##gff-version 3 Q9NZC7 UniProtKB Chain 1 414 . . . ID=PRO_0000054815;Note=WW domain-containing oxidoreductase Q9NZC7 UniProtKB Domain 16 49 . . . Note=WW 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00224 Q9NZC7 UniProtKB Domain 57 90 . . . Note=WW 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00224 Q9NZC7 UniProtKB Region 1 23 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NZC7 UniProtKB Region 125 414 . . . Note=Interaction with MAPT;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9NZC7 UniProtKB Region 209 273 . . . Note=Mediates targeting to the mitochondria;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9NZC7 UniProtKB Motif 50 55 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9NZC7 UniProtKB Active site 293 293 . . . Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9NZC7 UniProtKB Binding site 131 137 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9NZC7 UniProtKB Binding site 260 260 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9NZC7 UniProtKB Modified residue 12 12 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Q9NZC7 UniProtKB Modified residue 14 14 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Q9NZC7 UniProtKB Modified residue 33 33 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15070730,ECO:0000269|PubMed:19366691;Dbxref=PMID:15070730,PMID:19366691 Q9NZC7 UniProtKB Modified residue 287 287 . . . Note=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16288044;Dbxref=PMID:16288044 Q9NZC7 UniProtKB Alternative sequence 36 36 . . . ID=VSP_016358;Note=In isoform 4. N->K;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10861292;Dbxref=PMID:10861292 Q9NZC7 UniProtKB Alternative sequence 37 414 . . . ID=VSP_016359;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10861292;Dbxref=PMID:10861292 Q9NZC7 UniProtKB Alternative sequence 137 414 . . . ID=VSP_016360;Note=In isoform 6. GFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG->ATGSCHHRVLCCCPRTGGSGRDVLQQLLPLHALTRSSERRDGPDPVGAQREADPRTAWQPVRLSGAQSGWAHTPALCVSPHASARAGPLPNVPPTQIRKSKGNKSSHNRVKNLKYQWEAGNSWGKVSLFWGWARHRSLCFLVVACLKVKTCLVCRFRISLEKHQQFSFFYCYRIA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11719429;Dbxref=PMID:11719429 Q9NZC7 UniProtKB Alternative sequence 138 213 . . . ID=VSP_016362;Note=In isoform 7. FETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAAT->KASCHVGRTLKHTRVEELSLLPTAINRELPPPCTVLLSQNWRVWEGCTSTTAAAACPHQKLRAKRRPGPCGRSARG;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9NZC7 UniProtKB Alternative sequence 173 352 . . . ID=VSP_016363;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11719429,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.7;Dbxref=PMID:11719429,PMID:15489334 Q9NZC7 UniProtKB Alternative sequence 173 189 . . . ID=VSP_016364;Note=In isoform 3. HKAKVEAMTLDLALLRS->KTKYHPPPEKCRIKIFH;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10861292;Dbxref=PMID:10861292 Q9NZC7 UniProtKB Alternative sequence 190 414 . . . ID=VSP_016365;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10861292;Dbxref=PMID:10861292 Q9NZC7 UniProtKB Alternative sequence 214 414 . . . ID=VSP_016366;Note=In isoform 7. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9NZC7 UniProtKB Alternative sequence 353 363 . . . ID=VSP_016367;Note=In isoform 2. QQGAATTVYCA->VSDCLVEGGHF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10861292;Dbxref=PMID:10861292 Q9NZC7 UniProtKB Alternative sequence 364 414 . . . ID=VSP_016369;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10861292;Dbxref=PMID:10861292 Q9NZC7 UniProtKB Natural variant 47 47 . . . ID=VAR_072351;Note=In DEE28. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25411445;Dbxref=dbSNP:rs730880292,PMID:25411445 Q9NZC7 UniProtKB Natural variant 47 47 . . . ID=VAR_070992;Note=In SCAR12. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24369382;Dbxref=dbSNP:rs587777128,PMID:24369382 Q9NZC7 UniProtKB Natural variant 98 98 . . . ID=VAR_023916;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11572989;Dbxref=dbSNP:rs144601717,PMID:11572989 Q9NZC7 UniProtKB Natural variant 111 111 . . . ID=VAR_023917;Note=In a Burkitt lymphoma cell line. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11572989;Dbxref=dbSNP:rs114755364,PMID:11572989 Q9NZC7 UniProtKB Natural variant 120 120 . . . ID=VAR_023918;Note=In a primary colorectal tumor and a histiocytic lymphoma cell line. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11572989;Dbxref=dbSNP:rs141361080,PMID:11572989 Q9NZC7 UniProtKB Natural variant 179 179 . . . ID=VAR_023919;Note=A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11572989,ECO:0000269|Ref.5;Dbxref=dbSNP:rs11545029,PMID:11572989 Q9NZC7 UniProtKB Natural variant 216 216 . . . ID=VAR_052323;Note=L->V;Dbxref=dbSNP:rs7201683 Q9NZC7 UniProtKB Natural variant 272 272 . . . ID=VAR_023920;Note=L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11572989;Dbxref=dbSNP:rs186745328,PMID:11572989 Q9NZC7 UniProtKB Natural variant 282 282 . . . ID=VAR_023921;Note=P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11572989;Dbxref=dbSNP:rs3764340,PMID:11572989 Q9NZC7 UniProtKB Natural variant 291 291 . . . ID=VAR_023922;Note=Found in a esophageal cancer sample%3B somatic mutation. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11956080;Dbxref=dbSNP:rs119487098,PMID:11956080 Q9NZC7 UniProtKB Natural variant 314 314 . . . ID=VAR_023923;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11572989;Dbxref=dbSNP:rs73572838,PMID:11572989 Q9NZC7 UniProtKB Natural variant 372 372 . . . ID=VAR_070993;Note=In SCAR12. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24369382;Dbxref=dbSNP:rs587777127,PMID:24369382 Q9NZC7 UniProtKB Mutagenesis 28 28 . . . Note=No effect on interaction with TP53. Abolishes interaction with MAPK8%3B when associated with V-29. K->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12514174;Dbxref=PMID:12514174 Q9NZC7 UniProtKB Mutagenesis 29 29 . . . Note=No effect on interaction with TP53. Abolishes interaction with MAPK8%3B when associated with T-28. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12514174;Dbxref=PMID:12514174 Q9NZC7 UniProtKB Mutagenesis 33 33 . . . Note=Loss of phosphorylation. Y->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12514174,ECO:0000269|PubMed:15070730;Dbxref=PMID:12514174,PMID:15070730 Q9NZC7 UniProtKB Mutagenesis 33 33 . . . Note=Abolishes interaction with TP53%2C TP73%2C MAPK8 and ERBB4. Partial loss of interaction with TFAP2C. Loss of phosphorylation. Loss of the proapoptotic activity. Abolishes binding to VOPP1. Y->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12514174,ECO:0000269|PubMed:15070730,ECO:0000269|PubMed:30285739;Dbxref=PMID:12514174,PMID:15070730,PMID:30285739 Q9NZC7 UniProtKB Mutagenesis 44 47 . . . Note=Abolishes interaction with LITAF. WEHP->FEHA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15064722;Dbxref=PMID:15064722 Q9NZC7 UniProtKB Mutagenesis 61 61 . . . Note=No effect on interaction with TP73. Y->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15070730;Dbxref=PMID:15070730 Q9NZC7 UniProtKB Mutagenesis 85 88 . . . Note=No effect on interaction with LITAF. YLDP->ALDA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15064722;Dbxref=PMID:15064722 Q9NZC7 UniProtKB Mutagenesis 287 287 . . . Note=Loss of phosphorylation by TNK2. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16288044;Dbxref=PMID:16288044 Q9NZC7 UniProtKB Beta strand 63 67 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1WMV Q9NZC7 UniProtKB Beta strand 73 80 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1WMV Q9NZC7 UniProtKB Beta strand 83 86 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1WMV Q9NZC7 UniProtKB Natural variant 182 182 . . . ID=VAR_082915;Note=Found in a primary colorectal tumor and tumor cells. K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305;Dbxref=dbSNP:rs77067228