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Protein

Ninjurin-2

Gene

NINJ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues.

GO - Biological processi

  • nervous system development Source: ProtInc
  • neuron cell-cell adhesion Source: ProtInc
  • tissue regeneration Source: InterPro

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Ninjurin-2
Alternative name(s):
Nerve injury-induced protein 2
Gene namesi
Name:NINJ2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000171840.11
HGNCiHGNC:7825 NINJ2
MIMi607297 gene
neXtProtiNX_Q9NZG7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 65ExtracellularSequence analysisAdd BLAST65
Transmembranei66 – 88HelicalSequence analysisAdd BLAST23
Topological domaini89 – 106CytoplasmicSequence analysisAdd BLAST18
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 142ExtracellularSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4815
PharmGKBiPA31632

Polymorphism and mutation databases

BioMutaiNINJ2
DMDMi18203328

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001596461 – 142Ninjurin-2Add BLAST142

Proteomic databases

PaxDbiQ9NZG7
PeptideAtlasiQ9NZG7
PRIDEiQ9NZG7

PTM databases

iPTMnetiQ9NZG7
PhosphoSitePlusiQ9NZG7

Expressioni

Tissue specificityi

Widely expressed. In adult, higher expression in the bone marrow and peripheral blood lymphocytes, medium in the lung, lymph node, thyroid, uterus, thymus, spleen, prostate and skeletal muscle, lower in the liver, placenta, brain, heart and kidney. In embryo, higher expression in the thymus, heart and liver, lower in the spleen, lung, brain and kidney.

Inductioni

By nerve injury; in Schwann cells.

Gene expression databases

BgeeiENSG00000171840
CleanExiHS_NINJ2
ExpressionAtlasiQ9NZG7 baseline and differential
GenevisibleiQ9NZG7 HS

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110880, 5 interactors
IntActiQ9NZG7, 9 interactors
STRINGi9606.ENSP00000307552

Family & Domainsi

Sequence similaritiesi

Belongs to the ninjurin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0D7 Eukaryota
ENOG4111YA5 LUCA
HOGENOMiHOG000037625
HOVERGENiHBG052622
InParanoidiQ9NZG7
OrthoDBiEOG091G0TAH
PhylomeDBiQ9NZG7
TreeFamiTF323538

Family and domain databases

InterProiView protein in InterPro
IPR007007 Ninjurin
PANTHERiPTHR12316 PTHR12316, 1 hit
PfamiView protein in Pfam
PF04923 Ninjurin, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NZG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESARENIDL QPGSSDPRSQ PINLNHYATK KSVAESMLDV ALFMSNAMRL
60 70 80 90 100
KAVLEQGPSS HYYTTLVTLI SLSLLLQVVI GVLLVVIARL NLNEVEKQWR
110 120 130 140
LNQLNNAATI LVFFTVVINV FITAFGAHKT GFLAARASRN PL
Length:142
Mass (Da):15,680
Last modified:October 1, 2000 - v1
Checksum:iB00A92F5EAFF6BD9
GO

Sequence cautioni

The sequence AAH57766 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205633 mRNA Translation: AAF42828.1
BC057766 mRNA Translation: AAH57766.2 Different initiation.
RefSeqiNP_001281274.1, NM_001294345.1
NP_001281275.1, NM_001294346.1
NP_057617.2, NM_016533.5
UniGeneiHs.655804
Hs.656450

Genome annotation databases

EnsembliENST00000305108; ENSP00000307552; ENSG00000171840
GeneIDi4815
KEGGihsa:4815
UCSCiuc001qil.4 human

Similar proteinsi

Entry informationi

Entry nameiNINJ2_HUMAN
AccessioniPrimary (citable) accession number: Q9NZG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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