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Protein

Stathmin-3

Gene

STMN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin-3
Alternative name(s):
SCG10-like protein
Gene namesi
Name:STMN3
Synonyms:SCLIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15926. STMN3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38049.

Polymorphism and mutation databases

DMDMi20141809.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Stathmin-3PRO_0000182402Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi22 – 221S-palmitoyl cysteineBy similarity
Lipidationi24 – 241S-palmitoyl cysteineBy similarity
Modified residuei50 – 501PhosphoserineBy similarity
Modified residuei60 – 601PhosphoserineBy similarity
Modified residuei65 – 651PhosphoserineBy similarity
Modified residuei68 – 681PhosphoserineBy similarity
Modified residuei72 – 721PhosphoserineBy similarity
Modified residuei73 – 731PhosphoserineBy similarity
Modified residuei81 – 811PhosphoserineBy similarity

Post-translational modificationi

N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ9NZ72.
MaxQBiQ9NZ72.
PaxDbiQ9NZ72.
PRIDEiQ9NZ72.

PTM databases

iPTMnetiQ9NZ72.
PhosphoSiteiQ9NZ72.
SwissPalmiQ9NZ72.

Expressioni

Tissue specificityi

Neuron specific.

Gene expression databases

BgeeiQ9NZ72.
CleanExiHS_STMN3.
ExpressionAtlasiQ9NZ72. baseline and differential.
GenevisibleiQ9NZ72. HS.

Organism-specific databases

HPAiHPA012947.

Interactioni

Subunit structurei

Interacts with STAT3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119161. 5 interactions.
IntActiQ9NZ72. 2 interactions.
MINTiMINT-1402424.
STRINGi9606.ENSP00000359070.

Structurei

3D structure databases

ProteinModelPortaliQ9NZ72.
SMRiQ9NZ72. Positions 40-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 180143SLDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili75 – 179105Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the stathmin family.Curated
Contains 1 SLD (stathmin-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEAZ. Eukaryota.
ENOG4111H1E. LUCA.
GeneTreeiENSGT00390000003691.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiQ9NZ72.
OMAiAEEKLNH.
OrthoDBiEOG744TBN.
PhylomeDBiQ9NZ72.
TreeFamiTF326935.

Family and domain databases

InterProiIPR028835. Stathmin-3.
IPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF17. PTHR10104:SF17. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NZ72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASTISAYKE KMKELSVLSL ICSCFYTQPH PNTVYQYGDM EVKQLDKRAS
60 70 80 90 100
GQSFEVILKS PSDLSPESPM LSSPPKKKDT SLEELQKRLE AAEERRKTQE
110 120 130 140 150
AQVLKQLAER REHEREVLHK ALEENNNFSR QAEEKLNYKM ELSKEIREAH
160 170 180
LAALRERLRE KELHAAEVRR NKEQREEMSG
Length:180
Mass (Da):21,017
Last modified:January 23, 2002 - v3
Checksum:i52F5E8A605FE10D0
GO
Isoform 2 (identifier: Q9NZ72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Note: No experimental confirmation available.
Show »
Length:169
Mass (Da):19,806
Checksum:iEAA6AE260D7BD4CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti72 – 721S → P in AAD12730 (PubMed:9603203).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1111Missing in isoform 2. 1 PublicationVSP_056525Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069709 mRNA. Translation: AAD12730.1.
AF217796 Genomic DNA. Translation: AAF35245.1.
AK094112 mRNA. Translation: BAG52817.1.
AK298903 mRNA. Translation: BAH12900.1.
AL353715 Genomic DNA. Translation: CAC16222.1.
BC009381 mRNA. Translation: AAH09381.1.
BC025234 mRNA. Translation: AAH25234.1.
CCDSiCCDS13529.1. [Q9NZ72-1]
CCDS63330.1. [Q9NZ72-2]
RefSeqiNP_001263239.1. NM_001276310.1. [Q9NZ72-2]
NP_056978.2. NM_015894.3. [Q9NZ72-1]
UniGeneiHs.639609.

Genome annotation databases

EnsembliENST00000370053; ENSP00000359070; ENSG00000197457. [Q9NZ72-1]
ENST00000540534; ENSP00000439840; ENSG00000197457. [Q9NZ72-2]
GeneIDi50861.
KEGGihsa:50861.
UCSCiuc002yfr.3. human. [Q9NZ72-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069709 mRNA. Translation: AAD12730.1.
AF217796 Genomic DNA. Translation: AAF35245.1.
AK094112 mRNA. Translation: BAG52817.1.
AK298903 mRNA. Translation: BAH12900.1.
AL353715 Genomic DNA. Translation: CAC16222.1.
BC009381 mRNA. Translation: AAH09381.1.
BC025234 mRNA. Translation: AAH25234.1.
CCDSiCCDS13529.1. [Q9NZ72-1]
CCDS63330.1. [Q9NZ72-2]
RefSeqiNP_001263239.1. NM_001276310.1. [Q9NZ72-2]
NP_056978.2. NM_015894.3. [Q9NZ72-1]
UniGeneiHs.639609.

3D structure databases

ProteinModelPortaliQ9NZ72.
SMRiQ9NZ72. Positions 40-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119161. 5 interactions.
IntActiQ9NZ72. 2 interactions.
MINTiMINT-1402424.
STRINGi9606.ENSP00000359070.

PTM databases

iPTMnetiQ9NZ72.
PhosphoSiteiQ9NZ72.
SwissPalmiQ9NZ72.

Polymorphism and mutation databases

DMDMi20141809.

Proteomic databases

EPDiQ9NZ72.
MaxQBiQ9NZ72.
PaxDbiQ9NZ72.
PRIDEiQ9NZ72.

Protocols and materials databases

DNASUi50861.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370053; ENSP00000359070; ENSG00000197457. [Q9NZ72-1]
ENST00000540534; ENSP00000439840; ENSG00000197457. [Q9NZ72-2]
GeneIDi50861.
KEGGihsa:50861.
UCSCiuc002yfr.3. human. [Q9NZ72-1]

Organism-specific databases

CTDi50861.
GeneCardsiSTMN3.
HGNCiHGNC:15926. STMN3.
HPAiHPA012947.
MIMi608362. gene.
neXtProtiNX_Q9NZ72.
PharmGKBiPA38049.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEAZ. Eukaryota.
ENOG4111H1E. LUCA.
GeneTreeiENSGT00390000003691.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiQ9NZ72.
OMAiAEEKLNH.
OrthoDBiEOG744TBN.
PhylomeDBiQ9NZ72.
TreeFamiTF326935.

Miscellaneous databases

ChiTaRSiSTMN3. human.
GeneWikiiSTMN3.
GenomeRNAii50861.
PROiQ9NZ72.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NZ72.
CleanExiHS_STMN3.
ExpressionAtlasiQ9NZ72. baseline and differential.
GenevisibleiQ9NZ72. HS.

Family and domain databases

InterProiIPR028835. Stathmin-3.
IPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF17. PTHR10104:SF17. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SCLIP: a novel SCG10-like protein of the stathmin family expressed in the nervous system."
    Ozon S., Byk T., Sobel A.
    J. Neurochem. 70:2386-2396(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster."
    Bai C., Connolly B., Metzker M.L., Hilliard C.A., Liu X., Sandig V., Soderman A., Galloway S.M., Liu Q., Austin C.P., Caskey C.T.
    Proc. Natl. Acad. Sci. U.S.A. 97:1230-1235(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Adrenal gland.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. "Subcellular Golgi localization of stathmin family proteins is promoted by a specific set of DHHC palmitoyl transferases."
    Levy A.D., Devignot V., Fukata Y., Fukata M., Sobel A., Chauvin S.
    Mol. Biol. Cell 22:1930-1942(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-22 AND CYS-24 BY ZDHHC3; ZDHHC7 AND ZDHHC15, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSTMN3_HUMAN
AccessioniPrimary (citable) accession number: Q9NZ72
Secondary accession number(s): B3KSQ5
, B7WP52, B7Z5G4, O75527, Q969Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2002
Last modified: June 8, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.