Q9NZE8 (RM35_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L35, mitochondrial
Short name=L35mt
Short name=MRP-L35

Gene names

Name:	MRPL35
ORF Names:	BM-007

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the ribosomal protein L35P family.
Sequence caution	The sequence AAF64263.1 differs from that shown. Reason: Frameshift at position 122.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Non-traceable author statement PubMed 11543634. Source: UniProtKB
Cellular_component	mitochondrial ribosome Non-traceable author statement PubMed 11543634. Source: UniProtKB
Molecular_function	structural constituent of ribosome Non-traceable author statement PubMed 11543634. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NZE8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NZE8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     171-188: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 188		39S ribosomal protein L35, mitochondrial		PRO_0000030525
Natural variations
	Alternative sequence	171 – 188	18	Missing in isoform 2.		VSP_036507
	Natural variant	19	1	P → S. Ref.5 Corresponds to variant rs12714176 [ dbSNP | Ensembl ].		VAR_030010
	Natural variant	24	1	A → T. Ref.5 Corresponds to variant rs17851803 [ dbSNP | Ensembl ].		VAR_054632
	Natural variant	29	1	R → H. Corresponds to variant rs1051949 [ dbSNP | Ensembl ].		VAR_054633
	Natural variant	80	1	A → P. Corresponds to variant rs34044771 [ dbSNP | Ensembl ].		VAR_034463
	Natural variant	81	1	P → L. Corresponds to variant rs3192352 [ dbSNP | Ensembl ].		VAR_051803
	Natural variant	180	1	Y → C. Corresponds to variant rs1052065 [ dbSNP | Ensembl ].		VAR_054634

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 3A44076927C5A54B	FASTA	188	21,514
	10 20 30 40 50 60 MAASAFAGAV RAASGILRPL NILASSTYRN CVKNASLISA LSTGRFSHIQ TPVVSSTPRL 70 80 90 100 110 120 TTSERNLTCG HTSVILNRMA PVLPSVLKLP VRSLTYFSAR KGKRKTVKAV IDRFLRLHCG 130 140 150 160 170 180 LWVRRKAGYK KKLWKKTPAR KKRLREFVFC NKTQSKLLDK MTTSFWKRRN WYVDDPYQKY HDRTNLKV
	Isoform 2 [UniParc]. Checksum: DF3B4AEF300F91D7	FASTA	170	19,192
	10 20 30 40 50 60 MAASAFAGAV RAASGILRPL NILASSTYRN CVKNASLISA LSTGRFSHIQ TPVVSSTPRL 70 80 90 100 110 120 TTSERNLTCG HTSVILNRMA PVLPSVLKLP VRSLTYFSAR KGKRKTVKAV IDRFLRLHCG 130 140 150 160 170 LWVRRKAGYK KKLWKKTPAR KKRLREFVFC NKTQSKLLDK MTTSFWKRRN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone marrow.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Stomach.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS SER-19 AND THR-24. Tissue: Liver.
[6]	"The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L. J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF208849 mRNA. Translation: AAF64263.1. Frameshift. AK314555 mRNA. Translation: BAG37140.1. AK314577 mRNA. Translation: BAG37154.1. AL832982 mRNA. Translation: CAH56349.1. AC009309 Genomic DNA. No translation available. BC020651 mRNA. Translation: AAH20651.1.
IPI	IPI00179019. IPI00828184.
RefSeq	NP_057706.2. NM_016622.3. NP_663619.1. NM_145644.2.
UniGene	Hs.433439.
3D structure databases
ProteinModelPortal	Q9NZE8.
SMR	Q9NZE8. Positions 103-162.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NZE8. 1 interaction.
STRING	9606.ENSP00000338389.
PTM databases
PhosphoSite	Q9NZE8.
Polymorphism databases
DMDM	124028627.
Proteomic databases
PaxDb	Q9NZE8.
PRIDE	Q9NZE8.
Protocols and materials databases
DNASU	51318.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000254644; ENSP00000254644; ENSG00000132313. ENST00000337109; ENSP00000338389; ENSG00000132313.
GeneID	51318.
KEGG	hsa:51318.
UCSC	uc002srf.4. human.
Organism-specific databases
CTD	51318.
GeneCards	GC02P086426.
HGNC	HGNC:14489. MRPL35.
HPA	HPA043482.
MIM	611841. gene.
neXtProt	NX_Q9NZE8.
PharmGKB	PA30966.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG288104.
HOGENOM	HOG000293335.
HOVERGEN	HBG050017.
InParanoid	Q9NZE8.
KO	K02916.
OMA	HFSHIQT.
PhylomeDB	Q9NZE8.
Gene expression databases
ArrayExpress	Q9NZE8.
Bgee	Q9NZE8.
CleanEx	HS_MRPL35.
Genevestigator	Q9NZE8.
GermOnline	ENSG00000132313. Homo sapiens.
Family and domain databases
InterPro	IPR019338. Ribosomal-L35_mit. IPR021137. Ribosomal_L35. [Graphical view]
PANTHER	PTHR15909. PTHR15909. 1 hit.
Pfam	PF01632. Ribosomal_L35p. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MRPL35. human.
GenomeRNAi	51318.
NextBio	54687.
SOURCE	Search...

Entry information

Entry name

RM35_HUMAN

Accession

Primary (citable) accession number: Q9NZE8
Secondary accession number(s): A6NKV6 , B2RB93, Q658U7, Q8WWA2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 94 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.