ID   IL1F8_HUMAN             Reviewed;         164 AA.
AC   Q9NZH7; Q53SR6; Q7RTZ7; Q9UHA5;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-NOV-2009, entry version 65.
DE   RecName: Full=Interleukin-1 family member 8;
DE            Short=IL-1F8;
DE   AltName: Full=Interleukin-1 eta;
DE            Short=IL-1 eta;
DE   AltName: Full=FIL1 eta;
DE   AltName: Full=Interleukin-1 homolog 2;
DE            Short=IL-1H2;
GN   Name=IL1F8; Synonyms=IL1H2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Osteoclastoma;
RX   MEDLINE=20209405; PubMed=10744718; DOI=10.1074/jbc.275.14.10308;
RA   Kumar S., McDonnell P.C., Lehr R., Tierney L., Tzimas M.N.,
RA   Griswold D.E., Capper E.A., Tal-Singer R., Wells G.I., Doyle M.L.,
RA   Young P.R.;
RT   "Identification and initial characterization of four novel members of
RT   the interleukin-1 family.";
RL   J. Biol. Chem. 275:10308-10314(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX   MEDLINE=20092888; PubMed=10625660; DOI=10.1074/jbc.275.2.1169;
RA   Smith D.E., Renshaw B.R., Ketchem R.R., Kubin M., Garka K.E.,
RA   Sims J.E.;
RT   "Four new members expand the IL-1 superfamily.";
RL   J. Biol. Chem. 275:1169-1175(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=21988050; PubMed=11991722; DOI=10.1006/geno.2002.6751;
RA   Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G.,
RA   Kornman K.;
RT   "A sequence-based map of the nine genes of the human interleukin-1
RT   cluster.";
RL   Genomics 79:718-725(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT CYS-36.
RG   SeattleSNPs variation discovery resource;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9NZH7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9NZH7-2; Sequence=VSP_002657;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Expression at low levels in tonsil, bone
CC       marrow, heart, placenta, lung, testis and colon but not in other
CC       tissues or in any hematopoietic cell lines.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry;
CC       URL="http://en.wikipedia.org/wiki/Interleukin_1";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il1f8/";
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DR   EMBL; AF200494; AAF69250.1; -; mRNA.
DR   EMBL; AF201833; AAF25213.1; -; mRNA.
DR   EMBL; BN000002; CAD29876.1; -; Genomic_DNA.
DR   EMBL; DQ224343; ABA60896.1; -; Genomic_DNA.
DR   EMBL; AC016724; AAY14989.1; -; Genomic_DNA.
DR   IPI; IPI00005404; -.
DR   IPI; IPI00218473; -.
DR   RefSeq; NP_055253.2; -.
DR   RefSeq; NP_775270.1; -.
DR   UniGene; Hs.278909; -.
DR   STRING; Q9NZH7; -.
DR   PRIDE; Q9NZH7; -.
DR   Ensembl; ENST00000259213; ENSP00000259213; ENSG00000136696; Homo sapiens.
DR   Ensembl; ENST00000327407; ENSP00000328420; ENSG00000136696; Homo sapiens.
DR   Ensembl; ENST00000422169; ENSP00000406343; ENSG00000136696; Homo sapiens.
DR   GeneID; 27177; -.
DR   KEGG; hsa:27177; -.
DR   UCSC; uc002tiq.1; human.
DR   UCSC; uc002tir.1; human.
DR   CTD; 27177; -.
DR   GeneCards; GC02M113496; -.
DR   H-InvDB; HIX0029829; -.
DR   HGNC; HGNC:15564; IL1F8.
DR   MIM; 605508; gene.
DR   PharmGKB; PA38391; -.
DR   OMA; GIHTCIN; -.
DR   NextBio; 49986; -.
DR   ArrayExpress; Q9NZH7; -.
DR   Bgee; Q9NZH7; -.
DR   CleanEx; HS_IL1F8; -.
DR   Genevestigator; Q9NZH7; -.
DR   GermOnline; ENSG00000136696; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; NAS:UniProtKB.
DR   GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR   InterPro; IPR000975; Interleukin_1.
DR   ProDom; PD002536; Interleukin_1; 1.
DR   SMART; SM00125; IL1; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; FALSE_NEG.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Cytokine; Polymorphism;
KW   Secreted.
FT   CHAIN         1    164       Interleukin-1 family member 8.
FT                                /FTId=PRO_0000153646.
FT   VAR_SEQ      88    164       LQGSQDNIGKDTCWKLVGIHTCINLDVRESCFMGTLDQWGI
FT                                GVGRKKWKSSFQHHHLRKKDKDFSSMRTNIGMPGRM -> E
FT                                KNIMDLYVEKKAQKPFLFFHNKEGSTSVFQSVSYPGWFIAT
FT                                STTSGQPIFLTKERGITNNTNFYLDSVE (in isoform
FT                                2).
FT                                /FTId=VSP_002657.
FT   VARIANT      36     36       R -> C.
FT                                /FTId=VAR_025057.
SQ   SEQUENCE   164 AA;  18522 MW;  F0D2099F4A357A0A CRC64;
     MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGN
     MVYLGIKGKD LCLFCAEIQG KPTLQLKLQG SQDNIGKDTC WKLVGIHTCI NLDVRESCFM
     GTLDQWGIGV GRKKWKSSFQ HHHLRKKDKD FSSMRTNIGM PGRM
//