Unreviewed, UniProtKB/TrEMBL Q9NZ70 (Q9NZ70_HUMAN)

Names and origin

Protein names

Submitted name:
    Mitogen-activated protein kinase kinase kinase 7 EMBL CAI19609.1
Submitted name:
    TGF beta-activated kinase splice variant d EMBL AAF27652.1
    Mitogen-activated protein kinase kinase kinase 7, isoform CRA_d EMBL EAW48529.1

Gene names

Name:	TAK1 EMBL AAF27652.1
Synonyms:	MAP3K7 EMBL EAW48529.1
ORF Names:	RP1-154G14.1-004 EMBL CAI19609.1, hCG_32402 EMBL EAW48529.1

Organism

Homo sapiens (Human) EMBL AAF27652.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the protein kinase superfamily.

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304V2 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase RuleBase RU000305V3 Transferase
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9NZ70-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: B7D8832E286A99C5	FASTA	491	53,740
	10 20 30 40 50 60 MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV 70 80 90 100 110 120 AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE 130 140 150 160 170 180 PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC 190 200 210 220 230 240 DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM 250 260 270 280 290 300 WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY 310 320 330 340 350 360 PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQVPA TNDTIKRLES KLLKNQAKQQ 370 380 390 400 410 420 SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA ATTGNGQPRR RSIQDLTVTG 430 440 450 460 470 480 TEPGQVSSRS SSPSVRMITT SGPTSEKPTR SHPWTPDDST DTNGSDNSIP MAYLTLDHQL 490 QARTSCRTGP G

References

[1]	"Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1." Dempsey C.E., Sakurai H., Sugita T., Guesdon F. Biochim. Biophys. Acta 1517:46-52(2000) [PubMed: 11118615] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Tracey A. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Mashreghi-Mohammadi M. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF218074 mRNA. Translation: AAF27652.1. AL121964, AL121837 Genomic DNA. Translation: CAI19609.1. AL121837, AL121964 Genomic DNA. Translation: CAI23531.1. CH471051 Genomic DNA. Translation: EAW48529.1.
IPI	IPI00241935.
RefSeq	NP_663306.1.
3D structure databases
HSSP	HSSP built from PDB template 1IAS based on UniProtKB P36897.
SMR	Q9NZ70. Positions 31-305.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NZ70.
Genome annotation databases
Ensembl	ENST00000369327; ENSP00000358333; ENSG00000135341; Homo sapiens. [Genome view]
GeneID	6885.
UCSC	uc003poc.1. human.
Organism-specific databases
CTD	6885.
HGNC	HGNC:6859. MAP3K7.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9NZ70.
Gene expression databases
ArrayExpress	Q9NZ70.
Bgee	Q9NZ70.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR015786. MAPKKK-related. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_prot_kinase_AS. [Graphical view]
PANTHER	PTHR23257:SF92. MAPKKK-related. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	26899.

Entry information

Entry name

Q9NZ70_HUMAN

Accession

Primary (citable) accession number: Q9NZ70
Secondary accession number(s): Q9NTR3

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	February 9, 2010
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.