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Protein

39S ribosomal protein L35, mitochondrial

Gene

MRPL35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L35, mitochondrial
Short name:
L35mt
Short name:
MRP-L35
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL35m
Gene namesi
Name:MRPL35
ORF Names:BM-007
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14489. MRPL35.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial large ribosomal subunit Source: UniProtKB
  • mitochondrial ribosome Source: UniProtKB

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132313.
PharmGKBiPA30966.

Polymorphism and mutation databases

BioMutaiMRPL35.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030525? – 18839S ribosomal protein L35, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ9NZE8.
MaxQBiQ9NZE8.
PaxDbiQ9NZE8.
PeptideAtlasiQ9NZE8.
PRIDEiQ9NZE8.

PTM databases

iPTMnetiQ9NZE8.
PhosphoSitePlusiQ9NZE8.

Expressioni

Gene expression databases

BgeeiENSG00000132313.
CleanExiHS_MRPL35.
ExpressionAtlasiQ9NZE8. baseline and differential.
GenevisibleiQ9NZE8. HS.

Organism-specific databases

HPAiHPA043482.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.2 Publications

Protein-protein interaction databases

BioGridi119469. 43 interactors.
IntActiQ9NZE8. 6 interactors.
STRINGi9606.ENSP00000338389.

Structurei

Secondary structure

1188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi99 – 101Combined sources3
Helixi108 – 113Combined sources6
Beta strandi114 – 116Combined sources3
Beta strandi122 – 125Combined sources4
Beta strandi129 – 131Combined sources3
Turni133 – 135Combined sources3
Helixi138 – 144Combined sources7
Beta strandi146 – 149Combined sources4
Helixi152 – 161Combined sources10
Helixi164 – 167Combined sources4
Beta strandi172 – 174Combined sources3
Helixi178 – 180Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4031-188[»]
3J9Melectron microscopy3.5031-188[»]
ProteinModelPortaliQ9NZE8.
SMRiQ9NZE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L35P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4316. Eukaryota.
ENOG4111VAN. LUCA.
GeneTreeiENSGT00390000007547.
HOGENOMiHOG000293335.
HOVERGENiHBG050017.
InParanoidiQ9NZE8.
KOiK02916.
OMAiWKKTPAR.
OrthoDBiEOG091G0UZ0.
PhylomeDBiQ9NZE8.
TreeFamiTF317642.

Family and domain databases

InterProiView protein in InterPro
IPR019338. Ribosomal-L35_mit.
IPR021137. Ribosomal_L35.
PANTHERiPTHR15909. PTHR15909. 1 hit.
PfamiView protein in Pfam
PF01632. Ribosomal_L35p. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NZE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASAFAGAV RAASGILRPL NILASSTYRN CVKNASLISA LSTGRFSHIQ
60 70 80 90 100
TPVVSSTPRL TTSERNLTCG HTSVILNRMA PVLPSVLKLP VRSLTYFSAR
110 120 130 140 150
KGKRKTVKAV IDRFLRLHCG LWVRRKAGYK KKLWKKTPAR KKRLREFVFC
160 170 180
NKTQSKLLDK MTTSFWKRRN WYVDDPYQKY HDRTNLKV
Length:188
Mass (Da):21,514
Last modified:January 23, 2007 - v3
Checksum:i3A44076927C5A54B
GO
Isoform 2 (identifier: Q9NZE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-188: Missing.

Show »
Length:170
Mass (Da):19,192
Checksum:iDF3B4AEF300F91D7
GO

Sequence cautioni

The sequence AAF64263 differs from that shown. Reason: Frameshift at position 122.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03001019P → S1 PublicationCorresponds to variant dbSNP:rs12714176Ensembl.1
Natural variantiVAR_05463224A → T1 PublicationCorresponds to variant dbSNP:rs17851803Ensembl.1
Natural variantiVAR_05463329R → H. Corresponds to variant dbSNP:rs1051949Ensembl.1
Natural variantiVAR_03446380A → P. Corresponds to variant dbSNP:rs34044771Ensembl.1
Natural variantiVAR_05180381P → L. Corresponds to variant dbSNP:rs3192352Ensembl.1
Natural variantiVAR_054634180Y → C. Corresponds to variant dbSNP:rs1052065Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036507171 – 188Missing in isoform 2. 2 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208849 mRNA. Translation: AAF64263.1. Frameshift.
AK314555 mRNA. Translation: BAG37140.1.
AK314577 mRNA. Translation: BAG37154.1.
AL832982 mRNA. Translation: CAH56349.1.
AC009309 Genomic DNA. No translation available.
BC020651 mRNA. Translation: AAH20651.1.
CCDSiCCDS1987.1. [Q9NZE8-2]
CCDS1988.1. [Q9NZE8-1]
RefSeqiNP_057706.2. NM_016622.3. [Q9NZE8-1]
NP_663619.1. NM_145644.2. [Q9NZE8-2]
UniGeneiHs.433439.

Genome annotation databases

EnsembliENST00000254644; ENSP00000254644; ENSG00000132313. [Q9NZE8-2]
ENST00000337109; ENSP00000338389; ENSG00000132313. [Q9NZE8-1]
GeneIDi51318.
KEGGihsa:51318.
UCSCiuc002srg.5. human. [Q9NZE8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208849 mRNA. Translation: AAF64263.1. Frameshift.
AK314555 mRNA. Translation: BAG37140.1.
AK314577 mRNA. Translation: BAG37154.1.
AL832982 mRNA. Translation: CAH56349.1.
AC009309 Genomic DNA. No translation available.
BC020651 mRNA. Translation: AAH20651.1.
CCDSiCCDS1987.1. [Q9NZE8-2]
CCDS1988.1. [Q9NZE8-1]
RefSeqiNP_057706.2. NM_016622.3. [Q9NZE8-1]
NP_663619.1. NM_145644.2. [Q9NZE8-2]
UniGeneiHs.433439.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4031-188[»]
3J9Melectron microscopy3.5031-188[»]
ProteinModelPortaliQ9NZE8.
SMRiQ9NZE8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119469. 43 interactors.
IntActiQ9NZE8. 6 interactors.
STRINGi9606.ENSP00000338389.

PTM databases

iPTMnetiQ9NZE8.
PhosphoSitePlusiQ9NZE8.

Polymorphism and mutation databases

BioMutaiMRPL35.

Proteomic databases

EPDiQ9NZE8.
MaxQBiQ9NZE8.
PaxDbiQ9NZE8.
PeptideAtlasiQ9NZE8.
PRIDEiQ9NZE8.

Protocols and materials databases

DNASUi51318.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254644; ENSP00000254644; ENSG00000132313. [Q9NZE8-2]
ENST00000337109; ENSP00000338389; ENSG00000132313. [Q9NZE8-1]
GeneIDi51318.
KEGGihsa:51318.
UCSCiuc002srg.5. human. [Q9NZE8-1]

Organism-specific databases

CTDi51318.
GeneCardsiMRPL35.
HGNCiHGNC:14489. MRPL35.
HPAiHPA043482.
MIMi611841. gene.
neXtProtiNX_Q9NZE8.
OpenTargetsiENSG00000132313.
PharmGKBiPA30966.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4316. Eukaryota.
ENOG4111VAN. LUCA.
GeneTreeiENSGT00390000007547.
HOGENOMiHOG000293335.
HOVERGENiHBG050017.
InParanoidiQ9NZE8.
KOiK02916.
OMAiWKKTPAR.
OrthoDBiEOG091G0UZ0.
PhylomeDBiQ9NZE8.
TreeFamiTF317642.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL35. human.
GenomeRNAii51318.
PROiQ9NZE8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132313.
CleanExiHS_MRPL35.
ExpressionAtlasiQ9NZE8. baseline and differential.
GenevisibleiQ9NZE8. HS.

Family and domain databases

InterProiView protein in InterPro
IPR019338. Ribosomal-L35_mit.
IPR021137. Ribosomal_L35.
PANTHERiPTHR15909. PTHR15909. 1 hit.
PfamiView protein in Pfam
PF01632. Ribosomal_L35p. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRM35_HUMAN
AccessioniPrimary (citable) accession number: Q9NZE8
Secondary accession number(s): A6NKV6
, B2RB93, Q658U7, Q8WWA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.