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Protein

Transcription factor CP2-like protein 1

Gene

TFCP2L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity). Required for normal duct development in the salivary gland and kidney (By similarity). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity). Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity). JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity). Modulates the placental expression of CYP11A1 (PubMed:10644752).By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor CP2-like protein 1
Alternative name(s):
CP2-related transcriptional repressor 1
Short name:
CRTR-1
Transcription factor LBP-9
Gene namesi
Name:TFCP2L1
Synonyms:CRTR1, LBP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115112.7
HGNCiHGNC:17925 TFCP2L1
MIMi609785 gene
neXtProtiNX_Q9NZI6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi345D → G: Impairs the formation of oligomeric homo-complexes in solution. 1 Publication1

Organism-specific databases

DisGeNETi29842
OpenTargetsiENSG00000115112
PharmGKBiPA134980544

Polymorphism and mutation databases

BioMutaiTFCP2L1
DMDMi74734729

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002280061 – 479Transcription factor CP2-like protein 1Add BLAST479

Proteomic databases

EPDiQ9NZI6
MaxQBiQ9NZI6
PaxDbiQ9NZI6
PeptideAtlasiQ9NZI6
PRIDEiQ9NZI6
ProteomicsDBi83407

PTM databases

iPTMnetiQ9NZI6
PhosphoSitePlusiQ9NZI6

Expressioni

Tissue specificityi

Highly expressed in placental JEG-3 cells and very low levels of expression in non-steroidogenic cells. No expression was seen in adrenal NCI-H295A cells or in adrenal tissue.1 Publication

Gene expression databases

BgeeiENSG00000115112
CleanExiHS_TFCP2L1
GenevisibleiQ9NZI6 HS

Organism-specific databases

HPAiHPA029708

Interactioni

Subunit structurei

Forms homohexamers via its SAM-like domain (PubMed:26906118). Interacts with MTA1; which is indispensable for TFCP2l1-mediated self-renewal-promoting effect and endoderm-inhibiting action (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi118929, 6 interactors
IntActiQ9NZI6, 1 interactor
STRINGi9606.ENSP00000263707

Structurei

3D structure databases

ProteinModelPortaliQ9NZI6
SMRiQ9NZI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 260CP2-like domain1 PublicationAdd BLAST240
Regioni261 – 365SAM2-like domain1 PublicationAdd BLAST105

Domaini

The CP2-like domain is required for direct DNA-binding (PubMed:26906118). The CP2-like domain is essential to maintain the undifferentiated state of embryonic stem cells (By similarity).By similarity1 Publication
The SAM-like domain is required for homohexamerization (PubMed:26906118).1 Publication

Sequence similaritiesi

Belongs to the grh/CP2 family. CP2 subfamily.Curated

Phylogenomic databases

eggNOGiKOG4091 Eukaryota
ENOG410XNZ6 LUCA
GeneTreeiENSGT00760000119235
HOGENOMiHOG000230625
HOVERGENiHBG053805
InParanoidiQ9NZI6
KOiK09275
OMAiHIILKCG
OrthoDBiEOG091G0YV2
PhylomeDBiQ9NZI6
TreeFamiTF314132

Family and domain databases

CDDicd09590 SAM_LBP9, 1 hit
InterProiView protein in InterPro
IPR007604 CP2
IPR013761 SAM/pointed_sf
IPR037598 TFCP2L1_SAM
PfamiView protein in Pfam
PF04516 CP2, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NZI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFWHTQPEH YNQHNSGSYL RDVLALPIFK QEEPQLSPEN EARLPPLQYV
60 70 80 90 100
LCAATSPAVK LHEETLTYLN QGQSYEIRLL ENRKLGDFQD LNTKYVKSII
110 120 130 140 150
RVVFHDRRLQ YTEHQQLEGW RWSRPGDRIL DIDIPLSVGI LDPRASPTQL
160 170 180 190 200
NAVEFLWDPA KRASAFIQVH CISTEFTPRK HGGEKGVPFR VQIDTFKQNE
210 220 230 240 250
NGEYTEHLHS ASCQIKVFKP KGADRKQKTD REKMEKRTAQ EKEKYQPSYE
260 270 280 290 300
TTILTECSPW PDVAYQVNSA PSPSYNGSPN SFGLGEGNAS PTHPVEALPV
310 320 330 340 350
GSDHLLPSAS IQDAQQWLHR NRFSQFCRLF ASFSGADLLK MSRDDLVQIC
360 370 380 390 400
GPADGIRLFN AIKGRNVRPK MTIYVCQELE QNRVPLQQKR DGSGDSNLSV
410 420 430 440 450
YHAIFLEELT TLELIEKIAN LYSISPQHIH RVYRQGPTGI HVVVSNEMVQ
460 470
NFQDESCFVL STIKAESNDG YHIILKCGL
Length:479
Mass (Da):54,627
Last modified:October 1, 2000 - v1
Checksum:iC2D0B56D0705AE75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198488 mRNA Translation: AAF32275.1
AC013399 Genomic DNA Translation: AAX88871.1
AC079988 Genomic DNA No translation available.
BC064698 mRNA Translation: AAH64698.1
CCDSiCCDS2134.1
RefSeqiNP_055368.1, NM_014553.2
UniGeneiHs.156471

Genome annotation databases

EnsembliENST00000263707; ENSP00000263707; ENSG00000115112
GeneIDi29842
KEGGihsa:29842
UCSCiuc002tmx.4 human

Similar proteinsi

Entry informationi

Entry nameiTF2L1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZI6
Secondary accession number(s): Q4ZG43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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