ID   GPC5D_HUMAN             Reviewed;         345 AA.
AC   Q9NZD1; Q3KNV3; Q7Z5J9; Q8TDS6;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   24-JAN-2024, entry version 150.
DE   RecName: Full=G-protein coupled receptor family C group 5 member D;
GN   Name=GPRC5D;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR
RP   LOCATION, AND INDUCTION.
RC   TISSUE=Testis;
RX   PubMed=11311935; DOI=10.1016/s0167-4781(01)00197-x;
RA   Braeuner-Osborne H., Jensen A.A., Sheppard P.O., Brodin B.,
RA   Krogsgaard-Larsen P., O'Hara P.;
RT   "Cloning and characterization of a human orphan family C G-protein coupled
RT   receptor GPRC5D.";
RL   Biochim. Biophys. Acta 1518:237-248(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC   TISSUE=Skin;
RA   Inoue S., Nanbu T., Shimomura T.;
RT   "Characterization of GPRC5D, a member of RAIG family in hard keratinized
RT   structures.";
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 3).
RX   PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA   Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT   "Identification of G protein-coupled receptor genes from the human genome
RT   sequence.";
RL   FEBS Lett. 520:97-101(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q9NZD1; O95236-2: APOL3; NbExp=3; IntAct=EBI-13067820, EBI-11976321;
CC       Q9NZD1; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-13067820, EBI-8648738;
CC       Q9NZD1; P13236: CCL4; NbExp=3; IntAct=EBI-13067820, EBI-2873970;
CC       Q9NZD1; P54849: EMP1; NbExp=3; IntAct=EBI-13067820, EBI-4319440;
CC       Q9NZD1; Q7Z2K6: ERMP1; NbExp=3; IntAct=EBI-13067820, EBI-10976398;
CC       Q9NZD1; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-13067820, EBI-12175685;
CC       Q9NZD1; P02724: GYPA; NbExp=3; IntAct=EBI-13067820, EBI-702665;
CC       Q9NZD1; Q01628: IFITM3; NbExp=3; IntAct=EBI-13067820, EBI-7932862;
CC       Q9NZD1; P24593: IGFBP5; NbExp=3; IntAct=EBI-13067820, EBI-720480;
CC       Q9NZD1; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-13067820, EBI-2820517;
CC       Q9NZD1; Q8N386: LRRC25; NbExp=3; IntAct=EBI-13067820, EBI-11304917;
CC       Q9NZD1; Q9H2W1: MS4A6A; NbExp=3; IntAct=EBI-13067820, EBI-1266965;
CC       Q9NZD1; Q8N912: NRAC; NbExp=3; IntAct=EBI-13067820, EBI-12051377;
CC       Q9NZD1; Q99650: OSMR; NbExp=3; IntAct=EBI-13067820, EBI-2804080;
CC       Q9NZD1; Q01453: PMP22; NbExp=3; IntAct=EBI-13067820, EBI-2845982;
CC       Q9NZD1; Q7Z6L0: PRRT2; NbExp=3; IntAct=EBI-13067820, EBI-722696;
CC       Q9NZD1; P15151: PVR; NbExp=3; IntAct=EBI-13067820, EBI-3919694;
CC       Q9NZD1; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-13067820, EBI-8644112;
CC       Q9NZD1; Q6ZP29-3: SLC66A1; NbExp=3; IntAct=EBI-13067820, EBI-12889586;
CC       Q9NZD1; Q9H7V2: SYNDIG1; NbExp=3; IntAct=EBI-13067820, EBI-726331;
CC       Q9NZD1; A0PK00: TMEM120B; NbExp=3; IntAct=EBI-13067820, EBI-10171534;
CC       Q9NZD1; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-13067820, EBI-741829;
CC       Q9NZD1; Q9BTX3: TMEM208; NbExp=3; IntAct=EBI-13067820, EBI-12876824;
CC       Q9NZD1; Q9BSE2: TMEM79; NbExp=3; IntAct=EBI-13067820, EBI-8649725;
CC       Q9NZD1; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-13067820, EBI-11988865;
CC       Q9NZD1; Q9GZX9: TWSG1; NbExp=3; IntAct=EBI-13067820, EBI-10304067;
CC       Q9NZD1; Q9H1C4: UNC93B1; NbExp=3; IntAct=EBI-13067820, EBI-4401271;
CC       Q9NZD1; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-13067820, EBI-7850136;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11311935};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:11311935}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q9NZD1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9NZD1-2; Sequence=VSP_010006, VSP_010007;
CC       Name=3;
CC         IsoId=Q9NZD1-3; Sequence=VSP_010008;
CC   -!- TISSUE SPECIFICITY: Widely expressed in the peripheral system.
CC       Expression pattern is high in pancreas, medium in kidney, small
CC       intestine, spleen and testis, low in lung, colon, leukocyte, prostate
CC       and thymus and not detectable in brain, heart, liver, placenta,
CC       skeletal muscle and ovary. {ECO:0000269|PubMed:11311935}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC       {ECO:0000305}.
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DR   EMBL; AF209923; AAF72873.1; -; mRNA.
DR   EMBL; AB099817; BAC79169.1; -; mRNA.
DR   EMBL; AB083629; BAB89342.1; -; Genomic_DNA.
DR   EMBL; BC069341; AAH69341.1; -; mRNA.
DR   EMBL; BC107077; AAI07078.1; -; mRNA.
DR   EMBL; BC107078; AAI07079.1; -; mRNA.
DR   CCDS; CCDS8658.1; -. [Q9NZD1-1]
DR   RefSeq; NP_061124.1; NM_018654.1. [Q9NZD1-1]
DR   RefSeq; XP_005253478.1; XM_005253421.3.
DR   RefSeq; XP_016875071.1; XM_017019582.1.
DR   RefSeq; XP_016875072.1; XM_017019583.1. [Q9NZD1-2]
DR   AlphaFoldDB; Q9NZD1; -.
DR   SMR; Q9NZD1; -.
DR   BioGRID; 120687; 73.
DR   IntAct; Q9NZD1; 28.
DR   STRING; 9606.ENSP00000228887; -.
DR   ChEMBL; CHEMBL4523925; -.
DR   iPTMnet; Q9NZD1; -.
DR   PhosphoSitePlus; Q9NZD1; -.
DR   BioMuta; GPRC5D; -.
DR   DMDM; 46396015; -.
DR   MassIVE; Q9NZD1; -.
DR   PaxDb; 9606-ENSP00000228887; -.
DR   PeptideAtlas; Q9NZD1; -.
DR   ProteomicsDB; 83372; -. [Q9NZD1-1]
DR   ProteomicsDB; 83373; -. [Q9NZD1-2]
DR   ProteomicsDB; 83374; -. [Q9NZD1-3]
DR   ABCD; Q9NZD1; 32 sequenced antibodies.
DR   Antibodypedia; 11949; 262 antibodies from 29 providers.
DR   DNASU; 55507; -.
DR   Ensembl; ENST00000228887.6; ENSP00000228887.1; ENSG00000111291.9. [Q9NZD1-1]
DR   Ensembl; ENST00000396333.3; ENSP00000379624.3; ENSG00000111291.9. [Q9NZD1-2]
DR   GeneID; 55507; -.
DR   KEGG; hsa:55507; -.
DR   MANE-Select; ENST00000228887.6; ENSP00000228887.1; NM_018654.2; NP_061124.1.
DR   UCSC; uc010shp.2; human. [Q9NZD1-1]
DR   AGR; HGNC:13310; -.
DR   CTD; 55507; -.
DR   DisGeNET; 55507; -.
DR   GeneCards; GPRC5D; -.
DR   HGNC; HGNC:13310; GPRC5D.
DR   HPA; ENSG00000111291; Tissue enriched (skin).
DR   MIM; 607437; gene.
DR   neXtProt; NX_Q9NZD1; -.
DR   OpenTargets; ENSG00000111291; -.
DR   PharmGKB; PA28940; -.
DR   VEuPathDB; HostDB:ENSG00000111291; -.
DR   eggNOG; ENOG502SKRS; Eukaryota.
DR   GeneTree; ENSGT00950000182961; -.
DR   HOGENOM; CLU_044162_0_1_1; -.
DR   InParanoid; Q9NZD1; -.
DR   OMA; QEYFIPR; -.
DR   OrthoDB; 4263681at2759; -.
DR   PhylomeDB; Q9NZD1; -.
DR   TreeFam; TF321410; -.
DR   PathwayCommons; Q9NZD1; -.
DR   SignaLink; Q9NZD1; -.
DR   BioGRID-ORCS; 55507; 10 hits in 1141 CRISPR screens.
DR   GeneWiki; GPRC5D; -.
DR   GenomeRNAi; 55507; -.
DR   Pharos; Q9NZD1; Tbio.
DR   PRO; PR:Q9NZD1; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q9NZD1; Protein.
DR   Bgee; ENSG00000111291; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 99 other cell types or tissues.
DR   ExpressionAtlas; Q9NZD1; baseline and differential.
DR   GO; GO:0070062; C:extracellular exosome; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR   InterPro; IPR017978; GPCR_3_C.
DR   PANTHER; PTHR14511; G PROTEIN COUPLED RECEPTOR, CLASS C, GROUP 5; 1.
DR   PANTHER; PTHR14511:SF16; G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 5 MEMBER D; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Genevisible; Q9NZD1; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; G-protein coupled receptor; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..345
FT                   /note="G-protein coupled receptor family C group 5 member
FT                   D"
FT                   /id="PRO_0000206897"
FT   TOPO_DOM        1..27
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..63
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        85..93
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..123
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        145..167
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        189..204
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        226..239
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..345
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         299..345
FT                   /note="ARDSDGAEEDVALTSYGTPIQPQTVDPTQECFIPQAKLSPQQDAGGV -> G
FT                   TFLGDSGSREVLLQEKQEKNHAVG (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_010008"
FT   VAR_SEQ         299..300
FT                   /note="AR -> DC (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_010006"
FT   VAR_SEQ         301..345
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_010007"
FT   VARIANT         18
FT                   /note="A -> D (in dbSNP:rs3741822)"
FT                   /id="VAR_018297"
SQ   SEQUENCE   345 AA;  38791 MW;  14B09E4C5E9F9B49 CRC64;
     MYKDCIESTG DYFLLCDAEG PWGIILESLA ILGIVVTILL LLAFLFLMRK IQDCSQWNVL
     PTQLLFLLSV LGLFGLAFAF IIELNQQTAP VRYFLFGVLF ALCFSCLLAH ASNLVKLVRG
     CVSFSWTTIL CIAIGCSLLQ IIIATEYVTL IMTRGMMFVN MTPCQLNVDF VVLLVYVLFL
     MALTFFVSKA TFCGPCENWK QHGRLIFITV LFSIIIWVVW ISMLLRGNPQ FQRQPQWDDP
     VVCIALVTNA WVFLLLYIVP ELCILYRSCR QECPLQGNAC PVTAYQHSFQ VENQELSRAR
     DSDGAEEDVA LTSYGTPIQP QTVDPTQECF IPQAKLSPQQ DAGGV
//