Q9NZI6 (TF2L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor CP2-like protein 1

Alternative name(s):
CP2-related transcriptional repressor 1
Short name=CRTR-1
Transcription factor LBP-9

Gene names

Name:	TFCP2L1
Synonyms:	CRTR1, LBP9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct development in the salivary gland and kidney By similarity. Modulates the placental expression of CYP11A1. Ref.1
Subcellular location	Nucleus Ref.1.
Tissue specificity	Highly expressed in placental JEG-3 cells and very low levels of expression in non-steroidogenic cells. No expression was seen in adrenal NCI-H295A cells or in adrenal tissue. Ref.1
Sequence similarities	Belongs to the grh/CP2 family. CP2 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell morphogenesis Inferred from electronic annotation. Source: Compara cytoplasm organization Inferred from electronic annotation. Source: Compara determination of adult lifespan Inferred from electronic annotation. Source: Compara epithelial cell maturation Inferred from electronic annotation. Source: Compara female pregnancy Traceable author statement Ref.1. Source: ProtInc negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of growth Inferred from electronic annotation. Source: Compara regulation of transcription from RNA polymerase II promoter Traceable author statement Ref.1. Source: ProtInc salivary gland development Inferred from electronic annotation. Source: Compara steroid biosynthetic process Traceable author statement Ref.1. Source: ProtInc transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	membrane Inferred from electronic annotation. Source: Compara mitochondrion Inferred from direct assay. Source: HPA nucleolus Inferred from direct assay. Source: HPA
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Traceable author statement Ref.1. Source: ProtInc transcription corepressor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	Transcription factor CP2-like protein 1		PRO_0000228006
Regions
	Region	1 – 52	52	Mediate transcriptional repression

Sequences

	Sequence		Length	Mass (Da)
	Q9NZI6 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: C2D0B56D0705AE75	FASTA	479	54,627
	10 20 30 40 50 60 MLFWHTQPEH YNQHNSGSYL RDVLALPIFK QEEPQLSPEN EARLPPLQYV LCAATSPAVK 70 80 90 100 110 120 LHEETLTYLN QGQSYEIRLL ENRKLGDFQD LNTKYVKSII RVVFHDRRLQ YTEHQQLEGW 130 140 150 160 170 180 RWSRPGDRIL DIDIPLSVGI LDPRASPTQL NAVEFLWDPA KRASAFIQVH CISTEFTPRK 190 200 210 220 230 240 HGGEKGVPFR VQIDTFKQNE NGEYTEHLHS ASCQIKVFKP KGADRKQKTD REKMEKRTAQ 250 260 270 280 290 300 EKEKYQPSYE TTILTECSPW PDVAYQVNSA PSPSYNGSPN SFGLGEGNAS PTHPVEALPV 310 320 330 340 350 360 GSDHLLPSAS IQDAQQWLHR NRFSQFCRLF ASFSGADLLK MSRDDLVQIC GPADGIRLFN 370 380 390 400 410 420 AIKGRNVRPK MTIYVCQELE QNRVPLQQKR DGSGDSNLSV YHAIFLEELT TLELIEKIAN 430 440 450 460 470 LYSISPQHIH RVYRQGPTGI HVVVSNEMVQ NFQDESCFVL STIKAESNDG YHIILKCGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc." Huang N., Miller W.L. J. Biol. Chem. 275:2852-2858(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Placenta.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF198488 mRNA. Translation: AAF32275.1. AC013399 Genomic DNA. Translation: AAX88871.1. AC079988 Genomic DNA. No translation available. BC064698 mRNA. Translation: AAH64698.1.
IPI	IPI00005099.
RefSeq	NP_055368.1. NM_014553.2.
UniGene	Hs.156471.
3D structure databases
ProteinModelPortal	Q9NZI6.
SMR	Q9NZI6. Positions 281-363.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NZI6. 1 interaction.
STRING	9606.ENSP00000263707.
PTM databases
PhosphoSite	Q9NZI6.
Polymorphism databases
DMDM	74734729.
Proteomic databases
PaxDb	Q9NZI6.
PRIDE	Q9NZI6.
Protocols and materials databases
DNASU	29842.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263707; ENSP00000263707; ENSG00000115112.
GeneID	29842.
KEGG	hsa:29842.
UCSC	uc002tmx.3. human.
Organism-specific databases
CTD	29842.
GeneCards	GC02M121974.
HGNC	HGNC:17925. TFCP2L1.
HPA	HPA029708.
MIM	609785. gene.
neXtProt	NX_Q9NZI6.
PharmGKB	PA134980544.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG275458.
HOGENOM	HOG000230625.
HOVERGEN	HBG053805.
InParanoid	Q9NZI6.
KO	K09275.
OMA	DESCFVI.
OrthoDB	EOG4K3KW2.
PhylomeDB	Q9NZI6.
Gene expression databases
ArrayExpress	Q9NZI6.
Bgee	Q9NZI6.
CleanEx	HS_TFCP2L1.
Genevestigator	Q9NZI6.
GermOnline	ENSG00000115112. Homo sapiens.
Family and domain databases
InterPro	IPR007604. CP2. IPR013761. SAM/pointed. [Graphical view]
Pfam	PF04516. CP2. 1 hit. [Graphical view]
SUPFAM	SSF47769. SAM_homology. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	TFCP2L1. human.
GenomeRNAi	29842.
NextBio	52375.
SOURCE	Search...

Entry information

Entry name

TF2L1_HUMAN

Accession

Primary (citable) accession number: Q9NZI6
Secondary accession number(s): Q4ZG43

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.