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Protein

Glycolipid transfer protein

Gene

GLTP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140Glycolipid1 Publication1
Binding sitei207Glycolipid1 Publication1

GO - Molecular functioni

  • glycolipid binding Source: HGNC
  • glycolipid transporter activity Source: HGNC
  • lipid binding Source: HGNC

GO - Biological processi

  • glycolipid transport Source: HGNC
  • glycosphingolipid metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139433-MONOMER.
ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycolipid transfer protein
Short name:
GLTP
Gene namesi
Name:GLTP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24867. GLTP.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • membrane Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi45I → N: 18% decrease in activity. 1 Publication1
Mutagenesisi48D → V: Significant inactivation; 15% residual activity. 1 Publication1
Mutagenesisi52N → I: Significant inactivation; 15% residual activity. 1 Publication1
Mutagenesisi55K → I: No loss of activity; 90-97% residual activity. 1 Publication1
Mutagenesisi96W → A: Almost complete inactivation; 1-3% residual activity. 1 Publication1
Mutagenesisi96W → F: Partial inactivation; 63% residual activity. 1 Publication1
Mutagenesisi103F → S: About 25% decrease in activity. 1 Publication1
Mutagenesisi136L → R: Significant inactivation; 5% residual activity. 1 Publication1
Mutagenesisi140H → L: Almost complete inactivation; 1-3% residual activity. 1 Publication1
Mutagenesisi148F → S: About 50% decrease in activity. 1 Publication1
Mutagenesisi165L → R: 46% decrease in activity. 1 Publication1
Mutagenesisi183F → S: No loss of activity; 90% residual activity. 1 Publication1
Mutagenesisi207Y → L: No loss of activity; 90-97% residual activity. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000139433.
PharmGKBiPA142671729.

Chemistry databases

DrugBankiDB04465. Lactose.
DB04224. Oleic Acid.

Polymorphism and mutation databases

BioMutaiGLTP.
DMDMi20138399.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001489152 – 209Glycolipid transfer proteinAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NZD2.
MaxQBiQ9NZD2.
PaxDbiQ9NZD2.
PeptideAtlasiQ9NZD2.
PRIDEiQ9NZD2.

PTM databases

iPTMnetiQ9NZD2.
PhosphoSitePlusiQ9NZD2.

Expressioni

Tissue specificityi

Detected in fibroblasts (at protein level). Detected in fibroblasts and in various cancer cell lines.2 Publications

Gene expression databases

BgeeiENSG00000139433.
CleanExiHS_GLTP.
ExpressionAtlasiQ9NZD2. baseline and differential.
GenevisibleiQ9NZD2. HS.

Organism-specific databases

HPAiHPA056461.

Interactioni

Subunit structurei

Monomer.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CMTM5Q96DZ93EBI-2859814,EBI-2548702

Protein-protein interaction databases

BioGridi119392. 6 interactors.
DIPiDIP-59418N.
IntActiQ9NZD2. 2 interactors.
STRINGi9606.ENSP00000315263.

Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 6Combined sources3
Helixi20 – 27Combined sources8
Turni28 – 30Combined sources3
Helixi31 – 36Combined sources6
Helixi40 – 42Combined sources3
Helixi43 – 62Combined sources20
Turni64 – 67Combined sources4
Helixi70 – 81Combined sources12
Helixi82 – 84Combined sources3
Helixi89 – 112Combined sources24
Beta strandi118 – 120Combined sources3
Helixi125 – 135Combined sources11
Helixi137 – 139Combined sources3
Helixi142 – 151Combined sources10
Helixi152 – 154Combined sources3
Helixi158 – 165Combined sources8
Turni166 – 168Combined sources3
Helixi173 – 200Combined sources28

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SWXX-ray1.65A1-209[»]
1SX6X-ray1.95A1-209[»]
2EUKX-ray1.85A1-209[»]
2EUMX-ray2.30A1-209[»]
2EVDX-ray2.00A1-209[»]
2EVLX-ray2.20A1-209[»]
2EVSX-ray2.20A/E1-209[»]
2EVTX-ray1.99A1-209[»]
3RICX-ray2.10A1-209[»]
3RWVX-ray1.50A/B1-209[»]
3RZNX-ray1.10A1-209[»]
3S0IX-ray1.50A1-209[»]
3S0KX-ray1.40A1-209[»]
4GH0X-ray1.35A1-209[»]
4GHPX-ray1.90A1-209[»]
4GHSX-ray3.20A/B1-209[»]
4GIXX-ray1.80A1-209[»]
4GJQX-ray2.00A/B1-209[»]
4GVTX-ray2.90A1-209[»]
4GXDX-ray2.10A1-209[»]
4GXGX-ray2.40A/B/D/E1-209[»]
4H2ZX-ray1.45A1-209[»]
ProteinModelPortaliQ9NZD2.
SMRiQ9NZD2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NZD2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 551Add BLAST11
Repeati56 – 662Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 662 X 12 AA approximate tandem repeatsAdd BLAST22
Regioni48 – 55Glycolipid binding8

Sequence similaritiesi

Belongs to the GLTP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3221. Eukaryota.
ENOG410YFEA. LUCA.
GeneTreeiENSGT00800000124166.
HOGENOMiHOG000199421.
HOVERGENiHBG019001.
InParanoidiQ9NZD2.
OMAiRGLEFTC.
OrthoDBiEOG091G0IIT.
PhylomeDBiQ9NZD2.
TreeFamiTF317467.

Family and domain databases

Gene3Di1.10.3520.10. 1 hit.
InterProiIPR014830. Glycolipid_transfer_prot_dom.
[Graphical view]
PfamiPF08718. GLTP. 1 hit.
[Graphical view]
SUPFAMiSSF110004. SSF110004. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NZD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLAEHLLK PLPADKQIET GPFLEAVSHL PPFFDCLGSP VFTPIKADIS
60 70 80 90 100
GNITKIKAVY DTNPAKFRTL QNILEVEKEM YGAEWPKVGA TLALMWLKRG
110 120 130 140 150
LRFIQVFLQS ICDGERDENH PNLIRVNATK AYEMALKKYH GWIVQKIFQA
160 170 180 190 200
ALYAAPYKSD FLKALSKGQN VTEEECLEKI RLFLVNYTAT IDVIYEMYTQ

MNAELNYKV
Length:209
Mass (Da):23,850
Last modified:January 23, 2007 - v3
Checksum:iF3DD96D702AE22CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF209704 mRNA. Translation: AAF33210.1.
AY372530 mRNA. Translation: AAR85984.1.
AY372531 mRNA. Translation: AAR85985.1.
AY372532 mRNA. Translation: AAR87373.1.
AK313457 mRNA. Translation: BAG36244.1.
CH471054 Genomic DNA. Translation: EAW97880.1.
BC009932 mRNA. Translation: AAH09932.1.
CCDSiCCDS9136.1.
RefSeqiNP_057517.1. NM_016433.3.
UniGeneiHs.381256.

Genome annotation databases

EnsembliENST00000318348; ENSP00000315263; ENSG00000139433.
GeneIDi51228.
KEGGihsa:51228.
UCSCiuc001tpm.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF209704 mRNA. Translation: AAF33210.1.
AY372530 mRNA. Translation: AAR85984.1.
AY372531 mRNA. Translation: AAR85985.1.
AY372532 mRNA. Translation: AAR87373.1.
AK313457 mRNA. Translation: BAG36244.1.
CH471054 Genomic DNA. Translation: EAW97880.1.
BC009932 mRNA. Translation: AAH09932.1.
CCDSiCCDS9136.1.
RefSeqiNP_057517.1. NM_016433.3.
UniGeneiHs.381256.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SWXX-ray1.65A1-209[»]
1SX6X-ray1.95A1-209[»]
2EUKX-ray1.85A1-209[»]
2EUMX-ray2.30A1-209[»]
2EVDX-ray2.00A1-209[»]
2EVLX-ray2.20A1-209[»]
2EVSX-ray2.20A/E1-209[»]
2EVTX-ray1.99A1-209[»]
3RICX-ray2.10A1-209[»]
3RWVX-ray1.50A/B1-209[»]
3RZNX-ray1.10A1-209[»]
3S0IX-ray1.50A1-209[»]
3S0KX-ray1.40A1-209[»]
4GH0X-ray1.35A1-209[»]
4GHPX-ray1.90A1-209[»]
4GHSX-ray3.20A/B1-209[»]
4GIXX-ray1.80A1-209[»]
4GJQX-ray2.00A/B1-209[»]
4GVTX-ray2.90A1-209[»]
4GXDX-ray2.10A1-209[»]
4GXGX-ray2.40A/B/D/E1-209[»]
4H2ZX-ray1.45A1-209[»]
ProteinModelPortaliQ9NZD2.
SMRiQ9NZD2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119392. 6 interactors.
DIPiDIP-59418N.
IntActiQ9NZD2. 2 interactors.
STRINGi9606.ENSP00000315263.

Chemistry databases

DrugBankiDB04465. Lactose.
DB04224. Oleic Acid.

PTM databases

iPTMnetiQ9NZD2.
PhosphoSitePlusiQ9NZD2.

Polymorphism and mutation databases

BioMutaiGLTP.
DMDMi20138399.

Proteomic databases

EPDiQ9NZD2.
MaxQBiQ9NZD2.
PaxDbiQ9NZD2.
PeptideAtlasiQ9NZD2.
PRIDEiQ9NZD2.

Protocols and materials databases

DNASUi51228.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318348; ENSP00000315263; ENSG00000139433.
GeneIDi51228.
KEGGihsa:51228.
UCSCiuc001tpm.3. human.

Organism-specific databases

CTDi51228.
GeneCardsiGLTP.
HGNCiHGNC:24867. GLTP.
HPAiHPA056461.
MIMi608949. gene.
neXtProtiNX_Q9NZD2.
OpenTargetsiENSG00000139433.
PharmGKBiPA142671729.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3221. Eukaryota.
ENOG410YFEA. LUCA.
GeneTreeiENSGT00800000124166.
HOGENOMiHOG000199421.
HOVERGENiHBG019001.
InParanoidiQ9NZD2.
OMAiRGLEFTC.
OrthoDBiEOG091G0IIT.
PhylomeDBiQ9NZD2.
TreeFamiTF317467.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139433-MONOMER.
ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.

Miscellaneous databases

ChiTaRSiGLTP. human.
EvolutionaryTraceiQ9NZD2.
GeneWikiiGLTP.
GenomeRNAii51228.
PROiQ9NZD2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139433.
CleanExiHS_GLTP.
ExpressionAtlasiQ9NZD2. baseline and differential.
GenevisibleiQ9NZD2. HS.

Family and domain databases

Gene3Di1.10.3520.10. 1 hit.
InterProiIPR014830. Glycolipid_transfer_prot_dom.
[Graphical view]
PfamiPF08718. GLTP. 1 hit.
[Graphical view]
SUPFAMiSSF110004. SSF110004. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLTP_HUMAN
AccessioniPrimary (citable) accession number: Q9NZD2
Secondary accession number(s): Q53Z13, Q96J68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.