Reviewed, UniProtKB/Swiss-Prot Q9NZH7 (IL1F8_HUMAN)

Names and origin

Protein names

Recommended name:
    Interleukin-1 family member 8
      Short name=IL-1F8
Alternative name(s):
    Interleukin-1 eta
      Short name=IL-1 eta
    FIL1 eta
    Interleukin-1 homolog 2
      Short name=IL-1H2

Gene names

Name:	IL1F8
Synonyms:	IL1H2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	164 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Secreted Potential.
Tissue specificity	Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in other tissues or in any hematopoietic cell lines.
Sequence similarities	Belongs to the IL-1 family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Cytokine
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	immune response Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW interleukin-1 receptor binding Ref.1 Ref.2 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NZH7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NZH7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     88-164: LQGSQDNIGK...RTNIGMPGRM → EKNIMDLYVE...NTNFYLDSVE

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 164	164	Interleukin-1 family member 8		PRO_0000153646
Natural variations
	Alternative sequence	88 – 164	77	LQGSQ…MPGRM → EKNIMDLYVEKKAQKPFLFF HNKEGSTSVFQSVSYPGWFI ATSTTSGQPIFLTKERGITN NTNFYLDSVE in isoform 2.		VSP_002657
	Natural variant	36	1	R → C		VAR_025057

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: F0D2099F4A357A0A	FASTA	164	18,522
	10 20 30 40 50 60 MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGN 70 80 90 100 110 120 MVYLGIKGKD LCLFCAEIQG KPTLQLKLQG SQDNIGKDTC WKLVGIHTCI NLDVRESCFM 130 140 150 160 GTLDQWGIGV GRKKWKSSFQ HHHLRKKDKD FSSMRTNIGM PGRM
	Isoform 2. Checksum: 7A54F3D7557A3EE3	FASTA	157	17,702
	10 20 30 40 50 60 MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGN 70 80 90 100 110 120 MVYLGIKGKD LCLFCAEIQG KPTLQLKEKN IMDLYVEKKA QKPFLFFHNK EGSTSVFQSV 130 140 150 SYPGWFIATS TTSGQPIFLT KERGITNNTN FYLDSVE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and initial characterization of four novel members of the interleukin-1 family." Kumar S., McDonnell P.C., Lehr R., Tierney L., Tzimas M.N., Griswold D.E., Capper E.A., Tal-Singer R., Wells G.I., Doyle M.L., Young P.R. J. Biol. Chem. 275:10308-10314(2000) [PubMed: 10744718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Osteoclastoma.
[2]	"Four new members expand the IL-1 superfamily." Smith D.E., Renshaw B.R., Ketchem R.R., Kubin M., Garka K.E., Sims J.E. J. Biol. Chem. 275:1169-1175(2000) [PubMed: 10625660] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"A sequence-based map of the nine genes of the human interleukin-1 cluster." Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G., Kornman K. Genomics 79:718-725(2002) [PubMed: 11991722] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	SeattleSNPs variation discovery resource Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT CYS-36.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-1 entry

SeattleSNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF200494 mRNA. Translation: AAF69250.1. AF201833 mRNA. Translation: AAF25213.1. BN000002 Genomic DNA. Translation: CAD29876.1. DQ224343 Genomic DNA. Translation: ABA60896.1. AC016724 Genomic DNA. Translation: AAY14989.1.
IPI	IPI00005404. IPI00218473.
RefSeq	NP_055253.2. NP_775270.1.
UniGene	Hs.278909
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NZH7.
Proteomic databases
PRIDE	Q9NZH7.
Genome annotation databases
Ensembl	ENST00000259213; ENSP00000259213; ENSG00000136696; Homo sapiens. [Genome view] ENST00000327407; ENSP00000328420; ENSG00000136696; Homo sapiens. [Genome view] ENST00000422169; ENSP00000406343; ENSG00000136696; Homo sapiens. [Genome view]
GeneID	27177.
KEGG	hsa:27177.
UCSC	uc002tiq.1. human. uc002tir.1. human.
Organism-specific databases
CTD	27177.
GeneCards	GC02M113496.
H-InvDB	HIX0029829.
HGNC	HGNC:15564. IL1F8.
MIM	605508. gene.
PharmGKB	PA38391.
GenAtlas	Search...
Phylogenomic databases
OMA	GIHTCIN.
Gene expression databases
ArrayExpress	Q9NZH7.
Bgee	Q9NZH7.
CleanEx	HS_IL1F8.
Genevestigator	Q9NZH7.
GermOnline	ENSG00000136696. Homo sapiens.
Family and domain databases
InterPro	IPR000975. Interleukin_1. [Graphical view]
ProDom	PD002536. Interleukin_1. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00125. IL1. 1 hit. [Graphical view]
PROSITE	PS00253. INTERLEUKIN_1. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	49986.
SOURCE	Search...

Entry information

Entry name

IL1F8_HUMAN

Accession

Primary (citable) accession number: Q9NZH7
Secondary accession number(s): Q53SR6, Q7RTZ7, Q9UHA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2000
Last modified:	November 3, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.