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Protein

Proline-rich protein 13

Gene

PRR13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis.1 Publication

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 13
Alternative name(s):
Taxane-resistance protein
Gene namesi
Name:PRR13
Synonyms:TXR1
ORF Names:BM-041
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000205352.10.
HGNCiHGNC:24528. PRR13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54458.
OpenTargetsiENSG00000205352.
PharmGKBiPA143485583.

Polymorphism and mutation databases

BioMutaiPRR13.
DMDMi74734721.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002439461 – 148Proline-rich protein 13Add BLAST148

Proteomic databases

PaxDbiQ9NZ81.
PeptideAtlasiQ9NZ81.
PRIDEiQ9NZ81.

PTM databases

iPTMnetiQ9NZ81.
PhosphoSitePlusiQ9NZ81.

Expressioni

Gene expression databases

BgeeiENSG00000205352.
CleanExiHS_PRR13.
ExpressionAtlasiQ9NZ81. baseline and differential.
GenevisibleiQ9NZ81. HS.

Organism-specific databases

HPAiHPA039396.
HPA046219.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119965. 24 interactors.
IntActiQ9NZ81. 48 interactors.
MINTiMINT-1432022.
STRINGi9606.ENSP00000412064.

Structurei

3D structure databases

ProteinModelPortaliQ9NZ81.
SMRiQ9NZ81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 101Pro-richAdd BLAST98
Compositional biasi117 – 135His-richAdd BLAST19
Compositional biasi136 – 147Ser-richAdd BLAST12

Phylogenomic databases

eggNOGiENOG410JJAP. Eukaryota.
ENOG41117N2. LUCA.
GeneTreeiENSGT00730000111608.
HOGENOMiHOG000115714.
HOVERGENiHBG082199.
InParanoidiQ9NZ81.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NZ81-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWNPNAGQPG PNPYPPNIGC PGGSNPAHPP PINPPFPPGP CPPPPGAPHG
60 70 80 90 100
NPAFPPGGPP HPVPQPGYPG CQPLGPYPPP YPPPAPGIPP VNPLAPGMVG
110 120 130 140
PAVIVDKKMQ KKMKKAHKKM HKHQKHHKYH KHGKHSSSSS SSSSSDSD
Length:148
Mass (Da):15,385
Last modified:October 1, 2000 - v1
Checksum:i56BFEE6A15935A2E
GO
Isoform 2 (identifier: Q9NZ81-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-56: Missing.

Note: No experimental confirmation available.
Show »
Length:98
Mass (Da):10,531
Checksum:i69D555BE51FC4EE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56P → S in CAG38490 (Ref. 2) Curated1
Sequence conflicti73P → L in AAH66943 (PubMed:15489334).Curated1
Sequence conflicti137S → P in CAE45980 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0243947 – 56Missing in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217517 mRNA. Translation: AAF67628.1.
CR533459 mRNA. Translation: CAG38490.1.
BX640962 mRNA. Translation: CAE45980.1.
CH471054 Genomic DNA. Translation: EAW96703.1.
BC014257 mRNA. Translation: AAH14257.1.
BC016064 mRNA. Translation: AAH16064.1.
BC066943 mRNA. Translation: AAH66943.1.
BK005847 mRNA. Translation: DAA05782.1.
CCDSiCCDS31811.1. [Q9NZ81-2]
CCDS44899.1. [Q9NZ81-1]
RefSeqiNP_001005354.1. NM_001005354.2. [Q9NZ81-2]
NP_060927.1. NM_018457.3. [Q9NZ81-1]
UniGeneiHs.744894.

Genome annotation databases

EnsembliENST00000379786; ENSP00000369112; ENSG00000205352. [Q9NZ81-2]
ENST00000429243; ENSP00000412064; ENSG00000205352. [Q9NZ81-1]
ENST00000549135; ENSP00000447777; ENSG00000205352. [Q9NZ81-1]
ENST00000549581; ENSP00000448153; ENSG00000205352. [Q9NZ81-2]
ENST00000549924; ENSP00000448761; ENSG00000205352. [Q9NZ81-1]
GeneIDi54458.
KEGGihsa:54458.
UCSCiuc001scy.5. human. [Q9NZ81-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPRR13_HUMAN
AccessioniPrimary (citable) accession number: Q9NZ81
Secondary accession number(s): Q0V8U0
, Q6FIG7, Q6MZP8, Q6NXQ6, Q6PKF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot