar 1Add
    BLAST
    Repeati192 – 28089Solcar 2Add
    BLAST

    Sequence similaritiesi

    Contains 2 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG311439.
    HOVERGENiHBG058632.
    InParanoidiQ9NZJ7.
    KOiK17885.
    OMAiFTYARHI.
    OrthoDBiEOG7966H6.
    PhylomeDBiQ9NZJ7.
    TreeFamiTF313721.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NZJ7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGASDPEVAP WARGGAAGMA GAGAGAGARG GAAAGVEARA RDPPPAHRAH    50
    PRHPRPAAQP SARRMDGGSG GLGSGDNAPT TEALFVALGA GVTALSHPLL 100
    YVKLLIQVGH EPMPPTLGTN VLGRKVLYLP SFFTYAKYIV QVDGKIGLFR 150
    GLSPRLMSNA LSTVTRGSMK KVFPPDEIEQ VSNKDDMKTS LKKVVKETSY 200
    EMMMQCVSRM LAHPLHVISM RCMVQFVGRE AKYSGVLSSI GKIFKEEGLL 250
    GFFVGLIPHL LGDVVFLWGC NLLAHFINAY LVDDSVSDTP GGLGNDQNPG 300
    SQFSQALAIR SYTKFVMGIA VSMLTYPFLL VGDLMAVNNC GLQAGLPPYS 350
    PVFKSWIHCW KYLSVQGQLF RGSSLLFRRV SSGSCFALE 389
    Length:389
    Mass (Da):41,544
    Last modified:October 1, 2000 - v1
    Checksum:i13C37758C4D22F4F
    GO
    Isoform 2 (identifier: Q9NZJ7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         286-302: Missing.

    Show »
    Length:372
    Mass (Da):39,920
    Checksum:iC579F8F4CD688A2F
    GO
    Isoform 3 (identifier: Q9NZJ7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-201: Missing.
         286-302: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:171
    Mass (Da):19,058
    Checksum:iFAD41D7FE484D975
    GO

    Sequence cautioni

    The sequence AAF07936.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 201201Missing in isoform 3. 1 PublicationVSP_017881Add
    BLAST
    Alternative sequencei286 – 30217Missing in isoform 2 and isoform 3. 4 PublicationsVSP_017882Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF176006 mRNA. Translation: AAD52644.3.
    AF192559 mRNA. Translation: AAF12793.3.
    AY358519 mRNA. Translation: AAQ88883.1.
    AK315067 mRNA. Translation: BAG37540.1.
    AL122034 Genomic DNA. Translation: CAI23305.1.
    AL122034 Genomic DNA. Translation: CAI23306.1.
    CH471081 Genomic DNA. Translation: EAX03927.1.
    CH471081 Genomic DNA. Translation: EAX03928.1.
    BC000702 mRNA. Translation: AAH00702.2.
    BC006507 mRNA. Translation: AAH06507.1.
    BC009962 mRNA. Translation: AAH09962.2.
    BC110914 mRNA. Translation: AAI10915.1.
    BC153873 mRNA. Translation: AAI53874.1.
    AF189289 mRNA. Translation: AAF07936.1. Different initiation.
    CCDSiCCDS4828.1. [Q9NZJ7-2]
    CCDS64411.1. [Q9NZJ7-1]
    RefSeqiNP_001258570.1. NM_001271641.1. [Q9NZJ7-1]
    NP_055156.1. NM_014341.2. [Q9NZJ7-2]
    UniGeneiHs.485262.

    Genome annotation databases

    EnsembliENST00000373616; ENSP00000362718; ENSG00000137409. [Q9NZJ7-2]
    ENST00000373627; ENSP00000362730; ENSG00000137409. [Q9NZJ7-1]
    GeneIDi23787.
    KEGGihsa:23787.
    UCSCiuc003onc.2. human. [Q9NZJ7-2]
    uc003ond.2. human. [Q9NZJ7-1]

    Polymorphism databases

    DMDMi74753085.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF176006 mRNA. Translation: AAD52644.3 .
    AF192559 mRNA. Translation: AAF12793.3 .
    AY358519 mRNA. Translation: AAQ88883.1 .
    AK315067 mRNA. Translation: BAG37540.1 .
    AL122034 Genomic DNA. Translation: CAI23305.1 .
    AL122034 Genomic DNA. Translation: CAI23306.1 .
    CH471081 Genomic DNA. Translation: EAX03927.1 .
    CH471081 Genomic DNA. Translation: EAX03928.1 .
    BC000702 mRNA. Translation: AAH00702.2 .
    BC006507 mRNA. Translation: AAH06507.1 .
    BC009962 mRNA. Translation: AAH09962.2 .
    BC110914 mRNA. Translation: AAI10915.1 .
    BC153873 mRNA. Translation: AAI53874.1 .
    AF189289 mRNA. Translation: AAF07936.1 . Different initiation.
    CCDSi CCDS4828.1. [Q9NZJ7-2 ]
    CCDS64411.1. [Q9NZJ7-1 ]
    RefSeqi NP_001258570.1. NM_001271641.1. [Q9NZJ7-1 ]
    NP_055156.1. NM_014341.2. [Q9NZJ7-2 ]
    UniGenei Hs.485262.

    3D structure databases

    ProteinModelPortali Q9NZJ7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117286. 7 interactions.
    IntActi Q9NZJ7. 3 interactions.

    Protein family/group databases

    TCDBi 2.A.29.25.1. the mitochondrial carrier (mc) family.

    PTM databases

    PhosphoSitei Q9NZJ7.

    Polymorphism databases

    DMDMi 74753085.

    Proteomic databases

    MaxQBi Q9NZJ7.
    PaxDbi Q9NZJ7.
    PRIDEi Q9NZJ7.

    Protocols and materials databases

    DNASUi 23787.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373616 ; ENSP00000362718 ; ENSG00000137409 . [Q9NZJ7-2 ]
    ENST00000373627 ; ENSP00000362730 ; ENSG00000137409 . [Q9NZJ7-1 ]
    GeneIDi 23787.
    KEGGi hsa:23787.
    UCSCi uc003onc.2. human. [Q9NZJ7-2 ]
    uc003ond.2. human. [Q9NZJ7-1 ]

    Organism-specific databases

    CTDi 23787.
    GeneCardsi GC06M036982.
    HGNCi HGNC:17586. MTCH1.
    HPAi HPA015971.
    MIMi 610449. gene.
    neXtProti NX_Q9NZJ7.
    PharmGKBi PA134958992.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG311439.
    HOVERGENi HBG058632.
    InParanoidi Q9NZJ7.
    KOi K17885.
    OMAi FTYARHI.
    OrthoDBi EOG7966H6.
    PhylomeDBi Q9NZJ7.
    TreeFami TF313721.

    Miscellaneous databases

    ChiTaRSi MTCH1. human.
    GeneWikii MTCH1.
    GenomeRNAii 23787.
    NextBioi 46793.
    PROi Q9NZJ7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NZJ7.
    Bgeei Q9NZJ7.
    CleanExi HS_MTCH1.
    HS_PSAP.
    Genevestigatori Q9NZJ7.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of an evolutionary conserved mitochondrial carrier family from various organisms."
      Jang J.S., Hahn Y., Park C., Chung J.H.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain, Kidney, Muscle and Pancreas.
    7. "Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1."
      Xu X., Shi Y.-C., Wu X., Gambetti P., Sui D., Cui M.-Z.
      J. Biol. Chem. 274:32543-32546(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-389, TISSUE SPECIFICITY, INTERACTION WITH PSEN1.
      Tissue: Brain.
    8. "The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein."
      Xu X., Shi Y.-C., Gao W., Mao G., Zhao G., Agrawal S., Chisolm G.M., Sui D., Cui M.-Z.
      J. Biol. Chem. 277:48913-48922(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PSEN1.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMTCH1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NZJ7
    Secondary accession number(s): A8KAX5
    , B2RCE3, Q6PK60, Q6UX45, Q7L465, Q9BW23, Q9NZR6, Q9UJZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3