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Q9NZ63

- CI078_HUMAN

UniProt

Q9NZ63 - CI078_HUMAN

Protein

Uncharacterized protein C9orf78

Gene

C9orf78

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein C9orf78
    Alternative name(s):
    Hepatocellular carcinoma-associated antigen 59
    Gene namesi
    Name:C9orf78
    Synonyms:HCA59
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:24932. C9orf78.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: HPA

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134929438.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Uncharacterized protein C9orf78PRO_0000227523Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei15 – 151Phosphoserine3 Publications
    Modified residuei17 – 171Phosphoserine3 Publications
    Modified residuei147 – 1471Phosphotyrosine1 Publication
    Modified residuei253 – 2531Phosphothreonine1 Publication
    Modified residuei261 – 2611Phosphoserine4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NZ63.
    PaxDbiQ9NZ63.
    PeptideAtlasiQ9NZ63.
    PRIDEiQ9NZ63.

    PTM databases

    PhosphoSiteiQ9NZ63.

    Expressioni

    Gene expression databases

    BgeeiQ9NZ63.
    CleanExiHS_C9orf78.
    GenevestigatoriQ9NZ63.

    Organism-specific databases

    HPAiHPA021216.
    HPA021232.
    HPA021242.

    Interactioni

    Protein-protein interaction databases

    BioGridi119716. 17 interactions.
    IntActiQ9NZ63. 4 interactions.
    MINTiMINT-6782836.
    STRINGi9606.ENSP00000361524.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NZ63.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG238834.
    HOGENOMiHOG000240083.
    HOVERGENiHBG055019.
    InParanoidiQ9NZ63.
    OMAiAEQRNKK.
    OrthoDBiEOG7FBRJ6.
    PhylomeDBiQ9NZ63.
    TreeFamiTF105871.

    Family and domain databases

    InterProiIPR010756. Hep_59.
    [Graphical view]
    PANTHERiPTHR13486. PTHR13486. 1 hit.
    PfamiPF07052. Hep_59. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NZ63-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVVRKIFRR RRGDSESEED EQDSEEVRLK LEETREVQNL RKRPNGVSAV    50
    ALLVGEKVQE ETTLVDDPFQ MKTGGMVDMK KLKERGKDKI SEEEDLHLGT 100
    SFSAETNRRD EDADMMKYIE TELKKRKGIV EHEEQKVKPK NAEDCLYELP 150
    ENIRVSSAKK TEEMLSNQML SGIPEVDLGI DAKIKNIIST EDAKARLLAE 200
    QQNKKKDSET SFVPTNMAVN YVQHNRFYHE ELNAPIRRNK EEPKARPLRV 250
    GDTEKPEPER SPPNRKRPAN EKATDDYHYE KFKKMNRRY 289
    Length:289
    Mass (Da):33,688
    Last modified:October 1, 2000 - v1
    Checksum:i3F691E6D17D1360E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti139 – 1391P → S in AAH17570. (PubMed:15489334)Curated
    Sequence conflicti203 – 2031N → S in AAH17570. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti70 – 701Q → H.
    Corresponds to variant rs1237745 [ dbSNP | Ensembl ].
    VAR_050828

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218421 mRNA. Translation: AAF37561.1.
    AK057004 mRNA. Translation: BAG51840.1.
    AL158207 Genomic DNA. Translation: CAC88169.1.
    CH471090 Genomic DNA. Translation: EAW87910.1.
    BC007664 mRNA. Translation: AAH07664.1.
    BC017570 mRNA. Translation: AAH17570.1.
    AL137549 mRNA. Translation: CAB70805.1.
    CCDSiCCDS6931.1.
    PIRiT46390.
    RefSeqiNP_057604.1. NM_016520.2.
    UniGeneiHs.278429.

    Genome annotation databases

    EnsembliENST00000372447; ENSP00000361524; ENSG00000136819.
    GeneIDi51759.
    KEGGihsa:51759.
    UCSCiuc004byp.3. human.

    Polymorphism databases

    DMDMi74753081.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218421 mRNA. Translation: AAF37561.1 .
    AK057004 mRNA. Translation: BAG51840.1 .
    AL158207 Genomic DNA. Translation: CAC88169.1 .
    CH471090 Genomic DNA. Translation: EAW87910.1 .
    BC007664 mRNA. Translation: AAH07664.1 .
    BC017570 mRNA. Translation: AAH17570.1 .
    AL137549 mRNA. Translation: CAB70805.1 .
    CCDSi CCDS6931.1.
    PIRi T46390.
    RefSeqi NP_057604.1. NM_016520.2.
    UniGenei Hs.278429.

    3D structure databases

    ProteinModelPortali Q9NZ63.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119716. 17 interactions.
    IntActi Q9NZ63. 4 interactions.
    MINTi MINT-6782836.
    STRINGi 9606.ENSP00000361524.

    PTM databases

    PhosphoSitei Q9NZ63.

    Polymorphism databases

    DMDMi 74753081.

    Proteomic databases

    MaxQBi Q9NZ63.
    PaxDbi Q9NZ63.
    PeptideAtlasi Q9NZ63.
    PRIDEi Q9NZ63.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372447 ; ENSP00000361524 ; ENSG00000136819 .
    GeneIDi 51759.
    KEGGi hsa:51759.
    UCSCi uc004byp.3. human.

    Organism-specific databases

    CTDi 51759.
    GeneCardsi GC09M132590.
    H-InvDB HIX0008458.
    HGNCi HGNC:24932. C9orf78.
    HPAi HPA021216.
    HPA021232.
    HPA021242.
    neXtProti NX_Q9NZ63.
    PharmGKBi PA134929438.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238834.
    HOGENOMi HOG000240083.
    HOVERGENi HBG055019.
    InParanoidi Q9NZ63.
    OMAi AEQRNKK.
    OrthoDBi EOG7FBRJ6.
    PhylomeDBi Q9NZ63.
    TreeFami TF105871.

    Miscellaneous databases

    ChiTaRSi C9orf78. human.
    GeneWikii C9orf78.
    GenomeRNAii 51759.
    NextBioi 55862.

    Gene expression databases

    Bgeei Q9NZ63.
    CleanExi HS_C9orf78.
    Genevestigatori Q9NZ63.

    Family and domain databases

    InterProi IPR010756. Hep_59.
    [Graphical view ]
    PANTHERi PTHR13486. PTHR13486. 1 hit.
    Pfami PF07052. Hep_59. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies."
      Wang Y., Han K.-J., Pang X.-W., Vaughan H.A., Qu W., Dong X.-Y., Peng J.-R., Zhao H.-T., Rui J.-A., Leng X.-S., Cebon J., Burgess A.W., Chen W.-F.
      J. Immunol. 169:1102-1109(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hepatoma.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow and Placenta.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 49-289.
      Tissue: Testis.
    7. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-147, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
      Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
      J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: T-cell.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-17 AND SER-261, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-17; THR-253 AND SER-261, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCI078_HUMAN
    AccessioniPrimary (citable) accession number: Q9NZ63
    Secondary accession number(s): B3KPX8, Q8WVU6, Q9NT39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3