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Protein

Ninjurin-2

Gene

NINJ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues.

GO - Biological processi

  • nervous system development Source: ProtInc
  • neuron cell-cell adhesion Source: ProtInc
  • tissue regeneration Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Ninjurin-2
Alternative name(s):
Nerve injury-induced protein 2
Gene namesi
Name:NINJ2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:7825. NINJ2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6565ExtracellularSequence analysisAdd
BLAST
Transmembranei66 – 8823HelicalSequence analysisAdd
BLAST
Topological domaini89 – 10618CytoplasmicSequence analysisAdd
BLAST
Transmembranei107 – 12721HelicalSequence analysisAdd
BLAST
Topological domaini128 – 14215ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31632.

Polymorphism and mutation databases

BioMutaiNINJ2.
DMDMi18203328.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Ninjurin-2PRO_0000159646Add
BLAST

Proteomic databases

PaxDbiQ9NZG7.
PeptideAtlasiQ9NZG7.
PRIDEiQ9NZG7.

PTM databases

iPTMnetiQ9NZG7.
PhosphoSiteiQ9NZG7.

Expressioni

Tissue specificityi

Widely expressed. In adult, higher expression in the bone marrow and peripheral blood lymphocytes, medium in the lung, lymph node, thyroid, uterus, thymus, spleen, prostate and skeletal muscle, lower in the liver, placenta, brain, heart and kidney. In embryo, higher expression in the thymus, heart and liver, lower in the spleen, lung, brain and kidney.

Inductioni

By nerve injury; in Schwann cells.

Gene expression databases

BgeeiENSG00000171840.
CleanExiHS_NINJ2.
ExpressionAtlasiQ9NZG7. baseline and differential.
GenevisibleiQ9NZG7. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL2L13Q9BXK53EBI-10317425,EBI-747430
CLEC7AQ9BXN23EBI-10317425,EBI-3939278

Protein-protein interaction databases

BioGridi110880. 3 interactions.
IntActiQ9NZG7. 2 interactions.
STRINGi9606.ENSP00000307552.

Family & Domainsi

Sequence similaritiesi

Belongs to the ninjurin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0D7. Eukaryota.
ENOG4111YA5. LUCA.
HOGENOMiHOG000037625.
HOVERGENiHBG052622.
InParanoidiQ9NZG7.
OrthoDBiEOG091G0TAH.
PhylomeDBiQ9NZG7.
TreeFamiTF323538.

Family and domain databases

InterProiIPR007007. Ninjurin.
[Graphical view]
PANTHERiPTHR12316. PTHR12316. 1 hit.
PfamiPF04923. Ninjurin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NZG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESARENIDL QPGSSDPRSQ PINLNHYATK KSVAESMLDV ALFMSNAMRL
60 70 80 90 100
KAVLEQGPSS HYYTTLVTLI SLSLLLQVVI GVLLVVIARL NLNEVEKQWR
110 120 130 140
LNQLNNAATI LVFFTVVINV FITAFGAHKT GFLAARASRN PL
Length:142
Mass (Da):15,680
Last modified:October 1, 2000 - v1
Checksum:iB00A92F5EAFF6BD9
GO

Sequence cautioni

The sequence AAH57766 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205633 mRNA. Translation: AAF42828.1.
BC057766 mRNA. Translation: AAH57766.2. Different initiation.
RefSeqiNP_001281274.1. NM_001294345.1.
NP_001281275.1. NM_001294346.1.
NP_057617.2. NM_016533.5.
UniGeneiHs.655804.
Hs.656450.

Genome annotation databases

EnsembliENST00000305108; ENSP00000307552; ENSG00000171840.
GeneIDi4815.
KEGGihsa:4815.
UCSCiuc001qil.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205633 mRNA. Translation: AAF42828.1.
BC057766 mRNA. Translation: AAH57766.2. Different initiation.
RefSeqiNP_001281274.1. NM_001294345.1.
NP_001281275.1. NM_001294346.1.
NP_057617.2. NM_016533.5.
UniGeneiHs.655804.
Hs.656450.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110880. 3 interactions.
IntActiQ9NZG7. 2 interactions.
STRINGi9606.ENSP00000307552.

PTM databases

iPTMnetiQ9NZG7.
PhosphoSiteiQ9NZG7.

Polymorphism and mutation databases

BioMutaiNINJ2.
DMDMi18203328.

Proteomic databases

PaxDbiQ9NZG7.
PeptideAtlasiQ9NZG7.
PRIDEiQ9NZG7.

Protocols and materials databases

DNASUi4815.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305108; ENSP00000307552; ENSG00000171840.
GeneIDi4815.
KEGGihsa:4815.
UCSCiuc001qil.4. human.

Organism-specific databases

CTDi4815.
GeneCardsiNINJ2.
H-InvDBHIX0036714.
HGNCiHGNC:7825. NINJ2.
MIMi607297. gene.
neXtProtiNX_Q9NZG7.
PharmGKBiPA31632.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0D7. Eukaryota.
ENOG4111YA5. LUCA.
HOGENOMiHOG000037625.
HOVERGENiHBG052622.
InParanoidiQ9NZG7.
OrthoDBiEOG091G0TAH.
PhylomeDBiQ9NZG7.
TreeFamiTF323538.

Miscellaneous databases

GenomeRNAii4815.
PROiQ9NZG7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171840.
CleanExiHS_NINJ2.
ExpressionAtlasiQ9NZG7. baseline and differential.
GenevisibleiQ9NZG7. HS.

Family and domain databases

InterProiIPR007007. Ninjurin.
[Graphical view]
PANTHERiPTHR12316. PTHR12316. 1 hit.
PfamiPF04923. Ninjurin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNINJ2_HUMAN
AccessioniPrimary (citable) accession number: Q9NZG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.