##gff-version 3 Q9NZI8 UniProtKB Chain 1 577 . . . ID=PRO_0000282533;Note=Insulin-like growth factor 2 mRNA-binding protein 1 Q9NZI8 UniProtKB Domain 2 75 . . . Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176 Q9NZI8 UniProtKB Domain 81 156 . . . Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176 Q9NZI8 UniProtKB Domain 195 260 . . . Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 Q9NZI8 UniProtKB Domain 276 343 . . . Note=KH 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 Q9NZI8 UniProtKB Domain 405 470 . . . Note=KH 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 Q9NZI8 UniProtKB Domain 487 553 . . . Note=KH 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 Q9NZI8 UniProtKB Region 160 190 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NZI8 UniProtKB Region 187 570 . . . Note=Necessary for interaction with ELAVL4 and binding to TAU mRNA;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9NZI8 UniProtKB Region 310 324 . . . Note=Sufficient for nuclear export Q9NZI8 UniProtKB Region 485 495 . . . Note=Sufficient for nuclear export Q9NZI8 UniProtKB Modified residue 12 12 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9NZI8 UniProtKB Modified residue 73 73 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9NZI8 UniProtKB Modified residue 181 181 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:17081983,PMID:20068231,PMID:23186163 Q9NZI8 UniProtKB Modified residue 528 528 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9NZI8 UniProtKB Alternative sequence 135 273 . . . ID=VSP_045366;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Q9NZI8 UniProtKB Mutagenesis 213 214 . . . Note=50-fold decrease in RNA-binding affinity%2C decreased location in cytoplasmic RNP%2C increased nuclear location%3B when associated with 294-E-L-295 and 423-E-L-424. KE->EL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12921532;Dbxref=PMID:12921532 Q9NZI8 UniProtKB Mutagenesis 213 213 . . . Note=Partial reduction in interaction with m6A-modified mRNA%3B when associated with E-294. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29476152;Dbxref=PMID:29476152 Q9NZI8 UniProtKB Mutagenesis 294 295 . . . Note=50-fold decrease in RNA-binding affinity%2C decreased location in cytoplasmic RNP%2C increased nuclear location%3B when associated with 213-E-L-214 and 423-E-L-424. KE->EL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12921532;Dbxref=PMID:12921532 Q9NZI8 UniProtKB Mutagenesis 294 294 . . . Note=Partial reduction in interaction with m6A-modified mRNA%3B when associated with E-213. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29476152;Dbxref=PMID:29476152 Q9NZI8 UniProtKB Mutagenesis 423 424 . . . Note=Loss of binding to RBPR and loss of interaction with m6A-modified mRNA%3B when associated with 505-E-E-506. KK->EE;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:29476152,ECO:0000269|PubMed:32245947;Dbxref=PMID:29476152,PMID:32245947 Q9NZI8 UniProtKB Mutagenesis 423 424 . . . Note=50-fold decrease in RNA-binding affinity%2C decreased location in cytoplasmic RNP%2C increased nuclear location%3B when associated with 213-E-L-214 and 294-E-L-295. KK->EL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12921532;Dbxref=PMID:12921532 Q9NZI8 UniProtKB Mutagenesis 505 506 . . . Note=Loss of binding to RBPR and loss of interaction with m6A-modified mRNA%3B when associated with 423-E-E-424. KG->EE;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:29476152,ECO:0000269|PubMed:32245947;Dbxref=PMID:29476152,PMID:32245947 Q9NZI8 UniProtKB Sequence conflict 10 10 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9NZI8 UniProtKB Sequence conflict 281 281 . . . Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9NZI8 UniProtKB Sequence conflict 320 320 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9NZI8 UniProtKB Sequence conflict 365 365 . . . Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9NZI8 UniProtKB Beta strand 198 203 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QEY Q9NZI8 UniProtKB Helix 204 206 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QEY Q9NZI8 UniProtKB Helix 207 211 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QEY Q9NZI8 UniProtKB Helix 213 215 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QEY Q9NZI8 UniProtKB Helix 216 225 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QEY Q9NZI8 UniProtKB Beta strand 228 232 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QEY Q9NZI8 UniProtKB Beta strand 241 248 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QEY Q9NZI8 UniProtKB Helix 250 270 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QEY Q9NZI8 UniProtKB Beta strand 279 284 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QEY Q9NZI8 UniProtKB Helix 285 292 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QEY Q9NZI8 UniProtKB Helix 294 296 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QEY Q9NZI8 UniProtKB Helix 297 306 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QEY Q9NZI8 UniProtKB Beta strand 309 312 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QEY Q9NZI8 UniProtKB Helix 315 317 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QEY Q9NZI8 UniProtKB Beta strand 324 331 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QEY Q9NZI8 UniProtKB Helix 333 361 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QEY Q9NZI8 UniProtKB Beta strand 406 413 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3KRM Q9NZI8 UniProtKB Helix 414 416 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3KRM Q9NZI8 UniProtKB Helix 417 421 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3KRM Q9NZI8 UniProtKB Helix 423 425 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3KRM Q9NZI8 UniProtKB Helix 426 435 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3KRM Q9NZI8 UniProtKB Beta strand 438 441 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3KRM Q9NZI8 UniProtKB Beta strand 450 458 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3KRM Q9NZI8 UniProtKB Helix 460 476 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3KRM Q9NZI8 UniProtKB Beta strand 488 495 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3KRM Q9NZI8 UniProtKB Turn 496 498 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3KRM Q9NZI8 UniProtKB Helix 499 503 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3KRM Q9NZI8 UniProtKB Helix 505 507 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3KRM Q9NZI8 UniProtKB Helix 508 517 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3KRM Q9NZI8 UniProtKB Beta strand 520 522 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3KRM Q9NZI8 UniProtKB Beta strand 533 541 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3KRM Q9NZI8 UniProtKB Helix 543 560 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3KRM