Reviewed, UniProtKB/Swiss-Prot Q9NZH8 (IL1F9_HUMAN)

Names and origin

Protein names

Recommended name:
    Interleukin-1 family member 9
      Short name=IL-1F9
Alternative name(s):
    Interleukin-1 homolog 1
      Short name=IL-1H1
    Interleukin-1 epsilon
      Short name=IL-1 epsilon
    IL-1-related protein 2
      Short name=IL-1RP2

Gene names

Name:	IL1F9
Synonyms:	IL1E, IL1H1, IL1RP2
ORF Names:	UNQ2456/PRO5737

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	169 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
Subcellular location	Secreted.
Tissue specificity	Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up-regulated in lesional psoriasis skin.
Induction	By TNF-alpha and by IFN-gamma in keratinocytes.
Sequence similarities	Belongs to the IL-1 family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Cytokine
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell-cell signaling Ref.1 Traceable author statement. Source: ProtInc
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW interleukin-1 receptor antagonist activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NZH8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NZH8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     19-54: MCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPV → I

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 169	169	Interleukin-1 family member 9		PRO_0000153648
Natural variations
	Alternative sequence	19 – 54	36	MCKPI…SVTPV → I in isoform 2.		VSP_013002
	Natural variant	69	1	Q → K: dbSNP rs6707930.		VAR_024505

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: F00A9243706F4154	FASTA	169	18,721
	10 20 30 40 50 60 MRGTPGDADG GGRAVYQSMC KPITGTINDL NQQVWTLQGQ NLVAVPRSDS VTPVTVAVIT 70 80 90 100 110 120 CKYPEALEQG RGDPIYLGIQ NPEMCLYCEK VGEQPTLQLK EQKIMDLYGQ PEPVKPFLFY 130 140 150 160 RAKTGRTSTL ESVAFPDWFI ASSKRDQPII LTSELGKSYN TAFELNIND
	Isoform 2. Checksum: D5369C5AD44A9752	FASTA	134	14,928
	10 20 30 40 50 60 MRGTPGDADG GGRAVYQSIT VAVITCKYPE ALEQGRGDPI YLGIQNPEMC LYCEKVGEQP 70 80 90 100 110 120 TLQLKEQKIM DLYGQPEPVK PFLFYRAKTG RTSTLESVAF PDWFIASSKR DQPIILTSEL 130 GKSYNTAFEL NIND

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and initial characterization of four novel members of the interleukin-1 family." Kumar S., McDonnell P.C., Lehr R., Tierney L., Tzimas M.N., Griswold D.E., Capper E.A., Tal-Singer R., Wells G.I., Doyle M.L., Young P.R. J. Biol. Chem. 275:10308-10314(2000) [PubMed: 10744718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Keratinocyte.
[2]	"Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2." Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S., Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F., Kastelein R.A. J. Immunol. 167:1440-1446(2001) [PubMed: 11466363] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION. Tissue: Epithelium.
[3]	"Identification and gene organization of three novel members of the IL-1 family on human chromosome 2." Busfield S.J., Comrack C.A., Yu G., Chickering T.W., Smutko J.S., Zhou H., Leiby K.R., Holmgren L.M., Gearing D.P., Pan Y. Genomics 66:213-216(2000) [PubMed: 10860666] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"A sequence-based map of the nine genes of the human interleukin-1 cluster." Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G., Kornman K. Genomics 79:718-725(2002) [PubMed: 11991722] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[6]	SeattleSNPs variation discovery resource Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+	Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-1 entry

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF200492 mRNA. Translation: AAF69248.1. AF206696 mRNA. Translation: AAG35670.1. BN000002 Genomic DNA. Translation: CAD29874.1. AY359111 mRNA. Translation: AAQ89469.1. AY968311 Genomic DNA. Translation: AAX59035.1. AC016724 Genomic DNA. Translation: AAY14987.1. BC096721 mRNA. Translation: AAH96721.1. BC098130 mRNA. Translation: AAH98130.1. BC098155 mRNA. Translation: AAH98155.1. BC098337 mRNA. Translation: AAH98337.1.
IPI	IPI00021343. IPI00432063.
RefSeq	NP_062564.1.
UniGene	Hs.211238
3D structure databases
SMR	Q9NZH8. Positions 24-166.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NZH8.
PTM databases
PhosphoSite	Q9NZH8.
Proteomic databases
PRIDE	Q9NZH8.
Genome annotation databases
Ensembl	ENST00000259205; ENSP00000259205; ENSG00000136688; Homo sapiens. [Genome view]
GeneID	56300.
KEGG	hsa:56300.
UCSC	uc002tio.1. human. uc010fkr.1. human.
Organism-specific databases
CTD	56300.
GeneCards	GC02P113451.
H-InvDB	HIX0029828.
HGNC	HGNC:15741. IL1F9.
MIM	605542. gene.
PharmGKB	PA38395.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15159.
HOGENOM	HBG281875.
HOVERGEN	Q9NZH8.
InParanoid	Q9NZH8.
OMA	PCKYPES.
PhylomeDB	Q9NZH8.
Gene expression databases
ArrayExpress	Q9NZH8.
Bgee	Q9NZH8.
CleanEx	HS_IL1F9.
Genevestigator	Q9NZH8.
GermOnline	ENSG00000136688. Homo sapiens.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR003297. IL_rcpt_IL1RA. IPR000975. Interleukin_1. [Graphical view]
Pfam	PF00340. IL1. 1 hit. [Graphical view]
PRINTS	PR00264. INTERLEUKIN1. PR01360. INTRLEUKIN1X.
SMART	SM00125. IL1. 1 hit. [Graphical view]
PROSITE	PS00253. INTERLEUKIN_1. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	61963.
SOURCE	Search...

Entry information

Entry name

IL1F9_HUMAN

Accession

Primary (citable) accession number: Q9NZH8
Secondary accession number(s): Q56B91, Q6UVX7, Q7RTZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2000
Last modified:	January 19, 2010
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.