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Protein

G-protein coupled receptor family C group 5 member B

Gene

GPRC5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor family C group 5 member B
Alternative name(s):
A-69G12.1
Retinoic acid-induced gene 2 protein
Short name:
RAIG-2
Gene namesi
Name:GPRC5B
Synonyms:RAIG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:13308. GPRC5B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 56ExtracellularSequence analysisAdd BLAST28
Transmembranei57 – 77Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini78 – 94CytoplasmicSequence analysisAdd BLAST17
Transmembranei95 – 115Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini116 – 126ExtracellularSequence analysisAdd BLAST11
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 162CytoplasmicSequence analysisAdd BLAST15
Transmembranei163 – 183Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini184 – 199ExtracellularSequence analysisAdd BLAST16
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 234CytoplasmicSequence analysisAdd BLAST14
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini256 – 271ExtracellularSequence analysisAdd BLAST16
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 403CytoplasmicSequence analysisAdd BLAST111

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51704.
OpenTargetsiENSG00000167191.
PharmGKBiPA28938.

Polymorphism and mutation databases

BioMutaiGPRC5B.
DMDMi46396016.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001296529 – 403G-protein coupled receptor family C group 5 member BAdd BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...)Sequence analysis1
Modified residuei354PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9NZH0.
MaxQBiQ9NZH0.
PaxDbiQ9NZH0.
PeptideAtlasiQ9NZH0.
PRIDEiQ9NZH0.

PTM databases

iPTMnetiQ9NZH0.
PhosphoSitePlusiQ9NZH0.

Expressioni

Tissue specificityi

Expression is high in kidney, pancreas, and testis, medium in brain, heart, prostate, small intestine, and spleen, low in liver, placenta, skeletal muscle, colon, ovary, and thymus, and not detectable in lung and peripheral leukocyte. According to PubMed:10945465, highly expressed in most brain areas examined, with the highest levels observed in corpus callosum, caudate nucleus, putamen, substantia nigra, thalamus, hippocampus, and spinal chord as well as in dorsal root ganglia (DRG). In the periphery, expression levels are relatively low, compared to the CNS, with the strongest expression detected in pancreas, testis, uterus, and stomach.2 Publications

Inductioni

By all-trans retinoic acid (ATRA).1 Publication

Gene expression databases

BgeeiENSG00000167191.
CleanExiHS_GPRC5B.
ExpressionAtlasiQ9NZH0. baseline and differential.
GenevisibleiQ9NZH0. HS.

Organism-specific databases

HPAiHPA015247.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119688. 18 interactors.
IntActiQ9NZH0. 2 interactors.
STRINGi9606.ENSP00000300571.

Structurei

3D structure databases

ProteinModelPortaliQ9NZH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE42. Eukaryota.
ENOG410Y0Z8. LUCA.
GeneTreeiENSGT00520000055551.
HOVERGENiHBG051794.
InParanoidiQ9NZH0.
KOiK04619.
OMAiGKSPSGW.
OrthoDBiEOG091G0DAG.
TreeFamiTF321410.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NZH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFVASERKMR AHQVLTFLLL FVITSVASEN ASTSRGCGLD LLPQYVSLCD
60 70 80 90 100
LDAIWGIVVE AVAGAGALIT LLLMLILLVR LPFIKEKEKK SPVGLHFLFL
110 120 130 140 150
LGTLGLFGLT FAFIIQEDET ICSVRRFLWG VLFALCFSCL LSQAWRVRRL
160 170 180 190 200
VRHGTGPAGW QLVGLALCLM LVQVIIAVEW LVLTVLRDTR PACAYEPMDF
210 220 230 240 250
VMALIYDMVL LVVTLGLALF TLCGKFKRWK LNGAFLLITA FLSVLIWVAW
260 270 280 290 300
MTMYLFGNVK LQQGDAWNDP TLAITLAASG WVFVIFHAIP EIHCTLLPAL
310 320 330 340 350
QENTPNYFDT SQPRMRETAF EEDVQLPRAY MENKAFSMDE HNAALRTAGF
360 370 380 390 400
PNGSLGKRPS GSLGKRPSAP FRSNVYQPTE MAVVLNGGTI PTAPPSHTGR

HLW
Length:403
Mass (Da):44,795
Last modified:April 13, 2004 - v2
Checksum:i3902A16C4F69C26E
GO
Isoform 2 (identifier: Q9NZH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-403: IPTAPPSHTGRHLW → EMVTHPRSLESFGAF

Show »
Length:404
Mass (Da):44,933
Checksum:i4DE2B3914E6C396A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46V → A in BAC11414 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047585390 – 403IPTAP…GRHLW → EMVTHPRSLESFGAF in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202640 mRNA. Translation: AAF67321.1.
AJ276101 mRNA. Translation: CAC00632.1.
AF181862 mRNA. Translation: AAF05331.1.
FJ529380 mRNA. Translation: ACU30030.1.
AK075119 mRNA. Translation: BAC11414.1.
AC004131 Genomic DNA. Translation: AAC27544.1.
AC134300 Genomic DNA. No translation available.
BC034467 mRNA. Translation: AAH34467.1.
CCDSiCCDS10581.1. [Q9NZH0-1]
RefSeqiNP_057319.1. NM_016235.2. [Q9NZH0-1]
XP_006721114.1. XM_006721051.2. [Q9NZH0-1]
XP_006721115.1. XM_006721052.2. [Q9NZH0-1]
UniGeneiHs.148685.

Genome annotation databases

EnsembliENST00000300571; ENSP00000300571; ENSG00000167191. [Q9NZH0-1]
ENST00000535671; ENSP00000442858; ENSG00000167191. [Q9NZH0-2]
ENST00000569479; ENSP00000454727; ENSG00000167191. [Q9NZH0-1]
ENST00000569847; ENSP00000457283; ENSG00000167191. [Q9NZH0-1]
GeneIDi51704.
KEGGihsa:51704.
UCSCiuc002dgt.4. human. [Q9NZH0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202640 mRNA. Translation: AAF67321.1.
AJ276101 mRNA. Translation: CAC00632.1.
AF181862 mRNA. Translation: AAF05331.1.
FJ529380 mRNA. Translation: ACU30030.1.
AK075119 mRNA. Translation: BAC11414.1.
AC004131 Genomic DNA. Translation: AAC27544.1.
AC134300 Genomic DNA. No translation available.
BC034467 mRNA. Translation: AAH34467.1.
CCDSiCCDS10581.1. [Q9NZH0-1]
RefSeqiNP_057319.1. NM_016235.2. [Q9NZH0-1]
XP_006721114.1. XM_006721051.2. [Q9NZH0-1]
XP_006721115.1. XM_006721052.2. [Q9NZH0-1]
UniGeneiHs.148685.

3D structure databases

ProteinModelPortaliQ9NZH0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119688. 18 interactors.
IntActiQ9NZH0. 2 interactors.
STRINGi9606.ENSP00000300571.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9NZH0.
PhosphoSitePlusiQ9NZH0.

Polymorphism and mutation databases

BioMutaiGPRC5B.
DMDMi46396016.

Proteomic databases

EPDiQ9NZH0.
MaxQBiQ9NZH0.
PaxDbiQ9NZH0.
PeptideAtlasiQ9NZH0.
PRIDEiQ9NZH0.

Protocols and materials databases

DNASUi51704.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300571; ENSP00000300571; ENSG00000167191. [Q9NZH0-1]
ENST00000535671; ENSP00000442858; ENSG00000167191. [Q9NZH0-2]
ENST00000569479; ENSP00000454727; ENSG00000167191. [Q9NZH0-1]
ENST00000569847; ENSP00000457283; ENSG00000167191. [Q9NZH0-1]
GeneIDi51704.
KEGGihsa:51704.
UCSCiuc002dgt.4. human. [Q9NZH0-1]

Organism-specific databases

CTDi51704.
DisGeNETi51704.
GeneCardsiGPRC5B.
HGNCiHGNC:13308. GPRC5B.
HPAiHPA015247.
MIMi605948. gene.
neXtProtiNX_Q9NZH0.
OpenTargetsiENSG00000167191.
PharmGKBiPA28938.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE42. Eukaryota.
ENOG410Y0Z8. LUCA.
GeneTreeiENSGT00520000055551.
HOVERGENiHBG051794.
InParanoidiQ9NZH0.
KOiK04619.
OMAiGKSPSGW.
OrthoDBiEOG091G0DAG.
TreeFamiTF321410.

Miscellaneous databases

ChiTaRSiGPRC5B. human.
GeneWikiiGPRC5B.
GenomeRNAii51704.
PROiQ9NZH0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167191.
CleanExiHS_GPRC5B.
ExpressionAtlasiQ9NZH0. baseline and differential.
GenevisibleiQ9NZH0. HS.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPC5B_HUMAN
AccessioniPrimary (citable) accession number: Q9NZH0
Secondary accession number(s): D2DFB0, O75205, Q8NBZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.