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Q9NZH5 (PTTG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Securin-2
Alternative name(s):
Pituitary tumor-transforming gene 2 protein
Gene names
Name:PTTG2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length202 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Tissue specificity

Expressed at low levels in the pituitary, liver, spleen, prostate, testis, ovary, small intestine and colon. Also expressed in various pituitary, testicular, liver and ovarian tumors. Ref.1 Ref.2

Domain

The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway By similarity.

Sequence similarities

Belongs to the securin family.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseProto-oncogene
   DomainSH3-binding
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA metabolic process

Inferred from electronic annotation. Source: InterPro

chromosome organization

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NZH5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NZH5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     179-202: LQSPSSILSTLDVELPAVCYDIDI → FAVSFKHSVDPGC

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 202201Securin-2
PRO_0000319106

Regions

Motif61 – 644D-box By similarity
Motif163 – 17311SH3-binding By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue1651Phosphoserine By similarity

Natural variations

Alternative sequence179 – 20224LQSPS…YDIDI → FAVSFKHSVDPGC in isoform 2.
VSP_031444
Natural variant441R → P. Ref.1 Ref.2 Ref.3
Corresponds to variant rs6811863 [ dbSNP | Ensembl ].
VAR_038956

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 16, 2011. Version 2.
Checksum: 3CBE738EC7817263

FASTA20222,302
        10         20         30         40         50         60 
MATLIYVDKE IGEPGTRVAA KDVLKLESRP SIKALDGISQ VLTRRFGKTY DAPSALPKAT 

        70         80         90        100        110        120 
RKALGTVNRA TEKSVKTNGP RKQKQPSFSA KKMTEKTVKT KSSVPASDDA YPEIEKFFPF 

       130        140        150        160        170        180 
NLLDFESFDL PEERQIAHLP LSGVPLMILD EEGELEKLFQ LGPPSPVKMP SPPWECNLLQ 

       190        200 
SPSSILSTLD VELPAVCYDI DI 

« Hide

Isoform 2 [UniParc].

Checksum: 73308EC5E36811C5
Show »

FASTA19121,103

References

« Hide 'large scale' references
[1]"An intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tumors: evidence for hPTTG family."
Prezant T.R., Kadioglu P., Melmed S.
J. Clin. Endocrinol. Metab. 84:1149-1152(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2), TISSUE SPECIFICITY, VARIANT PRO-44.
[2]"Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization."
Chen L., Puri R., Lefkowitz E.J., Kakar S.S.
Gene 248:41-50(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT PRO-44.
[3]Mu Y.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT PRO-44.
Tissue: Pituitary adenoma.
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF116538 Genomic DNA. Translation: AAD41262.2.
AF200719 Genomic DNA. Translation: AAF72579.1.
AF095288 mRNA. Translation: AAC64410.1.
AC021106 Genomic DNA. No translation available.
BC069114 mRNA. Translation: AAH69114.1.
BC069400 mRNA. Translation: AAH69400.1.
RefSeqNP_006598.2. NM_006607.2.
UniGeneHs.668806.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115967. 1 interaction.

PTM databases

PhosphoSiteQ9NZH5.

Polymorphism databases

DMDM357529040.

Proteomic databases

PRIDEQ9NZH5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000504686; ENSP00000424261; ENSG00000250254. [Q9NZH5-2]
GeneID10744.
KEGGhsa:10744.
UCSCuc011bye.2. human. [Q9NZH5-2]

Organism-specific databases

CTD10744.
GeneCardsGC04P037964.
HGNCHGNC:9691. PTTG2.
HPACAB008373.
HPA008890.
MIM604231. gene.
neXtProtNX_Q9NZH5.
PharmGKBPA34035.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG053264.
InParanoidQ9NZH5.
KOK06635.
OrthoDBEOG7MPRH0.
TreeFamTF330797.

Gene expression databases

CleanExHS_PTTG2.
GenevestigatorQ9NZH5.

Family and domain databases

InterProIPR018008. Securin_separation-inh_met.
IPR006940. Securin_separation_inhibitor.
[Graphical view]
PANTHERPTHR10418. PTHR10418. 1 hit.
PfamPF04856. Securin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi10744.
NextBio40797.
PROQ9NZH5.
SOURCESearch...

Entry information

Entry namePTTG2_HUMAN
AccessionPrimary (citable) accession number: Q9NZH5
Secondary accession number(s): O95355, Q6NTC9, Q9UNJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 16, 2011
Last modified: April 16, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM