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Q9NZ94

- NLGN3_HUMAN

UniProt

Q9NZ94 - NLGN3_HUMAN

Protein

Neuroligin-3

Gene

NLGN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (23 May 2003)
      Previous versions | rss
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    Functioni

    Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system By similarity.By similarity

    GO - Molecular functioni

    1. cell adhesion molecule binding Source: BHF-UCL
    2. neurexin family protein binding Source: BHF-UCL
    3. protein binding Source: UniProtKB
    4. receptor activity Source: BHF-UCL

    GO - Biological processi

    1. adult behavior Source: BHF-UCL
    2. axon extension Source: BHF-UCL
    3. learning Source: BHF-UCL
    4. neuron cell-cell adhesion Source: BHF-UCL
    5. positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: BHF-UCL
    6. positive regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
    7. positive regulation of synapse assembly Source: BHF-UCL
    8. positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
    9. postsynaptic membrane assembly Source: BHF-UCL
    10. presynaptic membrane assembly Source: BHF-UCL
    11. receptor-mediated endocytosis Source: BHF-UCL
    12. regulation of dendritic spine morphogenesis Source: Ensembl
    13. regulation of inhibitory postsynaptic membrane potential Source: BHF-UCL
    14. regulation of long-term synaptic potentiation Source: Ensembl
    15. regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: Ensembl
    16. regulation of respiratory gaseous exchange by neurological system process Source: BHF-UCL
    17. regulation of synaptic transmission Source: BHF-UCL
    18. regulation of terminal button organization Source: Ensembl
    19. rhythmic synaptic transmission Source: BHF-UCL
    20. social behavior Source: UniProtKB
    21. synapse assembly Source: BHF-UCL
    22. synapse organization Source: UniProtKB
    23. visual learning Source: Ensembl
    24. vocalization behavior Source: BHF-UCL

    Keywords - Biological processi

    Cell adhesion

    Protein family/group databases

    MEROPSiS09.987.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuroligin-3
    Alternative name(s):
    Gliotactin homolog
    Gene namesi
    Name:NLGN3
    Synonyms:KIAA1480, NL3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:14289. NLGN3.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell junctionsynapse By similarity
    Note: Detected at both glutamatergic and GABAergic synapses.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cell surface Source: UniProtKB
    3. endocytic vesicle Source: BHF-UCL
    4. excitatory synapse Source: BHF-UCL
    5. integral component of plasma membrane Source: BHF-UCL
    6. synapse Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Synapse

    Pathology & Biotechi

    Involvement in diseasei

    Autism, X-linked 1 (AUTSX1) [MIM:300425]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti451 – 4511R → C in AUTSX1 and ASPGX1. 1 Publication
    VAR_015668
    Asperger syndrome, X-linked, 1 (ASPGX1) [MIM:300494]: A syndrome with features similar to autism. Affected individuals exhibit qualitative impairment in social interaction, as manifest by impairment in the use of non-verbal behaviors such as eye-to-eye gaze, facial expression, body postures, and gestures, failure to develop appropriate peer relationships, and lack of social sharing or reciprocity. Patients also exhibit restricted, repetitive and stereotyped patterns of behavior, interests, and activities, including abnormal preoccupation with certain activities and inflexible adherence to routines or rituals. Asperger syndrome is primarily distinguished from autism by the higher cognitive abilities and a more normal and timely development of language and communicative phrases.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti451 – 4511R → C in AUTSX1 and ASPGX1. 1 Publication
    VAR_015668

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi300425. phenotype.
    300494. phenotype.
    Orphaneti1162. Asperger syndrome.
    106. Autism.
    PharmGKBiPA31649.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3737Sequence AnalysisAdd
    BLAST
    Chaini38 – 848811Neuroligin-3PRO_0000008645Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi106 ↔ 141By similarity
    Disulfide bondi340 ↔ 351By similarity
    Disulfide bondi510 ↔ 544By similarity
    Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence Analysis
    Modified residuei792 – 7921PhosphotyrosineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9NZ94.
    PRIDEiQ9NZ94.

    PTM databases

    PhosphoSiteiQ9NZ94.

    Expressioni

    Tissue specificityi

    Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells.3 Publications

    Gene expression databases

    ArrayExpressiQ9NZ94.
    BgeeiQ9NZ94.
    CleanExiHS_NLGN3.
    GenevestigatoriQ9NZ94.

    Organism-specific databases

    HPAiHPA003183.

    Interactioni

    Subunit structurei

    Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3) By similarity. Homodimer, and heterodimer with NLGN1 and NLGN2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi119944. 6 interactions.
    IntActiQ9NZ94. 1 interaction.
    MINTiMINT-199096.
    STRINGi9606.ENSP00000363163.

    Structurei

    3D structure databases

    DisProtiDP00553.
    ProteinModelPortaliQ9NZ94.
    SMRiQ9NZ94. Positions 42-632.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini38 – 709672ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini731 – 848118CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei710 – 73021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2272.
    HOVERGENiHBG008839.
    InParanoidiQ9NZ94.
    KOiK07378.
    OMAiKPNKKIC.
    OrthoDBiEOG7RBZ7R.
    PhylomeDBiQ9NZ94.
    TreeFamiTF326187.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019819. Carboxylesterase_B_CS.
    IPR000460. Neuroligin.
    [Graphical view]
    PfamiPF00135. COesterase. 1 hit.
    [Graphical view]
    PRINTSiPR01090. NEUROLIGIN.
    SUPFAMiSSF53474. SSF53474. 2 hits.
    PROSITEiPS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NZ94-1) [UniParc]FASTAAdd to Basket

    Also known as: HNL3s

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWLRLGPPSL SLSPKPTVGR SLCLTLWFLS LALRASTQAP APTVNTHFGK    50
    LRGARVPLPS EILGPVDQYL GVPYAAPPIG EKRFLPPEPP PSWSGIRNAT 100
    HFPPVCPQNI HTAVPEVMLP VWFTANLDIV ATYIQEPNED CLYLNVYVPT 150
    EDVKRISKEC ARKPNKKICR KGGSGAKKQG EDLADNDGDE DEDIRDSGAK 200
    PVMVYIHGGS YMEGTGNMID GSILASYGNV IVITLNYRVG VLGFLSTGDQ 250
    AAKGNYGLLD QIQALRWVSE NIAFFGGDPR RITVFGSGIG ASCVSLLTLS 300
    HHSEGLFQRA IIQSGSALSS WAVNYQPVKY TSLLADKVGC NVLDTVDMVD 350
    CLRQKSAKEL VEQDIQPARY HVAFGPVIDG DVIPDDPEIL MEQGEFLNYD 400
    IMLGVNQGEG LKFVEGVVDP EDGVSGTDFD YSVSNFVDNL YGYPEGKDTL 450
    RETIKFMYTD WADRDNPETR RKTLVALFTD HQWVEPSVVT ADLHARYGSP 500
    TYFYAFYHHC QSLMKPAWSD AAHGDEVPYV FGVPMVGPTD LFPCNFSKND 550
    VMLSAVVMTY WTNFAKTGDP NKPVPQDTKF IHTKANRFEE VAWSKYNPRD 600
    QLYLHIGLKP RVRDHYRATK VAFWKHLVPH LYNLHDMFHY TSTTTKVPPP 650
    DTTHSSHITR RPNGKTWSTK RPAISPAYSN ENAQGSWNGD QDAGPLLVEN 700
    PRDYSTELSV TIAVGASLLF LNVLAFAALY YRKDKRRQEP LRQPSPQRGA 750
    GAPELGAAPE EELAALQLGP THHECEAGPP HDTLRLTALP DYTLTLRRSP 800
    DDIPLMTPNT ITMIPNSLVG LQTLHPYNTF AAGFNSTGLP HSHSTTRV 848
    Length:848
    Mass (Da):93,895
    Last modified:May 23, 2003 - v2
    Checksum:iB3EE2FAB7E427C82
    GO
    Isoform 2 (identifier: Q9NZ94-2) [UniParc]FASTAAdd to Basket

    Also known as: HNL3

    The sequence of this isoform differs from the canonical sequence as follows:
         153-172: Missing.

    Show »
    Length:828
    Mass (Da):91,570
    Checksum:iB72E4F3472678692
    GO
    Isoform 3 (identifier: Q9NZ94-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         153-192: Missing.

    Note: No experimental evidence available. Gene prediction based on EST data.

    Show »
    Length:808
    Mass (Da):89,538
    Checksum:iA0686FBADE342331
    GO

    Sequence cautioni

    The sequence AAF71231.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence BAA96004.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC11226.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti224 – 2241L → P in AAF71230. (PubMed:10767552)Curated
    Sequence conflicti274 – 2741F → S in BAG37248. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti92 – 921S → Y.1 Publication
    Corresponds to variant rs17854698 [ dbSNP | Ensembl ].
    VAR_068887
    Natural varianti451 – 4511R → C in AUTSX1 and ASPGX1. 1 Publication
    VAR_015668
    Natural varianti718 – 7181L → I.1 Publication
    Corresponds to variant rs17854697 [ dbSNP | Ensembl ].
    VAR_068888
    Natural varianti751 – 7511G → W.1 Publication
    Corresponds to variant rs17857400 [ dbSNP | Ensembl ].
    VAR_068889
    Natural varianti778 – 7781G → S.1 Publication
    Corresponds to variant rs17857401 [ dbSNP | Ensembl ].
    VAR_068890

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei153 – 19240Missing in isoform 3. CuratedVSP_053827Add
    BLAST
    Alternative sequencei153 – 17220Missing in isoform 2. 4 PublicationsVSP_007534Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF217411 mRNA. Translation: AAF71230.1.
    AF217412 mRNA. Translation: AAF71231.1. Sequence problems.
    AF217413 Genomic DNA. Translation: AAF71232.1.
    AF217413 Genomic DNA. Translation: AAF71233.1.
    GQ489207 mRNA. Translation: ADB12634.1.
    AK074814 mRNA. Translation: BAC11226.1. Different initiation.
    AK314699 mRNA. Translation: BAG37248.1.
    AL590764 Genomic DNA. No translation available.
    CH471132 Genomic DNA. Translation: EAX05307.1.
    CH471132 Genomic DNA. Translation: EAX05308.1.
    CH471132 Genomic DNA. Translation: EAX05309.1.
    CH471132 Genomic DNA. Translation: EAX05310.1.
    CH471132 Genomic DNA. Translation: EAX05312.1.
    CH471132 Genomic DNA. Translation: EAX05313.1.
    BC051715 mRNA. Translation: AAH51715.1.
    AB040913 mRNA. Translation: BAA96004.1. Different initiation.
    CCDSiCCDS14407.1. [Q9NZ94-2]
    CCDS55441.1. [Q9NZ94-1]
    CCDS55442.1. [Q9NZ94-3]
    RefSeqiNP_001160132.1. NM_001166660.1. [Q9NZ94-3]
    NP_061850.2. NM_018977.3. [Q9NZ94-2]
    NP_851820.1. NM_181303.1. [Q9NZ94-1]
    UniGeneiHs.438877.

    Genome annotation databases

    EnsembliENST00000358741; ENSP00000351591; ENSG00000196338. [Q9NZ94-1]
    ENST00000374051; ENSP00000363163; ENSG00000196338. [Q9NZ94-2]
    ENST00000536169; ENSP00000445298; ENSG00000196338. [Q9NZ94-3]
    GeneIDi54413.
    KEGGihsa:54413.
    UCSCiuc004dzb.3. human. [Q9NZ94-2]
    uc004dzd.2. human. [Q9NZ94-1]
    uc011mps.2. human.

    Polymorphism databases

    DMDMi31076855.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF217411 mRNA. Translation: AAF71230.1 .
    AF217412 mRNA. Translation: AAF71231.1 . Sequence problems.
    AF217413 Genomic DNA. Translation: AAF71232.1 .
    AF217413 Genomic DNA. Translation: AAF71233.1 .
    GQ489207 mRNA. Translation: ADB12634.1 .
    AK074814 mRNA. Translation: BAC11226.1 . Different initiation.
    AK314699 mRNA. Translation: BAG37248.1 .
    AL590764 Genomic DNA. No translation available.
    CH471132 Genomic DNA. Translation: EAX05307.1 .
    CH471132 Genomic DNA. Translation: EAX05308.1 .
    CH471132 Genomic DNA. Translation: EAX05309.1 .
    CH471132 Genomic DNA. Translation: EAX05310.1 .
    CH471132 Genomic DNA. Translation: EAX05312.1 .
    CH471132 Genomic DNA. Translation: EAX05313.1 .
    BC051715 mRNA. Translation: AAH51715.1 .
    AB040913 mRNA. Translation: BAA96004.1 . Different initiation.
    CCDSi CCDS14407.1. [Q9NZ94-2 ]
    CCDS55441.1. [Q9NZ94-1 ]
    CCDS55442.1. [Q9NZ94-3 ]
    RefSeqi NP_001160132.1. NM_001166660.1. [Q9NZ94-3 ]
    NP_061850.2. NM_018977.3. [Q9NZ94-2 ]
    NP_851820.1. NM_181303.1. [Q9NZ94-1 ]
    UniGenei Hs.438877.

    3D structure databases

    DisProti DP00553.
    ProteinModelPortali Q9NZ94.
    SMRi Q9NZ94. Positions 42-632.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119944. 6 interactions.
    IntActi Q9NZ94. 1 interaction.
    MINTi MINT-199096.
    STRINGi 9606.ENSP00000363163.

    Protein family/group databases

    MEROPSi S09.987.

    PTM databases

    PhosphoSitei Q9NZ94.

    Polymorphism databases

    DMDMi 31076855.

    Proteomic databases

    PaxDbi Q9NZ94.
    PRIDEi Q9NZ94.

    Protocols and materials databases

    DNASUi 54413.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358741 ; ENSP00000351591 ; ENSG00000196338 . [Q9NZ94-1 ]
    ENST00000374051 ; ENSP00000363163 ; ENSG00000196338 . [Q9NZ94-2 ]
    ENST00000536169 ; ENSP00000445298 ; ENSG00000196338 . [Q9NZ94-3 ]
    GeneIDi 54413.
    KEGGi hsa:54413.
    UCSCi uc004dzb.3. human. [Q9NZ94-2 ]
    uc004dzd.2. human. [Q9NZ94-1 ]
    uc011mps.2. human.

    Organism-specific databases

    CTDi 54413.
    GeneCardsi GC0XP070364.
    GeneReviewsi NLGN3.
    HGNCi HGNC:14289. NLGN3.
    HPAi HPA003183.
    MIMi 300336. gene.
    300425. phenotype.
    300494. phenotype.
    neXtProti NX_Q9NZ94.
    Orphaneti 1162. Asperger syndrome.
    106. Autism.
    PharmGKBi PA31649.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2272.
    HOVERGENi HBG008839.
    InParanoidi Q9NZ94.
    KOi K07378.
    OMAi KPNKKIC.
    OrthoDBi EOG7RBZ7R.
    PhylomeDBi Q9NZ94.
    TreeFami TF326187.

    Miscellaneous databases

    GeneWikii NLGN3.
    GenomeRNAii 54413.
    NextBioi 35468089.
    PROi Q9NZ94.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NZ94.
    Bgeei Q9NZ94.
    CleanExi HS_NLGN3.
    Genevestigatori Q9NZ94.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019819. Carboxylesterase_B_CS.
    IPR000460. Neuroligin.
    [Graphical view ]
    Pfami PF00135. COesterase. 1 hit.
    [Graphical view ]
    PRINTSi PR01090. NEUROLIGIN.
    SUPFAMi SSF53474. SSF53474. 2 hits.
    PROSITEi PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The structure and expression of the human neuroligin-3 gene."
      Philibert R.A., Winfield S.L., Sandhu H.K., Martin B.M., Ginns E.I.
      Gene 246:303-310(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    2. "Characterization of the neuroligin gene family expression and evolution in zebrafish."
      Rissone A., Sangiorgio L., Monopoli M., Beltrame M., Zucchi I., Bussolino F., Arese M., Cotelli F.
      Dev. Dyn. 239:688-702(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 410-848 (ISOFORM 1).
      Tissue: Brain.
    4. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS TYR-92; ILE-718; TRP-751 AND SER-778.
      Tissue: Brain.
    7. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-848.
      Tissue: Brain.
    8. Cited for: INTERACTION WITH DLG4.
    9. "Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins."
      Graf E.R., Zhang X., Jin S.X., Linhoff M.W., Craig A.M.
      Cell 119:1013-1026(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion."
      Suckow A.T., Comoletti D., Waldrop M.A., Mosedale M., Egodage S., Taylor P., Chessler S.D.
      Endocrinology 149:6006-6017(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    11. "The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions."
      Bottos A., Destro E., Rissone A., Graziano S., Cordara G., Assenzio B., Cera M.R., Mascia L., Bussolino F., Arese M.
      Proc. Natl. Acad. Sci. U.S.A. 106:20782-20787(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    12. Cited for: VARIANT AUTSX1 CYS-451, VARIANT ASPGX1 CYS-451.

    Entry informationi

    Entry nameiNLGN3_HUMAN
    AccessioniPrimary (citable) accession number: Q9NZ94
    Secondary accession number(s): B2RBK1
    , D2X2H6, D3DVV0, D3DVV1, Q86V51, Q8NCD0, Q9NZ95, Q9NZ96, Q9NZ97, Q9P248
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 23, 2003
    Last sequence update: May 23, 2003
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3