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Q9NZE8

- RM35_HUMAN

UniProt

Q9NZE8 - RM35_HUMAN

Protein

39S ribosomal protein L35, mitochondrial

Gene

MRPL35

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L35, mitochondrial
    Short name:
    L35mt
    Short name:
    MRP-L35
    Gene namesi
    Name:MRPL35
    ORF Names:BM-007
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:14489. MRPL35.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial ribosome Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30966.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 18839S ribosomal protein L35, mitochondrialPRO_0000030525
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiQ9NZE8.
    PaxDbiQ9NZE8.
    PRIDEiQ9NZE8.

    PTM databases

    PhosphoSiteiQ9NZE8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NZE8.
    BgeeiQ9NZE8.
    CleanExiHS_MRPL35.
    GenevestigatoriQ9NZE8.

    Organism-specific databases

    HPAiHPA043482.

    Interactioni

    Protein-protein interaction databases

    BioGridi119469. 1 interaction.
    IntActiQ9NZE8. 1 interaction.
    STRINGi9606.ENSP00000338389.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NZE8.
    SMRiQ9NZE8. Positions 103-162.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L35P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG288104.
    HOGENOMiHOG000293335.
    HOVERGENiHBG050017.
    InParanoidiQ9NZE8.
    KOiK02916.
    OMAiHFSHIQT.
    PhylomeDBiQ9NZE8.
    TreeFamiTF317642.

    Family and domain databases

    InterProiIPR019338. Ribosomal-L35_mit.
    IPR021137. Ribosomal_L35.
    [Graphical view]
    PANTHERiPTHR15909. PTHR15909. 1 hit.
    PfamiPF01632. Ribosomal_L35p. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NZE8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAASAFAGAV RAASGILRPL NILASSTYRN CVKNASLISA LSTGRFSHIQ    50
    TPVVSSTPRL TTSERNLTCG HTSVILNRMA PVLPSVLKLP VRSLTYFSAR 100
    KGKRKTVKAV IDRFLRLHCG LWVRRKAGYK KKLWKKTPAR KKRLREFVFC 150
    NKTQSKLLDK MTTSFWKRRN WYVDDPYQKY HDRTNLKV 188
    Length:188
    Mass (Da):21,514
    Last modified:January 23, 2007 - v3
    Checksum:i3A44076927C5A54B
    GO
    Isoform 2 (identifier: Q9NZE8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         171-188: Missing.

    Show »
    Length:170
    Mass (Da):19,192
    Checksum:iDF3B4AEF300F91D7
    GO

    Sequence cautioni

    The sequence AAF64263.1 differs from that shown. Reason: Frameshift at position 122.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti19 – 191P → S.1 Publication
    Corresponds to variant rs12714176 [ dbSNP | Ensembl ].
    VAR_030010
    Natural varianti24 – 241A → T.1 Publication
    Corresponds to variant rs17851803 [ dbSNP | Ensembl ].
    VAR_054632
    Natural varianti29 – 291R → H.
    Corresponds to variant rs1051949 [ dbSNP | Ensembl ].
    VAR_054633
    Natural varianti80 – 801A → P.
    Corresponds to variant rs34044771 [ dbSNP | Ensembl ].
    VAR_034463
    Natural varianti81 – 811P → L.
    Corresponds to variant rs3192352 [ dbSNP | Ensembl ].
    VAR_051803
    Natural varianti180 – 1801Y → C.
    Corresponds to variant rs1052065 [ dbSNP | Ensembl ].
    VAR_054634

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei171 – 18818Missing in isoform 2. 2 PublicationsVSP_036507Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF208849 mRNA. Translation: AAF64263.1. Frameshift.
    AK314555 mRNA. Translation: BAG37140.1.
    AK314577 mRNA. Translation: BAG37154.1.
    AL832982 mRNA. Translation: CAH56349.1.
    AC009309 Genomic DNA. No translation available.
    BC020651 mRNA. Translation: AAH20651.1.
    CCDSiCCDS1987.1. [Q9NZE8-2]
    CCDS1988.1. [Q9NZE8-1]
    RefSeqiNP_057706.2. NM_016622.3. [Q9NZE8-1]
    NP_663619.1. NM_145644.2. [Q9NZE8-2]
    UniGeneiHs.433439.

    Genome annotation databases

    EnsembliENST00000254644; ENSP00000254644; ENSG00000132313. [Q9NZE8-2]
    ENST00000337109; ENSP00000338389; ENSG00000132313. [Q9NZE8-1]
    GeneIDi51318.
    KEGGihsa:51318.
    UCSCiuc002srf.4. human. [Q9NZE8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF208849 mRNA. Translation: AAF64263.1 . Frameshift.
    AK314555 mRNA. Translation: BAG37140.1 .
    AK314577 mRNA. Translation: BAG37154.1 .
    AL832982 mRNA. Translation: CAH56349.1 .
    AC009309 Genomic DNA. No translation available.
    BC020651 mRNA. Translation: AAH20651.1 .
    CCDSi CCDS1987.1. [Q9NZE8-2 ]
    CCDS1988.1. [Q9NZE8-1 ]
    RefSeqi NP_057706.2. NM_016622.3. [Q9NZE8-1 ]
    NP_663619.1. NM_145644.2. [Q9NZE8-2 ]
    UniGenei Hs.433439.

    3D structure databases

    ProteinModelPortali Q9NZE8.
    SMRi Q9NZE8. Positions 103-162.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119469. 1 interaction.
    IntActi Q9NZE8. 1 interaction.
    STRINGi 9606.ENSP00000338389.

    PTM databases

    PhosphoSitei Q9NZE8.

    Proteomic databases

    MaxQBi Q9NZE8.
    PaxDbi Q9NZE8.
    PRIDEi Q9NZE8.

    Protocols and materials databases

    DNASUi 51318.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254644 ; ENSP00000254644 ; ENSG00000132313 . [Q9NZE8-2 ]
    ENST00000337109 ; ENSP00000338389 ; ENSG00000132313 . [Q9NZE8-1 ]
    GeneIDi 51318.
    KEGGi hsa:51318.
    UCSCi uc002srf.4. human. [Q9NZE8-1 ]

    Organism-specific databases

    CTDi 51318.
    GeneCardsi GC02P086426.
    HGNCi HGNC:14489. MRPL35.
    HPAi HPA043482.
    MIMi 611841. gene.
    neXtProti NX_Q9NZE8.
    PharmGKBi PA30966.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288104.
    HOGENOMi HOG000293335.
    HOVERGENi HBG050017.
    InParanoidi Q9NZE8.
    KOi K02916.
    OMAi HFSHIQT.
    PhylomeDBi Q9NZE8.
    TreeFami TF317642.

    Miscellaneous databases

    ChiTaRSi MRPL35. human.
    GenomeRNAii 51318.
    NextBioi 54687.
    PROi Q9NZE8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NZE8.
    Bgeei Q9NZE8.
    CleanExi HS_MRPL35.
    Genevestigatori Q9NZE8.

    Family and domain databases

    InterProi IPR019338. Ribosomal-L35_mit.
    IPR021137. Ribosomal_L35.
    [Graphical view ]
    PANTHERi PTHR15909. PTHR15909. 1 hit.
    Pfami PF01632. Ribosomal_L35p. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Stomach.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS SER-19 AND THR-24.
      Tissue: Liver.
    6. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM35_HUMAN
    AccessioniPrimary (citable) accession number: Q9NZE8
    Secondary accession number(s): A6NKV6
    , B2RB93, Q658U7, Q8WWA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 103 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3