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Q9NZI6

- TF2L1_HUMAN

UniProt

Q9NZI6 - TF2L1_HUMAN

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Protein

Transcription factor CP2-like protein 1

Gene

TFCP2L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct development in the salivary gland and kidney (By similarity). Modulates the placental expression of CYP11A1.By similarity1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc
  3. transcription corepressor activity Source: ProtInc

GO - Biological processi

  1. cell morphogenesis Source: Ensembl
  2. cytoplasm organization Source: Ensembl
  3. determination of adult lifespan Source: Ensembl
  4. epithelial cell maturation Source: Ensembl
  5. female pregnancy Source: ProtInc
  6. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  7. positive regulation of growth Source: Ensembl
  8. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  9. salivary gland development Source: Ensembl
  10. steroid biosynthetic process Source: ProtInc
  11. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor CP2-like protein 1
Alternative name(s):
CP2-related transcriptional repressor 1
Short name:
CRTR-1
Transcription factor LBP-9
Gene namesi
Name:TFCP2L1
Synonyms:CRTR1, LBP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:17925. TFCP2L1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. membrane Source: Ensembl
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134980544.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Transcription factor CP2-like protein 1PRO_0000228006Add
BLAST

Proteomic databases

MaxQBiQ9NZI6.
PaxDbiQ9NZI6.
PRIDEiQ9NZI6.

PTM databases

PhosphoSiteiQ9NZI6.

Expressioni

Tissue specificityi

Highly expressed in placental JEG-3 cells and very low levels of expression in non-steroidogenic cells. No expression was seen in adrenal NCI-H295A cells or in adrenal tissue.1 Publication

Gene expression databases

BgeeiQ9NZI6.
CleanExiHS_TFCP2L1.
ExpressionAtlasiQ9NZI6. baseline and differential.
GenevestigatoriQ9NZI6.

Organism-specific databases

HPAiHPA029708.

Interactioni

Protein-protein interaction databases

BioGridi118929. 3 interactions.
IntActiQ9NZI6. 1 interaction.
STRINGi9606.ENSP00000263707.

Structurei

3D structure databases

ProteinModelPortaliQ9NZI6.
SMRiQ9NZI6. Positions 302-362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5252Mediate transcriptional repressionAdd
BLAST

Sequence similaritiesi

Belongs to the grh/CP2 family. CP2 subfamily.Curated

Phylogenomic databases

eggNOGiNOG275458.
GeneTreeiENSGT00760000119235.
HOGENOMiHOG000230625.
HOVERGENiHBG053805.
InParanoidiQ9NZI6.
KOiK09275.
OMAiDVAYQVN.
OrthoDBiEOG7FBRHB.
PhylomeDBiQ9NZI6.
TreeFamiTF314132.

Family and domain databases

InterProiIPR007604. CP2.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF04516. CP2. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NZI6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFWHTQPEH YNQHNSGSYL RDVLALPIFK QEEPQLSPEN EARLPPLQYV
60 70 80 90 100
LCAATSPAVK LHEETLTYLN QGQSYEIRLL ENRKLGDFQD LNTKYVKSII
110 120 130 140 150
RVVFHDRRLQ YTEHQQLEGW RWSRPGDRIL DIDIPLSVGI LDPRASPTQL
160 170 180 190 200
NAVEFLWDPA KRASAFIQVH CISTEFTPRK HGGEKGVPFR VQIDTFKQNE
210 220 230 240 250
NGEYTEHLHS ASCQIKVFKP KGADRKQKTD REKMEKRTAQ EKEKYQPSYE
260 270 280 290 300
TTILTECSPW PDVAYQVNSA PSPSYNGSPN SFGLGEGNAS PTHPVEALPV
310 320 330 340 350
GSDHLLPSAS IQDAQQWLHR NRFSQFCRLF ASFSGADLLK MSRDDLVQIC
360 370 380 390 400
GPADGIRLFN AIKGRNVRPK MTIYVCQELE QNRVPLQQKR DGSGDSNLSV
410 420 430 440 450
YHAIFLEELT TLELIEKIAN LYSISPQHIH RVYRQGPTGI HVVVSNEMVQ
460 470
NFQDESCFVL STIKAESNDG YHIILKCGL
Length:479
Mass (Da):54,627
Last modified:October 1, 2000 - v1
Checksum:iC2D0B56D0705AE75
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF198488 mRNA. Translation: AAF32275.1.
AC013399 Genomic DNA. Translation: AAX88871.1.
AC079988 Genomic DNA. No translation available.
BC064698 mRNA. Translation: AAH64698.1.
CCDSiCCDS2134.1.
RefSeqiNP_055368.1. NM_014553.2.
UniGeneiHs.156471.

Genome annotation databases

EnsembliENST00000263707; ENSP00000263707; ENSG00000115112.
GeneIDi29842.
KEGGihsa:29842.
UCSCiuc002tmx.3. human.

Polymorphism databases

DMDMi74734729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF198488 mRNA. Translation: AAF32275.1 .
AC013399 Genomic DNA. Translation: AAX88871.1 .
AC079988 Genomic DNA. No translation available.
BC064698 mRNA. Translation: AAH64698.1 .
CCDSi CCDS2134.1.
RefSeqi NP_055368.1. NM_014553.2.
UniGenei Hs.156471.

3D structure databases

ProteinModelPortali Q9NZI6.
SMRi Q9NZI6. Positions 302-362.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118929. 3 interactions.
IntActi Q9NZI6. 1 interaction.
STRINGi 9606.ENSP00000263707.

PTM databases

PhosphoSitei Q9NZI6.

Polymorphism databases

DMDMi 74734729.

Proteomic databases

MaxQBi Q9NZI6.
PaxDbi Q9NZI6.
PRIDEi Q9NZI6.

Protocols and materials databases

DNASUi 29842.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263707 ; ENSP00000263707 ; ENSG00000115112 .
GeneIDi 29842.
KEGGi hsa:29842.
UCSCi uc002tmx.3. human.

Organism-specific databases

CTDi 29842.
GeneCardsi GC02M121974.
HGNCi HGNC:17925. TFCP2L1.
HPAi HPA029708.
MIMi 609785. gene.
neXtProti NX_Q9NZI6.
PharmGKBi PA134980544.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG275458.
GeneTreei ENSGT00760000119235.
HOGENOMi HOG000230625.
HOVERGENi HBG053805.
InParanoidi Q9NZI6.
KOi K09275.
OMAi DVAYQVN.
OrthoDBi EOG7FBRHB.
PhylomeDBi Q9NZI6.
TreeFami TF314132.

Miscellaneous databases

ChiTaRSi TFCP2L1. human.
GenomeRNAii 29842.
NextBioi 52375.
PROi Q9NZI6.
SOURCEi Search...

Gene expression databases

Bgeei Q9NZI6.
CleanExi HS_TFCP2L1.
ExpressionAtlasi Q9NZI6. baseline and differential.
Genevestigatori Q9NZI6.

Family and domain databases

InterProi IPR007604. CP2.
IPR013761. SAM/pointed.
[Graphical view ]
Pfami PF04516. CP2. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc."
    Huang N., Miller W.L.
    J. Biol. Chem. 275:2852-2858(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Placenta.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiTF2L1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZI6
Secondary accession number(s): Q4ZG43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3