Q9NZC9 (SMAL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
EC=3.6.4.-

Alternative name(s):
HepA-related protein
Short name=hHARP
Sucrose nonfermenting protein 2-like 1

Gene names

Name:	SMARCAL1
Synonyms:	HARP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	954 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. Ref.12
Subcellular location	Nucleus By similarity.
Tissue specificity	Ubiquitously expressed, with high levels in testis. Ref.1 Ref.2
Involvement in disease	Schimke immuno-osseous dysplasia (SIOD) [MIM:242900]: Causes spondyloepiphyseal dysplasia, renal dysfunction and T-cell immunodeficiency. Approximately half of all patients also exhibit hyperthyroidism, while around half also exhibit episodal cerebral ischema. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.2 Ref.12
Sequence similarities	Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. Contains 2 HARP domains. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.
Sequence caution	The sequence BAA90955.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Disease	Disease mutation
Domain	Coiled coil Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chromatin modification Inferred from electronic annotation. Source: InterPro regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype Ref.12. Source: UniProtKB
Cellular_component	nucleus Inferred from direct assay Ref.12. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro DNA-dependent ATPase activity Inferred from mutant phenotype Ref.12. Source: UniProtKB annealing helicase activity Inferred from direct assay PubMed 22705370. Source: UniProtKB helicase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 954	954	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1		PRO_0000074348
Regions
	Domain	226 – 303	78	HARP 1
	Domain	327 – 398	72	HARP 2
	Domain	445 – 600	156	Helicase ATP-binding
	Domain	716 – 869	154	Helicase C-terminal
	Nucleotide binding	458 – 465	8	ATP By similarity
	Coiled coil	3 – 34	32	Potential
	Motif	549 – 552	4	DESH box
Amino acid modifications
	Modified residue	151	1	Phosphoserine Ref.9
Natural variations
	Natural variant	22	1	A → G. Ref.5 Corresponds to variant rs17851400 [ dbSNP | Ensembl ].		VAR_038370
	Natural variant	43	1	A → T. Corresponds to variant rs2066524 [ dbSNP | Ensembl ].		VAR_021363
	Natural variant	114	1	R → H. Corresponds to variant rs11555797 [ dbSNP | Ensembl ].		VAR_021364
	Natural variant	206	1	Y → D. Corresponds to variant rs5014982 [ dbSNP | Ensembl ].		VAR_021365
	Natural variant	207	1	I → F. Corresponds to variant rs6734114 [ dbSNP | Ensembl ].		VAR_021366
	Natural variant	315	1	S → R. Corresponds to variant rs2066522 [ dbSNP | Ensembl ].		VAR_021367
	Natural variant	377	1	E → Q. Ref.5 Ref.7 Corresponds to variant rs2066518 [ dbSNP | Ensembl ].		VAR_021368
	Natural variant	424	1	D → V. Corresponds to variant rs2066520 [ dbSNP | Ensembl ].		VAR_021369
	Natural variant	432	1	L → V in a breast cancer sample; somatic mutation. Ref.11		VAR_036026
	Natural variant	468	1	A → P in SIOD. Ref.2		VAR_021370
	Natural variant	548	1	I → N in SIOD. Ref.2		VAR_021371
	Natural variant	579	1	S → L in SIOD. Ref.2		VAR_021372
	Natural variant	586	1	R → W in SIOD; impairs without abolishing annealing helicase activity but still binds selectively to fork DNA relative to ssDNA or dsDNA. Ref.2 Ref.12		VAR_021373
	Natural variant	644	1	R → W in SIOD. Ref.2		VAR_021374
	Natural variant	645	1	R → C in SIOD. Ref.2		VAR_021375
	Natural variant	647	1	K → Q in SIOD. Ref.2		VAR_021376
	Natural variant	647	1	K → T in SIOD. Ref.2		VAR_021377
	Natural variant	649	1	D → N. Corresponds to variant rs2066523 [ dbSNP | Ensembl ].		VAR_021378
	Natural variant	705	1	T → I in SIOD. Ref.2		VAR_021379
	Natural variant	742	1	T → M. Corresponds to variant rs2271336 [ dbSNP | Ensembl ].		VAR_021380
	Natural variant	764	1	R → Q in SIOD; abolishes annealing helicase activity but still binds selectively to fork DNA relative to ssDNA or dsDNA. Ref.2 Ref.12		VAR_021381
	Natural variant	820	1	R → H in SIOD. Ref.2		VAR_021382
Experimental info
	Sequence conflict	118	1	A → T in AAF24984. Ref.1
	Sequence conflict	335	1	C → G in AAF24984. Ref.1
	Sequence conflict	344	1	E → K in BAA90955. Ref.7
	Sequence conflict	882	1	I → M in AAF24984. Ref.1
	Sequence conflict	900	1	L → V in AAF24984. Ref.1
	Sequence conflict	911	1	A → G in AAF24984. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9NZC9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: C5C762C24A2FDD3A	FASTA	954	105,938
	10 20 30 40 50 60 MSLPLTEEQR KKIEENRQKA LARRAEKLLA EQHQRTSSGT SIAGNPFQAK QGPSQNFPRE 70 80 90 100 110 120 SCKPVSHGVI FKQQNLSSSS NADQRPHDSH SFQAKGIWKK PEEMPTACPG HSPRSQMALT 130 140 150 160 170 180 GISPPLAQSP PEVPKQQLLS YELGQGHAQA SPEIRFTPFA NPTHKPLAKP KSSQETPAHS 190 200 210 220 230 240 SGQPPRDAKL EAKTAKASPS GQNISYIHSS SESVTPRTEG RLQQKSGSSV QKGVNSQKGK 250 260 270 280 290 300 CVRNGDRFQV LIGYNAELIA VFKTLPSKNY DPDTKTWNFS MNDYSALMKA AQSLPTVNLQ 310 320 330 340 350 360 PLEWAYGSSE SPSTSSEGQA GLPSAPSLSF VKGRCMLISR AYFEADISYS QDLIALFKQM 370 380 390 400 410 420 DSRRYDVKTR KWSFLLEEHS KLIAKVRCLP QVQLDPLPTT LTLAFASQLK KTSLSLTPDV 430 440 450 460 470 480 PEADLSEVDP KLVSNLMPFQ RAGVNFAIAK GGRLLLADDM GLGKTIQAIC IAAFYRKEWP 490 500 510 520 530 540 LLVVVPSSVR FTWEQAFLRW LPSLSPDCIN VVVTGKDRLT AGLINIVSFD LLSKLEKQLK 550 560 570 580 590 600 TPFKVVIIDE SHFLKNSRTA RCRAAMPVLK VAKRVILLSG TPAMSRPAEL YTQIIAVKPT 610 620 630 640 650 660 FFPQFHAFGL RYCDAKRMPW GWDYSGSSNL GELKLLLEEA VMLRRLKSDV LSQLPAKQRK 670 680 690 700 710 720 IVVIAPGRIN ARTRAALDAA AKEMTTKDKT KQQQKDALIL FFNRTAEAKI PSVIEYILDL 730 740 750 760 770 780 LESGREKFLV FAHHKVVLDA ITQELERKHV QHIRIDGSTS SAEREDLCQQ FQLSERHAVA 790 800 810 820 830 840 VLSITAANMG LTFSSADLVV FAELFWNPGV LIQAEDRVHR IGQTSSVGIH YLVAKGTADD 850 860 870 880 890 900 YLWPLIQEKI KVLAEAGLSE TNFSEMTEST DYLYKDPKQQ KIYDLFQKSF EKEGSDMELL 910 920 930 940 950 EAAESFDPGS ASGTSGSSSQ NMGDTLDESS LTASPQKKRR FEFFDNWDSF TSPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of HARP/SMARCAL1: a prokaryotic HepA-related SNF2 helicase protein from human and mouse." Coleman M.A., Eisen J.A., Mohrenweiser H.W. Genomics 65:274-282(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
[2]	"Mutant chromatin remodeling protein SMARCAL1 causes Schimke immuno-osseous dysplasia." Boerkoel C.F., Takashima H., John J., Yan J., Stankiewicz P., Rosenbarker L., Andre J.-L., Bogdanovic R., Burguet A., Cockfield S., Cordeiro I., Frund S., Illies F., Joseph M., Kaitila I., Lama G., Loirat C., McLeod D.R. , Milford D.V., Petty E.M., Rodrigo F., Saraiva J.M., Schmidt B., Smith G.C., Spranger J., Stein A., Thiele H., Tizard J., Weksberg R., Lupski J.R., Stockton D.W. Nat. Genet. 30:215-220(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS SIOD PRO-468; ASN-548; LEU-579; TRP-586; TRP-644; CYS-645; GLN-647; THR-647; ILE-705; GLN-764 AND HIS-820.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-22 AND GLN-377. Tissue: Lung and Lymph.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 147-954. Tissue: Testis.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 335-954, VARIANT GLN-377.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-432.
[12]	"HARP is an ATP-driven annealing helicase." Yusufzai T., Kadonaga J.T. Science 322:748-750(2008) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION OF VARIANTS SIOD TRP-586 AND GLN-764, FUNCTION, DNA-BINDING.
+	Additional computationally mapped references.

Web resources

SMARCAL1base

SMARCAL1 mutation db

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF082179 mRNA. Translation: AAF24984.1. AF210842 , AF210833, AF210834, AF210835, AF210836, AF210837, AF210838, AF210839, AF210840, AF210841 Genomic DNA. Translation: AAF70454.1. AF432223 mRNA. Translation: AAL73034.1. AC098820 Genomic DNA. Translation: AAX93097.1. CH471063 Genomic DNA. Translation: EAW70567.1. BC016482 mRNA. Translation: AAH16482.1. BC043341 mRNA. Translation: AAH43341.1. AL122076 mRNA. Translation: CAB59251.1. AK000117 mRNA. Translation: BAA90955.1. Different initiation.
IPI	IPI00386311.
PIR	T34557.
RefSeq	NP_001120679.1. NM_001127207.1. NP_054859.2. NM_014140.3.
UniGene	Hs.516674.
3D structure databases
ProteinModelPortal	Q9NZC9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NZC9. 1 interaction.
MINT	MINT-8415341.
STRING	9606.ENSP00000349823.
PTM databases
PhosphoSite	Q9NZC9.
Polymorphism databases
DMDM	60390962.
Proteomic databases
PaxDb	Q9NZC9.
PRIDE	Q9NZC9.
Protocols and materials databases
DNASU	50485.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357276; ENSP00000349823; ENSG00000138375. ENST00000358207; ENSP00000350940; ENSG00000138375.
GeneID	50485.
KEGG	hsa:50485.
UCSC	uc002vgc.4. human.
Organism-specific databases
CTD	50485.
GeneCards	GC02P217277.
HGNC	HGNC:11102. SMARCAL1.
HPA	HPA020337.
MIM	242900. phenotype. 606622. gene.
neXtProt	NX_Q9NZC9.
Orphanet	1830. Schimke immuno-osseous dysplasia.
PharmGKB	PA35952.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0553.
HOVERGEN	HBG054110.
InParanoid	Q9NZC9.
KO	K14440.
OMA	FKQQNLS.
OrthoDB	EOG4RFKRT.
Gene expression databases
ArrayExpress	Q9NZC9.
Bgee	Q9NZC9.
CleanEx	HS_SMARCAL1.
Genevestigator	Q9NZC9.
GermOnline	ENSG00000138375. Homo sapiens.
Family and domain databases
InterPro	IPR010003. HARP_dom. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR027417. P-loop_NTPase. IPR000330. SNF2_N. [Graphical view]
Pfam	PF07443. HARP. 2 hits. PF00271. Helicase_C. 1 hit. PF00176. SNF2_N. 1 hit. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 2 hits.
PROSITE	PS51467. HARP. 2 hits. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	50485.
NextBio	53040.
SOURCE	Search...

Entry information

Entry name

SMAL1_HUMAN

Accession

Primary (citable) accession number: Q9NZC9
Secondary accession number(s): A6NEH0 , Q53R00, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	October 1, 2000
Last modified:	May 29, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.