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Protein

Proline-rich protein 13

Gene

PRR13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 13
Alternative name(s):
Taxane-resistance protein
Gene namesi
Name:PRR13
Synonyms:TXR1
ORF Names:BM-041
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24528. PRR13.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485583.

Polymorphism and mutation databases

BioMutaiPRR13.
DMDMi74734721.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 148148Proline-rich protein 13PRO_0000243946Add
BLAST

Proteomic databases

PaxDbiQ9NZ81.
PRIDEiQ9NZ81.

PTM databases

iPTMnetiQ9NZ81.
PhosphoSiteiQ9NZ81.

Expressioni

Gene expression databases

BgeeiQ9NZ81.
CleanExiHS_PRR13.
ExpressionAtlasiQ9NZ81. baseline and differential.
GenevisibleiQ9NZ81. HS.

Organism-specific databases

HPAiHPA046219.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BAIAP2Q9UQB83EBI-740924,EBI-525456
EWSR1Q018443EBI-740924,EBI-739737
FAM133AQ8N9E03EBI-740924,EBI-10268158
hCG_1744368A0A024RA763EBI-740924,EBI-10180729
KLHL12Q53G594EBI-740924,EBI-740929
KRTAP10-5P603703EBI-740924,EBI-10172150
KRTAP10-7P604093EBI-740924,EBI-10172290
KRTAP10-8P604103EBI-740924,EBI-10171774
LGALS3P179313EBI-740924,EBI-1170392
LGALS3Q6NVH93EBI-740924,EBI-10187804
LNX1Q8TBB14EBI-740924,EBI-739832
PEX5P505423EBI-740924,EBI-597835
PLSCR1O151623EBI-740924,EBI-740019
PSMA3P257883EBI-740924,EBI-348380
PSME3P612893EBI-740924,EBI-355546
SDCBPO005603EBI-740924,EBI-727004
SDCBP2Q9H1904EBI-740924,EBI-742426
SRIP306263EBI-740924,EBI-750459
TNFAIP8O953793EBI-740924,EBI-1049336
VAC14Q08AM63EBI-740924,EBI-2107455
ZCCHC10Q8TBK63EBI-740924,EBI-597063

Protein-protein interaction databases

BioGridi119965. 24 interactions.
IntActiQ9NZ81. 25 interactions.
MINTiMINT-1432022.
STRINGi9606.ENSP00000412064.

Structurei

3D structure databases

ProteinModelPortaliQ9NZ81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 10198Pro-richAdd
BLAST
Compositional biasi117 – 13519His-richAdd
BLAST
Compositional biasi136 – 14712Ser-richAdd
BLAST

Phylogenomic databases

eggNOGiENOG410JJAP. Eukaryota.
ENOG41117N2. LUCA.
GeneTreeiENSGT00730000111608.
HOGENOMiHOG000115714.
HOVERGENiHBG082199.
InParanoidiQ9NZ81.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NZ81-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWNPNAGQPG PNPYPPNIGC PGGSNPAHPP PINPPFPPGP CPPPPGAPHG
60 70 80 90 100
NPAFPPGGPP HPVPQPGYPG CQPLGPYPPP YPPPAPGIPP VNPLAPGMVG
110 120 130 140
PAVIVDKKMQ KKMKKAHKKM HKHQKHHKYH KHGKHSSSSS SSSSSDSD
Length:148
Mass (Da):15,385
Last modified:October 1, 2000 - v1
Checksum:i56BFEE6A15935A2E
GO
Isoform 2 (identifier: Q9NZ81-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-56: Missing.

Note: No experimental confirmation available.
Show »
Length:98
Mass (Da):10,531
Checksum:i69D555BE51FC4EE2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561P → S in CAG38490 (Ref. 2) Curated
Sequence conflicti73 – 731P → L in AAH66943 (PubMed:15489334).Curated
Sequence conflicti137 – 1371S → P in CAE45980 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei7 – 5650Missing in isoform 2. 1 PublicationVSP_024394Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217517 mRNA. Translation: AAF67628.1.
CR533459 mRNA. Translation: CAG38490.1.
BX640962 mRNA. Translation: CAE45980.1.
CH471054 Genomic DNA. Translation: EAW96703.1.
BC014257 mRNA. Translation: AAH14257.1.
BC016064 mRNA. Translation: AAH16064.1.
BC066943 mRNA. Translation: AAH66943.1.
BK005847 mRNA. Translation: DAA05782.1.
CCDSiCCDS31811.1. [Q9NZ81-2]
CCDS44899.1. [Q9NZ81-1]
RefSeqiNP_001005354.1. NM_001005354.2. [Q9NZ81-2]
NP_060927.1. NM_018457.3. [Q9NZ81-1]
UniGeneiHs.744894.

Genome annotation databases

EnsembliENST00000379786; ENSP00000369112; ENSG00000205352. [Q9NZ81-2]
ENST00000429243; ENSP00000412064; ENSG00000205352. [Q9NZ81-1]
ENST00000549135; ENSP00000447777; ENSG00000205352. [Q9NZ81-1]
ENST00000549581; ENSP00000448153; ENSG00000205352. [Q9NZ81-2]
ENST00000549924; ENSP00000448761; ENSG00000205352. [Q9NZ81-1]
GeneIDi54458.
KEGGihsa:54458.
UCSCiuc001scy.5. human. [Q9NZ81-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217517 mRNA. Translation: AAF67628.1.
CR533459 mRNA. Translation: CAG38490.1.
BX640962 mRNA. Translation: CAE45980.1.
CH471054 Genomic DNA. Translation: EAW96703.1.
BC014257 mRNA. Translation: AAH14257.1.
BC016064 mRNA. Translation: AAH16064.1.
BC066943 mRNA. Translation: AAH66943.1.
BK005847 mRNA. Translation: DAA05782.1.
CCDSiCCDS31811.1. [Q9NZ81-2]
CCDS44899.1. [Q9NZ81-1]
RefSeqiNP_001005354.1. NM_001005354.2. [Q9NZ81-2]
NP_060927.1. NM_018457.3. [Q9NZ81-1]
UniGeneiHs.744894.

3D structure databases

ProteinModelPortaliQ9NZ81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119965. 24 interactions.
IntActiQ9NZ81. 25 interactions.
MINTiMINT-1432022.
STRINGi9606.ENSP00000412064.

PTM databases

iPTMnetiQ9NZ81.
PhosphoSiteiQ9NZ81.

Polymorphism and mutation databases

BioMutaiPRR13.
DMDMi74734721.

Proteomic databases

PaxDbiQ9NZ81.
PRIDEiQ9NZ81.

Protocols and materials databases

DNASUi54458.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379786; ENSP00000369112; ENSG00000205352. [Q9NZ81-2]
ENST00000429243; ENSP00000412064; ENSG00000205352. [Q9NZ81-1]
ENST00000549135; ENSP00000447777; ENSG00000205352. [Q9NZ81-1]
ENST00000549581; ENSP00000448153; ENSG00000205352. [Q9NZ81-2]
ENST00000549924; ENSP00000448761; ENSG00000205352. [Q9NZ81-1]
GeneIDi54458.
KEGGihsa:54458.
UCSCiuc001scy.5. human. [Q9NZ81-1]

Organism-specific databases

CTDi54458.
GeneCardsiPRR13.
HGNCiHGNC:24528. PRR13.
HPAiHPA046219.
MIMi610459. gene.
neXtProtiNX_Q9NZ81.
PharmGKBiPA143485583.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JJAP. Eukaryota.
ENOG41117N2. LUCA.
GeneTreeiENSGT00730000111608.
HOGENOMiHOG000115714.
HOVERGENiHBG082199.
InParanoidiQ9NZ81.

Miscellaneous databases

ChiTaRSiPRR13. human.
GenomeRNAii54458.
PROiQ9NZ81.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NZ81.
CleanExiHS_PRR13.
ExpressionAtlasiQ9NZ81. baseline and differential.
GenevisibleiQ9NZ81. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Placenta.
  6. "Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes."
    Lih C.-J., Wei W., Cohen S.N.
    Genes Dev. 20:2082-2095(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.

Entry informationi

Entry nameiPRR13_HUMAN
AccessioniPrimary (citable) accession number: Q9NZ81
Secondary accession number(s): Q0V8U0
, Q6FIG7, Q6MZP8, Q6NXQ6, Q6PKF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.