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Q9NZC4

- EHF_HUMAN

UniProt

Q9NZC4 - EHF_HUMAN

Protein

ETS homologous factor

Gene

EHF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.5 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi207 – 28983ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
    5. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. cell proliferation Source: UniProtKB
    2. epithelial cell differentiation Source: UniProtKB
    3. multicellular organismal development Source: UniProtKB
    4. positive regulation of transcription, DNA-templated Source: UniProtKB
    5. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    6. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    7. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ETS homologous factor
    Short name:
    hEHF
    Alternative name(s):
    ETS domain-containing transcription factor
    Epithelium-specific Ets transcription factor 3
    Short name:
    ESE-3
    Gene namesi
    Name:EHFImported
    Synonyms:ESE3, ESE3BImported, ESEJImported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:3246. EHF.

    Subcellular locationi

    Nucleus 2 PublicationsPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27681.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 300300ETS homologous factorPRO_0000257969Add
    BLAST

    Proteomic databases

    MaxQBiQ9NZC4.
    PaxDbiQ9NZC4.
    PRIDEiQ9NZC4.

    PTM databases

    PhosphoSiteiQ9NZC4.

    Expressioni

    Tissue specificityi

    Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, prostate, and lung. Weakly expressed in kidney and colon. Not detected in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, testis, ovary, small intestine or peripheral blood leukocytes.4 Publications

    Inductioni

    By IL1B/interleukin-1 beta and TNF in bronchial smooth muscle cells and fibroblasts. By IL10/interleukin-10 and IFNG/IFN-gamma in monocyte-derived dendritic cells.2 Publications

    Gene expression databases

    ArrayExpressiQ9NZC4.
    BgeeiQ9NZC4.
    CleanExiHS_EHF.
    GenevestigatoriQ9NZC4.

    Interactioni

    Protein-protein interaction databases

    BioGridi117675. 2 interactions.
    IntActiQ9NZC4. 1 interaction.
    MINTiMINT-8247463.
    STRINGi9606.ENSP00000257831.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NZC4.
    SMRiQ9NZC4. Positions 40-111, 206-299.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 11587PNTPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The PNT domain acts as a transcriptional activator.By similarity

    Sequence similaritiesi

    Belongs to the ETS family.Sequence Analysis
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG307806.
    HOVERGENiHBG074143.
    InParanoidiQ9NZC4.
    KOiK17102.
    OMAiVMNLNPG.
    OrthoDBiEOG7M0NRR.
    PhylomeDBiQ9NZC4.
    TreeFamiTF318679.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    PROSITEiPS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 13 Publications (identifier: Q9NZC4-1) [UniParc]FASTAAdd to Basket

    Also known as: ESE-3B1 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MILEGGGVMN LNPGNNLLHQ PPAWTDSYST CNVSSGFFGG QWHEIHPQYW    50
    TKYQVWEWLQ HLLDTNQLDA NCIPFQEFDI NGEHLCSMSL QEFTRAAGTA 100
    GQLLYSNLQH LKWNGQCSSD LFQSTHNVIV KTEQTEPSIM NTWKDENYLY 150
    DTNYGSTVDL LDSKTFCRAQ ISMTTTSHLP VAESPDMKKE QDPPAKCHTK 200
    KHNPRGTHLW EFIRDILLNP DKNPGLIKWE DRSEGVFRFL KSEAVAQLWG 250
    KKKNNSSMTY EKLSRAMRYY YKREILERVD GRRLVYKFGK NARGWRENEN 300
    Length:300
    Mass (Da):34,892
    Last modified:October 1, 2000 - v1
    Checksum:i5CABB38BAF852ED0
    GO
    Isoform 21 Publication (identifier: Q9NZC4-2) [UniParc]FASTAAdd to Basket

    Also known as: ESE-3A1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         159-181: Missing.

    Show »
    Length:277
    Mass (Da):32,345
    Checksum:i3BF620E8F1164811
    GO
    Isoform 3 (identifier: Q9NZC4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MGLPERRGLVLLLSLAEILFKIM

    Note: No experimental confirmation available.

    Show »
    Length:322
    Mass (Da):37,356
    Checksum:i62D08E04E9C0FFDE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti40 – 401G → S in AAD30990. (PubMed:10644770)Curated
    Sequence conflicti40 – 401G → S in AAD30991. (PubMed:10644770)Curated
    Sequence conflicti163 – 1631S → G in AAD30991. (PubMed:10644770)Curated
    Sequence conflicti169 – 1691A → V in AAD30991. (PubMed:10644770)Curated
    Sequence conflicti196 – 1961K → E in AAF06998. (PubMed:10527851)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti96 – 961A → V.
    Corresponds to variant rs9804460 [ dbSNP | Ensembl ].
    VAR_048941

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MGLPERRGLVLLLSLAEILF KIM in isoform 3. 1 PublicationVSP_046373
    Alternative sequencei159 – 18123Missing in isoform 2. 1 PublicationVSP_052190Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF170583 mRNA. Translation: AAF06998.1.
    AF124438 mRNA. Translation: AAD30990.1.
    AF124439 mRNA. Translation: AAD30991.1.
    AF212848 mRNA. Translation: AAF61670.1.
    AF203977 mRNA. Translation: AAG35644.1.
    AY882601 mRNA. Translation: AAW80658.1.
    AK310867 mRNA. No translation available.
    AC087783 Genomic DNA. No translation available.
    AL157952 Genomic DNA. Translation: CAC12700.1.
    AL157952 Genomic DNA. Translation: CAC12701.1.
    CH471064 Genomic DNA. Translation: EAW68162.1.
    CH471064 Genomic DNA. Translation: EAW68163.1.
    CH471064 Genomic DNA. Translation: EAW68164.1.
    CH471064 Genomic DNA. Translation: EAW68165.1.
    CH471064 Genomic DNA. Translation: EAW68166.1.
    BC038995 mRNA. Translation: AAH38995.1.
    CCDSiCCDS55752.1. [Q9NZC4-3]
    CCDS55753.1. [Q9NZC4-2]
    CCDS7894.1. [Q9NZC4-1]
    PIRiJC7115.
    RefSeqiNP_001193544.1. NM_001206615.1. [Q9NZC4-2]
    NP_001193545.1. NM_001206616.1. [Q9NZC4-3]
    NP_036285.2. NM_012153.5. [Q9NZC4-1]
    XP_005252917.1. XM_005252860.1. [Q9NZC4-1]
    XP_005252919.1. XM_005252862.1. [Q9NZC4-2]
    UniGeneiHs.653859.

    Genome annotation databases

    EnsembliENST00000257831; ENSP00000257831; ENSG00000135373. [Q9NZC4-1]
    ENST00000450654; ENSP00000399733; ENSG00000135373. [Q9NZC4-2]
    ENST00000530286; ENSP00000433508; ENSG00000135373. [Q9NZC4-1]
    ENST00000531794; ENSP00000435835; ENSG00000135373. [Q9NZC4-3]
    ENST00000533754; ENSP00000435837; ENSG00000135373. [Q9NZC4-1]
    GeneIDi26298.
    KEGGihsa:26298.
    UCSCiuc001mvr.2. human. [Q9NZC4-1]
    uc009yke.2. human. [Q9NZC4-2]

    Polymorphism databases

    DMDMi74762761.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF170583 mRNA. Translation: AAF06998.1 .
    AF124438 mRNA. Translation: AAD30990.1 .
    AF124439 mRNA. Translation: AAD30991.1 .
    AF212848 mRNA. Translation: AAF61670.1 .
    AF203977 mRNA. Translation: AAG35644.1 .
    AY882601 mRNA. Translation: AAW80658.1 .
    AK310867 mRNA. No translation available.
    AC087783 Genomic DNA. No translation available.
    AL157952 Genomic DNA. Translation: CAC12700.1 .
    AL157952 Genomic DNA. Translation: CAC12701.1 .
    CH471064 Genomic DNA. Translation: EAW68162.1 .
    CH471064 Genomic DNA. Translation: EAW68163.1 .
    CH471064 Genomic DNA. Translation: EAW68164.1 .
    CH471064 Genomic DNA. Translation: EAW68165.1 .
    CH471064 Genomic DNA. Translation: EAW68166.1 .
    BC038995 mRNA. Translation: AAH38995.1 .
    CCDSi CCDS55752.1. [Q9NZC4-3 ]
    CCDS55753.1. [Q9NZC4-2 ]
    CCDS7894.1. [Q9NZC4-1 ]
    PIRi JC7115.
    RefSeqi NP_001193544.1. NM_001206615.1. [Q9NZC4-2 ]
    NP_001193545.1. NM_001206616.1. [Q9NZC4-3 ]
    NP_036285.2. NM_012153.5. [Q9NZC4-1 ]
    XP_005252917.1. XM_005252860.1. [Q9NZC4-1 ]
    XP_005252919.1. XM_005252862.1. [Q9NZC4-2 ]
    UniGenei Hs.653859.

    3D structure databases

    ProteinModelPortali Q9NZC4.
    SMRi Q9NZC4. Positions 40-111, 206-299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117675. 2 interactions.
    IntActi Q9NZC4. 1 interaction.
    MINTi MINT-8247463.
    STRINGi 9606.ENSP00000257831.

    PTM databases

    PhosphoSitei Q9NZC4.

    Polymorphism databases

    DMDMi 74762761.

    Proteomic databases

    MaxQBi Q9NZC4.
    PaxDbi Q9NZC4.
    PRIDEi Q9NZC4.

    Protocols and materials databases

    DNASUi 26298.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000257831 ; ENSP00000257831 ; ENSG00000135373 . [Q9NZC4-1 ]
    ENST00000450654 ; ENSP00000399733 ; ENSG00000135373 . [Q9NZC4-2 ]
    ENST00000530286 ; ENSP00000433508 ; ENSG00000135373 . [Q9NZC4-1 ]
    ENST00000531794 ; ENSP00000435835 ; ENSG00000135373 . [Q9NZC4-3 ]
    ENST00000533754 ; ENSP00000435837 ; ENSG00000135373 . [Q9NZC4-1 ]
    GeneIDi 26298.
    KEGGi hsa:26298.
    UCSCi uc001mvr.2. human. [Q9NZC4-1 ]
    uc009yke.2. human. [Q9NZC4-2 ]

    Organism-specific databases

    CTDi 26298.
    GeneCardsi GC11P034599.
    HGNCi HGNC:3246. EHF.
    MIMi 605439. gene.
    neXtProti NX_Q9NZC4.
    PharmGKBi PA27681.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307806.
    HOVERGENi HBG074143.
    InParanoidi Q9NZC4.
    KOi K17102.
    OMAi VMNLNPG.
    OrthoDBi EOG7M0NRR.
    PhylomeDBi Q9NZC4.
    TreeFami TF318679.

    Miscellaneous databases

    ChiTaRSi EHF. human.
    GeneWikii EHF_(gene).
    GenomeRNAii 26298.
    NextBioi 48647.
    PROi Q9NZC4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NZC4.
    Bgeei Q9NZC4.
    CleanExi HS_EHF.
    Genevestigatori Q9NZC4.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    PROSITEi PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF."
      Kleinbaum L.A., Duggan C., Ferreira E., Coffey G.P., Buttice G., Burton F.H.
      Biochem. Biophys. Res. Commun. 264:119-126(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ALTERNATIVE SPLICING (ISOFORM 2), TISSUE SPECIFICITY.
      Tissue: ProstateImported.
    2. "ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1."
      Kas K., Finger E., Grall F., Gu X., Akbarali Y., Boltax J., Weiss A., Oettgen P., Kapeller R., Libermann T.A.
      J. Biol. Chem. 275:2986-2998(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.
      Tissue: ProstateImported.
    3. "The epithelium-specific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades."
      Tugores A., Le J., Sorokina I., Snijders A.J., Duyao M., Reddy P.S., Carlee L., Ronshaugen M., Mushegian A., Watanaskul T., Chu S., Buckler A., Emtage S., McCormick M.K.
      J. Biol. Chem. 276:20397-20406(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    4. "Up-regulation of the epithelial-specific transcription factor Genes hEHF and ESX in advanced prostate cancer."
      Mitchell S.C., Levin E., Hubert R., Yeramian C., Saffran D.C., Afar D.E.H.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "New human ESE3B coding sequence from H441 cells."
      Lei W., Harrod K.S.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Trachea.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: SkinImported.
    10. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
    11. "ESE-3 transcription factor is involved in the expression of death receptor (DR)-5 through putative Ets sites."
      Lim J.H., Cho J.-Y., Park Y.B., Park J.-W., Kwon T.K.
      Biochem. Biophys. Res. Commun. 350:736-741(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs."
      Appel S., Bringmann A., Grunebach F., Weck M.M., Bauer J., Brossart P.
      Blood 107:3265-3270(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiEHF_HUMAN
    AccessioniPrimary (citable) accession number: Q9NZC4
    Secondary accession number(s): D3DR08
    , D3DR10, E9PSB2, Q9H509, Q9UKF9, Q9Y5V4, Q9Y5V5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3