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Q9NZ94

- NLGN3_HUMAN

UniProt

Q9NZ94 - NLGN3_HUMAN

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Protein

Neuroligin-3

Gene

NLGN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system By similarity.By similarity

GO - Molecular functioni

  1. cell adhesion molecule binding Source: BHF-UCL
  2. neurexin family protein binding Source: BHF-UCL
  3. receptor activity Source: BHF-UCL

GO - Biological processi

  1. adult behavior Source: BHF-UCL
  2. axon extension Source: BHF-UCL
  3. learning Source: BHF-UCL
  4. neuron cell-cell adhesion Source: BHF-UCL
  5. oligodendrocyte differentiation Source: Ensembl
  6. positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: BHF-UCL
  7. positive regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
  8. positive regulation of synapse assembly Source: BHF-UCL
  9. positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
  10. postsynaptic membrane assembly Source: BHF-UCL
  11. presynaptic membrane assembly Source: BHF-UCL
  12. receptor-mediated endocytosis Source: BHF-UCL
  13. regulation of dendritic spine morphogenesis Source: Ensembl
  14. regulation of inhibitory postsynaptic membrane potential Source: BHF-UCL
  15. regulation of long-term synaptic potentiation Source: Ensembl
  16. regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: Ensembl
  17. regulation of respiratory gaseous exchange by neurological system process Source: BHF-UCL
  18. regulation of synaptic transmission Source: BHF-UCL
  19. regulation of terminal button organization Source: Ensembl
  20. rhythmic synaptic transmission Source: BHF-UCL
  21. social behavior Source: UniProtKB
  22. synapse assembly Source: BHF-UCL
  23. synapse organization Source: UniProtKB
  24. visual learning Source: Ensembl
  25. vocalization behavior Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Protein family/group databases

MEROPSiS09.987.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroligin-3
Alternative name(s):
Gliotactin homolog
Gene namesi
Name:NLGN3
Synonyms:KIAA1480, NL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:14289. NLGN3.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell junctionsynapse By similarity
Note: Detected at both glutamatergic and GABAergic synapses.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cell surface Source: UniProtKB
  3. endocytic vesicle Source: BHF-UCL
  4. excitatory synapse Source: BHF-UCL
  5. integral component of plasma membrane Source: BHF-UCL
  6. synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Autism, X-linked 1 (AUTSX1) [MIM:300425]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.1 Publication
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti451 – 4511R → C in AUTSX1 and ASPGX1. 1 Publication
VAR_015668
Asperger syndrome, X-linked, 1 (ASPGX1) [MIM:300494]: A syndrome with features similar to autism. Affected individuals exhibit qualitative impairment in social interaction, as manifest by impairment in the use of non-verbal behaviors such as eye-to-eye gaze, facial expression, body postures, and gestures, failure to develop appropriate peer relationships, and lack of social sharing or reciprocity. Patients also exhibit restricted, repetitive and stereotyped patterns of behavior, interests, and activities, including abnormal preoccupation with certain activities and inflexible adherence to routines or rituals. Asperger syndrome is primarily distinguished from autism by the higher cognitive abilities and a more normal and timely development of language and communicative phrases.1 Publication
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti451 – 4511R → C in AUTSX1 and ASPGX1. 1 Publication
VAR_015668

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi300425. phenotype.
300494. phenotype.
Orphaneti1162. Asperger syndrome.
106. Autism.
PharmGKBiPA31649.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737Sequence AnalysisAdd
BLAST
Chaini38 – 848811Neuroligin-3PRO_0000008645Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi106 ↔ 141By similarity
Disulfide bondi340 ↔ 351By similarity
Disulfide bondi510 ↔ 544By similarity
Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence Analysis
Modified residuei792 – 7921PhosphotyrosineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9NZ94.
PRIDEiQ9NZ94.

PTM databases

PhosphoSiteiQ9NZ94.

Expressioni

Tissue specificityi

Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells.3 Publications

Gene expression databases

BgeeiQ9NZ94.
CleanExiHS_NLGN3.
ExpressionAtlasiQ9NZ94. baseline and differential.
GenevestigatoriQ9NZ94.

Organism-specific databases

HPAiHPA003183.

Interactioni

Subunit structurei

Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3) By similarity. Homodimer, and heterodimer with NLGN1 and NLGN2 By similarity.By similarity

Protein-protein interaction databases

BioGridi119944. 7 interactions.
IntActiQ9NZ94. 1 interaction.
MINTiMINT-199096.
STRINGi9606.ENSP00000363163.

Structurei

3D structure databases

DisProtiDP00553.
ProteinModelPortaliQ9NZ94.
SMRiQ9NZ94. Positions 42-632.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini38 – 709672ExtracellularSequence AnalysisAdd
BLAST
Topological domaini731 – 848118CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei710 – 73021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2272.
HOVERGENiHBG008839.
InParanoidiQ9NZ94.
KOiK07378.
OMAiKPNKKIC.
OrthoDBiEOG7RBZ7R.
PhylomeDBiQ9NZ94.
TreeFamiTF326187.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
IPR000460. Neuroligin.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR01090. NEUROLIGIN.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NZ94-1) [UniParc]FASTAAdd to Basket

Also known as: HNL3s

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWLRLGPPSL SLSPKPTVGR SLCLTLWFLS LALRASTQAP APTVNTHFGK
60 70 80 90 100
LRGARVPLPS EILGPVDQYL GVPYAAPPIG EKRFLPPEPP PSWSGIRNAT
110 120 130 140 150
HFPPVCPQNI HTAVPEVMLP VWFTANLDIV ATYIQEPNED CLYLNVYVPT
160 170 180 190 200
EDVKRISKEC ARKPNKKICR KGGSGAKKQG EDLADNDGDE DEDIRDSGAK
210 220 230 240 250
PVMVYIHGGS YMEGTGNMID GSILASYGNV IVITLNYRVG VLGFLSTGDQ
260 270 280 290 300
AAKGNYGLLD QIQALRWVSE NIAFFGGDPR RITVFGSGIG ASCVSLLTLS
310 320 330 340 350
HHSEGLFQRA IIQSGSALSS WAVNYQPVKY TSLLADKVGC NVLDTVDMVD
360 370 380 390 400
CLRQKSAKEL VEQDIQPARY HVAFGPVIDG DVIPDDPEIL MEQGEFLNYD
410 420 430 440 450
IMLGVNQGEG LKFVEGVVDP EDGVSGTDFD YSVSNFVDNL YGYPEGKDTL
460 470 480 490 500
RETIKFMYTD WADRDNPETR RKTLVALFTD HQWVEPSVVT ADLHARYGSP
510 520 530 540 550
TYFYAFYHHC QSLMKPAWSD AAHGDEVPYV FGVPMVGPTD LFPCNFSKND
560 570 580 590 600
VMLSAVVMTY WTNFAKTGDP NKPVPQDTKF IHTKANRFEE VAWSKYNPRD
610 620 630 640 650
QLYLHIGLKP RVRDHYRATK VAFWKHLVPH LYNLHDMFHY TSTTTKVPPP
660 670 680 690 700
DTTHSSHITR RPNGKTWSTK RPAISPAYSN ENAQGSWNGD QDAGPLLVEN
710 720 730 740 750
PRDYSTELSV TIAVGASLLF LNVLAFAALY YRKDKRRQEP LRQPSPQRGA
760 770 780 790 800
GAPELGAAPE EELAALQLGP THHECEAGPP HDTLRLTALP DYTLTLRRSP
810 820 830 840
DDIPLMTPNT ITMIPNSLVG LQTLHPYNTF AAGFNSTGLP HSHSTTRV
Length:848
Mass (Da):93,895
Last modified:May 23, 2003 - v2
Checksum:iB3EE2FAB7E427C82
GO
Isoform 2 (identifier: Q9NZ94-2) [UniParc]FASTAAdd to Basket

Also known as: HNL3

The sequence of this isoform differs from the canonical sequence as follows:
     153-172: Missing.

Show »
Length:828
Mass (Da):91,570
Checksum:iB72E4F3472678692
GO
Isoform 3 (identifier: Q9NZ94-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-192: Missing.

Note: No experimental evidence available. Gene prediction based on EST data.

Show »
Length:808
Mass (Da):89,538
Checksum:iA0686FBADE342331
GO

Sequence cautioni

The sequence AAF71231.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence BAA96004.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC11226.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti224 – 2241L → P in AAF71230. (PubMed:10767552)Curated
Sequence conflicti274 – 2741F → S in BAG37248. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921S → Y.1 Publication
Corresponds to variant rs17854698 [ dbSNP | Ensembl ].
VAR_068887
Natural varianti451 – 4511R → C in AUTSX1 and ASPGX1. 1 Publication
VAR_015668
Natural varianti718 – 7181L → I.1 Publication
Corresponds to variant rs17854697 [ dbSNP | Ensembl ].
VAR_068888
Natural varianti751 – 7511G → W.1 Publication
Corresponds to variant rs17857400 [ dbSNP | Ensembl ].
VAR_068889
Natural varianti778 – 7781G → S.1 Publication
Corresponds to variant rs17857401 [ dbSNP | Ensembl ].
VAR_068890

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei153 – 19240Missing in isoform 3. CuratedVSP_053827Add
BLAST
Alternative sequencei153 – 17220Missing in isoform 2. 4 PublicationsVSP_007534Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF217411 mRNA. Translation: AAF71230.1.
AF217412 mRNA. Translation: AAF71231.1. Sequence problems.
AF217413 Genomic DNA. Translation: AAF71232.1.
AF217413 Genomic DNA. Translation: AAF71233.1.
GQ489207 mRNA. Translation: ADB12634.1.
AK074814 mRNA. Translation: BAC11226.1. Different initiation.
AK314699 mRNA. Translation: BAG37248.1.
AL590764 Genomic DNA. No translation available.
CH471132 Genomic DNA. Translation: EAX05307.1.
CH471132 Genomic DNA. Translation: EAX05308.1.
CH471132 Genomic DNA. Translation: EAX05309.1.
CH471132 Genomic DNA. Translation: EAX05310.1.
CH471132 Genomic DNA. Translation: EAX05312.1.
CH471132 Genomic DNA. Translation: EAX05313.1.
BC051715 mRNA. Translation: AAH51715.1.
AB040913 mRNA. Translation: BAA96004.1. Different initiation.
CCDSiCCDS14407.1. [Q9NZ94-2]
CCDS55441.1. [Q9NZ94-1]
CCDS55442.1. [Q9NZ94-3]
RefSeqiNP_001160132.1. NM_001166660.1. [Q9NZ94-3]
NP_061850.2. NM_018977.3. [Q9NZ94-2]
NP_851820.1. NM_181303.1. [Q9NZ94-1]
UniGeneiHs.438877.

Genome annotation databases

EnsembliENST00000358741; ENSP00000351591; ENSG00000196338. [Q9NZ94-1]
ENST00000374051; ENSP00000363163; ENSG00000196338. [Q9NZ94-2]
ENST00000536169; ENSP00000445298; ENSG00000196338. [Q9NZ94-3]
GeneIDi54413.
KEGGihsa:54413.
UCSCiuc004dzb.3. human. [Q9NZ94-2]
uc004dzd.2. human. [Q9NZ94-1]
uc011mps.2. human.

Polymorphism databases

DMDMi31076855.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF217411 mRNA. Translation: AAF71230.1 .
AF217412 mRNA. Translation: AAF71231.1 . Sequence problems.
AF217413 Genomic DNA. Translation: AAF71232.1 .
AF217413 Genomic DNA. Translation: AAF71233.1 .
GQ489207 mRNA. Translation: ADB12634.1 .
AK074814 mRNA. Translation: BAC11226.1 . Different initiation.
AK314699 mRNA. Translation: BAG37248.1 .
AL590764 Genomic DNA. No translation available.
CH471132 Genomic DNA. Translation: EAX05307.1 .
CH471132 Genomic DNA. Translation: EAX05308.1 .
CH471132 Genomic DNA. Translation: EAX05309.1 .
CH471132 Genomic DNA. Translation: EAX05310.1 .
CH471132 Genomic DNA. Translation: EAX05312.1 .
CH471132 Genomic DNA. Translation: EAX05313.1 .
BC051715 mRNA. Translation: AAH51715.1 .
AB040913 mRNA. Translation: BAA96004.1 . Different initiation.
CCDSi CCDS14407.1. [Q9NZ94-2 ]
CCDS55441.1. [Q9NZ94-1 ]
CCDS55442.1. [Q9NZ94-3 ]
RefSeqi NP_001160132.1. NM_001166660.1. [Q9NZ94-3 ]
NP_061850.2. NM_018977.3. [Q9NZ94-2 ]
NP_851820.1. NM_181303.1. [Q9NZ94-1 ]
UniGenei Hs.438877.

3D structure databases

DisProti DP00553.
ProteinModelPortali Q9NZ94.
SMRi Q9NZ94. Positions 42-632.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119944. 7 interactions.
IntActi Q9NZ94. 1 interaction.
MINTi MINT-199096.
STRINGi 9606.ENSP00000363163.

Protein family/group databases

MEROPSi S09.987.

PTM databases

PhosphoSitei Q9NZ94.

Polymorphism databases

DMDMi 31076855.

Proteomic databases

PaxDbi Q9NZ94.
PRIDEi Q9NZ94.

Protocols and materials databases

DNASUi 54413.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358741 ; ENSP00000351591 ; ENSG00000196338 . [Q9NZ94-1 ]
ENST00000374051 ; ENSP00000363163 ; ENSG00000196338 . [Q9NZ94-2 ]
ENST00000536169 ; ENSP00000445298 ; ENSG00000196338 . [Q9NZ94-3 ]
GeneIDi 54413.
KEGGi hsa:54413.
UCSCi uc004dzb.3. human. [Q9NZ94-2 ]
uc004dzd.2. human. [Q9NZ94-1 ]
uc011mps.2. human.

Organism-specific databases

CTDi 54413.
GeneCardsi GC0XP070364.
GeneReviewsi NLGN3.
HGNCi HGNC:14289. NLGN3.
HPAi HPA003183.
MIMi 300336. gene.
300425. phenotype.
300494. phenotype.
neXtProti NX_Q9NZ94.
Orphaneti 1162. Asperger syndrome.
106. Autism.
PharmGKBi PA31649.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2272.
HOVERGENi HBG008839.
InParanoidi Q9NZ94.
KOi K07378.
OMAi KPNKKIC.
OrthoDBi EOG7RBZ7R.
PhylomeDBi Q9NZ94.
TreeFami TF326187.

Miscellaneous databases

GeneWikii NLGN3.
GenomeRNAii 54413.
NextBioi 35468089.
PROi Q9NZ94.
SOURCEi Search...

Gene expression databases

Bgeei Q9NZ94.
CleanExi HS_NLGN3.
ExpressionAtlasi Q9NZ94. baseline and differential.
Genevestigatori Q9NZ94.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
IPR000460. Neuroligin.
[Graphical view ]
Pfami PF00135. COesterase. 1 hit.
[Graphical view ]
PRINTSi PR01090. NEUROLIGIN.
SUPFAMi SSF53474. SSF53474. 2 hits.
PROSITEi PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The structure and expression of the human neuroligin-3 gene."
    Philibert R.A., Winfield S.L., Sandhu H.K., Martin B.M., Ginns E.I.
    Gene 246:303-310(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
  2. "Characterization of the neuroligin gene family expression and evolution in zebrafish."
    Rissone A., Sangiorgio L., Monopoli M., Beltrame M., Zucchi I., Bussolino F., Arese M., Cotelli F.
    Dev. Dyn. 239:688-702(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 410-848 (ISOFORM 1).
    Tissue: Brain.
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS TYR-92; ILE-718; TRP-751 AND SER-778.
    Tissue: Brain.
  7. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-848.
    Tissue: Brain.
  8. Cited for: INTERACTION WITH DLG4.
  9. "Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins."
    Graf E.R., Zhang X., Jin S.X., Linhoff M.W., Craig A.M.
    Cell 119:1013-1026(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion."
    Suckow A.T., Comoletti D., Waldrop M.A., Mosedale M., Egodage S., Taylor P., Chessler S.D.
    Endocrinology 149:6006-6017(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
  11. "The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions."
    Bottos A., Destro E., Rissone A., Graziano S., Cordara G., Assenzio B., Cera M.R., Mascia L., Bussolino F., Arese M.
    Proc. Natl. Acad. Sci. U.S.A. 106:20782-20787(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  12. Cited for: VARIANT AUTSX1 CYS-451, VARIANT ASPGX1 CYS-451.

Entry informationi

Entry nameiNLGN3_HUMAN
AccessioniPrimary (citable) accession number: Q9NZ94
Secondary accession number(s): B2RBK1
, D2X2H6, D3DVV0, D3DVV1, Q86V51, Q8NCD0, Q9NZ95, Q9NZ96, Q9NZ97, Q9P248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: May 23, 2003
Last modified: October 29, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3