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Q9NZE8 (RM35_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
39S ribosomal protein L35, mitochondrial

Short name=L35mt
Short name=MRP-L35
Gene names
Name:MRPL35
ORF Names:BM-007
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length188 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the ribosomal protein L35P family.

Sequence caution

The sequence AAF64263.1 differs from that shown. Reason: Frameshift at position 122.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransit peptide
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Non-traceable author statement PubMed 11543634. Source: UniProtKB

   Cellular_componentmitochondrial ribosome

Non-traceable author statement PubMed 11543634. Source: UniProtKB

   Molecular_functionstructural constituent of ribosome

Non-traceable author statement PubMed 11543634. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NZE8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NZE8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     171-188: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 18839S ribosomal protein L35, mitochondrialPRO_0000030525

Natural variations

Alternative sequence171 – 18818Missing in isoform 2.
VSP_036507
Natural variant191P → S. Ref.5
Corresponds to variant rs12714176 [ dbSNP | Ensembl ].
VAR_030010
Natural variant241A → T. Ref.5
Corresponds to variant rs17851803 [ dbSNP | Ensembl ].
VAR_054632
Natural variant291R → H.
Corresponds to variant rs1051949 [ dbSNP | Ensembl ].
VAR_054633
Natural variant801A → P.
Corresponds to variant rs34044771 [ dbSNP | Ensembl ].
VAR_034463
Natural variant811P → L.
Corresponds to variant rs3192352 [ dbSNP | Ensembl ].
VAR_051803
Natural variant1801Y → C.
Corresponds to variant rs1052065 [ dbSNP | Ensembl ].
VAR_054634

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 3A44076927C5A54B

FASTA18821,514
        10         20         30         40         50         60 
MAASAFAGAV RAASGILRPL NILASSTYRN CVKNASLISA LSTGRFSHIQ TPVVSSTPRL 

        70         80         90        100        110        120 
TTSERNLTCG HTSVILNRMA PVLPSVLKLP VRSLTYFSAR KGKRKTVKAV IDRFLRLHCG 

       130        140        150        160        170        180 
LWVRRKAGYK KKLWKKTPAR KKRLREFVFC NKTQSKLLDK MTTSFWKRRN WYVDDPYQKY 


HDRTNLKV 

« Hide

Isoform 2 [UniParc].

Checksum: DF3B4AEF300F91D7
Show »

FASTA17019,192

References

« Hide 'large scale' references
[1]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Bone marrow.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Stomach.
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS SER-19 AND THR-24.
Tissue: Liver.
[6]"The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF208849 mRNA. Translation: AAF64263.1. Frameshift.
AK314555 mRNA. Translation: BAG37140.1.
AK314577 mRNA. Translation: BAG37154.1.
AL832982 mRNA. Translation: CAH56349.1.
AC009309 Genomic DNA. No translation available.
BC020651 mRNA. Translation: AAH20651.1.
CCDSCCDS1987.1. [Q9NZE8-2]
CCDS1988.1. [Q9NZE8-1]
RefSeqNP_057706.2. NM_016622.3. [Q9NZE8-1]
NP_663619.1. NM_145644.2. [Q9NZE8-2]
UniGeneHs.433439.

3D structure databases

ProteinModelPortalQ9NZE8.
SMRQ9NZE8. Positions 103-162.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119469. 1 interaction.
IntActQ9NZE8. 1 interaction.
STRING9606.ENSP00000338389.

PTM databases

PhosphoSiteQ9NZE8.

Proteomic databases

MaxQBQ9NZE8.
PaxDbQ9NZE8.
PRIDEQ9NZE8.

Protocols and materials databases

DNASU51318.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254644; ENSP00000254644; ENSG00000132313. [Q9NZE8-2]
ENST00000337109; ENSP00000338389; ENSG00000132313. [Q9NZE8-1]
GeneID51318.
KEGGhsa:51318.
UCSCuc002srf.4. human. [Q9NZE8-1]

Organism-specific databases

CTD51318.
GeneCardsGC02P086426.
HGNCHGNC:14489. MRPL35.
HPAHPA043482.
MIM611841. gene.
neXtProtNX_Q9NZE8.
PharmGKBPA30966.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG288104.
HOGENOMHOG000293335.
HOVERGENHBG050017.
InParanoidQ9NZE8.
KOK02916.
OMAHFSHIQT.
PhylomeDBQ9NZE8.
TreeFamTF317642.

Gene expression databases

ArrayExpressQ9NZE8.
BgeeQ9NZE8.
CleanExHS_MRPL35.
GenevestigatorQ9NZE8.

Family and domain databases

InterProIPR019338. Ribosomal-L35_mit.
IPR021137. Ribosomal_L35.
[Graphical view]
PANTHERPTHR15909. PTHR15909. 1 hit.
PfamPF01632. Ribosomal_L35p. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMRPL35. human.
GenomeRNAi51318.
NextBio54687.
PROQ9NZE8.
SOURCESearch...

Entry information

Entry nameRM35_HUMAN
AccessionPrimary (citable) accession number: Q9NZE8
Secondary accession number(s): A6NKV6 expand/collapse secondary AC list , B2RB93, Q658U7, Q8WWA2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM