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Protein

Placenta-specific gene 8 protein

Gene

PLAC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Placenta-specific gene 8 protein
Alternative name(s):
Protein C15
Gene namesi
Name:PLAC8
ORF Names:BM-004
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:19254. PLAC8.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950814.

Polymorphism and mutation databases

BioMutaiPLAC8.
DMDMi34922849.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 115115Placenta-specific gene 8 proteinPRO_0000186092Add
BLAST

Proteomic databases

PaxDbiQ9NZF1.
PRIDEiQ9NZF1.

PTM databases

PhosphoSiteiQ9NZF1.

Expressioni

Tissue specificityi

Expressed at high levels in plasmacytoid dendritic cells. High expression in spleen, lymph nodes, peripheral blood leukocytes, and bone marrow, with lower expression in thymus, appendix, and fetal liver.

Gene expression databases

BgeeiQ9NZF1.
CleanExiHS_PLAC8.
ExpressionAtlasiQ9NZF1. baseline and differential.
GenevisibleiQ9NZF1. HS.

Organism-specific databases

HPAiHPA040465.

Interactioni

Protein-protein interaction databases

BioGridi119467. 5 interactions.
IntActiQ9NZF1. 2 interactions.
STRINGi9606.ENSP00000309509.

Structurei

3D structure databases

ProteinModelPortaliQ9NZF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cornifelin family.Curated

Phylogenomic databases

eggNOGiENOG410IZNB. Eukaryota.
ENOG410YWYC. LUCA.
HOGENOMiHOG000007259.
HOVERGENiHBG053607.
InParanoidiQ9NZF1.
OMAiFTDCEIC.
OrthoDBiEOG7W155X.
PhylomeDBiQ9NZF1.
TreeFamiTF330308.

Family and domain databases

InterProiIPR006461. PLAC_motif_containing.
[Graphical view]
PfamiPF04749. PLAC8. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01571. A_thal_Cys_rich. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NZF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAQAPVVVV TQPGVGPGPA PQNSNWQTGM CDCFSDCGVC LCGTFCFPCL
60 70 80 90 100
GCQVAADMNE CCLCGTSVAM RTLYRTRYGI PGSICDDYMA TLCCPHCTLC
110
QIKRDINRRR AMRTF
Length:115
Mass (Da):12,507
Last modified:October 1, 2000 - v1
Checksum:i24B6D7940390C6BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ422147 mRNA. Translation: CAD19530.1.
FJ795024 mRNA. Translation: ACO37643.1.
AF208846 mRNA. Translation: AAF64260.1.
CH471057 Genomic DNA. Translation: EAX05923.1.
CCDSiCCDS3601.1.
RefSeqiNP_001124187.1. NM_001130715.1.
NP_001124188.1. NM_001130716.1.
NP_057703.1. NM_016619.2.
UniGeneiHs.546392.

Genome annotation databases

EnsembliENST00000311507; ENSP00000309509; ENSG00000145287.
ENST00000411416; ENSP00000412230; ENSG00000145287.
ENST00000426923; ENSP00000399700; ENSG00000145287.
ENST00000505406; ENSP00000422526; ENSG00000145287.
GeneIDi51316.
KEGGihsa:51316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ422147 mRNA. Translation: CAD19530.1.
FJ795024 mRNA. Translation: ACO37643.1.
AF208846 mRNA. Translation: AAF64260.1.
CH471057 Genomic DNA. Translation: EAX05923.1.
CCDSiCCDS3601.1.
RefSeqiNP_001124187.1. NM_001130715.1.
NP_001124188.1. NM_001130716.1.
NP_057703.1. NM_016619.2.
UniGeneiHs.546392.

3D structure databases

ProteinModelPortaliQ9NZF1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119467. 5 interactions.
IntActiQ9NZF1. 2 interactions.
STRINGi9606.ENSP00000309509.

PTM databases

PhosphoSiteiQ9NZF1.

Polymorphism and mutation databases

BioMutaiPLAC8.
DMDMi34922849.

Proteomic databases

PaxDbiQ9NZF1.
PRIDEiQ9NZF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311507; ENSP00000309509; ENSG00000145287.
ENST00000411416; ENSP00000412230; ENSG00000145287.
ENST00000426923; ENSP00000399700; ENSG00000145287.
ENST00000505406; ENSP00000422526; ENSG00000145287.
GeneIDi51316.
KEGGihsa:51316.

Organism-specific databases

CTDi51316.
GeneCardsiPLAC8.
HGNCiHGNC:19254. PLAC8.
HPAiHPA040465.
MIMi607515. gene.
neXtProtiNX_Q9NZF1.
PharmGKBiPA134950814.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZNB. Eukaryota.
ENOG410YWYC. LUCA.
HOGENOMiHOG000007259.
HOVERGENiHBG053607.
InParanoidiQ9NZF1.
OMAiFTDCEIC.
OrthoDBiEOG7W155X.
PhylomeDBiQ9NZF1.
TreeFamiTF330308.

Miscellaneous databases

ChiTaRSiPLAC8. human.
GenomeRNAii51316.
NextBioi54677.
PROiQ9NZF1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NZF1.
CleanExiHS_PLAC8.
ExpressionAtlasiQ9NZF1. baseline and differential.
GenevisibleiQ9NZF1. HS.

Family and domain databases

InterProiIPR006461. PLAC_motif_containing.
[Graphical view]
PfamiPF04749. PLAC8. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01571. A_thal_Cys_rich. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Subtractive hybridization reveals the expression of immunoglobulin like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells."
    Rissoan M.-C., Duhen T., Bridon J.-M., Bendriss-Vermare N., Peronne C., de Saint-Vis B.M., Briere F., Bates E.E.M.
    Blood 100:3295-3303(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Plasmacytoid dendritic cell.
  2. Guan W.J., Ma Y.H., Yu L.L.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPLAC8_HUMAN
AccessioniPrimary (citable) accession number: Q9NZF1
Secondary accession number(s): C1K3N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2000
Last modified: March 16, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.