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Protein

Vesicle transport protein USE1

Gene

USE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.1 Publication

GO - Biological processi

  1. endoplasmic reticulum tubular network organization Source: Ensembl
  2. lysosomal transport Source: HGNC
  3. protein catabolic process Source: HGNC
  4. protein transport Source: UniProtKB-KW
  5. regulation of ER to Golgi vesicle-mediated transport Source: Ensembl
  6. secretion by cell Source: HGNC
  7. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport protein USE1
Alternative name(s):
Putative MAPK-activating protein PM26
USE1-like protein
p31
Gene namesi
Name:USE1
Synonyms:USE1L
ORF Names:MDS032
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30882. USE1.

Subcellular locationi

  1. Endoplasmic reticulum membrane 1 Publication; Single-pass type IV membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 231231CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei232 – 25221Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST
Topological domaini253 – 2597LumenalSequence Analysis

GO - Cellular componenti

  1. endoplasmic reticulum Source: HGNC
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162408692.

Polymorphism and mutation databases

BioMutaiUSE1.
DMDMi296452858.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Vesicle transport protein USE1PRO_0000215579Add
BLAST

Proteomic databases

MaxQBiQ9NZ43.
PaxDbiQ9NZ43.
PRIDEiQ9NZ43.

PTM databases

PhosphoSiteiQ9NZ43.

Miscellaneous databases

PMAP-CutDBQ9NZ43.

Expressioni

Gene expression databases

BgeeiQ9NZ43.
CleanExiHS_USE1.
ExpressionAtlasiQ9NZ43. baseline and differential.
GenevestigatoriQ9NZ43.

Organism-specific databases

HPAiHPA026851.
HPA047562.

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2A4D1273EBI-742842,EBI-10172134
TRIM27P143733EBI-742842,EBI-719493

Protein-protein interaction databases

BioGridi120952. 18 interactions.
IntActiQ9NZ43. 4 interactions.
MINTiMINT-1463844.
STRINGi9606.ENSP00000263897.

Structurei

3D structure databases

ProteinModelPortaliQ9NZ43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili152 – 23180Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the USE1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299387.
GeneTreeiENSGT00390000014361.
HOGENOMiHOG000007677.
HOVERGENiHBG079328.
InParanoidiQ9NZ43.
KOiK08507.
PhylomeDBiQ9NZ43.
TreeFamiTF325006.

Family and domain databases

InterProiIPR019150. Vesicle_transport_protein_Use1.
[Graphical view]
PfamiPF09753. Use1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NZ43-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASRLELNL VRLLSRCEAM AAEKRDPDEW RLEKYVGALE DMLQALKVHA
60 70 80 90 100
SKPASEVINE YSWKVDFLKG MLQAEKLTSS SEKALANQFL APGRVPTTAR
110 120 130 140 150
ERVPATKTVH LQSRARYTSE MRSELLGTDS AEPEMDVRKR TGVAGSQPVS
160 170 180 190 200
EKQLAAELDL VLQRHQNLQE KLAEEMLGLA RSLKTNTLAA QSVIKKDNQT
210 220 230 240 250
LSHSLKMADQ NLEKLKTESE RLEQHTQKSV NWLLWAMLII VCFIFISMIL

FIRIMPKLK
Length:259
Mass (Da):29,371
Last modified:May 18, 2010 - v2
Checksum:i6538ED0B231AEC05
GO
Isoform 2 (identifier: Q9NZ43-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-146: GVAGS → PCHTH
     147-259: Missing.

Note: No experimental confirmation available.

Show »
Length:146
Mass (Da):16,511
Checksum:i307946785B1BAC38
GO
Isoform 3 (identifier: Q9NZ43-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-135: EPEM → GESP
     136-259: Missing.

Note: No experimental confirmation available.

Show »
Length:135
Mass (Da):15,063
Checksum:i22DF3FEF395B8489
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381A → V in AAH06005 (PubMed:15057824).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti154 – 1541L → S.3 Publications
Corresponds to variant rs414528 [ dbSNP | Ensembl ].
VAR_021052

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei132 – 1354EPEM → GESP in isoform 3. 1 PublicationVSP_012662
Alternative sequencei136 – 259124Missing in isoform 3. 1 PublicationVSP_012663Add
BLAST
Alternative sequencei142 – 1465GVAGS → PCHTH in isoform 2. 1 PublicationVSP_012664
Alternative sequencei147 – 259113Missing in isoform 2. 1 PublicationVSP_012665Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097050 mRNA. Translation: BAC77403.1.
AK074683 mRNA. Translation: BAC11136.1.
AF220052 mRNA. Translation: AAF67645.1.
AC020913 Genomic DNA. No translation available.
BC006005 mRNA. Translation: AAH06005.1.
BC008455 mRNA. Translation: AAH08455.1.
CCDSiCCDS46011.1. [Q9NZ43-1]
RefSeqiNP_060937.1. NM_018467.3.
UniGeneiHs.16187.

Genome annotation databases

EnsembliENST00000263897; ENSP00000263897; ENSG00000053501. [Q9NZ43-1]
ENST00000595101; ENSP00000472362; ENSG00000053501. [Q9NZ43-3]
ENST00000596136; ENSP00000473239; ENSG00000053501. [Q9NZ43-2]
GeneIDi55850.
KEGGihsa:55850.
UCSCiuc002nfn.2. human. [Q9NZ43-3]
uc002nfo.2. human. [Q9NZ43-1]
uc010eal.1. human. [Q9NZ43-2]

Polymorphism and mutation databases

BioMutaiUSE1.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097050 mRNA. Translation: BAC77403.1.
AK074683 mRNA. Translation: BAC11136.1.
AF220052 mRNA. Translation: AAF67645.1.
AC020913 Genomic DNA. No translation available.
BC006005 mRNA. Translation: AAH06005.1.
BC008455 mRNA. Translation: AAH08455.1.
CCDSiCCDS46011.1. [Q9NZ43-1]
RefSeqiNP_060937.1. NM_018467.3.
UniGeneiHs.16187.

3D structure databases

ProteinModelPortaliQ9NZ43.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120952. 18 interactions.
IntActiQ9NZ43. 4 interactions.
MINTiMINT-1463844.
STRINGi9606.ENSP00000263897.

PTM databases

PhosphoSiteiQ9NZ43.

Polymorphism and mutation databases

BioMutaiUSE1.
DMDMi296452858.

Proteomic databases

MaxQBiQ9NZ43.
PaxDbiQ9NZ43.
PRIDEiQ9NZ43.

Protocols and materials databases

DNASUi55850.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263897; ENSP00000263897; ENSG00000053501. [Q9NZ43-1]
ENST00000595101; ENSP00000472362; ENSG00000053501. [Q9NZ43-3]
ENST00000596136; ENSP00000473239; ENSG00000053501. [Q9NZ43-2]
GeneIDi55850.
KEGGihsa:55850.
UCSCiuc002nfn.2. human. [Q9NZ43-3]
uc002nfo.2. human. [Q9NZ43-1]
uc010eal.1. human. [Q9NZ43-2]

Organism-specific databases

CTDi55850.
GeneCardsiGC19P017326.
HGNCiHGNC:30882. USE1.
HPAiHPA026851.
HPA047562.
MIMi610675. gene.
neXtProtiNX_Q9NZ43.
PharmGKBiPA162408692.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG299387.
GeneTreeiENSGT00390000014361.
HOGENOMiHOG000007677.
HOVERGENiHBG079328.
InParanoidiQ9NZ43.
KOiK08507.
PhylomeDBiQ9NZ43.
TreeFamiTF325006.

Miscellaneous databases

GeneWikiiUSE1.
GenomeRNAii55850.
NextBioi61111.
PMAP-CutDBQ9NZ43.
PROiQ9NZ43.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NZ43.
CleanExiHS_USE1.
ExpressionAtlasiQ9NZ43. baseline and differential.
GenevestigatoriQ9NZ43.

Family and domain databases

InterProiIPR019150. Vesicle_transport_protein_Use1.
[Graphical view]
PfamiPF09753. Use1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
    Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
    Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-154.
    Tissue: Lung fibroblast.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Mammary gland.
  3. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
    Zhao M., Gu J., Li N., Peng Y., Han Z., Chen Z.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-154.
    Tissue: Hematopoietic stem cell.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-154.
    Tissue: Brain and Skeletal muscle.
  6. "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi."
    Hirose H., Arasaki K., Dohmae N., Takio K., Hatsuzawa K., Nagahama M., Tani K., Yamamoto A., Tohyama M., Tagaya M.
    EMBO J. 23:1267-1278(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH STX18 AND SEC22B, INTERACTION WITH STX18.
  7. "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion."
    Nakajima K., Hirose H., Taniguchi M., Kurashina H., Arasaki K., Nagahama M., Tani K., Yamamoto A., Tagaya M.
    EMBO J. 23:3216-3226(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH STX18; BNIP1 AND SEC22B.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUSE1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZ43
Secondary accession number(s): Q8NCK1, Q9BRT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 18, 2010
Last modified: April 29, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.