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Protein

Transcription factor CP2-like protein 1

Gene

TFCP2L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity). Required for normal duct development in the salivary gland and kidney (By similarity). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity). Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity). JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity). Modulates the placental expression of CYP11A1 (PubMed:10644752).By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor CP2-like protein 1
Alternative name(s):
CP2-related transcriptional repressor 1
Short name:
CRTR-1
Transcription factor LBP-9
Gene namesi
Name:TFCP2L1
Synonyms:CRTR1, LBP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115112.7.
HGNCiHGNC:17925. TFCP2L1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi345D → G: Impairs the formation of oligomeric homo-complexes in solution. 1 Publication1

Organism-specific databases

DisGeNETi29842.
OpenTargetsiENSG00000115112.
PharmGKBiPA134980544.

Polymorphism and mutation databases

BioMutaiTFCP2L1.
DMDMi74734729.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002280061 – 479Transcription factor CP2-like protein 1Add BLAST479

Proteomic databases

EPDiQ9NZI6.
MaxQBiQ9NZI6.
PaxDbiQ9NZI6.
PeptideAtlasiQ9NZI6.
PRIDEiQ9NZI6.

PTM databases

iPTMnetiQ9NZI6.
PhosphoSitePlusiQ9NZI6.

Expressioni

Tissue specificityi

Highly expressed in placental JEG-3 cells and very low levels of expression in non-steroidogenic cells. No expression was seen in adrenal NCI-H295A cells or in adrenal tissue.1 Publication

Gene expression databases

BgeeiENSG00000115112.
CleanExiHS_TFCP2L1.
GenevisibleiQ9NZI6. HS.

Organism-specific databases

HPAiHPA029708.

Interactioni

Subunit structurei

Forms homohexamers via its SAM-like domain (PubMed:26906118). Interacts with MTA1; which is indispensable for TFCP2l1-mediated self-renewal-promoting effect and endoderm-inhibiting action (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi118929. 6 interactors.
IntActiQ9NZI6. 1 interactor.
STRINGi9606.ENSP00000263707.

Structurei

3D structure databases

ProteinModelPortaliQ9NZI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 260CP2-like domain1 PublicationAdd BLAST240
Regioni261 – 365SAM2-like domain1 PublicationAdd BLAST105

Domaini

The CP2-like domain is required for direct DNA-binding (PubMed:26906118). The CP2-like domain is essential to maintain the undifferentiated state of embryonic stem cells (By similarity).By similarity1 Publication
The SAM-like domain is required for homohexamerization (PubMed:26906118).1 Publication

Sequence similaritiesi

Belongs to the grh/CP2 family. CP2 subfamily.Curated

Phylogenomic databases

eggNOGiKOG4091. Eukaryota.
ENOG410XNZ6. LUCA.
GeneTreeiENSGT00760000119235.
HOGENOMiHOG000230625.
HOVERGENiHBG053805.
InParanoidiQ9NZI6.
KOiK09275.
OMAiHIILKCG.
OrthoDBiEOG091G0YV2.
PhylomeDBiQ9NZI6.
TreeFamiTF314132.

Family and domain databases

InterProiView protein in InterPro
IPR007604. CP2.
IPR013761. SAM/pointed_sf.
PfamiView protein in Pfam
PF04516. CP2. 1 hit.
SUPFAMiSSF47769. SSF47769. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NZI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFWHTQPEH YNQHNSGSYL RDVLALPIFK QEEPQLSPEN EARLPPLQYV
60 70 80 90 100
LCAATSPAVK LHEETLTYLN QGQSYEIRLL ENRKLGDFQD LNTKYVKSII
110 120 130 140 150
RVVFHDRRLQ YTEHQQLEGW RWSRPGDRIL DIDIPLSVGI LDPRASPTQL
160 170 180 190 200
NAVEFLWDPA KRASAFIQVH CISTEFTPRK HGGEKGVPFR VQIDTFKQNE
210 220 230 240 250
NGEYTEHLHS ASCQIKVFKP KGADRKQKTD REKMEKRTAQ EKEKYQPSYE
260 270 280 290 300
TTILTECSPW PDVAYQVNSA PSPSYNGSPN SFGLGEGNAS PTHPVEALPV
310 320 330 340 350
GSDHLLPSAS IQDAQQWLHR NRFSQFCRLF ASFSGADLLK MSRDDLVQIC
360 370 380 390 400
GPADGIRLFN AIKGRNVRPK MTIYVCQELE QNRVPLQQKR DGSGDSNLSV
410 420 430 440 450
YHAIFLEELT TLELIEKIAN LYSISPQHIH RVYRQGPTGI HVVVSNEMVQ
460 470
NFQDESCFVL STIKAESNDG YHIILKCGL
Length:479
Mass (Da):54,627
Last modified:October 1, 2000 - v1
Checksum:iC2D0B56D0705AE75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198488 mRNA. Translation: AAF32275.1.
AC013399 Genomic DNA. Translation: AAX88871.1.
AC079988 Genomic DNA. No translation available.
BC064698 mRNA. Translation: AAH64698.1.
CCDSiCCDS2134.1.
RefSeqiNP_055368.1. NM_014553.2.
UniGeneiHs.156471.

Genome annotation databases

EnsembliENST00000263707; ENSP00000263707; ENSG00000115112.
GeneIDi29842.
KEGGihsa:29842.
UCSCiuc002tmx.4. human.

Similar proteinsi

Entry informationi

Entry nameiTF2L1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZI6
Secondary accession number(s): Q4ZG43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families