Q9NZD1 (GPC5D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G-protein coupled receptor family C group 5 member D

Gene names

Name:

GPRC5D

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein Ref.1.
Tissue specificity	Widely expressed in the peripheral system. Expression pattern is high in pancreas, medium in kidney, small intestine, spleen and testis, low in lung, colon, leukocyte, prostate and thymus and not detectable in brain, heart, liver, placenta, skeletal muscle and ovary. Ref.1
Sequence similarities	Belongs to the G-protein coupled receptor 3 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NZD1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NZD1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     299-300: AR → DC
     301-345: Missing.

Isoform 3 (identifier: Q9NZD1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     299-345: ARDSDGAEEDVALTSYGTPIQPQTVDPTQECFIPQAKLSPQQDAGGV → GTFLGDSGSREVLLQEKQEKNHAVG

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	G-protein coupled receptor family C group 5 member D		PRO_0000206897
Regions
	Topological domain	1 – 27	27	Extracellular Potential
	Transmembrane	28 – 48	21	Helical; Name=1; Potential
	Topological domain	49 – 63	15	Cytoplasmic Potential
	Transmembrane	64 – 84	21	Helical; Name=2; Potential
	Topological domain	85 – 93	9	Extracellular Potential
	Transmembrane	94 – 114	21	Helical; Name=3; Potential
	Topological domain	115 – 123	9	Cytoplasmic Potential
	Transmembrane	124 – 144	21	Helical; Name=4; Potential
	Topological domain	145 – 167	23	Extracellular Potential
	Transmembrane	168 – 188	21	Helical; Name=5; Potential
	Topological domain	189 – 204	16	Cytoplasmic Potential
	Transmembrane	205 – 225	21	Helical; Name=6; Potential
	Topological domain	226 – 239	14	Extracellular Potential
	Transmembrane	240 – 260	21	Helical; Name=7; Potential
	Topological domain	261 – 345	85	Cytoplasmic Potential
Natural variations
	Alternative sequence	299 – 345	47	ARDSD…DAGGV → GTFLGDSGSREVLLQEKQEK NHAVG in isoform 3.		VSP_010008
	Alternative sequence	299 – 300	2	AR → DC in isoform 2.		VSP_010006
	Alternative sequence	301 – 345	45	Missing in isoform 2.		VSP_010007
	Natural variant	18	1	A → D. Corresponds to variant rs3741822 [ dbSNP | Ensembl ].		VAR_018297

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 14B09E4C5E9F9B49	FASTA	345	38,791
	10 20 30 40 50 60 MYKDCIESTG DYFLLCDAEG PWGIILESLA ILGIVVTILL LLAFLFLMRK IQDCSQWNVL 70 80 90 100 110 120 PTQLLFLLSV LGLFGLAFAF IIELNQQTAP VRYFLFGVLF ALCFSCLLAH ASNLVKLVRG 130 140 150 160 170 180 CVSFSWTTIL CIAIGCSLLQ IIIATEYVTL IMTRGMMFVN MTPCQLNVDF VVLLVYVLFL 190 200 210 220 230 240 MALTFFVSKA TFCGPCENWK QHGRLIFITV LFSIIIWVVW ISMLLRGNPQ FQRQPQWDDP 250 260 270 280 290 300 VVCIALVTNA WVFLLLYIVP ELCILYRSCR QECPLQGNAC PVTAYQHSFQ VENQELSRAR 310 320 330 340 DSDGAEEDVA LTSYGTPIQP QTVDPTQECF IPQAKLSPQQ DAGGV
	Isoform 2 [UniParc]. Checksum: DC99870AB178A061	FASTA	300	34,095
	10 20 30 40 50 60 MYKDCIESTG DYFLLCDAEG PWGIILESLA ILGIVVTILL LLAFLFLMRK IQDCSQWNVL 70 80 90 100 110 120 PTQLLFLLSV LGLFGLAFAF IIELNQQTAP VRYFLFGVLF ALCFSCLLAH ASNLVKLVRG 130 140 150 160 170 180 CVSFSWTTIL CIAIGCSLLQ IIIATEYVTL IMTRGMMFVN MTPCQLNVDF VVLLVYVLFL 190 200 210 220 230 240 MALTFFVSKA TFCGPCENWK QHGRLIFITV LFSIIIWVVW ISMLLRGNPQ FQRQPQWDDP 250 260 270 280 290 300 VVCIALVTNA WVFLLLYIVP ELCILYRSCR QECPLQGNAC PVTAYQHSFQ VENQELSRDC
	Isoform 3 [UniParc]. Checksum: FEF5CB0A1066B28E	FASTA	323	36,559
	10 20 30 40 50 60 MYKDCIESTG DYFLLCDAEG PWGIILESLA ILGIVVTILL LLAFLFLMRK IQDCSQWNVL 70 80 90 100 110 120 PTQLLFLLSV LGLFGLAFAF IIELNQQTAP VRYFLFGVLF ALCFSCLLAH ASNLVKLVRG 130 140 150 160 170 180 CVSFSWTTIL CIAIGCSLLQ IIIATEYVTL IMTRGMMFVN MTPCQLNVDF VVLLVYVLFL 190 200 210 220 230 240 MALTFFVSKA TFCGPCENWK QHGRLIFITV LFSIIIWVVW ISMLLRGNPQ FQRQPQWDDP 250 260 270 280 290 300 VVCIALVTNA WVFLLLYIVP ELCILYRSCR QECPLQGNAC PVTAYQHSFQ VENQELSRGT 310 320 FLGDSGSREV LLQEKQEKNH AVG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D." Braeuner-Osborne H., Jensen A.A., Sheppard P.O., Brodin B., Krogsgaard-Larsen P., O'Hara P. Biochim. Biophys. Acta 1518:237-248(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION. Tissue: Testis.
[2]	"Characterization of GPRC5D, a member of RAIG family in hard keratinized structures." Inoue S., Nanbu T., Shimomura T. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Skin.
[3]	"Identification of G protein-coupled receptor genes from the human genome sequence." Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S. FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 3).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF209923 mRNA. Translation: AAF72873.1. AB099817 mRNA. Translation: BAC79169.1. AB083629 Genomic DNA. Translation: BAB89342.1. BC069341 mRNA. Translation: AAH69341.1. BC107077 mRNA. Translation: AAI07078.1. BC107078 mRNA. Translation: AAI07079.1.
IPI	IPI00032870. IPI00382997. IPI00410023.
RefSeq	NP_061124.1. NM_018654.1.
UniGene	Hs.644599.
3D structure databases
ProteinModelPortal	Q9NZD1.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9NZD1.
Polymorphism databases
DMDM	46396015.
Proteomic databases
PaxDb	Q9NZD1.
PRIDE	Q9NZD1.
Protocols and materials databases
DNASU	55507.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000228887; ENSP00000228887; ENSG00000111291. ENST00000396333; ENSP00000379624; ENSG00000111291.
GeneID	55507.
KEGG	hsa:55507.
UCSC	uc010shp.2. human.
Organism-specific databases
CTD	55507.
GeneCards	GC12M013093.
HGNC	HGNC:13310. GPRC5D.
MIM	607437. gene.
neXtProt	NX_Q9NZD1.
PharmGKB	PA28940.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44023.
HOGENOM	HOG000116197.
HOVERGEN	HBG049967.
InParanoid	Q9NZD1.
KO	K04621.
OMA	LVTNAWV.
OrthoDB	EOG4RXZ0S.
PhylomeDB	Q9NZD1.
Gene expression databases
ArrayExpress	Q9NZD1.
Bgee	Q9NZD1.
CleanEx	HS_GPRC5D.
Genevestigator	Q9NZD1.
GermOnline	ENSG00000111291. Homo sapiens.
Family and domain databases
InterPro	IPR017978. GPCR_3_C. [Graphical view]
Pfam	PF00003. 7tm_3. 1 hit. [Graphical view]
PROSITE	PS00979. G_PROTEIN_RECEP_F3_1. False negative. PS00980. G_PROTEIN_RECEP_F3_2. False negative. PS00981. G_PROTEIN_RECEP_F3_3. False negative. PS50259. G_PROTEIN_RECEP_F3_4. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55507.
NextBio	59907.
SOURCE	Search...

Entry information

Entry name

GPC5D_HUMAN

Accession

Primary (citable) accession number: Q9NZD1
Secondary accession number(s): Q3KNV3, Q7Z5J9, Q8TDS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.