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Protein

G-protein coupled receptor family C group 5 member B

Gene

GPRC5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor family C group 5 member B
Alternative name(s):
A-69G12.1
Retinoic acid-induced gene 2 protein
Short name:
RAIG-2
Gene namesi
Name:GPRC5B
Synonyms:RAIG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000167191.11
HGNCiHGNC:13308 GPRC5B
MIMi605948 gene
neXtProtiNX_Q9NZH0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 56ExtracellularSequence analysisAdd BLAST28
Transmembranei57 – 77Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini78 – 94CytoplasmicSequence analysisAdd BLAST17
Transmembranei95 – 115Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini116 – 126ExtracellularSequence analysisAdd BLAST11
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 162CytoplasmicSequence analysisAdd BLAST15
Transmembranei163 – 183Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini184 – 199ExtracellularSequence analysisAdd BLAST16
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 234CytoplasmicSequence analysisAdd BLAST14
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini256 – 271ExtracellularSequence analysisAdd BLAST16
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 403CytoplasmicSequence analysisAdd BLAST111

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51704
OpenTargetsiENSG00000167191
PharmGKBiPA28938

Polymorphism and mutation databases

BioMutaiGPRC5B
DMDMi46396016

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001296529 – 403G-protein coupled receptor family C group 5 member BAdd BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei354PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9NZH0
MaxQBiQ9NZH0
PaxDbiQ9NZH0
PeptideAtlasiQ9NZH0
PRIDEiQ9NZH0

PTM databases

iPTMnetiQ9NZH0
PhosphoSitePlusiQ9NZH0

Expressioni

Tissue specificityi

Expression is high in kidney, pancreas, and testis, medium in brain, heart, prostate, small intestine, and spleen, low in liver, placenta, skeletal muscle, colon, ovary, and thymus, and not detectable in lung and peripheral leukocyte. According to PubMed:10945465, highly expressed in most brain areas examined, with the highest levels observed in corpus callosum, caudate nucleus, putamen, substantia nigra, thalamus, hippocampus, and spinal chord as well as in dorsal root ganglia (DRG). In the periphery, expression levels are relatively low, compared to the CNS, with the strongest expression detected in pancreas, testis, uterus, and stomach.2 Publications

Inductioni

By all-trans retinoic acid (ATRA).1 Publication

Gene expression databases

BgeeiENSG00000167191
CleanExiHS_GPRC5B
ExpressionAtlasiQ9NZH0 baseline and differential
GenevisibleiQ9NZH0 HS

Organism-specific databases

HPAiHPA015247

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119688, 21 interactors
IntActiQ9NZH0, 2 interactors
MINTiQ9NZH0

Structurei

3D structure databases

ProteinModelPortaliQ9NZH0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE42 Eukaryota
ENOG410Y0Z8 LUCA
GeneTreeiENSGT00520000055551
HOVERGENiHBG051794
InParanoidiQ9NZH0
KOiK04619
OMAiGKSPSGW
OrthoDBiEOG091G0DAG
TreeFamiTF321410

Family and domain databases

InterProiView protein in InterPro
IPR017978 GPCR_3_C
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PROSITEiView protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NZH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFVASERKMR AHQVLTFLLL FVITSVASEN ASTSRGCGLD LLPQYVSLCD
60 70 80 90 100
LDAIWGIVVE AVAGAGALIT LLLMLILLVR LPFIKEKEKK SPVGLHFLFL
110 120 130 140 150
LGTLGLFGLT FAFIIQEDET ICSVRRFLWG VLFALCFSCL LSQAWRVRRL
160 170 180 190 200
VRHGTGPAGW QLVGLALCLM LVQVIIAVEW LVLTVLRDTR PACAYEPMDF
210 220 230 240 250
VMALIYDMVL LVVTLGLALF TLCGKFKRWK LNGAFLLITA FLSVLIWVAW
260 270 280 290 300
MTMYLFGNVK LQQGDAWNDP TLAITLAASG WVFVIFHAIP EIHCTLLPAL
310 320 330 340 350
QENTPNYFDT SQPRMRETAF EEDVQLPRAY MENKAFSMDE HNAALRTAGF
360 370 380 390 400
PNGSLGKRPS GSLGKRPSAP FRSNVYQPTE MAVVLNGGTI PTAPPSHTGR

HLW
Length:403
Mass (Da):44,795
Last modified:April 13, 2004 - v2
Checksum:i3902A16C4F69C26E
GO
Isoform 2 (identifier: Q9NZH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-403: IPTAPPSHTGRHLW → EMVTHPRSLESFGAF

Show »
Length:404
Mass (Da):44,933
Checksum:i4DE2B3914E6C396A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46V → A in BAC11414 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047585390 – 403IPTAP…GRHLW → EMVTHPRSLESFGAF in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202640 mRNA Translation: AAF67321.1
AJ276101 mRNA Translation: CAC00632.1
AF181862 mRNA Translation: AAF05331.1
FJ529380 mRNA Translation: ACU30030.1
AK075119 mRNA Translation: BAC11414.1
AC004131 Genomic DNA Translation: AAC27544.1
AC134300 Genomic DNA No translation available.
BC034467 mRNA Translation: AAH34467.1
CCDSiCCDS10581.1 [Q9NZH0-1]
RefSeqiNP_057319.1, NM_016235.2 [Q9NZH0-1]
XP_006721114.1, XM_006721051.2 [Q9NZH0-1]
XP_006721115.1, XM_006721052.2 [Q9NZH0-1]
UniGeneiHs.148685

Genome annotation databases

EnsembliENST00000300571; ENSP00000300571; ENSG00000167191 [Q9NZH0-1]
ENST00000535671; ENSP00000442858; ENSG00000167191 [Q9NZH0-2]
ENST00000569479; ENSP00000454727; ENSG00000167191 [Q9NZH0-1]
ENST00000569847; ENSP00000457283; ENSG00000167191 [Q9NZH0-1]
GeneIDi51704
KEGGihsa:51704
UCSCiuc002dgt.4 human [Q9NZH0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGPC5B_HUMAN
AccessioniPrimary (citable) accession number: Q9NZH0
Secondary accession number(s): D2DFB0, O75205, Q8NBZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: February 28, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health