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Protein

ETS homologous factor

Gene

EHF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.5 Publications

Caution

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi207 – 289ETSPROSITE-ProRule annotationAdd BLAST83

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: UniProtKB
  • epithelial cell differentiation Source: UniProtKB
  • epithelial cell proliferation Source: InterPro
  • multicellular organism development Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ9NZC4

Names & Taxonomyi

Protein namesi
Recommended name:
ETS homologous factor
Short name:
hEHF
Alternative name(s):
ETS domain-containing transcription factor
Epithelium-specific Ets transcription factor 3
Short name:
ESE-3
Gene namesi
Name:EHFImported
Synonyms:ESE3, ESE3BImported, ESEJImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000135373.12
HGNCiHGNC:3246 EHF
MIMi605439 gene
neXtProtiNX_Q9NZC4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26298
OpenTargetsiENSG00000135373
PharmGKBiPA27681

Polymorphism and mutation databases

BioMutaiEHF
DMDMi74762761

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002579691 – 300ETS homologous factorAdd BLAST300

Proteomic databases

MaxQBiQ9NZC4
PaxDbiQ9NZC4
PeptideAtlasiQ9NZC4
PRIDEiQ9NZC4

PTM databases

iPTMnetiQ9NZC4
PhosphoSitePlusiQ9NZC4

Expressioni

Tissue specificityi

Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, prostate, and lung. Weakly expressed in kidney and colon. Not detected in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, testis, ovary, small intestine or peripheral blood leukocytes.4 Publications

Inductioni

By IL1B/interleukin-1 beta and TNF in bronchial smooth muscle cells and fibroblasts. By IL10/interleukin-10 and IFNG/IFN-gamma in monocyte-derived dendritic cells.2 Publications

Gene expression databases

BgeeiENSG00000135373
CleanExiHS_EHF
ExpressionAtlasiQ9NZC4 baseline and differential
GenevisibleiQ9NZC4 HS

Organism-specific databases

HPAiHPA050923
HPA060734

Interactioni

Protein-protein interaction databases

BioGridi1176759 interactors.
IntActiQ9NZC4 2 interactors.
MINTiQ9NZC4
STRINGi9606.ENSP00000435835

Structurei

3D structure databases

ProteinModelPortaliQ9NZC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 115PNTPROSITE-ProRule annotationAdd BLAST87

Domaini

The PNT domain acts as a transcriptional activator.By similarity

Sequence similaritiesi

Belongs to the ETS family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3804 Eukaryota
ENOG4111K4J LUCA
GeneTreeiENSGT00760000118996
HOVERGENiHBG074143
InParanoidiQ9NZC4
KOiK17102
OMAiSEGIFRF
OrthoDBiEOG091G0BE6
PhylomeDBiQ9NZC4
TreeFamiTF318679

Family and domain databases

Gene3Di1.10.10.101 hit
InterProiView protein in InterPro
IPR033071 EHF
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11849:SF171 PTHR11849:SF171, 1 hit
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 13 Publications (identifier: Q9NZC4-1) [UniParc]FASTAAdd to basket
Also known as: ESE-3B1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MILEGGGVMN LNPGNNLLHQ PPAWTDSYST CNVSSGFFGG QWHEIHPQYW
60 70 80 90 100
TKYQVWEWLQ HLLDTNQLDA NCIPFQEFDI NGEHLCSMSL QEFTRAAGTA
110 120 130 140 150
GQLLYSNLQH LKWNGQCSSD LFQSTHNVIV KTEQTEPSIM NTWKDENYLY
160 170 180 190 200
DTNYGSTVDL LDSKTFCRAQ ISMTTTSHLP VAESPDMKKE QDPPAKCHTK
210 220 230 240 250
KHNPRGTHLW EFIRDILLNP DKNPGLIKWE DRSEGVFRFL KSEAVAQLWG
260 270 280 290 300
KKKNNSSMTY EKLSRAMRYY YKREILERVD GRRLVYKFGK NARGWRENEN
Length:300
Mass (Da):34,892
Last modified:October 1, 2000 - v1
Checksum:i5CABB38BAF852ED0
GO
Isoform 21 Publication (identifier: Q9NZC4-2) [UniParc]FASTAAdd to basket
Also known as: ESE-3A1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     159-181: Missing.

Show »
Length:277
Mass (Da):32,345
Checksum:i3BF620E8F1164811
GO
Isoform 3 (identifier: Q9NZC4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGLPERRGLVLLLSLAEILFKIM

Note: No experimental confirmation available.
Show »
Length:322
Mass (Da):37,356
Checksum:i62D08E04E9C0FFDE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40G → S in AAD30990 (PubMed:10644770).Curated1
Sequence conflicti40G → S in AAD30991 (PubMed:10644770).Curated1
Sequence conflicti163S → G in AAD30991 (PubMed:10644770).Curated1
Sequence conflicti169A → V in AAD30991 (PubMed:10644770).Curated1
Sequence conflicti196K → E in AAF06998 (PubMed:10527851).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04894196A → V. Corresponds to variant dbSNP:rs9804460Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0463731M → MGLPERRGLVLLLSLAEILF KIM in isoform 3. 1 Publication1
Alternative sequenceiVSP_052190159 – 181Missing in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170583 mRNA Translation: AAF06998.1
AF124438 mRNA Translation: AAD30990.1
AF124439 mRNA Translation: AAD30991.1
AF212848 mRNA Translation: AAF61670.1
AF203977 mRNA Translation: AAG35644.1
AY882601 mRNA Translation: AAW80658.1
AK310867 mRNA No translation available.
AC087783 Genomic DNA No translation available.
AL157952 Genomic DNA Translation: CAC12700.1
AL157952 Genomic DNA Translation: CAC12701.1
CH471064 Genomic DNA Translation: EAW68162.1
CH471064 Genomic DNA Translation: EAW68163.1
CH471064 Genomic DNA Translation: EAW68164.1
CH471064 Genomic DNA Translation: EAW68165.1
CH471064 Genomic DNA Translation: EAW68166.1
BC038995 mRNA Translation: AAH38995.1
CCDSiCCDS55752.1 [Q9NZC4-3]
CCDS55753.1 [Q9NZC4-2]
CCDS7894.1 [Q9NZC4-1]
PIRiJC7115
RefSeqiNP_001193544.1, NM_001206615.1 [Q9NZC4-2]
NP_001193545.1, NM_001206616.1 [Q9NZC4-3]
NP_036285.2, NM_012153.5 [Q9NZC4-1]
XP_005252917.1, XM_005252860.1 [Q9NZC4-1]
XP_005252919.1, XM_005252862.1 [Q9NZC4-2]
XP_011518286.1, XM_011519984.1 [Q9NZC4-1]
XP_011518287.1, XM_011519985.1 [Q9NZC4-1]
UniGeneiHs.653859

Genome annotation databases

EnsembliENST00000257831; ENSP00000257831; ENSG00000135373 [Q9NZC4-1]
ENST00000450654; ENSP00000399733; ENSG00000135373 [Q9NZC4-2]
ENST00000530286; ENSP00000433508; ENSG00000135373 [Q9NZC4-1]
ENST00000531794; ENSP00000435835; ENSG00000135373 [Q9NZC4-3]
ENST00000533754; ENSP00000435837; ENSG00000135373 [Q9NZC4-1]
GeneIDi26298
KEGGihsa:26298
UCSCiuc001mvr.3 human [Q9NZC4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEHF_HUMAN
AccessioniPrimary (citable) accession number: Q9NZC4
Secondary accession number(s): D3DR08
, D3DR10, E9PSB2, Q9H509, Q9UKF9, Q9Y5V4, Q9Y5V5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome