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Protein

Putative pituitary tumor-transforming gene 3 protein

Gene

PTTG3P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pituitary tumor-transforming gene 3 protein
Short name:
hPTTG3
Alternative name(s):
Securin-3
rcPTTG1
Gene namesi
Name:PTTG3P
Synonyms:PTTG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:13422. PTTG3P.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Polymorphism and mutation databases

DMDMi74719651.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Putative pituitary tumor-transforming gene 3 proteinPRO_0000333860Add
BLAST

Proteomic databases

PeptideAtlasiQ9NZH4.
PRIDEiQ9NZH4.

PTM databases

iPTMnetiQ9NZH4.
PhosphoSiteiQ9NZH4.

Expressioni

Tissue specificityi

Expressed in ovarian tumor and tumor cell lines (SK-OV-3 and PA1).1 Publication

Gene expression databases

CleanExiHS_PTTG3.

Organism-specific databases

HPAiHPA008890.
HPA045034.

Structurei

3D structure databases

ProteinModelPortaliQ9NZH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi61 – 644D-boxBy similarity
Motifi163 – 17311SH3-bindingBy similarityAdd
BLAST

Domaini

The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.By similarity

Sequence similaritiesi

Belongs to the securin family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

HOVERGENiHBG053264.
InParanoidiQ9NZH4.
PhylomeDBiQ9NZH4.

Family and domain databases

InterProiIPR018008. Securin_separation-inh_met.
IPR006940. Securin_separation_inhibitor.
[Graphical view]
PANTHERiPTHR10418. PTHR10418. 1 hit.
PfamiPF04856. Securin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NZH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLIYVDKE NEEPGILVAT KDGLKLGSGP SIKALDGRSQ VSISCFGKTF
60 70 80 90 100
DAPTSLPKAT RKALGTVNRA TEKSVKTNGP LKQKQPSFSA KKMTEKTVKA
110 120 130 140 150
KNSVPASDDG YPEIEKLFPF NPLGFESFDL PEEHQIAHLP LSEVPLMILD
160 170 180 190 200
EERELEKLFQ LGPPSPLKMP SPPWKSNLLQ SPLSILLTLD VELPPVCSDI

DI
Length:202
Mass (Da):22,064
Last modified:October 1, 2000 - v1
Checksum:iC19E6E9FE344A539
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981S → C in AAC64411 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200720 Genomic DNA. Translation: AAF72580.1.
DQ120700 Genomic DNA. Translation: ABC40663.1.
AF095289 mRNA. Translation: AAC64411.1.
AY028471 Genomic DNA. Translation: AAK40241.1.
UniGeneiHs.647156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200720 Genomic DNA. Translation: AAF72580.1.
DQ120700 Genomic DNA. Translation: ABC40663.1.
AF095289 mRNA. Translation: AAC64411.1.
AY028471 Genomic DNA. Translation: AAK40241.1.
UniGeneiHs.647156.

3D structure databases

ProteinModelPortaliQ9NZH4.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9NZH4.
PhosphoSiteiQ9NZH4.

Polymorphism and mutation databases

DMDMi74719651.

Proteomic databases

PeptideAtlasiQ9NZH4.
PRIDEiQ9NZH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiPTTG3P.
HGNCiHGNC:13422. PTTG3P.
HPAiHPA008890.
HPA045034.
neXtProtiNX_Q9NZH4.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG053264.
InParanoidiQ9NZH4.
PhylomeDBiQ9NZH4.

Miscellaneous databases

PROiQ9NZH4.

Gene expression databases

CleanExiHS_PTTG3.

Family and domain databases

InterProiIPR018008. Securin_separation-inh_met.
IPR006940. Securin_separation_inhibitor.
[Graphical view]
PANTHERiPTHR10418. PTHR10418. 1 hit.
PfamiPF04856. Securin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization."
    Chen L., Puri R., Lefkowitz E.J., Kakar S.S.
    Gene 248:41-50(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  2. "Emergence of young human genes after a burst of retroposition in primates."
    Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H.
    PLoS Biol. 3:E357-E357(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Mu Y.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary adenoma.
  4. "Distinct expression patterns and functions of the human pituitary tumor transforming gene (PTTG) family."
    Prezant T.R., Heaney A.P., Yu R., Kim K.W., Gutman S.F., Wang Z., Melmed S.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPTTG3_HUMAN
AccessioniPrimary (citable) accession number: Q9NZH4
Secondary accession number(s): O95356
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.