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Q9NZH7 (IL36B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 16, 2012. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-36 beta
Alternative name(s):
FIL1 eta
Interleukin-1 eta
Short name=IL-1 eta
Interleukin-1 family member 8
Short name=IL-1F8
Interleukin-1 homolog 2
Short name=IL-1H2
Gene names
Name:IL36B
Synonyms:IL1F8, IL1H2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length164 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Ref.8 Ref.9 Ref.10

Subcellular location

Secreted Potential.

Tissue specificity

Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue. Ref.9 Ref.10

Induction

By proinflammatory cytokines IL1A, IL1B and TNF in synovial fibroblasts. By IL1A and TNF in keratinocytes. Constitutive in articular chondrocytes. Ref.8

Sequence similarities

Belongs to the IL-1 family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   Molecular functionCytokine
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processimmune response

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncytokine activity

Inferred from electronic annotation. Source: UniProtKB-KW

interleukin-1 receptor binding

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NZH7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NZH7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     88-164: LQGSQDNIGK...RTNIGMPGRM → EKNIMDLYVE...NTNFYLDSVE
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 164164Interleukin-36 beta
PRO_0000153646

Natural variations

Alternative sequence88 – 16477LQGSQ…MPGRM → EKNIMDLYVEKKAQKPFLFF HNKEGSTSVFQSVSYPGWFI ATSTTSGQPIFLTKERGITN NTNFYLDSVE in isoform 2.
VSP_002657
Natural variant361R → C. Ref.4
Corresponds to variant rs34754959 [ dbSNP | Ensembl ].
VAR_025057

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F0D2099F4A357A0A

FASTA16418,522
        10         20         30         40         50         60 
MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGN 

        70         80         90        100        110        120 
MVYLGIKGKD LCLFCAEIQG KPTLQLKLQG SQDNIGKDTC WKLVGIHTCI NLDVRESCFM 

       130        140        150        160 
GTLDQWGIGV GRKKWKSSFQ HHHLRKKDKD FSSMRTNIGM PGRM

« Hide

Isoform 2 [UniParc].

Checksum: 7A54F3D7557A3EE3
Show »

FASTA15717,702

References

« Hide 'large scale' references
[1]"Identification and initial characterization of four novel members of the interleukin-1 family."
Kumar S., McDonnell P.C., Lehr R., Tierney L., Tzimas M.N., Griswold D.E., Capper E.A., Tal-Singer R., Wells G.I., Doyle M.L., Young P.R.
J. Biol. Chem. 275:10308-10314(2000) [PubMed: 10744718] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Osteoclastoma.
[2]"Four new members expand the IL-1 superfamily."
Smith D.E., Renshaw B.R., Ketchem R.R., Kubin M., Garka K.E., Sims J.E.
J. Biol. Chem. 275:1169-1175(2000) [PubMed: 10625660] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]"A sequence-based map of the nine genes of the human interleukin-1 cluster."
Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G., Kornman K.
Genomics 79:718-725(2002) [PubMed: 11991722] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]SeattleSNPs variation discovery resource
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT CYS-36.
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed: 15815621] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Lung and Placenta.
[8]"The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes."
Magne D., Palmer G., Barton J.L., Mezin F., Talabot-Ayer D., Bas S., Duffy T., Noger M., Guerne P.A., Nicklin M.J., Gabay C.
Arthritis Res. Ther. 8:R80-R80(2006) [PubMed: 16646978] [Abstract]
Cited for: FUNCTION, INDUCTION.
[9]"The effect of the interleukin-1 cytokine family members IL-1F6 and IL-1F8 on adipocyte differentiation."
van Asseldonk E.J., Stienstra R., Koenen T.B., van Tits L.J., Joosten L.A., Tack C.J., Netea M.G.
Obesity 18:2234-2236(2010) [PubMed: 20300079] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[10]"IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression."
Johnston A., Xing X., Guzman A.M., Riblett M., Loyd C.M., Ward N.L., Wohn C., Prens E.P., Wang F., Maier L.E., Kang S., Voorhees J.J., Elder J.T., Gudjonsson J.E.
J. Immunol. 186:2613-2622(2011) [PubMed: 21242515] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-1 entry

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF200494 mRNA. Translation: AAF69250.1.
AF201833 mRNA. Translation: AAF25213.1.
CH471217 Genomic DNA. Translation: EAW73615.1.
BC101831 mRNA. Translation: AAI01832.1.
BC101833 mRNA. Translation: AAI01834.1.
BN000002 Genomic DNA. Translation: CAD29876.1.
DQ224343 Genomic DNA. Translation: ABA60896.1.
AC016724 Genomic DNA. Translation: AAY14989.1.
IPIIPI00005404.
IPI00218473.
RefSeqNP_055253.2. NM_014438.3.
NP_775270.1. NM_173178.1.
UniGeneHs.278909.

3D structure databases

ProteinModelPortalQ9NZH7.
SMRQ9NZH7. Positions 10-98.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9NZH7.

PTM databases

PhosphoSiteQ3MIH0.

Polymorphism databases

DMDM25008595.

Proteomic databases

PRIDEQ9NZH7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000259213; ENSP00000259213; ENSG00000136696.
GeneID27177.
KEGGhsa:27177.
UCSCuc002tiq.1. human.
uc002tir.1. human.

Organism-specific databases

CTD27177.
GeneCardsGC02M113779.
H-InvDBHIX0029829.
HGNCHGNC:15564. IL36B.
HPAHPA035664.
MIM605508. gene.
neXtProtNX_Q9NZH7.
PharmGKBPA38391.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG68028.
GeneTreeENSGT00620000088272.
HOVERGENHBG052100.
InParanoidQ9NZH7.
KOK05486.
OMAAQKPFLF.
OrthoDBEOG4N8R5X.
PhylomeDBQ9NZH7.

Gene expression databases

ArrayExpressQ3MIH0.
BgeeQ9NZH7.
CleanExHS_IL1F8.
GenevestigatorQ9NZH7.
GermOnlineENSG00000136696. Homo sapiens.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR000975. Interleukin_1.
[Graphical view]
SMARTSM00125. IL1. 1 hit.
[Graphical view]
SUPFAMSSF50353. Cytok_IL1_like. 1 hit.
PROSITEPS00253. INTERLEUKIN_1. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio49986.
SOURCESearch...

Entry information

Entry nameIL36B_HUMAN
AccessionPrimary (citable) accession number: Q9NZH7
Secondary accession number(s): Q3MIH0 expand/collapse secondary AC list , Q53SR6, Q7RTZ7, Q9UHA5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2000
Last modified: May 16, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents