##gff-version 3 Q9NZJ0 UniProtKB Chain 1 730 . . . ID=PRO_0000274867;Note=Denticleless protein homolog Q9NZJ0 UniProtKB Repeat 47 89 . . . Note=WD 1 Q9NZJ0 UniProtKB Repeat 96 135 . . . Note=WD 2 Q9NZJ0 UniProtKB Repeat 138 178 . . . Note=WD 3 Q9NZJ0 UniProtKB Repeat 214 253 . . . Note=WD 4 Q9NZJ0 UniProtKB Repeat 267 308 . . . Note=WD 5 Q9NZJ0 UniProtKB Repeat 313 354 . . . Note=WD 6 Q9NZJ0 UniProtKB Repeat 358 398 . . . Note=WD 7 Q9NZJ0 UniProtKB Region 188 210 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NZJ0 UniProtKB Region 399 443 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NZJ0 UniProtKB Region 465 498 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NZJ0 UniProtKB Region 599 631 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NZJ0 UniProtKB Region 644 703 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NZJ0 UniProtKB Motif 168 171 . . . Note=DDB1-binding motif Q9NZJ0 UniProtKB Motif 197 203 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9NZJ0 UniProtKB Motif 243 246 . . . Note=DDB1-binding motif Q9NZJ0 UniProtKB Compositional bias 417 443 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NZJ0 UniProtKB Compositional bias 481 498 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NZJ0 UniProtKB Compositional bias 599 630 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NZJ0 UniProtKB Compositional bias 675 703 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NZJ0 UniProtKB Modified residue 1 1 . . . Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22223895;Dbxref=PMID:22223895 Q9NZJ0 UniProtKB Modified residue 196 196 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9NZJ0 UniProtKB Modified residue 410 410 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 Q9NZJ0 UniProtKB Modified residue 426 426 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9NZJ0 UniProtKB Modified residue 464 464 . . . Note=Phosphothreonine%3B by CDK1 and CDK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23478441;Dbxref=PMID:23478441 Q9NZJ0 UniProtKB Modified residue 485 485 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Q9NZJ0 UniProtKB Modified residue 490 490 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163 Q9NZJ0 UniProtKB Modified residue 495 495 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Q9NZJ0 UniProtKB Modified residue 512 512 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Q9NZJ0 UniProtKB Modified residue 516 516 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Q9NZJ0 UniProtKB Modified residue 557 557 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Q9NZJ0 UniProtKB Modified residue 676 676 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Q9NZJ0 UniProtKB Modified residue 679 679 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Q9NZJ0 UniProtKB Modified residue 684 684 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Q9NZJ0 UniProtKB Modified residue 702 702 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9NZJ0 UniProtKB Modified residue 717 717 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9NZJ0 UniProtKB Alternative sequence 18 59 . . . ID=VSP_022879;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q9NZJ0 UniProtKB Alternative sequence 240 253 . . . ID=VSP_022880;Note=In isoform 2. IKVWDLRKNYTAYR->FKSDFGFHWLYFIC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q9NZJ0 UniProtKB Alternative sequence 254 730 . . . ID=VSP_022881;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q9NZJ0 UniProtKB Natural variant 425 425 . . . ID=VAR_062095;Note=S->N;Dbxref=dbSNP:rs35137676 Q9NZJ0 UniProtKB Natural variant 436 436 . . . ID=VAR_030353;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11278750,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:16861906,ECO:0000269|Ref.3,ECO:0000269|Ref.6;Dbxref=dbSNP:rs3135474,PMID:11278750,PMID:14702039,PMID:15489334,PMID:16861906 Q9NZJ0 UniProtKB Natural variant 694 694 . . . ID=VAR_030354;Note=K->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:11278750,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:16861906,ECO:0000269|Ref.3,ECO:0007744|PubMed:23186163;Dbxref=dbSNP:rs6540718,PMID:11278750,PMID:14702039,PMID:15489334,PMID:16861906,PMID:23186163 Q9NZJ0 UniProtKB Mutagenesis 246 246 . . . Note=Blocks association with DDB1 and ubiquitination by DCX(DTL). No effect on ubiquitination by SCF(FBXO11). R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16949367,ECO:0000269|PubMed:23478445;Dbxref=PMID:16949367,PMID:23478445 Q9NZJ0 UniProtKB Mutagenesis 457 457 . . . Note=Increases protein stability%2C but no effect on interaction with FBXO11 and polyubiquitination. Delays cell migration. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23478445;Dbxref=PMID:23478445 Q9NZJ0 UniProtKB Mutagenesis 462 462 . . . Note=Blocks interaction with FBXO11 and ubiquitination%2C increasing protein stability. Delays cell migration. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23478445;Dbxref=PMID:23478445 Q9NZJ0 UniProtKB Mutagenesis 463 463 . . . Note=No effect on interaction with FBXO11. Increases protein stability. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23478441;Dbxref=PMID:23478441 Q9NZJ0 UniProtKB Mutagenesis 464 464 . . . Note=Blocks interaction with FBXO11 and increases protein stability. Not phosphorylated by CDK1 or CDK2. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23478441;Dbxref=PMID:23478441 Q9NZJ0 UniProtKB Mutagenesis 464 464 . . . Note=Blocks interaction with FBXO11. T->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23478441;Dbxref=PMID:23478441 Q9NZJ0 UniProtKB Mutagenesis 465 465 . . . Note=Inhibits phosphorylation on T-464. No effect on interaction with FBXO11. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23478441;Dbxref=PMID:23478441 Q9NZJ0 UniProtKB Mutagenesis 466 466 . . . Note=No effect on interaction with FBXO11. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23478441;Dbxref=PMID:23478441 Q9NZJ0 UniProtKB Mutagenesis 466 466 . . . Note=No effect on interaction with FBXO11. T->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23478441;Dbxref=PMID:23478441 Q9NZJ0 UniProtKB Mutagenesis 467 467 . . . Note=No effect on interaction with FBXO11. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23478441;Dbxref=PMID:23478441 Q9NZJ0 UniProtKB Mutagenesis 468 468 . . . Note=No effect on interaction with FBXO11. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23478441;Dbxref=PMID:23478441 Q9NZJ0 UniProtKB Mutagenesis 468 468 . . . Note=No effect on interaction with FBXO11. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23478441;Dbxref=PMID:23478441 Q9NZJ0 UniProtKB Mutagenesis 471 471 . . . Note=No effect on interaction with FBXO11. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23478441;Dbxref=PMID:23478441 Q9NZJ0 UniProtKB Mutagenesis 471 471 . . . Note=No effect on interaction with FBXO11. T->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23478441;Dbxref=PMID:23478441 Q9NZJ0 UniProtKB Mutagenesis 472 472 . . . Note=No effect on interaction with FBXO11. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23478441;Dbxref=PMID:23478441 Q9NZJ0 UniProtKB Mutagenesis 472 472 . . . Note=No effect on interaction with FBXO11. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23478441;Dbxref=PMID:23478441 Q9NZJ0 UniProtKB Sequence conflict 83 83 . . . Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9NZJ0 UniProtKB Sequence conflict 356 356 . . . Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9NZJ0 UniProtKB Sequence conflict 532 532 . . . Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9NZJ0 UniProtKB Turn 709 712 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QC0