ID   IL36B_HUMAN             Reviewed;         164 AA.
AC   Q9NZH7; Q3MIH0; Q53SR6; Q7RTZ7; Q9UHA5;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-JAN-2012, entry version 82.
DE   RecName: Full=Interleukin-36 beta;
DE   AltName: Full=FIL1 eta;
DE   AltName: Full=Interleukin-1 eta;
DE            Short=IL-1 eta;
DE   AltName: Full=Interleukin-1 family member 8;
DE            Short=IL-1F8;
DE   AltName: Full=Interleukin-1 homolog 2;
DE            Short=IL-1H2;
GN   Name=IL36B; Synonyms=IL1F8, IL1H2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Osteoclastoma;
RX   MEDLINE=20209405; PubMed=10744718; DOI=10.1074/jbc.275.14.10308;
RA   Kumar S., McDonnell P.C., Lehr R., Tierney L., Tzimas M.N.,
RA   Griswold D.E., Capper E.A., Tal-Singer R., Wells G.I., Doyle M.L.,
RA   Young P.R.;
RT   "Identification and initial characterization of four novel members of
RT   the interleukin-1 family.";
RL   J. Biol. Chem. 275:10308-10314(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX   MEDLINE=20092888; PubMed=10625660; DOI=10.1074/jbc.275.2.1169;
RA   Smith D.E., Renshaw B.R., Ketchem R.R., Kubin M., Garka K.E.,
RA   Sims J.E.;
RT   "Four new members expand the IL-1 superfamily.";
RL   J. Biol. Chem. 275:1169-1175(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=21988050; PubMed=11991722; DOI=10.1006/geno.2002.6751;
RA   Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G.,
RA   Kornman K.;
RT   "A sequence-based map of the nine genes of the human interleukin-1
RT   cluster.";
RL   Genomics 79:718-725(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT CYS-36.
RG   SeattleSNPs variation discovery resource;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Lung, and Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=16646978; DOI=10.1186/ar1946;
RA   Magne D., Palmer G., Barton J.L., Mezin F., Talabot-Ayer D., Bas S.,
RA   Duffy T., Noger M., Guerne P.A., Nicklin M.J., Gabay C.;
RT   "The new IL-1 family member IL-1F8 stimulates production of
RT   inflammatory mediators by synovial fibroblasts and articular
RT   chondrocytes.";
RL   Arthritis Res. Ther. 8:R80-R80(2006).
RN   [9]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=20300079; DOI=10.1038/oby.2010.55;
RA   van Asseldonk E.J., Stienstra R., Koenen T.B., van Tits L.J.,
RA   Joosten L.A., Tack C.J., Netea M.G.;
RT   "The effect of the interleukin-1 cytokine family members IL-1F6 and
RT   IL-1F8 on adipocyte differentiation.";
RL   Obesity 18:2234-2236(2010).
RN   [10]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=21242515; DOI=10.4049/jimmunol.1003162;
RA   Johnston A., Xing X., Guzman A.M., Riblett M., Loyd C.M., Ward N.L.,
RA   Wohn C., Prens E.P., Wang F., Maier L.E., Kang S., Voorhees J.J.,
RA   Elder J.T., Gudjonsson J.E.;
RT   "IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that
RT   is active in psoriasis and promotes keratinocyte antimicrobial peptide
RT   expression.";
RL   J. Immunol. 186:2613-2622(2011).
CC   -!- FUNCTION: Stimulates production of interleukin-6 and interleukin-8
CC       in synovial fibrobasts, articular chondrocytes and mature
CC       adipocytes. Induces expression of a number of antimicrobial
CC       peptides including beta-defensins 4 and 103 as well as a number of
CC       matrix metalloproteases.
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9NZH7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9NZH7-2; Sequence=VSP_002657;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Expression at low levels in tonsil, bone
CC       marrow, heart, placenta, lung, testis and colon but not in any
CC       hematopoietic cell lines. Not detected in adipose tissue.
CC       Expressed at higher levels in psoriatic plaques than in
CC       symptomless psoriatic skin or healthy control skin. Increased
CC       levels are not detected in inflamed joint tissue.
CC   -!- INDUCTION: By proinflammatory cytokines IL1A, IL1B and TNF in
CC       synovial fibroblasts. By IL1A and TNF in keratinocytes.
CC       Constitutive in articular chondrocytes.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry;
CC       URL="http://en.wikipedia.org/wiki/Interleukin_1";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il1f8/";
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DR   EMBL; AF200494; AAF69250.1; -; mRNA.
DR   EMBL; AF201833; AAF25213.1; -; mRNA.
DR   EMBL; CH471217; EAW73615.1; -; Genomic_DNA.
DR   EMBL; BC101831; AAI01832.1; -; mRNA.
DR   EMBL; BC101833; AAI01834.1; -; mRNA.
DR   EMBL; BN000002; CAD29876.1; -; Genomic_DNA.
DR   EMBL; DQ224343; ABA60896.1; -; Genomic_DNA.
DR   EMBL; AC016724; AAY14989.1; -; Genomic_DNA.
DR   IPI; IPI00005404; -.
DR   IPI; IPI00218473; -.
DR   RefSeq; NP_055253.2; NM_014438.3.
DR   RefSeq; NP_775270.1; NM_173178.1.
DR   UniGene; Hs.278909; -.
DR   ProteinModelPortal; Q9NZH7; -.
DR   SMR; Q9NZH7; 10-98.
DR   STRING; Q9NZH7; -.
DR   DMDM; 25008595; -.
DR   PRIDE; Q9NZH7; -.
DR   Ensembl; ENST00000259213; ENSP00000259213; ENSG00000136696.
DR   GeneID; 27177; -.
DR   KEGG; hsa:27177; -.
DR   UCSC; uc002tiq.1; human.
DR   UCSC; uc002tir.1; human.
DR   CTD; 27177; -.
DR   GeneCards; GC02M113779; -.
DR   H-InvDB; HIX0029829; -.
DR   HGNC; HGNC:15564; IL36B.
DR   HPA; HPA035664; -.
DR   MIM; 605508; gene.
DR   neXtProt; NX_Q9NZH7; -.
DR   PharmGKB; PA38391; -.
DR   GeneTree; ENSGT00530000062899; -.
DR   InParanoid; Q9NZH7; -.
DR   OMA; AQKPFLF; -.
DR   OrthoDB; EOG4N8R5X; -.
DR   PhylomeDB; Q9NZH7; -.
DR   NextBio; 49986; -.
DR   ArrayExpress; Q9NZH7; -.
DR   Bgee; Q9NZH7; -.
DR   CleanEx; HS_IL1F8; -.
DR   Genevestigator; Q9NZH7; -.
DR   GermOnline; ENSG00000136696; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; NAS:UniProtKB.
DR   GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; Interleukin_1.
DR   KO; K05486; -.
DR   SMART; SM00125; IL1; 1.
DR   SUPFAM; SSF50353; Cytok_IL1_like; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; FALSE_NEG.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Cytokine; Polymorphism;
KW   Reference proteome; Secreted.
FT   CHAIN         1    164       Interleukin-36 beta.
FT                                /FTId=PRO_0000153646.
FT   VAR_SEQ      88    164       LQGSQDNIGKDTCWKLVGIHTCINLDVRESCFMGTLDQWGI
FT                                GVGRKKWKSSFQHHHLRKKDKDFSSMRTNIGMPGRM -> E
FT                                KNIMDLYVEKKAQKPFLFFHNKEGSTSVFQSVSYPGWFIAT
FT                                STTSGQPIFLTKERGITNNTNFYLDSVE (in isoform
FT                                2).
FT                                /FTId=VSP_002657.
FT   VARIANT      36     36       R -> C (in dbSNP:rs34754959).
FT                                /FTId=VAR_025057.
SQ   SEQUENCE   164 AA;  18522 MW;  F0D2099F4A357A0A CRC64;
     MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGN
     MVYLGIKGKD LCLFCAEIQG KPTLQLKLQG SQDNIGKDTC WKLVGIHTCI NLDVRESCFM
     GTLDQWGIGV GRKKWKSSFQ HHHLRKKDKD FSSMRTNIGM PGRM
//