Q9NZ94 (NLGN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuroligin-3

Alternative name(s):
Gliotactin homolog

Gene names

Name:	NLGN3
Synonyms:	KIAA1480, NL3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	848 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system By similarity. Ref.9
Subunit structure	Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3) By similarity. Homodimer, and heterodimer with NLGN1 and NLGN2 By similarity. Ref.8
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity. Cell junction › synapse By similarity. Note: Detected at both glutamatergic and GABAergic synapses By similarity.
Tissue specificity	Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells. Ref.1 Ref.10 Ref.11
Involvement in disease	Autism, X-linked 1 (AUTSX1) [MIM:300425]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.12 X-linked Asperger syndrome 1 (ASPGX1) [MIM:300494]: Considered to be a form of childhood autism. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.12
Sequence similarities	Belongs to the type-B carboxylesterase/lipase family.
Sequence caution	The sequence AAF71231.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence BAA96004.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC11226.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell junction Cell membrane Membrane Synapse
Coding sequence diversity	Alternative splicing
Disease	Disease mutation
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon extension Inferred from sequence or structural similarity. Source: BHF-UCL neuron cell-cell adhesion Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of excitatory postsynaptic membrane potential Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of synapse assembly Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of synaptic transmission, glutamatergic Inferred from sequence or structural similarity. Source: BHF-UCL postsynaptic membrane assembly Inferred from sequence or structural similarity. Source: BHF-UCL presynaptic membrane assembly Inferred from sequence or structural similarity. Source: BHF-UCL receptor-mediated endocytosis Inferred from sequence or structural similarity. Source: BHF-UCL regulation of N-methyl-D-aspartate selective glutamate receptor activity Inferred from electronic annotation. Source: Compara regulation of dendritic spine morphogenesis Inferred from electronic annotation. Source: Compara regulation of inhibitory postsynaptic membrane potential Inferred from sequence or structural similarity. Source: BHF-UCL regulation of long-term synaptic potentiation Inferred from electronic annotation. Source: Compara regulation of respiratory gaseous exchange by neurological system process Inferred from electronic annotation. Source: Compara regulation of terminal button organization Inferred from electronic annotation. Source: Compara rhythmic synaptic transmission Inferred from sequence or structural similarity. Source: BHF-UCL social behavior Inferred from mutant phenotype Ref.12. Source: UniProtKB visual learning Inferred from electronic annotation. Source: Compara
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW cell surface Inferred from direct assay PubMed 15150161PubMed 17292328. Source: UniProtKB endocytic vesicle Inferred from sequence or structural similarity. Source: BHF-UCL excitatory synapse Inferred from direct assay Ref.9. Source: BHF-UCL integral to plasma membrane Inferred from sequence or structural similarity. Source: BHF-UCL
Molecular_function	cell adhesion molecule binding Inferred from sequence or structural similarity PubMed 15152050. Source: BHF-UCL neurexin family protein binding Inferred from sequence or structural similarity PubMed 15152050. Source: BHF-UCL receptor activity Inferred from sequence or structural similarity. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NZ94-1)

Also known as: HNL3s;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NZ94-2)

Also known as: HNL3;

The sequence of this isoform differs from the canonical sequence as follows:
     153-172: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 37	37	Potential
	Chain	38 – 848	811	Neuroligin-3		PRO_0000008645
Regions
	Topological domain	38 – 709	672	Extracellular Potential
	Transmembrane	710 – 730	21	Helical; Potential
	Topological domain	731 – 848	118	Cytoplasmic Potential
Amino acid modifications
	Modified residue	792	1	Phosphotyrosine By similarity
	Glycosylation	98	1	N-linked (GlcNAc...) Potential
	Glycosylation	545	1	N-linked (GlcNAc...) Potential
	Disulfide bond	106 ↔ 141		By similarity
	Disulfide bond	340 ↔ 351		By similarity
	Disulfide bond	510 ↔ 544		By similarity
Natural variations
	Alternative sequence	153 – 172	20	Missing in isoform 2.		VSP_007534
	Natural variant	92	1	S → Y. Ref.6 Corresponds to variant rs17854698 [ dbSNP | Ensembl ].		VAR_068887
	Natural variant	451	1	R → C in AUTSX1 and ASPGX1. Ref.12		VAR_015668
	Natural variant	718	1	L → I. Ref.6 Corresponds to variant rs17854697 [ dbSNP | Ensembl ].		VAR_068888
	Natural variant	751	1	G → W. Ref.6 Corresponds to variant rs17857400 [ dbSNP | Ensembl ].		VAR_068889
	Natural variant	778	1	G → S. Ref.6 Corresponds to variant rs17857401 [ dbSNP | Ensembl ].		VAR_068890
Experimental info
	Sequence conflict	224	1	L → P in AAF71230. Ref.1
	Sequence conflict	274	1	F → S in BAG37248. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (HNL3s) [UniParc]. Last modified May 23, 2003. Version 2. Checksum: B3EE2FAB7E427C82	FASTA	848	93,895
	10 20 30 40 50 60 MWLRLGPPSL SLSPKPTVGR SLCLTLWFLS LALRASTQAP APTVNTHFGK LRGARVPLPS 70 80 90 100 110 120 EILGPVDQYL GVPYAAPPIG EKRFLPPEPP PSWSGIRNAT HFPPVCPQNI HTAVPEVMLP 130 140 150 160 170 180 VWFTANLDIV ATYIQEPNED CLYLNVYVPT EDVKRISKEC ARKPNKKICR KGGSGAKKQG 190 200 210 220 230 240 EDLADNDGDE DEDIRDSGAK PVMVYIHGGS YMEGTGNMID GSILASYGNV IVITLNYRVG 250 260 270 280 290 300 VLGFLSTGDQ AAKGNYGLLD QIQALRWVSE NIAFFGGDPR RITVFGSGIG ASCVSLLTLS 310 320 330 340 350 360 HHSEGLFQRA IIQSGSALSS WAVNYQPVKY TSLLADKVGC NVLDTVDMVD CLRQKSAKEL 370 380 390 400 410 420 VEQDIQPARY HVAFGPVIDG DVIPDDPEIL MEQGEFLNYD IMLGVNQGEG LKFVEGVVDP 430 440 450 460 470 480 EDGVSGTDFD YSVSNFVDNL YGYPEGKDTL RETIKFMYTD WADRDNPETR RKTLVALFTD 490 500 510 520 530 540 HQWVEPSVVT ADLHARYGSP TYFYAFYHHC QSLMKPAWSD AAHGDEVPYV FGVPMVGPTD 550 560 570 580 590 600 LFPCNFSKND VMLSAVVMTY WTNFAKTGDP NKPVPQDTKF IHTKANRFEE VAWSKYNPRD 610 620 630 640 650 660 QLYLHIGLKP RVRDHYRATK VAFWKHLVPH LYNLHDMFHY TSTTTKVPPP DTTHSSHITR 670 680 690 700 710 720 RPNGKTWSTK RPAISPAYSN ENAQGSWNGD QDAGPLLVEN PRDYSTELSV TIAVGASLLF 730 740 750 760 770 780 LNVLAFAALY YRKDKRRQEP LRQPSPQRGA GAPELGAAPE EELAALQLGP THHECEAGPP 790 800 810 820 830 840 HDTLRLTALP DYTLTLRRSP DDIPLMTPNT ITMIPNSLVG LQTLHPYNTF AAGFNSTGLP HSHSTTRV
	Isoform 2 (HNL3) [UniParc]. Checksum: B72E4F3472678692	FASTA	828	91,570
	10 20 30 40 50 60 MWLRLGPPSL SLSPKPTVGR SLCLTLWFLS LALRASTQAP APTVNTHFGK LRGARVPLPS 70 80 90 100 110 120 EILGPVDQYL GVPYAAPPIG EKRFLPPEPP PSWSGIRNAT HFPPVCPQNI HTAVPEVMLP 130 140 150 160 170 180 VWFTANLDIV ATYIQEPNED CLYLNVYVPT EDGSGAKKQG EDLADNDGDE DEDIRDSGAK 190 200 210 220 230 240 PVMVYIHGGS YMEGTGNMID GSILASYGNV IVITLNYRVG VLGFLSTGDQ AAKGNYGLLD 250 260 270 280 290 300 QIQALRWVSE NIAFFGGDPR RITVFGSGIG ASCVSLLTLS HHSEGLFQRA IIQSGSALSS 310 320 330 340 350 360 WAVNYQPVKY TSLLADKVGC NVLDTVDMVD CLRQKSAKEL VEQDIQPARY HVAFGPVIDG 370 380 390 400 410 420 DVIPDDPEIL MEQGEFLNYD IMLGVNQGEG LKFVEGVVDP EDGVSGTDFD YSVSNFVDNL 430 440 450 460 470 480 YGYPEGKDTL RETIKFMYTD WADRDNPETR RKTLVALFTD HQWVEPSVVT ADLHARYGSP 490 500 510 520 530 540 TYFYAFYHHC QSLMKPAWSD AAHGDEVPYV FGVPMVGPTD LFPCNFSKND VMLSAVVMTY 550 560 570 580 590 600 WTNFAKTGDP NKPVPQDTKF IHTKANRFEE VAWSKYNPRD QLYLHIGLKP RVRDHYRATK 610 620 630 640 650 660 VAFWKHLVPH LYNLHDMFHY TSTTTKVPPP DTTHSSHITR RPNGKTWSTK RPAISPAYSN 670 680 690 700 710 720 ENAQGSWNGD QDAGPLLVEN PRDYSTELSV TIAVGASLLF LNVLAFAALY YRKDKRRQEP 730 740 750 760 770 780 LRQPSPQRGA GAPELGAAPE EELAALQLGP THHECEAGPP HDTLRLTALP DYTLTLRRSP 790 800 810 820 DDIPLMTPNT ITMIPNSLVG LQTLHPYNTF AAGFNSTGLP HSHSTTRV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The structure and expression of the human neuroligin-3 gene." Philibert R.A., Winfield S.L., Sandhu H.K., Martin B.M., Ginns E.I. Gene 246:303-310(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
[2]	"Characterization of the neuroligin gene family expression and evolution in zebrafish." Rissone A., Sangiorgio L., Monopoli M., Beltrame M., Zucchi I., Bussolino F., Arese M., Cotelli F. Dev. Dyn. 239:688-702(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 410-848 (ISOFORM 1). Tissue: Brain.
[4]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS TYR-92; ILE-718; TRP-751 AND SER-778. Tissue: Brain.
[7]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-848. Tissue: Brain.
[8]	"Binding of neuroligins to PSD-95." Irie M., Hata Y., Takeuchi M., Ichtchenko K., Toyoda A., Hirao K., Takai Y., Rosahl T.W., Suedhof T.C. Science 277:1511-1515(1997) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DLG4.
[9]	"Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins." Graf E.R., Zhang X., Jin S.X., Linhoff M.W., Craig A.M. Cell 119:1013-1026(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[10]	"Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion." Suckow A.T., Comoletti D., Waldrop M.A., Mosedale M., Egodage S., Taylor P., Chessler S.D. Endocrinology 149:6006-6017(2008) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
[11]	"The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions." Bottos A., Destro E., Rissone A., Graziano S., Cordara G., Assenzio B., Cera M.R., Mascia L., Bussolino F., Arese M. Proc. Natl. Acad. Sci. U.S.A. 106:20782-20787(2009) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[12]	"Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism." Jamain S., Quach H., Betancur C., Rastam M., Colineaux C., Gillberg I.C., Soderstrom H., Giros B., Leboyer M., Gillberg C., Bourgeron T., Nyden A., Philippe A., Cohen D., Chabane N., Mouren-Simeoni M.C., Brice A., Sponheim E. , Spurkland I., Skjeldal O.H., Coleman M., Pearl P.L., Cohen I.L., Tsiouris J., Zappella M., Menchetti G., Pompella A., Aschauer H., Van Maldergem L. Nat. Genet. 34:27-29(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT AUTSX1 CYS-451, VARIANT ASPGX1 CYS-451.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF217411 mRNA. Translation: AAF71230.1. AF217412 mRNA. Translation: AAF71231.1. Sequence problems. AF217413 Genomic DNA. Translation: AAF71232.1. AF217413 Genomic DNA. Translation: AAF71233.1. GQ489207 mRNA. Translation: ADB12634.1. AK074814 mRNA. Translation: BAC11226.1. Different initiation. AK314699 mRNA. Translation: BAG37248.1. AL590764 Genomic DNA. No translation available. CH471132 Genomic DNA. Translation: EAX05307.1. CH471132 Genomic DNA. Translation: EAX05308.1. CH471132 Genomic DNA. Translation: EAX05310.1. CH471132 Genomic DNA. Translation: EAX05312.1. BC051715 mRNA. Translation: AAH51715.1. AB040913 mRNA. Translation: BAA96004.1. Different initiation.
IPI	IPI00002307. IPI00184861.
RefSeq	NP_001160132.1. NM_001166660.1. NP_061850.2. NM_018977.3. NP_851820.1. NM_181303.1.
UniGene	Hs.438877.
3D structure databases
ProteinModelPortal	Q9NZ94.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NZ94. 1 interaction.
STRING	9606.ENSP00000363163.
Protein family/group databases
MEROPS	S09.987.
PTM databases
PhosphoSite	Q9NZ94.
Polymorphism databases
DMDM	31076855.
Proteomic databases
PaxDb	Q9NZ94.
PRIDE	Q9NZ94.
Protocols and materials databases
DNASU	54413.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358741; ENSP00000351591; ENSG00000196338. ENST00000374051; ENSP00000363163; ENSG00000196338.
GeneID	54413.
KEGG	hsa:54413.
UCSC	uc004dzb.3. human. uc004dzd.2. human.
Organism-specific databases
CTD	54413.
GeneCards	GC0XP070364.
HGNC	HGNC:14289. NLGN3.
HPA	HPA003183.
MIM	300336. gene. 300425. phenotype. 300494. phenotype.
neXtProt	NX_Q9NZ94.
Orphanet	1162. Asperger syndrome. 106. Autism.
PharmGKB	PA31649.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2272.
HOVERGEN	HBG008839.
InParanoid	Q9NZ94.
KO	K07378.
OMA	KPNKKIC.
PhylomeDB	Q9NZ94.
Gene expression databases
ArrayExpress	Q9NZ94.
Bgee	Q9NZ94.
CleanEx	HS_NLGN3.
Genevestigator	Q9NZ94.
GermOnline	ENSG00000196338. Homo sapiens.
Family and domain databases
InterPro	IPR002018. CarbesteraseB. IPR019819. Carboxylesterase_B_CS. IPR000460. Neuroligin. [Graphical view]
Pfam	PF00135. COesterase. 1 hit. [Graphical view]
PRINTS	PR01090. NEUROLIGIN.
PROSITE	PS00941. CARBOXYLESTERASE_B_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	54413.
NextBio	35468089.
SOURCE	Search...

Entry information

Entry name

NLGN3_HUMAN

Accession

Primary (citable) accession number: Q9NZ94
Secondary accession number(s): B2RBK1 , D2X2H6, D3DVV0, Q86V51, Q8NCD0, Q9NZ95, Q9NZ96, Q9NZ97, Q9P248

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 23, 2003
Last sequence update:	May 23, 2003
Last modified:	May 1, 2013
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.