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Q9NZH5

- PTTG2_HUMAN

UniProt

Q9NZH5 - PTTG2_HUMAN

Protein

Securin-2

Gene

PTTG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. chromosome organization Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Securin-2
    Alternative name(s):
    Pituitary tumor-transforming gene 2 protein
    Gene namesi
    Name:PTTG2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:9691. PTTG2.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA34035.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 202201Securin-2PRO_0000319106Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei165 – 1651PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ9NZH5.

    PTM databases

    PhosphoSiteiQ9NZH5.

    Expressioni

    Tissue specificityi

    Expressed at low levels in the pituitary, liver, spleen, prostate, testis, ovary, small intestine and colon. Also expressed in various pituitary, testicular, liver and ovarian tumors.2 Publications

    Gene expression databases

    CleanExiHS_PTTG2.
    GenevestigatoriQ9NZH5.

    Organism-specific databases

    HPAiCAB008373.
    HPA008890.

    Interactioni

    Protein-protein interaction databases

    BioGridi115967. 1 interaction.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi61 – 644D-boxBy similarity
    Motifi163 – 17311SH3-bindingBy similarityAdd
    BLAST

    Domaini

    The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.By similarity

    Sequence similaritiesi

    Belongs to the securin family.Curated

    Keywords - Domaini

    SH3-binding

    Phylogenomic databases

    HOVERGENiHBG053264.
    InParanoidiQ9NZH5.
    KOiK06635.
    OMAiPELCALN.
    OrthoDBiEOG7MPRH0.
    TreeFamiTF330797.

    Family and domain databases

    InterProiIPR018008. Securin_separation-inh_met.
    IPR006940. Securin_separation_inhibitor.
    [Graphical view]
    PANTHERiPTHR10418. PTHR10418. 1 hit.
    PfamiPF04856. Securin. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NZH5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATLIYVDKE IGEPGTRVAA KDVLKLESRP SIKALDGISQ VLTRRFGKTY    50
    DAPSALPKAT RKALGTVNRA TEKSVKTNGP RKQKQPSFSA KKMTEKTVKT 100
    KSSVPASDDA YPEIEKFFPF NLLDFESFDL PEERQIAHLP LSGVPLMILD 150
    EEGELEKLFQ LGPPSPVKMP SPPWECNLLQ SPSSILSTLD VELPAVCYDI 200
    DI 202
    Length:202
    Mass (Da):22,302
    Last modified:November 16, 2011 - v2
    Checksum:i3CBE738EC7817263
    GO
    Isoform 2 (identifier: Q9NZH5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         179-202: LQSPSSILSTLDVELPAVCYDIDI → FAVSFKHSVDPGC

    Show »
    Length:191
    Mass (Da):21,103
    Checksum:i73308EC5E36811C5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti44 – 441R → P.3 Publications
    Corresponds to variant rs6811863 [ dbSNP | Ensembl ].
    VAR_038956

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei179 – 20224LQSPS…YDIDI → FAVSFKHSVDPGC in isoform 2. 2 PublicationsVSP_031444Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF116538 Genomic DNA. Translation: AAD41262.2.
    AF200719 Genomic DNA. Translation: AAF72579.1.
    AF095288 mRNA. Translation: AAC64410.1.
    AC021106 Genomic DNA. No translation available.
    BC069114 mRNA. Translation: AAH69114.1.
    BC069400 mRNA. Translation: AAH69400.1.
    CCDSiCCDS54755.1. [Q9NZH5-2]
    RefSeqiNP_006598.2. NM_006607.2. [Q9NZH5-2]
    UniGeneiHs.668806.

    Genome annotation databases

    EnsembliENST00000504686; ENSP00000424261; ENSG00000250254. [Q9NZH5-2]
    GeneIDi10744.
    KEGGihsa:10744.
    UCSCiuc011bye.2. human. [Q9NZH5-2]

    Polymorphism databases

    DMDMi357529040.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF116538 Genomic DNA. Translation: AAD41262.2 .
    AF200719 Genomic DNA. Translation: AAF72579.1 .
    AF095288 mRNA. Translation: AAC64410.1 .
    AC021106 Genomic DNA. No translation available.
    BC069114 mRNA. Translation: AAH69114.1 .
    BC069400 mRNA. Translation: AAH69400.1 .
    CCDSi CCDS54755.1. [Q9NZH5-2 ]
    RefSeqi NP_006598.2. NM_006607.2. [Q9NZH5-2 ]
    UniGenei Hs.668806.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115967. 1 interaction.

    PTM databases

    PhosphoSitei Q9NZH5.

    Polymorphism databases

    DMDMi 357529040.

    Proteomic databases

    PRIDEi Q9NZH5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000504686 ; ENSP00000424261 ; ENSG00000250254 . [Q9NZH5-2 ]
    GeneIDi 10744.
    KEGGi hsa:10744.
    UCSCi uc011bye.2. human. [Q9NZH5-2 ]

    Organism-specific databases

    CTDi 10744.
    GeneCardsi GC04P037964.
    HGNCi HGNC:9691. PTTG2.
    HPAi CAB008373.
    HPA008890.
    MIMi 604231. gene.
    neXtProti NX_Q9NZH5.
    PharmGKBi PA34035.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG053264.
    InParanoidi Q9NZH5.
    KOi K06635.
    OMAi PELCALN.
    OrthoDBi EOG7MPRH0.
    TreeFami TF330797.

    Miscellaneous databases

    GenomeRNAii 10744.
    NextBioi 40797.
    PROi Q9NZH5.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_PTTG2.
    Genevestigatori Q9NZH5.

    Family and domain databases

    InterProi IPR018008. Securin_separation-inh_met.
    IPR006940. Securin_separation_inhibitor.
    [Graphical view ]
    PANTHERi PTHR10418. PTHR10418. 1 hit.
    Pfami PF04856. Securin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tumors: evidence for hPTTG family."
      Prezant T.R., Kadioglu P., Melmed S.
      J. Clin. Endocrinol. Metab. 84:1149-1152(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2), TISSUE SPECIFICITY, VARIANT PRO-44.
    2. "Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization."
      Chen L., Puri R., Lefkowitz E.J., Kakar S.S.
      Gene 248:41-50(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT PRO-44.
    3. Mu Y.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT PRO-44.
      Tissue: Pituitary adenoma.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

    Entry informationi

    Entry nameiPTTG2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NZH5
    Secondary accession number(s): O95355, Q6NTC9, Q9UNJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3