Q9NZH5 (PTTG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Securin-2

Alternative name(s):
Pituitary tumor-transforming gene 2 protein

Gene names

Name:

PTTG2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Tissue specificity	Expressed at low levels in the pituitary, liver, spleen, prostate, testis, ovary, small intestine and colon. Also expressed in various pituitary, testicular, liver and ovarian tumors. Ref.1 Ref.2
Domain	The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway By similarity.
Sequence similarities	Belongs to the securin family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Proto-oncogene
Domain	SH3-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA metabolic process Inferred from electronic annotation. Source: InterPro chromosome organization Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NZH5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NZH5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     179-202: LQSPSSILSTLDVELPAVCYDIDI → FAVSFKHSVDPGC

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	Securin-2		PRO_0000319106
Regions
	Motif	61 – 64	4	D-box By similarity
	Motif	163 – 173	11	SH3-binding By similarity
Natural variations
	Alternative sequence	179 – 202	24	LQSPS…YDIDI → FAVSFKHSVDPGC in isoform 2.		VSP_031444
	Natural variant	44	1	R → P. Ref.1 Ref.2 Ref.3 Corresponds to variant rs6811863 [ dbSNP | Ensembl ].		VAR_038956

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 16, 2011. Version 2. Checksum: 3CBE738EC7817263	FASTA	202	22,302
	10 20 30 40 50 60 MATLIYVDKE IGEPGTRVAA KDVLKLESRP SIKALDGISQ VLTRRFGKTY DAPSALPKAT 70 80 90 100 110 120 RKALGTVNRA TEKSVKTNGP RKQKQPSFSA KKMTEKTVKT KSSVPASDDA YPEIEKFFPF 130 140 150 160 170 180 NLLDFESFDL PEERQIAHLP LSGVPLMILD EEGELEKLFQ LGPPSPVKMP SPPWECNLLQ 190 200 SPSSILSTLD VELPAVCYDI DI
	Isoform 2 [UniParc]. Checksum: 73308EC5E36811C5	FASTA	191	21,103
	10 20 30 40 50 60 MATLIYVDKE IGEPGTRVAA KDVLKLESRP SIKALDGISQ VLTRRFGKTY DAPSALPKAT 70 80 90 100 110 120 RKALGTVNRA TEKSVKTNGP RKQKQPSFSA KKMTEKTVKT KSSVPASDDA YPEIEKFFPF 130 140 150 160 170 180 NLLDFESFDL PEERQIAHLP LSGVPLMILD EEGELEKLFQ LGPPSPVKMP SPPWECNLFA 190 VSFKHSVDPG C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tumors: evidence for hPTTG family." Prezant T.R., Kadioglu P., Melmed S. J. Clin. Endocrinol. Metab. 84:1149-1152(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2), TISSUE SPECIFICITY, VARIANT PRO-44.
[2]	"Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization." Chen L., Puri R., Lefkowitz E.J., Kakar S.S. Gene 248:41-50(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT PRO-44.
[3]	Mu Y. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT PRO-44. Tissue: Pituitary adenoma.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF116538 Genomic DNA. Translation: AAD41262.2. AF200719 Genomic DNA. Translation: AAF72579.1. AF095288 mRNA. Translation: AAC64410.1. AC021106 Genomic DNA. No translation available. BC069114 mRNA. Translation: AAH69114.1. BC069400 mRNA. Translation: AAH69400.1.
IPI	IPI00008631. IPI00021381.
RefSeq	NP_006598.2. NM_006607.2.
UniGene	Hs.668806.
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9NZH5.
Polymorphism databases
DMDM	74719652.
Proteomic databases
PRIDE	Q9NZH5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000504686; ENSP00000424261; ENSG00000250254.
GeneID	10744.
KEGG	hsa:10744.
UCSC	uc011bye.2. human.
Organism-specific databases
CTD	10744.
GeneCards	GC04P037964.
HGNC	HGNC:9691. PTTG2.
HPA	CAB008373. HPA008890.
MIM	604231. gene.
neXtProt	NX_Q9NZH5.
PharmGKB	PA34035.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG053264.
InParanoid	Q9NZH5.
KO	K06635.
Gene expression databases
CleanEx	HS_PTTG2.
Genevestigator	Q9NZH5.
Family and domain databases
InterPro	IPR018008. Securin_separation-inh_met. IPR006940. Securin_separation_inhibitor. [Graphical view]
PANTHER	PTHR10418. PTHR10418. 1 hit.
Pfam	PF04856. Securin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10744.
NextBio	40797.
SOURCE	Search...

Entry information

Entry name

PTTG2_HUMAN

Accession

Primary (citable) accession number: Q9NZH5
Secondary accession number(s): O95355, Q6NTC9, Q9UNJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	November 16, 2011
Last modified:	April 3, 2013
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.