ID   IL1F9_HUMAN             Reviewed;         169 AA.
AC   Q9NZH8; Q56B91; Q6UVX7; Q7RTZ9;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   19-JAN-2010, entry version 77.
DE   RecName: Full=Interleukin-1 family member 9;
DE            Short=IL-1F9;
DE   AltName: Full=Interleukin-1 homolog 1;
DE            Short=IL-1H1;
DE   AltName: Full=Interleukin-1 epsilon;
DE            Short=IL-1 epsilon;
DE   AltName: Full=IL-1-related protein 2;
DE            Short=IL-1RP2;
GN   Name=IL1F9; Synonyms=IL1E, IL1H1, IL1RP2; ORFNames=UNQ2456/PRO5737;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Keratinocyte;
RX   MEDLINE=20209405; PubMed=10744718; DOI=10.1074/jbc.275.14.10308;
RA   Kumar S., McDonnell P.C., Lehr R., Tierney L., Tzimas M.N.,
RA   Griswold D.E., Capper E.A., Tal-Singer R., Wells G.I., Doyle M.L.,
RA   Young P.R.;
RT   "Identification and initial characterization of four novel members of
RT   the interleukin-1 family.";
RL   J. Biol. Chem. 275:10308-10314(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND CHARACTERIZATION.
RC   TISSUE=Epithelium;
RX   MEDLINE=21359532; PubMed=11466363;
RA   Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S.,
RA   Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F.,
RA   Kastelein R.A.;
RT   "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function
RT   as an antagonist and agonist of NF-kappa B activation through the
RT   orphan IL-1 receptor-related protein 2.";
RL   J. Immunol. 167:1440-1446(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=20318623; PubMed=10860666; DOI=10.1006/geno.2000.6184;
RA   Busfield S.J., Comrack C.A., Yu G., Chickering T.W., Smutko J.S.,
RA   Zhou H., Leiby K.R., Holmgren L.M., Gearing D.P., Pan Y.;
RT   "Identification and gene organization of three novel members of the
RT   IL-1 family on human chromosome 2.";
RL   Genomics 66:213-216(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=21988050; PubMed=11991722; DOI=10.1006/geno.2002.6751;
RA   Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G.,
RA   Kornman K.;
RT   "A sequence-based map of the nine genes of the human interleukin-1
RT   cluster.";
RL   Genomics 79:718-725(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG   SeattleSNPs variation discovery resource;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Function as an agonist of NF-kappa B activation through
CC       the orphan IL-1-receptor-related protein 2. Could constitute part
CC       of an independent signaling system analogous to interleukin-1
CC       alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1
CC       receptor type I (IL-1R1), that is present in epithelial barriers
CC       and takes part in local inflammatory response.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9NZH8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9NZH8-2; Sequence=VSP_013002;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Highly expressed in tissues containing
CC       epithelial cells: skin, lung, stomach and esophagus. In skin is
CC       expressed only in keratinocytes but not in fibroblasts,
CC       endothelial cells or melanocytes. Up-regulated in lesional
CC       psoriasis skin.
CC   -!- INDUCTION: By TNF-alpha and by IFN-gamma in keratinocytes.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry;
CC       URL="http://en.wikipedia.org/wiki/Interleukin_1";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il1f9/";
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DR   EMBL; AF200492; AAF69248.1; -; mRNA.
DR   EMBL; AF206696; AAG35670.1; -; mRNA.
DR   EMBL; BN000002; CAD29874.1; -; Genomic_DNA.
DR   EMBL; AY359111; AAQ89469.1; -; mRNA.
DR   EMBL; AY968311; AAX59035.1; -; Genomic_DNA.
DR   EMBL; AC016724; AAY14987.1; -; Genomic_DNA.
DR   EMBL; BC096721; AAH96721.1; -; mRNA.
DR   EMBL; BC098130; AAH98130.1; -; mRNA.
DR   EMBL; BC098155; AAH98155.1; -; mRNA.
DR   EMBL; BC098337; AAH98337.1; -; mRNA.
DR   IPI; IPI00021343; -.
DR   IPI; IPI00432063; -.
DR   RefSeq; NP_062564.1; -.
DR   UniGene; Hs.211238; -.
DR   SMR; Q9NZH8; 24-166.
DR   STRING; Q9NZH8; -.
DR   PhosphoSite; Q9NZH8; -.
DR   PRIDE; Q9NZH8; -.
DR   Ensembl; ENST00000259205; ENSP00000259205; ENSG00000136688; Homo sapiens.
DR   GeneID; 56300; -.
DR   KEGG; hsa:56300; -.
DR   UCSC; uc002tio.1; human.
DR   UCSC; uc010fkr.1; human.
DR   CTD; 56300; -.
DR   GeneCards; GC02P113451; -.
DR   H-InvDB; HIX0029828; -.
DR   HGNC; HGNC:15741; IL1F9.
DR   MIM; 605542; gene.
DR   PharmGKB; PA38395; -.
DR   eggNOG; prNOG15159; -.
DR   HOGENOM; HBG281875; -.
DR   HOVERGEN; Q9NZH8; -.
DR   InParanoid; Q9NZH8; -.
DR   OMA; PCKYPES; -.
DR   PhylomeDB; Q9NZH8; -.
DR   NextBio; 61963; -.
DR   ArrayExpress; Q9NZH8; -.
DR   Bgee; Q9NZH8; -.
DR   CleanEx; HS_IL1F9; -.
DR   Genevestigator; Q9NZH8; -.
DR   GermOnline; ENSG00000136688; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005152; F:interleukin-1 receptor antagonist activity; IEA:InterPro.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR003297; IL_rcpt_IL1RA.
DR   InterPro; IPR000975; Interleukin_1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SMART; SM00125; IL1; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; FALSE_NEG.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; Cytokine; Polymorphism;
KW   Secreted.
FT   CHAIN         1    169       Interleukin-1 family member 9.
FT                                /FTId=PRO_0000153648.
FT   VAR_SEQ      19     54       MCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPV -> I
FT                                (in isoform 2).
FT                                /FTId=VSP_013002.
FT   VARIANT      69     69       Q -> K (in dbSNP:rs6707930).
FT                                /FTId=VAR_024505.
SQ   SEQUENCE   169 AA;  18721 MW;  F00A9243706F4154 CRC64;
     MRGTPGDADG GGRAVYQSMC KPITGTINDL NQQVWTLQGQ NLVAVPRSDS VTPVTVAVIT
     CKYPEALEQG RGDPIYLGIQ NPEMCLYCEK VGEQPTLQLK EQKIMDLYGQ PEPVKPFLFY
     RAKTGRTSTL ESVAFPDWFI ASSKRDQPII LTSELGKSYN TAFELNIND
//