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Q9NZI6

- TF2L1_HUMAN

UniProt

Q9NZI6 - TF2L1_HUMAN

Protein

Transcription factor CP2-like protein 1

Gene

TFCP2L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct development in the salivary gland and kidney By similarity. Modulates the placental expression of CYP11A1.By similarity1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: ProtInc
    3. transcription corepressor activity Source: ProtInc

    GO - Biological processi

    1. cell morphogenesis Source: Ensembl
    2. cytoplasm organization Source: Ensembl
    3. determination of adult lifespan Source: Ensembl
    4. epithelial cell maturation Source: Ensembl
    5. female pregnancy Source: ProtInc
    6. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    7. positive regulation of growth Source: Ensembl
    8. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    9. salivary gland development Source: Ensembl
    10. steroid biosynthetic process Source: ProtInc
    11. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor CP2-like protein 1
    Alternative name(s):
    CP2-related transcriptional repressor 1
    Short name:
    CRTR-1
    Transcription factor LBP-9
    Gene namesi
    Name:TFCP2L1
    Synonyms:CRTR1, LBP9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:17925. TFCP2L1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. membrane Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134980544.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479Transcription factor CP2-like protein 1PRO_0000228006Add
    BLAST

    Proteomic databases

    MaxQBiQ9NZI6.
    PaxDbiQ9NZI6.
    PRIDEiQ9NZI6.

    PTM databases

    PhosphoSiteiQ9NZI6.

    Expressioni

    Tissue specificityi

    Highly expressed in placental JEG-3 cells and very low levels of expression in non-steroidogenic cells. No expression was seen in adrenal NCI-H295A cells or in adrenal tissue.1 Publication

    Gene expression databases

    ArrayExpressiQ9NZI6.
    BgeeiQ9NZI6.
    CleanExiHS_TFCP2L1.
    GenevestigatoriQ9NZI6.

    Organism-specific databases

    HPAiHPA029708.

    Interactioni

    Protein-protein interaction databases

    BioGridi118929. 3 interactions.
    IntActiQ9NZI6. 1 interaction.
    STRINGi9606.ENSP00000263707.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NZI6.
    SMRiQ9NZI6. Positions 302-362.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 5252Mediate transcriptional repressionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the grh/CP2 family. CP2 subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG275458.
    HOGENOMiHOG000230625.
    HOVERGENiHBG053805.
    InParanoidiQ9NZI6.
    KOiK09275.
    OMAiDVAYQVN.
    OrthoDBiEOG7FBRHB.
    PhylomeDBiQ9NZI6.
    TreeFamiTF314132.

    Family and domain databases

    InterProiIPR007604. CP2.
    IPR013761. SAM/pointed.
    [Graphical view]
    PfamiPF04516. CP2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9NZI6-1 [UniParc]FASTAAdd to Basket

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    MLFWHTQPEH YNQHNSGSYL RDVLALPIFK QEEPQLSPEN EARLPPLQYV    50
    LCAATSPAVK LHEETLTYLN QGQSYEIRLL ENRKLGDFQD LNTKYVKSII 100
    RVVFHDRRLQ YTEHQQLEGW RWSRPGDRIL DIDIPLSVGI LDPRASPTQL 150
    NAVEFLWDPA KRASAFIQVH CISTEFTPRK HGGEKGVPFR VQIDTFKQNE 200
    NGEYTEHLHS ASCQIKVFKP KGADRKQKTD REKMEKRTAQ EKEKYQPSYE 250
    TTILTECSPW PDVAYQVNSA PSPSYNGSPN SFGLGEGNAS PTHPVEALPV 300
    GSDHLLPSAS IQDAQQWLHR NRFSQFCRLF ASFSGADLLK MSRDDLVQIC 350
    GPADGIRLFN AIKGRNVRPK MTIYVCQELE QNRVPLQQKR DGSGDSNLSV 400
    YHAIFLEELT TLELIEKIAN LYSISPQHIH RVYRQGPTGI HVVVSNEMVQ 450
    NFQDESCFVL STIKAESNDG YHIILKCGL 479
    Length:479
    Mass (Da):54,627
    Last modified:October 1, 2000 - v1
    Checksum:iC2D0B56D0705AE75
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF198488 mRNA. Translation: AAF32275.1.
    AC013399 Genomic DNA. Translation: AAX88871.1.
    AC079988 Genomic DNA. No translation available.
    BC064698 mRNA. Translation: AAH64698.1.
    CCDSiCCDS2134.1.
    RefSeqiNP_055368.1. NM_014553.2.
    UniGeneiHs.156471.

    Genome annotation databases

    EnsembliENST00000263707; ENSP00000263707; ENSG00000115112.
    GeneIDi29842.
    KEGGihsa:29842.
    UCSCiuc002tmx.3. human.

    Polymorphism databases

    DMDMi74734729.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF198488 mRNA. Translation: AAF32275.1 .
    AC013399 Genomic DNA. Translation: AAX88871.1 .
    AC079988 Genomic DNA. No translation available.
    BC064698 mRNA. Translation: AAH64698.1 .
    CCDSi CCDS2134.1.
    RefSeqi NP_055368.1. NM_014553.2.
    UniGenei Hs.156471.

    3D structure databases

    ProteinModelPortali Q9NZI6.
    SMRi Q9NZI6. Positions 302-362.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118929. 3 interactions.
    IntActi Q9NZI6. 1 interaction.
    STRINGi 9606.ENSP00000263707.

    PTM databases

    PhosphoSitei Q9NZI6.

    Polymorphism databases

    DMDMi 74734729.

    Proteomic databases

    MaxQBi Q9NZI6.
    PaxDbi Q9NZI6.
    PRIDEi Q9NZI6.

    Protocols and materials databases

    DNASUi 29842.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263707 ; ENSP00000263707 ; ENSG00000115112 .
    GeneIDi 29842.
    KEGGi hsa:29842.
    UCSCi uc002tmx.3. human.

    Organism-specific databases

    CTDi 29842.
    GeneCardsi GC02M121974.
    HGNCi HGNC:17925. TFCP2L1.
    HPAi HPA029708.
    MIMi 609785. gene.
    neXtProti NX_Q9NZI6.
    PharmGKBi PA134980544.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG275458.
    HOGENOMi HOG000230625.
    HOVERGENi HBG053805.
    InParanoidi Q9NZI6.
    KOi K09275.
    OMAi DVAYQVN.
    OrthoDBi EOG7FBRHB.
    PhylomeDBi Q9NZI6.
    TreeFami TF314132.

    Miscellaneous databases

    ChiTaRSi TFCP2L1. human.
    GenomeRNAii 29842.
    NextBioi 52375.
    PROi Q9NZI6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NZI6.
    Bgeei Q9NZI6.
    CleanExi HS_TFCP2L1.
    Genevestigatori Q9NZI6.

    Family and domain databases

    InterProi IPR007604. CP2.
    IPR013761. SAM/pointed.
    [Graphical view ]
    Pfami PF04516. CP2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc."
      Huang N., Miller W.L.
      J. Biol. Chem. 275:2852-2858(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Placenta.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiTF2L1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NZI6
    Secondary accession number(s): Q4ZG43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3