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Q9NZH5

- PTTG2_HUMAN

UniProt

Q9NZH5 - PTTG2_HUMAN

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Protein

Securin-2

Gene

PTTG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. chromosome organization Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Securin-2
Alternative name(s):
Pituitary tumor-transforming gene 2 protein
Gene namesi
Name:PTTG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:9691. PTTG2.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA34035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 202201Securin-2PRO_0000319106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei165 – 1651PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ9NZH5.

PTM databases

PhosphoSiteiQ9NZH5.

Expressioni

Tissue specificityi

Expressed at low levels in the pituitary, liver, spleen, prostate, testis, ovary, small intestine and colon. Also expressed in various pituitary, testicular, liver and ovarian tumors.2 Publications

Gene expression databases

CleanExiHS_PTTG2.
GenevestigatoriQ9NZH5.

Organism-specific databases

HPAiCAB008373.
HPA008890.

Interactioni

Protein-protein interaction databases

BioGridi115967. 1 interaction.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi61 – 644D-boxBy similarity
Motifi163 – 17311SH3-bindingBy similarityAdd
BLAST

Domaini

The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.By similarity

Sequence similaritiesi

Belongs to the securin family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

GeneTreeiENSGT00390000009693.
HOVERGENiHBG053264.
InParanoidiQ9NZH5.
KOiK06635.
OMAiPELCALN.
OrthoDBiEOG7MPRH0.
TreeFamiTF330797.

Family and domain databases

InterProiIPR018008. Securin_separation-inh_met.
IPR006940. Securin_separation_inhibitor.
[Graphical view]
PANTHERiPTHR10418. PTHR10418. 1 hit.
PfamiPF04856. Securin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NZH5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATLIYVDKE IGEPGTRVAA KDVLKLESRP SIKALDGISQ VLTRRFGKTY
60 70 80 90 100
DAPSALPKAT RKALGTVNRA TEKSVKTNGP RKQKQPSFSA KKMTEKTVKT
110 120 130 140 150
KSSVPASDDA YPEIEKFFPF NLLDFESFDL PEERQIAHLP LSGVPLMILD
160 170 180 190 200
EEGELEKLFQ LGPPSPVKMP SPPWECNLLQ SPSSILSTLD VELPAVCYDI

DI
Length:202
Mass (Da):22,302
Last modified:November 16, 2011 - v2
Checksum:i3CBE738EC7817263
GO
Isoform 2 (identifier: Q9NZH5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-202: LQSPSSILSTLDVELPAVCYDIDI → FAVSFKHSVDPGC

Show »
Length:191
Mass (Da):21,103
Checksum:i73308EC5E36811C5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441R → P.3 Publications
Corresponds to variant rs6811863 [ dbSNP | Ensembl ].
VAR_038956

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei179 – 20224LQSPS…YDIDI → FAVSFKHSVDPGC in isoform 2. 2 PublicationsVSP_031444Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116538 Genomic DNA. Translation: AAD41262.2.
AF200719 Genomic DNA. Translation: AAF72579.1.
AF095288 mRNA. Translation: AAC64410.1.
AC021106 Genomic DNA. No translation available.
BC069114 mRNA. Translation: AAH69114.1.
BC069400 mRNA. Translation: AAH69400.1.
CCDSiCCDS54755.1. [Q9NZH5-2]
RefSeqiNP_006598.2. NM_006607.2. [Q9NZH5-2]
UniGeneiHs.668806.

Genome annotation databases

EnsembliENST00000504686; ENSP00000424261; ENSG00000250254. [Q9NZH5-2]
GeneIDi10744.
KEGGihsa:10744.
UCSCiuc011bye.2. human. [Q9NZH5-2]

Polymorphism databases

DMDMi357529040.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116538 Genomic DNA. Translation: AAD41262.2 .
AF200719 Genomic DNA. Translation: AAF72579.1 .
AF095288 mRNA. Translation: AAC64410.1 .
AC021106 Genomic DNA. No translation available.
BC069114 mRNA. Translation: AAH69114.1 .
BC069400 mRNA. Translation: AAH69400.1 .
CCDSi CCDS54755.1. [Q9NZH5-2 ]
RefSeqi NP_006598.2. NM_006607.2. [Q9NZH5-2 ]
UniGenei Hs.668806.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115967. 1 interaction.

PTM databases

PhosphoSitei Q9NZH5.

Polymorphism databases

DMDMi 357529040.

Proteomic databases

PRIDEi Q9NZH5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000504686 ; ENSP00000424261 ; ENSG00000250254 . [Q9NZH5-2 ]
GeneIDi 10744.
KEGGi hsa:10744.
UCSCi uc011bye.2. human. [Q9NZH5-2 ]

Organism-specific databases

CTDi 10744.
GeneCardsi GC04P037964.
HGNCi HGNC:9691. PTTG2.
HPAi CAB008373.
HPA008890.
MIMi 604231. gene.
neXtProti NX_Q9NZH5.
PharmGKBi PA34035.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00390000009693.
HOVERGENi HBG053264.
InParanoidi Q9NZH5.
KOi K06635.
OMAi PELCALN.
OrthoDBi EOG7MPRH0.
TreeFami TF330797.

Miscellaneous databases

GenomeRNAii 10744.
NextBioi 40797.
PROi Q9NZH5.
SOURCEi Search...

Gene expression databases

CleanExi HS_PTTG2.
Genevestigatori Q9NZH5.

Family and domain databases

InterProi IPR018008. Securin_separation-inh_met.
IPR006940. Securin_separation_inhibitor.
[Graphical view ]
PANTHERi PTHR10418. PTHR10418. 1 hit.
Pfami PF04856. Securin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tumors: evidence for hPTTG family."
    Prezant T.R., Kadioglu P., Melmed S.
    J. Clin. Endocrinol. Metab. 84:1149-1152(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2), TISSUE SPECIFICITY, VARIANT PRO-44.
  2. "Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization."
    Chen L., Puri R., Lefkowitz E.J., Kakar S.S.
    Gene 248:41-50(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT PRO-44.
  3. Mu Y.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT PRO-44.
    Tissue: Pituitary adenoma.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiPTTG2_HUMAN
AccessioniPrimary (citable) accession number: Q9NZH5
Secondary accession number(s): O95355, Q6NTC9, Q9UNJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 16, 2011
Last modified: October 29, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3