Reviewed, UniProtKB/Swiss-Prot Q9NZI7 (UBIP1_HUMAN)

Names and origin

Protein names

Recommended name:
    Upstream-binding protein 1
Alternative name(s):
    LBP-1

Gene names

Name:	UBP1
Synonyms:	LBP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	540 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 By similarity. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 By similarity. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.
Subunit structure	Interacts with TFCP2. Interacts with PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1 By similarity.
Subcellular location	Nucleus. Ref.1
Tissue specificity	Expressed in adrenal tissue, JEG-3, NCI-H295A, HepG2 and HeLa cell lines. Ref.2
Induction	Induced by HIV-1 infection of lymphocytes. Ref.6
Sequence similarities	Belongs to the grh/CP2 family. CP2 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	DNA-binding
Gene Ontology (GO)
Biological process	negative regulation of transcription Ref.1 Traceable author statement. Source: UniProtKB regulation of transcription from RNA polymerase II promoter Ref.1 Traceable author statement. Source: ProtInc transcription Inferred from electronic annotation. Source: UniProtKB-KW viral genome replication Ref.1 Traceable author statement. Source: ProtInc
Cellular component	nucleus Ref.1 Traceable author statement. Source: UniProtKB
Molecular function	specific transcriptional repressor activity Ref.1 Traceable author statement. Source: UniProtKB transcription corepressor activity Ref.1 Traceable author statement. Source: ProtInc transcription factor activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NZI7-1)

Also known as: LBP-1b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NZI7-4)

Also known as: LBP-1a;

The sequence of this isoform differs from the canonical sequence as follows:
     274-309: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 540	540	Upstream-binding protein 1		PRO_0000229026
Natural variations
	Alternative sequence	274 – 309	36	Missing in isoform 2.		VSP_017730
	Natural variant	109	1	N → S: dbSNP rs3736563. Ref.1		VAR_049294
	Natural variant	212	1	T → A: dbSNP rs17854430. Ref.4		VAR_025730
Experimental info
	Sequence conflict	93 – 94	2	EI → D in BAB14501. Ref.3
	Sequence conflict	273	1	E → EE Ref.1
	Sequence conflict	291 – 297	7	SSKRTLP → VQQADFA Ref.1
	Sequence conflict	418	1	Y → V Ref.1
	Sequence conflict	424	1	R → RR in CAH18658. Ref.5
	Sequence conflict	503	1	G → GH Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (LBP-1b) [UniParc]. Last modified October 1, 2000. Version 1. Checksum: CD95819AA86A7F39	FASTA	540	60,491
	10 20 30 40 50 60 MAWVLKMDEV IESGLVHDFD ASLSGIGQEL GAGAYSMSDV LALPIFKQED SSLPLDGETE 70 80 90 100 110 120 HPPFQYVMCA ATSPAVKLHD ETLTYLNQGQ SYEIRMLDNR KMGDMPEING KLVKSIIRVV 130 140 150 160 170 180 FHDRRLQYTE HQQLEGWKWN RPGDRLLDLD IPMSVGIIDT RTNPSQLNAV EFLWDPAKRT 190 200 210 220 230 240 SAFIQVHCIS TEFTPRKHGG EKGVPFRIQV DTFKQNENGE YTDHLHSASC QIKVFKPKGA 250 260 270 280 290 300 DRKQKTDREK MEKRTAHEKE KYQPSYDTTI LTEMRLEPII EDAVEHEQKK SSKRTLPADY 310 320 330 340 350 360 GDSLAKRGSC SPWPDAPTAY VNNSPSPAPT FTSPQQSTCS VPDSNSSSPN HQGDGASQTS 370 380 390 400 410 420 GEQIQPSATI QETQQWLLKN RFSSYTRLFS NFSGADLLKL TKEDLVQICG AADGIRLYNS 430 440 450 460 470 480 LKSRSVRPRL TIYVCREQPS STVLQGQQQA ASSASENGSG APYVYHAIYL EEMIASEVAR 490 500 510 520 530 540 KLALVFNIPL HQINQVYRQG PTGIHILVSD QMVQNFQDES CFLFSTVKAE SSDGIHIILK
	Isoform 2 (LBP-1a). Checksum: BF9A5F42A77A33A9	FASTA	504	56,453
	10 20 30 40 50 60 MAWVLKMDEV IESGLVHDFD ASLSGIGQEL GAGAYSMSDV LALPIFKQED SSLPLDGETE 70 80 90 100 110 120 HPPFQYVMCA ATSPAVKLHD ETLTYLNQGQ SYEIRMLDNR KMGDMPEING KLVKSIIRVV 130 140 150 160 170 180 FHDRRLQYTE HQQLEGWKWN RPGDRLLDLD IPMSVGIIDT RTNPSQLNAV EFLWDPAKRT 190 200 210 220 230 240 SAFIQVHCIS TEFTPRKHGG EKGVPFRIQV DTFKQNENGE YTDHLHSASC QIKVFKPKGA 250 260 270 280 290 300 DRKQKTDREK MEKRTAHEKE KYQPSYDTTI LTECSPWPDA PTAYVNNSPS PAPTFTSPQQ 310 320 330 340 350 360 STCSVPDSNS SSPNHQGDGA SQTSGEQIQP SATIQETQQW LLKNRFSSYT RLFSNFSGAD 370 380 390 400 410 420 LLKLTKEDLV QICGAADGIR LYNSLKSRSV RPRLTIYVCR EQPSSTVLQG QQQAASSASE 430 440 450 460 470 480 NGSGAPYVYH AIYLEEMIAS EVARKLALVF NIPLHQINQV YRQGPTGIHI LVSDQMVQNF 490 500 QDESCFLFST VKAESSDGIH IILK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro." Yoon J.-B., Li G., Roeder R.G. Mol. Cell. Biol. 14:1776-1785(1994) [PubMed: 8114710] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, VARIANT SER-109.
[2]	"Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc." Huang N., Miller W.L. J. Biol. Chem. 275:2852-2858(2000) [PubMed: 10644752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Placenta.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-212. Tissue: Brain.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 394-540. Tissue: Amygdala.
[6]	"Repression of HIV-1 transcription by a cellular protein." Kato H., Horikoshi M., Roeder R.G. Science 251:1476-1479(1991) [PubMed: 2006421] [Abstract] Cited for: FUNCTION, INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF198487 mRNA. Translation: AAF32274.1. AK023274 mRNA. Translation: BAB14501.1. BC047235 mRNA. Translation: AAH47235.1. CR749798 mRNA. Translation: CAH18658.1.
IPI	IPI00005018. IPI00294870.
PIR	A56205. B56205.
RefSeq	NP_001121632.1. NP_001121633.1. NP_055332.3.
UniGene	Hs.714881
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9NZI7.
Proteomic databases
PRIDE	Q9NZI7.
Genome annotation databases
Ensembl	ENSG00000153560. Homo sapiens. [Contig view]
GeneID	7342.
KEGG	hsa:7342.
Organism-specific databases
GeneCards	GC03M033404.
H-InvDB	HIX0003156.
HGNC	HGNC:12507. UBP1.
MIM	609784. gene.
PharmGKB	PA28420.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9NZI7.
HOVERGEN	Q9NZI7.
OMA	Q9NZI7. SPWPDTP.
Gene expression databases
Bgee	Q9NZI7.
CleanEx	HS_UBP1.
GermOnline	ENSG00000153560. Homo sapiens.
Family and domain databases
InterPro	IPR007604. CP2. [Graphical view]
Pfam	PF04516. CP2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	28742.
SOURCE	Search...

Entry information

Entry name

UBIP1_HUMAN

Accession

Primary (citable) accession number: Q9NZI7
Secondary accession number(s): Q68CT0 , Q86Y57, Q9H8V0, Q9UD76, Q9UD78

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)