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Protein

Upstream-binding protein 1

Gene

UBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.By similarity3 Publications

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • sequence-specific DNA binding Source: GO_Central
  • transcription corepressor activity Source: ProtInc
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • angiogenesis Source: Ensembl
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW
  • viral genome replication Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Upstream-binding protein 1
Alternative name(s):
Transcription factor LBP-1
Gene namesi
Name:UBP1
Synonyms:LBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:12507. UBP1.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37154.

Polymorphism and mutation databases

BioMutaiUBP1.
DMDMi74719655.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Upstream-binding protein 1PRO_0000229026Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221PhosphoserineCombined sources
Modified residuei390 – 3901PhosphoserineBy similarity
Modified residuei393 – 3931PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NZI7.
MaxQBiQ9NZI7.
PaxDbiQ9NZI7.
PRIDEiQ9NZI7.

PTM databases

iPTMnetiQ9NZI7.
PhosphoSiteiQ9NZI7.

Expressioni

Tissue specificityi

Expressed in adrenal tissue, JEG-3, NCI-H295A, Hep-G2 and HeLa cell lines.1 Publication

Inductioni

By HIV-1 infection of lymphocytes.1 Publication

Gene expression databases

BgeeiQ9NZI7.
CleanExiHS_UBP1.
ExpressionAtlasiQ9NZI7. baseline and differential.
GenevisibleiQ9NZI7. HS.

Interactioni

Subunit structurei

Interacts with TFCP2. Interacts with PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi113189. 27 interactions.
IntActiQ9NZI7. 13 interactions.
STRINGi9606.ENSP00000283628.

Structurei

3D structure databases

ProteinModelPortaliQ9NZI7.
SMRiQ9NZI7. Positions 356-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the grh/CP2 family. CP2 subfamily.Curated

Phylogenomic databases

eggNOGiKOG4091. Eukaryota.
ENOG410XNZ6. LUCA.
GeneTreeiENSGT00760000119235.
HOGENOMiHOG000230625.
HOVERGENiHBG053805.
InParanoidiQ9NZI7.
KOiK09275.
OMAiWPDTPTA.
OrthoDBiEOG7FBRHB.
PhylomeDBiQ9NZI7.
TreeFamiTF314132.

Family and domain databases

InterProiIPR007604. CP2.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF04516. CP2. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NZI7-1) [UniParc]FASTAAdd to basket

Also known as: LBP-1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWVLKMDEV IESGLVHDFD ASLSGIGQEL GAGAYSMSDV LALPIFKQED
60 70 80 90 100
SSLPLDGETE HPPFQYVMCA ATSPAVKLHD ETLTYLNQGQ SYEIRMLDNR
110 120 130 140 150
KMGDMPEING KLVKSIIRVV FHDRRLQYTE HQQLEGWKWN RPGDRLLDLD
160 170 180 190 200
IPMSVGIIDT RTNPSQLNAV EFLWDPAKRT SAFIQVHCIS TEFTPRKHGG
210 220 230 240 250
EKGVPFRIQV DTFKQNENGE YTDHLHSASC QIKVFKPKGA DRKQKTDREK
260 270 280 290 300
MEKRTAHEKE KYQPSYDTTI LTEMRLEPII EDAVEHEQKK SSKRTLPADY
310 320 330 340 350
GDSLAKRGSC SPWPDAPTAY VNNSPSPAPT FTSPQQSTCS VPDSNSSSPN
360 370 380 390 400
HQGDGASQTS GEQIQPSATI QETQQWLLKN RFSSYTRLFS NFSGADLLKL
410 420 430 440 450
TKEDLVQICG AADGIRLYNS LKSRSVRPRL TIYVCREQPS STVLQGQQQA
460 470 480 490 500
ASSASENGSG APYVYHAIYL EEMIASEVAR KLALVFNIPL HQINQVYRQG
510 520 530 540
PTGIHILVSD QMVQNFQDES CFLFSTVKAE SSDGIHIILK
Length:540
Mass (Da):60,491
Last modified:October 1, 2000 - v1
Checksum:iCD95819AA86A7F39
GO
Isoform 2 (identifier: Q9NZI7-4) [UniParc]FASTAAdd to basket

Also known as: LBP-1a

The sequence of this isoform differs from the canonical sequence as follows:
     274-309: Missing.

Show »
Length:504
Mass (Da):56,453
Checksum:iBF9A5F42A77A33A9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 942EI → D in BAB14501 (PubMed:14702039).Curated
Sequence conflicti273 – 2731E → EE (PubMed:8114710).Curated
Sequence conflicti291 – 2977SSKRTLP → VQQADFA (PubMed:8114710).Curated
Sequence conflicti418 – 4181Y → V (PubMed:8114710).Curated
Sequence conflicti424 – 4241R → RR in CAH18658 (PubMed:17974005).Curated
Sequence conflicti503 – 5031G → GH (PubMed:8114710).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti109 – 1091N → S.1 Publication
Corresponds to variant rs3736563 [ dbSNP | Ensembl ].
VAR_049294
Natural varianti212 – 2121T → A.1 Publication
Corresponds to variant rs17854430 [ dbSNP | Ensembl ].
VAR_025730

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei274 – 30936Missing in isoform 2. 2 PublicationsVSP_017730Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198487 mRNA. Translation: AAF32274.1.
AK023274 mRNA. Translation: BAB14501.1.
BC047235 mRNA. Translation: AAH47235.1.
CR749798 mRNA. Translation: CAH18658.1.
CCDSiCCDS2659.1. [Q9NZI7-1]
CCDS46788.1. [Q9NZI7-4]
PIRiA56205.
B56205.
RefSeqiNP_001121632.1. NM_001128160.1. [Q9NZI7-4]
NP_001121633.1. NM_001128161.1. [Q9NZI7-1]
NP_055332.3. NM_014517.4. [Q9NZI7-1]
UniGeneiHs.729120.

Genome annotation databases

EnsembliENST00000283628; ENSP00000283628; ENSG00000153560. [Q9NZI7-1]
ENST00000283629; ENSP00000283629; ENSG00000153560. [Q9NZI7-1]
ENST00000447368; ENSP00000395558; ENSG00000153560. [Q9NZI7-4]
GeneIDi7342.
KEGGihsa:7342.
UCSCiuc003cfq.5. human. [Q9NZI7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198487 mRNA. Translation: AAF32274.1.
AK023274 mRNA. Translation: BAB14501.1.
BC047235 mRNA. Translation: AAH47235.1.
CR749798 mRNA. Translation: CAH18658.1.
CCDSiCCDS2659.1. [Q9NZI7-1]
CCDS46788.1. [Q9NZI7-4]
PIRiA56205.
B56205.
RefSeqiNP_001121632.1. NM_001128160.1. [Q9NZI7-4]
NP_001121633.1. NM_001128161.1. [Q9NZI7-1]
NP_055332.3. NM_014517.4. [Q9NZI7-1]
UniGeneiHs.729120.

3D structure databases

ProteinModelPortaliQ9NZI7.
SMRiQ9NZI7. Positions 356-422.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113189. 27 interactions.
IntActiQ9NZI7. 13 interactions.
STRINGi9606.ENSP00000283628.

PTM databases

iPTMnetiQ9NZI7.
PhosphoSiteiQ9NZI7.

Polymorphism and mutation databases

BioMutaiUBP1.
DMDMi74719655.

Proteomic databases

EPDiQ9NZI7.
MaxQBiQ9NZI7.
PaxDbiQ9NZI7.
PRIDEiQ9NZI7.

Protocols and materials databases

DNASUi7342.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283628; ENSP00000283628; ENSG00000153560. [Q9NZI7-1]
ENST00000283629; ENSP00000283629; ENSG00000153560. [Q9NZI7-1]
ENST00000447368; ENSP00000395558; ENSG00000153560. [Q9NZI7-4]
GeneIDi7342.
KEGGihsa:7342.
UCSCiuc003cfq.5. human. [Q9NZI7-1]

Organism-specific databases

CTDi7342.
GeneCardsiUBP1.
HGNCiHGNC:12507. UBP1.
MIMi609784. gene.
neXtProtiNX_Q9NZI7.
PharmGKBiPA37154.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4091. Eukaryota.
ENOG410XNZ6. LUCA.
GeneTreeiENSGT00760000119235.
HOGENOMiHOG000230625.
HOVERGENiHBG053805.
InParanoidiQ9NZI7.
KOiK09275.
OMAiWPDTPTA.
OrthoDBiEOG7FBRHB.
PhylomeDBiQ9NZI7.
TreeFamiTF314132.

Miscellaneous databases

ChiTaRSiUBP1. human.
GenomeRNAii7342.
PROiQ9NZI7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NZI7.
CleanExiHS_UBP1.
ExpressionAtlasiQ9NZI7. baseline and differential.
GenevisibleiQ9NZI7. HS.

Family and domain databases

InterProiIPR007604. CP2.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF04516. CP2. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro."
    Yoon J.-B., Li G., Roeder R.G.
    Mol. Cell. Biol. 14:1776-1785(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, VARIANT SER-109.
  2. "Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc."
    Huang N., Miller W.L.
    J. Biol. Chem. 275:2852-2858(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Placenta.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-212.
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 394-540.
    Tissue: Amygdala.
  6. "Repression of HIV-1 transcription by a cellular protein."
    Kato H., Horikoshi M., Roeder R.G.
    Science 251:1476-1479(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiUBIP1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZI7
Secondary accession number(s): Q68CT0
, Q86Y57, Q9H8V0, Q9UD76, Q9UD78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.