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Q9NZE8

- RM35_HUMAN

UniProt

Q9NZE8 - RM35_HUMAN

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Protein
39S ribosomal protein L35, mitochondrial
Gene
MRPL35, BM-007
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L35, mitochondrial
Short name:
L35mt
Short name:
MRP-L35
Gene namesi
Name:MRPL35
ORF Names:BM-007
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:14489. MRPL35.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30966.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 18839S ribosomal protein L35, mitochondrialPRO_0000030525
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

MaxQBiQ9NZE8.
PaxDbiQ9NZE8.
PRIDEiQ9NZE8.

PTM databases

PhosphoSiteiQ9NZE8.

Expressioni

Gene expression databases

ArrayExpressiQ9NZE8.
BgeeiQ9NZE8.
CleanExiHS_MRPL35.
GenevestigatoriQ9NZE8.

Organism-specific databases

HPAiHPA043482.

Interactioni

Protein-protein interaction databases

BioGridi119469. 1 interaction.
IntActiQ9NZE8. 1 interaction.
STRINGi9606.ENSP00000338389.

Structurei

3D structure databases

ProteinModelPortaliQ9NZE8.
SMRiQ9NZE8. Positions 103-162.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG288104.
HOGENOMiHOG000293335.
HOVERGENiHBG050017.
InParanoidiQ9NZE8.
KOiK02916.
OMAiHFSHIQT.
PhylomeDBiQ9NZE8.
TreeFamiTF317642.

Family and domain databases

InterProiIPR019338. Ribosomal-L35_mit.
IPR021137. Ribosomal_L35.
[Graphical view]
PANTHERiPTHR15909. PTHR15909. 1 hit.
PfamiPF01632. Ribosomal_L35p. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NZE8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAASAFAGAV RAASGILRPL NILASSTYRN CVKNASLISA LSTGRFSHIQ    50
TPVVSSTPRL TTSERNLTCG HTSVILNRMA PVLPSVLKLP VRSLTYFSAR 100
KGKRKTVKAV IDRFLRLHCG LWVRRKAGYK KKLWKKTPAR KKRLREFVFC 150
NKTQSKLLDK MTTSFWKRRN WYVDDPYQKY HDRTNLKV 188
Length:188
Mass (Da):21,514
Last modified:January 23, 2007 - v3
Checksum:i3A44076927C5A54B
GO
Isoform 2 (identifier: Q9NZE8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-188: Missing.

Show »
Length:170
Mass (Da):19,192
Checksum:iDF3B4AEF300F91D7
GO

Sequence cautioni

The sequence AAF64263.1 differs from that shown. Reason: Frameshift at position 122.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191P → S.1 Publication
Corresponds to variant rs12714176 [ dbSNP | Ensembl ].
VAR_030010
Natural varianti24 – 241A → T.1 Publication
Corresponds to variant rs17851803 [ dbSNP | Ensembl ].
VAR_054632
Natural varianti29 – 291R → H.
Corresponds to variant rs1051949 [ dbSNP | Ensembl ].
VAR_054633
Natural varianti80 – 801A → P.
Corresponds to variant rs34044771 [ dbSNP | Ensembl ].
VAR_034463
Natural varianti81 – 811P → L.
Corresponds to variant rs3192352 [ dbSNP | Ensembl ].
VAR_051803
Natural varianti180 – 1801Y → C.
Corresponds to variant rs1052065 [ dbSNP | Ensembl ].
VAR_054634

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei171 – 18818Missing in isoform 2.
VSP_036507Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF208849 mRNA. Translation: AAF64263.1. Frameshift.
AK314555 mRNA. Translation: BAG37140.1.
AK314577 mRNA. Translation: BAG37154.1.
AL832982 mRNA. Translation: CAH56349.1.
AC009309 Genomic DNA. No translation available.
BC020651 mRNA. Translation: AAH20651.1.
CCDSiCCDS1987.1. [Q9NZE8-2]
CCDS1988.1. [Q9NZE8-1]
RefSeqiNP_057706.2. NM_016622.3. [Q9NZE8-1]
NP_663619.1. NM_145644.2. [Q9NZE8-2]
UniGeneiHs.433439.

Genome annotation databases

EnsembliENST00000254644; ENSP00000254644; ENSG00000132313. [Q9NZE8-2]
ENST00000337109; ENSP00000338389; ENSG00000132313. [Q9NZE8-1]
GeneIDi51318.
KEGGihsa:51318.
UCSCiuc002srf.4. human. [Q9NZE8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF208849 mRNA. Translation: AAF64263.1 . Frameshift.
AK314555 mRNA. Translation: BAG37140.1 .
AK314577 mRNA. Translation: BAG37154.1 .
AL832982 mRNA. Translation: CAH56349.1 .
AC009309 Genomic DNA. No translation available.
BC020651 mRNA. Translation: AAH20651.1 .
CCDSi CCDS1987.1. [Q9NZE8-2 ]
CCDS1988.1. [Q9NZE8-1 ]
RefSeqi NP_057706.2. NM_016622.3. [Q9NZE8-1 ]
NP_663619.1. NM_145644.2. [Q9NZE8-2 ]
UniGenei Hs.433439.

3D structure databases

ProteinModelPortali Q9NZE8.
SMRi Q9NZE8. Positions 103-162.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119469. 1 interaction.
IntActi Q9NZE8. 1 interaction.
STRINGi 9606.ENSP00000338389.

PTM databases

PhosphoSitei Q9NZE8.

Proteomic databases

MaxQBi Q9NZE8.
PaxDbi Q9NZE8.
PRIDEi Q9NZE8.

Protocols and materials databases

DNASUi 51318.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254644 ; ENSP00000254644 ; ENSG00000132313 . [Q9NZE8-2 ]
ENST00000337109 ; ENSP00000338389 ; ENSG00000132313 . [Q9NZE8-1 ]
GeneIDi 51318.
KEGGi hsa:51318.
UCSCi uc002srf.4. human. [Q9NZE8-1 ]

Organism-specific databases

CTDi 51318.
GeneCardsi GC02P086426.
HGNCi HGNC:14489. MRPL35.
HPAi HPA043482.
MIMi 611841. gene.
neXtProti NX_Q9NZE8.
PharmGKBi PA30966.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG288104.
HOGENOMi HOG000293335.
HOVERGENi HBG050017.
InParanoidi Q9NZE8.
KOi K02916.
OMAi HFSHIQT.
PhylomeDBi Q9NZE8.
TreeFami TF317642.

Miscellaneous databases

ChiTaRSi MRPL35. human.
GenomeRNAii 51318.
NextBioi 54687.
PROi Q9NZE8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NZE8.
Bgeei Q9NZE8.
CleanExi HS_MRPL35.
Genevestigatori Q9NZE8.

Family and domain databases

InterProi IPR019338. Ribosomal-L35_mit.
IPR021137. Ribosomal_L35.
[Graphical view ]
PANTHERi PTHR15909. PTHR15909. 1 hit.
Pfami PF01632. Ribosomal_L35p. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Stomach.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS SER-19 AND THR-24.
    Tissue: Liver.
  6. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM35_HUMAN
AccessioniPrimary (citable) accession number: Q9NZE8
Secondary accession number(s): A6NKV6
, B2RB93, Q658U7, Q8WWA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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