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Protein

Uncharacterized protein C9orf78

Gene

C9orf78

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C9orf78
Alternative name(s):
Hepatocellular carcinoma-associated antigen 59
Gene namesi
Name:C9orf78
Synonyms:HCA59
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:24932. C9orf78.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134929438.

Polymorphism and mutation databases

BioMutaiC9orf78.
DMDMi74753081.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Uncharacterized protein C9orf78PRO_0000227523Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151Phosphoserine3 Publications
Modified residuei17 – 171Phosphoserine3 Publications
Modified residuei147 – 1471Phosphotyrosine1 Publication
Modified residuei253 – 2531Phosphothreonine2 Publications
Modified residuei261 – 2611Phosphoserine4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NZ63.
PaxDbiQ9NZ63.
PeptideAtlasiQ9NZ63.
PRIDEiQ9NZ63.

PTM databases

PhosphoSiteiQ9NZ63.

Expressioni

Gene expression databases

BgeeiQ9NZ63.
CleanExiHS_C9orf78.
ExpressionAtlasiQ9NZ63. baseline and differential.
GenevestigatoriQ9NZ63.

Organism-specific databases

HPAiHPA021216.
HPA021232.
HPA021242.

Interactioni

Protein-protein interaction databases

BioGridi119716. 20 interactions.
IntActiQ9NZ63. 4 interactions.
MINTiMINT-6782836.
STRINGi9606.ENSP00000361524.

Structurei

3D structure databases

ProteinModelPortaliQ9NZ63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG238834.
GeneTreeiENSGT00390000009787.
HOGENOMiHOG000240083.
HOVERGENiHBG055019.
InParanoidiQ9NZ63.
OMAiAEQRNKK.
OrthoDBiEOG7FBRJ6.
PhylomeDBiQ9NZ63.
TreeFamiTF105871.

Family and domain databases

InterProiIPR010756. Hep_59.
[Graphical view]
PANTHERiPTHR13486. PTHR13486. 1 hit.
PfamiPF07052. Hep_59. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NZ63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVVRKIFRR RRGDSESEED EQDSEEVRLK LEETREVQNL RKRPNGVSAV
60 70 80 90 100
ALLVGEKVQE ETTLVDDPFQ MKTGGMVDMK KLKERGKDKI SEEEDLHLGT
110 120 130 140 150
SFSAETNRRD EDADMMKYIE TELKKRKGIV EHEEQKVKPK NAEDCLYELP
160 170 180 190 200
ENIRVSSAKK TEEMLSNQML SGIPEVDLGI DAKIKNIIST EDAKARLLAE
210 220 230 240 250
QQNKKKDSET SFVPTNMAVN YVQHNRFYHE ELNAPIRRNK EEPKARPLRV
260 270 280
GDTEKPEPER SPPNRKRPAN EKATDDYHYE KFKKMNRRY
Length:289
Mass (Da):33,688
Last modified:October 1, 2000 - v1
Checksum:i3F691E6D17D1360E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391P → S in AAH17570 (PubMed:15489334).Curated
Sequence conflicti203 – 2031N → S in AAH17570 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701Q → H.
Corresponds to variant rs1237745 [ dbSNP | Ensembl ].
VAR_050828

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218421 mRNA. Translation: AAF37561.1.
AK057004 mRNA. Translation: BAG51840.1.
AL158207 Genomic DNA. Translation: CAC88169.1.
CH471090 Genomic DNA. Translation: EAW87910.1.
BC007664 mRNA. Translation: AAH07664.1.
BC017570 mRNA. Translation: AAH17570.1.
AL137549 mRNA. Translation: CAB70805.1.
CCDSiCCDS6931.1.
PIRiT46390.
RefSeqiNP_057604.1. NM_016520.2.
UniGeneiHs.278429.

Genome annotation databases

EnsembliENST00000372447; ENSP00000361524; ENSG00000136819.
GeneIDi51759.
KEGGihsa:51759.
UCSCiuc004byp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218421 mRNA. Translation: AAF37561.1.
AK057004 mRNA. Translation: BAG51840.1.
AL158207 Genomic DNA. Translation: CAC88169.1.
CH471090 Genomic DNA. Translation: EAW87910.1.
BC007664 mRNA. Translation: AAH07664.1.
BC017570 mRNA. Translation: AAH17570.1.
AL137549 mRNA. Translation: CAB70805.1.
CCDSiCCDS6931.1.
PIRiT46390.
RefSeqiNP_057604.1. NM_016520.2.
UniGeneiHs.278429.

3D structure databases

ProteinModelPortaliQ9NZ63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119716. 20 interactions.
IntActiQ9NZ63. 4 interactions.
MINTiMINT-6782836.
STRINGi9606.ENSP00000361524.

PTM databases

PhosphoSiteiQ9NZ63.

Polymorphism and mutation databases

BioMutaiC9orf78.
DMDMi74753081.

Proteomic databases

MaxQBiQ9NZ63.
PaxDbiQ9NZ63.
PeptideAtlasiQ9NZ63.
PRIDEiQ9NZ63.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372447; ENSP00000361524; ENSG00000136819.
GeneIDi51759.
KEGGihsa:51759.
UCSCiuc004byp.3. human.

Organism-specific databases

CTDi51759.
GeneCardsiGC09M132590.
H-InvDBHIX0008458.
HGNCiHGNC:24932. C9orf78.
HPAiHPA021216.
HPA021232.
HPA021242.
neXtProtiNX_Q9NZ63.
PharmGKBiPA134929438.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG238834.
GeneTreeiENSGT00390000009787.
HOGENOMiHOG000240083.
HOVERGENiHBG055019.
InParanoidiQ9NZ63.
OMAiAEQRNKK.
OrthoDBiEOG7FBRJ6.
PhylomeDBiQ9NZ63.
TreeFamiTF105871.

Miscellaneous databases

ChiTaRSiC9orf78. human.
GeneWikiiC9orf78.
GenomeRNAii51759.
NextBioi55862.
PROiQ9NZ63.

Gene expression databases

BgeeiQ9NZ63.
CleanExiHS_C9orf78.
ExpressionAtlasiQ9NZ63. baseline and differential.
GenevestigatoriQ9NZ63.

Family and domain databases

InterProiIPR010756. Hep_59.
[Graphical view]
PANTHERiPTHR13486. PTHR13486. 1 hit.
PfamiPF07052. Hep_59. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies."
    Wang Y., Han K.-J., Pang X.-W., Vaughan H.A., Qu W., Dong X.-Y., Peng J.-R., Zhao H.-T., Rui J.-A., Leng X.-S., Cebon J., Burgess A.W., Chen W.-F.
    J. Immunol. 169:1102-1109(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hepatoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow and Placenta.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 49-289.
    Tissue: Testis.
  7. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-147, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-17 AND SER-261, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-17; THR-253 AND SER-261, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-253, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCI078_HUMAN
AccessioniPrimary (citable) accession number: Q9NZ63
Secondary accession number(s): B3KPX8, Q8WVU6, Q9NT39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2000
Last modified: April 29, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.