Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9NZ43 (USE1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vesicle transport protein USE1
Alternative name(s):
Putative MAPK-activating protein PM26
USE1-like protein
p31
Gene names
Name:USE1
Synonyms:USE1L
ORF Names:MDS032
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Ref.7

Subunit structure

Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18. Ref.6 Ref.7

Subcellular location

Endoplasmic reticulum membrane; Single-pass type IV membrane protein Ref.6.

Sequence similarities

Belongs to the USE1 family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NZ43-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NZ43-2)

The sequence of this isoform differs from the canonical sequence as follows:
     142-146: GVAGS → PCHTH
     147-259: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9NZ43-3)

The sequence of this isoform differs from the canonical sequence as follows:
     132-135: EPEM → GESP
     136-259: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259Vesicle transport protein USE1
PRO_0000215579

Regions

Topological domain1 – 231231Cytoplasmic Potential
Transmembrane232 – 25221Helical; Anchor for type IV membrane protein; Potential
Topological domain253 – 2597Lumenal Potential
Coiled coil152 – 23180 Potential

Natural variations

Alternative sequence132 – 1354EPEM → GESP in isoform 3.
VSP_012662
Alternative sequence136 – 259124Missing in isoform 3.
VSP_012663
Alternative sequence142 – 1465GVAGS → PCHTH in isoform 2.
VSP_012664
Alternative sequence147 – 259113Missing in isoform 2.
VSP_012665
Natural variant1541L → S. Ref.1 Ref.3 Ref.5
Corresponds to variant rs414528 [ dbSNP | Ensembl ].
VAR_021052

Experimental info

Sequence conflict381A → V in AAH06005. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 6538ED0B231AEC05

FASTA25929,371
        10         20         30         40         50         60 
MAASRLELNL VRLLSRCEAM AAEKRDPDEW RLEKYVGALE DMLQALKVHA SKPASEVINE 

        70         80         90        100        110        120 
YSWKVDFLKG MLQAEKLTSS SEKALANQFL APGRVPTTAR ERVPATKTVH LQSRARYTSE 

       130        140        150        160        170        180 
MRSELLGTDS AEPEMDVRKR TGVAGSQPVS EKQLAAELDL VLQRHQNLQE KLAEEMLGLA 

       190        200        210        220        230        240 
RSLKTNTLAA QSVIKKDNQT LSHSLKMADQ NLEKLKTESE RLEQHTQKSV NWLLWAMLII 

       250 
VCFIFISMIL FIRIMPKLK 

« Hide

Isoform 2 [UniParc].

Checksum: 307946785B1BAC38
Show »

FASTA14616,511
Isoform 3 [UniParc].

Checksum: 22DF3FEF395B8489
Show »

FASTA13515,063

References

« Hide 'large scale' references
[1]"Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-154.
Tissue: Lung fibroblast.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Mammary gland.
[3]"Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
Zhao M., Gu J., Li N., Peng Y., Han Z., Chen Z.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-154.
Tissue: Hematopoietic stem cell.
[4]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-154.
Tissue: Brain and Skeletal muscle.
[6]"Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi."
Hirose H., Arasaki K., Dohmae N., Takio K., Hatsuzawa K., Nagahama M., Tani K., Yamamoto A., Tohyama M., Tagaya M.
EMBO J. 23:1267-1278(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH STX18 AND SEC22B, INTERACTION WITH STX18.
[7]"Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion."
Nakajima K., Hirose H., Taniguchi M., Kurashina H., Arasaki K., Nagahama M., Tani K., Yamamoto A., Tagaya M.
EMBO J. 23:3216-3226(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH STX18; BNIP1 AND SEC22B.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB097050 mRNA. Translation: BAC77403.1.
AK074683 mRNA. Translation: BAC11136.1.
AF220052 mRNA. Translation: AAF67645.1.
AC020913 Genomic DNA. No translation available.
BC006005 mRNA. Translation: AAH06005.1.
BC008455 mRNA. Translation: AAH08455.1.
RefSeqNP_060937.1. NM_018467.3.
UniGeneHs.16187.

3D structure databases

ProteinModelPortalQ9NZ43.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120952. 3 interactions.
IntActQ9NZ43. 2 interactions.
MINTMINT-1463844.
STRING9606.ENSP00000263897.

PTM databases

PhosphoSiteQ9NZ43.

Polymorphism databases

DMDM296452858.

Proteomic databases

PaxDbQ9NZ43.
PRIDEQ9NZ43.

Protocols and materials databases

DNASU55850.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263897; ENSP00000263897; ENSG00000053501. [Q9NZ43-1]
ENST00000595101; ENSP00000472362; ENSG00000053501. [Q9NZ43-3]
ENST00000596136; ENSP00000473239; ENSG00000053501. [Q9NZ43-2]
GeneID55850.
KEGGhsa:55850.
UCSCuc002nfn.2. human. [Q9NZ43-3]
uc002nfo.2. human. [Q9NZ43-1]
uc010eal.1. human. [Q9NZ43-2]

Organism-specific databases

CTD55850.
GeneCardsGC19P017326.
HGNCHGNC:30882. USE1.
HPAHPA026851.
MIM610675. gene.
neXtProtNX_Q9NZ43.
PharmGKBPA162408692.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG299387.
HOGENOMHOG000007677.
HOVERGENHBG079328.
InParanoidQ9NZ43.
KOK08507.
PhylomeDBQ9NZ43.
TreeFamTF325006.

Gene expression databases

ArrayExpressQ9NZ43.
BgeeQ9NZ43.
CleanExHS_USE1.
GenevestigatorQ9NZ43.

Family and domain databases

InterProIPR019150. Vesicle_transport_protein_Use1.
[Graphical view]
PfamPF09753. Use1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiUSE1.
GenomeRNAi55850.
NextBio61111.
PMAP-CutDBQ9NZ43.
PROQ9NZ43.
SOURCESearch...

Entry information

Entry nameUSE1_HUMAN
AccessionPrimary (citable) accession number: Q9NZ43
Secondary accession number(s): Q8NCK1, Q9BRT4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM