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Protein

Stathmin-3

Gene

STMN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin-3
Alternative name(s):
SCG10-like protein
Gene namesi
Name:STMN3
Synonyms:SCLIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000197457.9.
HGNCiHGNC:15926. STMN3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

DisGeNETi50861.
OpenTargetsiENSG00000197457.
PharmGKBiPA38049.

Polymorphism and mutation databases

DMDMi20141809.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001824021 – 180Stathmin-3Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi22S-palmitoyl cysteineBy similarity1
Lipidationi24S-palmitoyl cysteineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Modified residuei60PhosphoserineBy similarity1
Modified residuei65PhosphoserineBy similarity1
Modified residuei68PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei73PhosphoserineBy similarity1
Modified residuei81PhosphoserineBy similarity1

Post-translational modificationi

N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ9NZ72.
MaxQBiQ9NZ72.
PaxDbiQ9NZ72.
PeptideAtlasiQ9NZ72.
PRIDEiQ9NZ72.

PTM databases

iPTMnetiQ9NZ72.
PhosphoSitePlusiQ9NZ72.
SwissPalmiQ9NZ72.

Expressioni

Tissue specificityi

Neuron specific.

Gene expression databases

BgeeiENSG00000197457.
CleanExiHS_STMN3.
ExpressionAtlasiQ9NZ72. baseline and differential.
GenevisibleiQ9NZ72. HS.

Organism-specific databases

HPAiHPA012947.

Interactioni

Subunit structurei

Interacts with STAT3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CARD9Q9H257-24EBI-725557,EBI-11530605

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119161. 10 interactors.
IntActiQ9NZ72. 4 interactors.
MINTiMINT-1402424.
STRINGi9606.ENSP00000359070.

Structurei

3D structure databases

ProteinModelPortaliQ9NZ72.
SMRiQ9NZ72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 180SLDPROSITE-ProRule annotationAdd BLAST143

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili75 – 179Sequence analysisAdd BLAST105

Sequence similaritiesi

Belongs to the stathmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEAZ. Eukaryota.
ENOG4111H1E. LUCA.
GeneTreeiENSGT00390000003691.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiQ9NZ72.
OrthoDBiEOG091G0Y2U.
PhylomeDBiQ9NZ72.
TreeFamiTF326935.

Family and domain databases

InterProiView protein in InterPro
IPR028835. Stathmin-3.
IPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF22. PTHR10104:SF22. 1 hit.
PfamiView protein in Pfam
PF00836. Stathmin. 1 hit.
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiView protein in PROSITE
PS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NZ72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASTISAYKE KMKELSVLSL ICSCFYTQPH PNTVYQYGDM EVKQLDKRAS
60 70 80 90 100
GQSFEVILKS PSDLSPESPM LSSPPKKKDT SLEELQKRLE AAEERRKTQE
110 120 130 140 150
AQVLKQLAER REHEREVLHK ALEENNNFSR QAEEKLNYKM ELSKEIREAH
160 170 180
LAALRERLRE KELHAAEVRR NKEQREEMSG
Length:180
Mass (Da):21,017
Last modified:January 23, 2002 - v3
Checksum:i52F5E8A605FE10D0
GO
Isoform 2 (identifier: Q9NZ72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Note: No experimental confirmation available.
Show »
Length:169
Mass (Da):19,806
Checksum:iEAA6AE260D7BD4CB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72S → P in AAD12730 (PubMed:9603203).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565251 – 11Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069709 mRNA. Translation: AAD12730.1.
AF217796 Genomic DNA. Translation: AAF35245.1.
AK094112 mRNA. Translation: BAG52817.1.
AK298903 mRNA. Translation: BAH12900.1.
AL353715 Genomic DNA. No translation available.
BC009381 mRNA. Translation: AAH09381.1.
BC025234 mRNA. Translation: AAH25234.1.
CCDSiCCDS13529.1. [Q9NZ72-1]
CCDS63330.1. [Q9NZ72-2]
RefSeqiNP_001263239.1. NM_001276310.1. [Q9NZ72-2]
NP_056978.2. NM_015894.3. [Q9NZ72-1]
UniGeneiHs.639609.

Genome annotation databases

EnsembliENST00000370053; ENSP00000359070; ENSG00000197457. [Q9NZ72-1]
ENST00000540534; ENSP00000439840; ENSG00000197457. [Q9NZ72-2]
GeneIDi50861.
KEGGihsa:50861.
UCSCiuc002yfr.3. human. [Q9NZ72-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTMN3_HUMAN
AccessioniPrimary (citable) accession number: Q9NZ72
Secondary accession number(s): B3KSQ5
, B7WP52, B7Z5G4, O75527, Q969Y4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2002
Last modified: September 27, 2017
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families