Q9NZB2 (F120A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Constitutive coactivator of PPAR-gamma-like protein 1

Alternative name(s):
Oxidative stress-associated Src activator
Protein FAM120A

Gene names

Name:	FAM120A
Synonyms:	C9orf10, KIAA0183, OSSA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1118 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May participate in mRNA transport in the cytoplasm By similarity. Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses. Ref.10
Subunit structure	Interacts with PURA By similarity. Interacts with YES1, SRC, FYN. Upon tyrosine phosphorylation, interacts with PIK3R1. Ref.10
Subcellular location	Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note: Translocates to plasma membrane upon ultraviolet exposure. Ref.10
Tissue specificity	Ubiquitously expressed. Highly expressed in scirrhous-type gastric cancer tissues compared with normal gastric mucosa (at protein level). Ref.6 Ref.10
Post-translational modification	Arg-982 is dimethylated, probably to asymmetric dimethylarginine. Phosphorylated on tyrosine by src family kinases upon ultraviolet exposure.
Sequence similarities	Belongs to the constitutive coactivator of PPAR-gamma family.
Sequence caution	The sequence AAF72866.1 differs from that shown. Reason: Frameshift at position 1055.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Tumor suppressor
Ligand	RNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q9NZB2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q9NZB2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     579-628: GEIKIAVSIE...SRKKTERLAF → VLSKGPWSGF...KFTFPFLNIE
     629-1118: Missing.

Isoform D (identifier: Q9NZB2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     890-935: Missing.

Isoform E (identifier: Q9NZB2-5)

The sequence of this isoform differs from the canonical sequence as follows:
     637-651: FSPVIIKEWAAYKGK → CMYCNNPLFVFLGTS
     652-1118: Missing.

Isoform F (identifier: Q9NZB2-6)

The sequence of this isoform differs from the canonical sequence as follows:
     473-473: N → KPFQLYLQKNFVFHKENSIVLCSRILRHG

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1118	1118	Constitutive coactivator of PPAR-gamma-like protein 1		PRO_0000221627
Regions
	Region	339 – 405	67	Interaction with YES1, SRC and FYN
	Region	829 – 1118	290	RNA binding
Amino acid modifications
	Modified residue	1023	1	Phosphoserine Ref.8
	Modified residue	1044	1	Phosphoserine Ref.11
	Modified residue	1045	1	Phosphoserine Ref.11
	Modified residue	1048	1	Phosphoserine Ref.11
Natural variations
	Alternative sequence	473	1	N → KPFQLYLQKNFVFHKENSIV LCSRILRHG in isoform F.		VSP_036324
	Alternative sequence	579 – 628	50	GEIKI…ERLAF → VLSKGPWSGFCYLMSGHSYG CFVLLSFFEPFFCLTNLLET KFTFPFLNIE in isoform B.		VSP_004147
	Alternative sequence	629 – 1118	490	Missing in isoform B.		VSP_004148
	Alternative sequence	637 – 651	15	FSPVI…AYKGK → CMYCNNPLFVFLGTS in isoform E.		VSP_017278
	Alternative sequence	652 – 1118	467	Missing in isoform E.		VSP_017279
	Alternative sequence	890 – 935	46	Missing in isoform D.		VSP_017280
	Natural variant	327	1	Y → H. Corresponds to variant rs11541747 [ dbSNP | Ensembl ].		VAR_054400
Experimental info
	Sequence conflict	517 – 520	4	EGKG → DSRR in AAF72867. Ref.1
	Sequence conflict	556	1	L → V in AAF72867. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified September 11, 2007. Version 2. Checksum: C9171EA01C8D17A0	FASTA	1,118	121,888
	10 20 30 40 50 60 MGVQGFQDYI EKHCPSAVVP VELQKLARGS LVGGGRQRPP QTPLRLLVDA DNCLHRLYGG 70 80 90 100 110 120 FYTDWVSGGQ WNHMLGYLAA LAKACFGGNI ELFVFFNGAL EKARLHEWVK RQGNERQTAQ 130 140 150 160 170 180 QIVSHVQNKG TPPPKVWFLP PVCMAHCIRL ALIRFHVKVA QSIEDHHQEV IGFCRENGFH 190 200 210 220 230 240 GLVAYDSDYA LCNIPYYFSA HALKLSRNGK SLTTSQYLMH EVAKQLDLNP NRFPIFAALL 250 260 270 280 290 300 GNHILPDEDL ASFHWSLLGP EHPLASLKVR AHQLVLPPCD VVIKAVADYV RNIQDTSDLD 310 320 330 340 350 360 AIAKDVFQHS QSRTDDKVIR FKRAIGYYSA TSKPMSFHPP HYLAARPGPF GMPGMVPPHV 370 380 390 400 410 420 PPQMLNIPQT SLQAKPVAPQ VPSPGGAPGQ GPYPYSLSEP APLTLDTSGK NLTEQNSYSN 430 440 450 460 470 480 IPHEGKHTPL YERSSPINPA QSGSPNHVDS AYFPGSSTSS SSDNDEGSGG ATNHISGNKI 490 500 510 520 530 540 GWEKTGSHSE PQARGDPGDQ TKAEGSSTAS SGSQLAEGKG SQMGTVQPIP CLLSMPTRNH 550 560 570 580 590 600 MDITTPPLPP VAPEVLRVAE HRHKKGLMYP YIFHVLTKGE IKIAVSIEDE ANKDLPPAAL 610 620 630 640 650 660 LYRPVRQYVY GVLFSLAESR KKTERLAFRK NRLPPEFSPV IIKEWAAYKG KSPQTPELVE 670 680 690 700 710 720 ALAFREWTCP NLKRLWLGKA VEDKNRRMRA FLACMRSDTP AMLNPANVPT HLMVLCCVLR 730 740 750 760 770 780 YMVQWPGARI LRRQELDAFL AQALSPKLYE PDQLQELKIE NLDPRGIQLS ALFMSGVDMA 790 800 810 820 830 840 LFANDACGQP IPWEHCCPWM YFDGKLFQSK LLKASREKTP LIDLCDGQAD QAAKVEKMRQ 850 860 870 880 890 900 SVLEGLSFSR QSHTLPFPPP PALPFYPASA YPRHFGPVPP SQGRGRGFAG VCGFGGPYGE 910 920 930 940 950 960 TVATGPYRAF RVAAASGHCG AFSGSDSSRT SKSQGGVQPI PSQGGKLEIA GTVVGHWAGS 970 980 990 1000 1010 1020 RRGRGGRGPF PLQVVSVGGP ARGRPRGVIS TPVIRTFGRG GRYYGRGYKN QAAIQGRPPY 1030 1040 1050 1060 1070 1080 AASAEEVAKE LKSKSGESKS SAMSSDGSLA ENGVMAEEKP APQMNGSTGD ARAPSHSESA 1090 1100 1110 LNNDSKTCNT NPHLNALSTD SACRREAALE AAVLNKEE
	Isoform B [UniParc]. Checksum: 4C39CFE952A4A18D	FASTA	628	68,993
	10 20 30 40 50 60 MGVQGFQDYI EKHCPSAVVP VELQKLARGS LVGGGRQRPP QTPLRLLVDA DNCLHRLYGG 70 80 90 100 110 120 FYTDWVSGGQ WNHMLGYLAA LAKACFGGNI ELFVFFNGAL EKARLHEWVK RQGNERQTAQ 130 140 150 160 170 180 QIVSHVQNKG TPPPKVWFLP PVCMAHCIRL ALIRFHVKVA QSIEDHHQEV IGFCRENGFH 190 200 210 220 230 240 GLVAYDSDYA LCNIPYYFSA HALKLSRNGK SLTTSQYLMH EVAKQLDLNP NRFPIFAALL 250 260 270 280 290 300 GNHILPDEDL ASFHWSLLGP EHPLASLKVR AHQLVLPPCD VVIKAVADYV RNIQDTSDLD 310 320 330 340 350 360 AIAKDVFQHS QSRTDDKVIR FKRAIGYYSA TSKPMSFHPP HYLAARPGPF GMPGMVPPHV 370 380 390 400 410 420 PPQMLNIPQT SLQAKPVAPQ VPSPGGAPGQ GPYPYSLSEP APLTLDTSGK NLTEQNSYSN 430 440 450 460 470 480 IPHEGKHTPL YERSSPINPA QSGSPNHVDS AYFPGSSTSS SSDNDEGSGG ATNHISGNKI 490 500 510 520 530 540 GWEKTGSHSE PQARGDPGDQ TKAEGSSTAS SGSQLAEGKG SQMGTVQPIP CLLSMPTRNH 550 560 570 580 590 600 MDITTPPLPP VAPEVLRVAE HRHKKGLMYP YIFHVLTKVL SKGPWSGFCY LMSGHSYGCF 610 620 VLLSFFEPFF CLTNLLETKF TFPFLNIE
	Isoform D [UniParc]. Checksum: 591F2B96B0E4DB49	FASTA	1,072	117,406
	10 20 30 40 50 60 MGVQGFQDYI EKHCPSAVVP VELQKLARGS LVGGGRQRPP QTPLRLLVDA DNCLHRLYGG 70 80 90 100 110 120 FYTDWVSGGQ WNHMLGYLAA LAKACFGGNI ELFVFFNGAL EKARLHEWVK RQGNERQTAQ 130 140 150 160 170 180 QIVSHVQNKG TPPPKVWFLP PVCMAHCIRL ALIRFHVKVA QSIEDHHQEV IGFCRENGFH 190 200 210 220 230 240 GLVAYDSDYA LCNIPYYFSA HALKLSRNGK SLTTSQYLMH EVAKQLDLNP NRFPIFAALL 250 260 270 280 290 300 GNHILPDEDL ASFHWSLLGP EHPLASLKVR AHQLVLPPCD VVIKAVADYV RNIQDTSDLD 310 320 330 340 350 360 AIAKDVFQHS QSRTDDKVIR FKRAIGYYSA TSKPMSFHPP HYLAARPGPF GMPGMVPPHV 370 380 390 400 410 420 PPQMLNIPQT SLQAKPVAPQ VPSPGGAPGQ GPYPYSLSEP APLTLDTSGK NLTEQNSYSN 430 440 450 460 470 480 IPHEGKHTPL YERSSPINPA QSGSPNHVDS AYFPGSSTSS SSDNDEGSGG ATNHISGNKI 490 500 510 520 530 540 GWEKTGSHSE PQARGDPGDQ TKAEGSSTAS SGSQLAEGKG SQMGTVQPIP CLLSMPTRNH 550 560 570 580 590 600 MDITTPPLPP VAPEVLRVAE HRHKKGLMYP YIFHVLTKGE IKIAVSIEDE ANKDLPPAAL 610 620 630 640 650 660 LYRPVRQYVY GVLFSLAESR KKTERLAFRK NRLPPEFSPV IIKEWAAYKG KSPQTPELVE 670 680 690 700 710 720 ALAFREWTCP NLKRLWLGKA VEDKNRRMRA FLACMRSDTP AMLNPANVPT HLMVLCCVLR 730 740 750 760 770 780 YMVQWPGARI LRRQELDAFL AQALSPKLYE PDQLQELKIE NLDPRGIQLS ALFMSGVDMA 790 800 810 820 830 840 LFANDACGQP IPWEHCCPWM YFDGKLFQSK LLKASREKTP LIDLCDGQAD QAAKVEKMRQ 850 860 870 880 890 900 SVLEGLSFSR QSHTLPFPPP PALPFYPASA YPRHFGPVPP SQGRGRGFAG VQPIPSQGGK 910 920 930 940 950 960 LEIAGTVVGH WAGSRRGRGG RGPFPLQVVS VGGPARGRPR GVISTPVIRT FGRGGRYYGR 970 980 990 1000 1010 1020 GYKNQAAIQG RPPYAASAEE VAKELKSKSG ESKSSAMSSD GSLAENGVMA EEKPAPQMNG 1030 1040 1050 1060 1070 STGDARAPSH SESALNNDSK TCNTNPHLNA LSTDSACRRE AALEAAVLNK EE
	Isoform E [UniParc]. Checksum: 013F2DADA8C3008E	FASTA	651	71,561
	10 20 30 40 50 60 MGVQGFQDYI EKHCPSAVVP VELQKLARGS LVGGGRQRPP QTPLRLLVDA DNCLHRLYGG 70 80 90 100 110 120 FYTDWVSGGQ WNHMLGYLAA LAKACFGGNI ELFVFFNGAL EKARLHEWVK RQGNERQTAQ 130 140 150 160 170 180 QIVSHVQNKG TPPPKVWFLP PVCMAHCIRL ALIRFHVKVA QSIEDHHQEV IGFCRENGFH 190 200 210 220 230 240 GLVAYDSDYA LCNIPYYFSA HALKLSRNGK SLTTSQYLMH EVAKQLDLNP NRFPIFAALL 250 260 270 280 290 300 GNHILPDEDL ASFHWSLLGP EHPLASLKVR AHQLVLPPCD VVIKAVADYV RNIQDTSDLD 310 320 330 340 350 360 AIAKDVFQHS QSRTDDKVIR FKRAIGYYSA TSKPMSFHPP HYLAARPGPF GMPGMVPPHV 370 380 390 400 410 420 PPQMLNIPQT SLQAKPVAPQ VPSPGGAPGQ GPYPYSLSEP APLTLDTSGK NLTEQNSYSN 430 440 450 460 470 480 IPHEGKHTPL YERSSPINPA QSGSPNHVDS AYFPGSSTSS SSDNDEGSGG ATNHISGNKI 490 500 510 520 530 540 GWEKTGSHSE PQARGDPGDQ TKAEGSSTAS SGSQLAEGKG SQMGTVQPIP CLLSMPTRNH 550 560 570 580 590 600 MDITTPPLPP VAPEVLRVAE HRHKKGLMYP YIFHVLTKGE IKIAVSIEDE ANKDLPPAAL 610 620 630 640 650 LYRPVRQYVY GVLFSLAESR KKTERLAFRK NRLPPECMYC NNPLFVFLGT S
	Isoform F [UniParc]. Checksum: 3E79D081CBABBD9C	FASTA	1,146	125,272
	10 20 30 40 50 60 MGVQGFQDYI EKHCPSAVVP VELQKLARGS LVGGGRQRPP QTPLRLLVDA DNCLHRLYGG 70 80 90 100 110 120 FYTDWVSGGQ WNHMLGYLAA LAKACFGGNI ELFVFFNGAL EKARLHEWVK RQGNERQTAQ 130 140 150 160 170 180 QIVSHVQNKG TPPPKVWFLP PVCMAHCIRL ALIRFHVKVA QSIEDHHQEV IGFCRENGFH 190 200 210 220 230 240 GLVAYDSDYA LCNIPYYFSA HALKLSRNGK SLTTSQYLMH EVAKQLDLNP NRFPIFAALL 250 260 270 280 290 300 GNHILPDEDL ASFHWSLLGP EHPLASLKVR AHQLVLPPCD VVIKAVADYV RNIQDTSDLD 310 320 330 340 350 360 AIAKDVFQHS QSRTDDKVIR FKRAIGYYSA TSKPMSFHPP HYLAARPGPF GMPGMVPPHV 370 380 390 400 410 420 PPQMLNIPQT SLQAKPVAPQ VPSPGGAPGQ GPYPYSLSEP APLTLDTSGK NLTEQNSYSN 430 440 450 460 470 480 IPHEGKHTPL YERSSPINPA QSGSPNHVDS AYFPGSSTSS SSDNDEGSGG ATKPFQLYLQ 490 500 510 520 530 540 KNFVFHKENS IVLCSRILRH GHISGNKIGW EKTGSHSEPQ ARGDPGDQTK AEGSSTASSG 550 560 570 580 590 600 SQLAEGKGSQ MGTVQPIPCL LSMPTRNHMD ITTPPLPPVA PEVLRVAEHR HKKGLMYPYI 610 620 630 640 650 660 FHVLTKGEIK IAVSIEDEAN KDLPPAALLY RPVRQYVYGV LFSLAESRKK TERLAFRKNR 670 680 690 700 710 720 LPPEFSPVII KEWAAYKGKS PQTPELVEAL AFREWTCPNL KRLWLGKAVE DKNRRMRAFL 730 740 750 760 770 780 ACMRSDTPAM LNPANVPTHL MVLCCVLRYM VQWPGARILR RQELDAFLAQ ALSPKLYEPD 790 800 810 820 830 840 QLQELKIENL DPRGIQLSAL FMSGVDMALF ANDACGQPIP WEHCCPWMYF DGKLFQSKLL 850 860 870 880 890 900 KASREKTPLI DLCDGQADQA AKVEKMRQSV LEGLSFSRQS HTLPFPPPPA LPFYPASAYP 910 920 930 940 950 960 RHFGPVPPSQ GRGRGFAGVC GFGGPYGETV ATGPYRAFRV AAASGHCGAF SGSDSSRTSK 970 980 990 1000 1010 1020 SQGGVQPIPS QGGKLEIAGT VVGHWAGSRR GRGGRGPFPL QVVSVGGPAR GRPRGVISTP 1030 1040 1050 1060 1070 1080 VIRTFGRGGR YYGRGYKNQA AIQGRPPYAA SAEEVAKELK SKSGESKSSA MSSDGSLAEN 1090 1100 1110 1120 1130 1140 GVMAEEKPAP QMNGSTGDAR APSHSESALN NDSKTCNTNP HLNALSTDSA CRREAALEAA VLNKEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Generating full-length coding sequence for 2 alternate transcripts of a novel gene C9orf10 and screening HSN-I patients for mutations." Brahmbhatt S.B., Hulme D.J., Dawkins J.L., Nicholson G.A. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), NUCLEOTIDE SEQUENCE [MRNA] OF 1-1102 (ISOFORM A).
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 157-1118 (ISOFORM E). Tissue: Lung and Placenta.
[4]	"Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N. DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-1069 (ISOFORM A). Tissue: Bone marrow.
[5]	Ohara O., Nagase T., Kikuno R., Nomura N. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[6]	"The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34." Holden S., Raymond F.L. Gene 318:149-161(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 393-512 (ISOFORM F), TISSUE SPECIFICITY.
[7]	Yu W., Gibbs R.A. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 579-1069 (ISOFORM D). Tissue: Brain.
[8]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1023, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"A novel RNA-binding protein, Ossa/C9orf10, regulates activity of Src kinases to protect cells from oxidative stress-induced apoptosis." Tanaka M., Sasaki K., Kamata R., Hoshino Y., Yanagihara K., Sakai R. Mol. Cell. Biol. 29:402-413(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH YES1; SRC AND FYN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1044; SER-1045 AND SER-1048, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF214737 mRNA. Translation: AAF72866.1. Frameshift. AF214738 mRNA. Translation: AAF72867.1. AL353629 Genomic DNA. Translation: CAI96105.1. AL353629 Genomic DNA. Translation: CAI96106.1. AL353629 Genomic DNA. Translation: CAI96108.1. AL353629 Genomic DNA. Translation: CAI96109.1. BC007879 mRNA. Translation: AAH07879.2. BC098584 mRNA. Translation: AAH98584.1. BC111736 mRNA. Translation: AAI11737.1. D80005 mRNA. Translation: BAA11500.2. AY266457 mRNA. Translation: AAP31031.1. AF055017 mRNA. Translation: AAC09364.1.
IPI	IPI00039626. IPI00220935. IPI00384265. IPI00472054. IPI00719085.
RefSeq	NP_055427.2. NM_014612.3.
UniGene	Hs.372003. Hs.707324. Hs.738743.
3D structure databases
ProteinModelPortal	Q9NZB2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NZB2. 7 interactions.
PTM databases
PhosphoSite	Q9NZB2.
Polymorphism databases
DMDM	158523294.
Proteomic databases
PaxDb	Q9NZB2.
PRIDE	Q9NZB2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000277165; ENSP00000277165; ENSG00000048828. ENST00000333936; ENSP00000334918; ENSG00000048828. ENST00000340893; ENSP00000344698; ENSG00000048828. ENST00000375389; ENSP00000364538; ENSG00000048828. ENST00000427765; ENSP00000412440; ENSG00000048828.
GeneID	23196.
KEGG	hsa:23196.
UCSC	uc004atv.3. human. uc004atw.3. human. uc004atx.3. human.
Organism-specific databases
CTD	23196.
GeneCards	GC09P096214.
HGNC	HGNC:13247. FAM120A.
HPA	HPA019734.
MIM	612265. gene.
neXtProt	NX_Q9NZB2.
PharmGKB	PA134954136.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40155.
HOVERGEN	HBG050957.
InParanoid	Q9NZB2.
OMA	EKPAPQM.
OrthoDB	EOG4R7V91.
PhylomeDB	Q9NZB2.
Gene expression databases
Bgee	Q9NZB2.
Genevestigator	Q9NZB2.
GermOnline	ENSG00000048828. Homo sapiens.
Family and domain databases
InterPro	IPR026783. Coact_PPARg-like_1. [Graphical view]
PANTHER	PTHR15976:SF4. PTHR15976:SF4. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	FAM120A. human.
GenomeRNAi	23196.
NextBio	44699.
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Entry information

Entry name

F120A_HUMAN

Accession

Primary (citable) accession number: Q9NZB2
Secondary accession number(s): A6NGU0 , C4AMC6, O60649, Q14688, Q4VXF4, Q4VXF5, Q4VXG2, Q86V69, Q96I21, Q9NZB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	September 11, 2007
Last modified:	April 3, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.