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Q9NZ43

- USE1_HUMAN

UniProt

Q9NZ43 - USE1_HUMAN

Protein

Vesicle transport protein USE1

Gene

USE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. endoplasmic reticulum tubular network organization Source: Ensembl
    2. lysosomal transport Source: HGNC
    3. protein catabolic process Source: HGNC
    4. protein transport Source: UniProtKB-KW
    5. regulation of ER to Golgi vesicle-mediated transport Source: Ensembl
    6. secretion by cell Source: HGNC
    7. vesicle-mediated transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vesicle transport protein USE1
    Alternative name(s):
    Putative MAPK-activating protein PM26
    USE1-like protein
    p31
    Gene namesi
    Name:USE1
    Synonyms:USE1L
    ORF Names:MDS032
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:30882. USE1.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Single-pass type IV membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: HGNC
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162408692.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 259259Vesicle transport protein USE1PRO_0000215579Add
    BLAST

    Proteomic databases

    MaxQBiQ9NZ43.
    PaxDbiQ9NZ43.
    PRIDEiQ9NZ43.

    PTM databases

    PhosphoSiteiQ9NZ43.

    Miscellaneous databases

    PMAP-CutDBQ9NZ43.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NZ43.
    BgeeiQ9NZ43.
    CleanExiHS_USE1.
    GenevestigatoriQ9NZ43.

    Organism-specific databases

    HPAiHPA026851.

    Interactioni

    Subunit structurei

    Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18.2 Publications

    Protein-protein interaction databases

    BioGridi120952. 3 interactions.
    IntActiQ9NZ43. 2 interactions.
    MINTiMINT-1463844.
    STRINGi9606.ENSP00000263897.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NZ43.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 231231CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini253 – 2597LumenalSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei232 – 25221Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili152 – 23180Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the USE1 family.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299387.
    HOGENOMiHOG000007677.
    HOVERGENiHBG079328.
    InParanoidiQ9NZ43.
    KOiK08507.
    PhylomeDBiQ9NZ43.
    TreeFamiTF325006.

    Family and domain databases

    InterProiIPR019150. Vesicle_transport_protein_Use1.
    [Graphical view]
    PfamiPF09753. Use1. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NZ43-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAASRLELNL VRLLSRCEAM AAEKRDPDEW RLEKYVGALE DMLQALKVHA    50
    SKPASEVINE YSWKVDFLKG MLQAEKLTSS SEKALANQFL APGRVPTTAR 100
    ERVPATKTVH LQSRARYTSE MRSELLGTDS AEPEMDVRKR TGVAGSQPVS 150
    EKQLAAELDL VLQRHQNLQE KLAEEMLGLA RSLKTNTLAA QSVIKKDNQT 200
    LSHSLKMADQ NLEKLKTESE RLEQHTQKSV NWLLWAMLII VCFIFISMIL 250
    FIRIMPKLK 259
    Length:259
    Mass (Da):29,371
    Last modified:May 18, 2010 - v2
    Checksum:i6538ED0B231AEC05
    GO
    Isoform 2 (identifier: Q9NZ43-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         142-146: GVAGS → PCHTH
         147-259: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:146
    Mass (Da):16,511
    Checksum:i307946785B1BAC38
    GO
    Isoform 3 (identifier: Q9NZ43-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         132-135: EPEM → GESP
         136-259: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:135
    Mass (Da):15,063
    Checksum:i22DF3FEF395B8489
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti38 – 381A → V in AAH06005. (PubMed:15057824)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti154 – 1541L → S.3 Publications
    Corresponds to variant rs414528 [ dbSNP | Ensembl ].
    VAR_021052

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei132 – 1354EPEM → GESP in isoform 3. 1 PublicationVSP_012662
    Alternative sequencei136 – 259124Missing in isoform 3. 1 PublicationVSP_012663Add
    BLAST
    Alternative sequencei142 – 1465GVAGS → PCHTH in isoform 2. 1 PublicationVSP_012664
    Alternative sequencei147 – 259113Missing in isoform 2. 1 PublicationVSP_012665Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB097050 mRNA. Translation: BAC77403.1.
    AK074683 mRNA. Translation: BAC11136.1.
    AF220052 mRNA. Translation: AAF67645.1.
    AC020913 Genomic DNA. No translation available.
    BC006005 mRNA. Translation: AAH06005.1.
    BC008455 mRNA. Translation: AAH08455.1.
    CCDSiCCDS46011.1. [Q9NZ43-1]
    RefSeqiNP_060937.1. NM_018467.3.
    UniGeneiHs.16187.

    Genome annotation databases

    EnsembliENST00000263897; ENSP00000263897; ENSG00000053501. [Q9NZ43-1]
    ENST00000595101; ENSP00000472362; ENSG00000053501. [Q9NZ43-3]
    ENST00000596136; ENSP00000473239; ENSG00000053501. [Q9NZ43-2]
    GeneIDi55850.
    KEGGihsa:55850.
    UCSCiuc002nfn.2. human. [Q9NZ43-3]
    uc002nfo.2. human. [Q9NZ43-1]
    uc010eal.1. human. [Q9NZ43-2]

    Polymorphism databases

    DMDMi296452858.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB097050 mRNA. Translation: BAC77403.1 .
    AK074683 mRNA. Translation: BAC11136.1 .
    AF220052 mRNA. Translation: AAF67645.1 .
    AC020913 Genomic DNA. No translation available.
    BC006005 mRNA. Translation: AAH06005.1 .
    BC008455 mRNA. Translation: AAH08455.1 .
    CCDSi CCDS46011.1. [Q9NZ43-1 ]
    RefSeqi NP_060937.1. NM_018467.3.
    UniGenei Hs.16187.

    3D structure databases

    ProteinModelPortali Q9NZ43.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120952. 3 interactions.
    IntActi Q9NZ43. 2 interactions.
    MINTi MINT-1463844.
    STRINGi 9606.ENSP00000263897.

    PTM databases

    PhosphoSitei Q9NZ43.

    Polymorphism databases

    DMDMi 296452858.

    Proteomic databases

    MaxQBi Q9NZ43.
    PaxDbi Q9NZ43.
    PRIDEi Q9NZ43.

    Protocols and materials databases

    DNASUi 55850.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263897 ; ENSP00000263897 ; ENSG00000053501 . [Q9NZ43-1 ]
    ENST00000595101 ; ENSP00000472362 ; ENSG00000053501 . [Q9NZ43-3 ]
    ENST00000596136 ; ENSP00000473239 ; ENSG00000053501 . [Q9NZ43-2 ]
    GeneIDi 55850.
    KEGGi hsa:55850.
    UCSCi uc002nfn.2. human. [Q9NZ43-3 ]
    uc002nfo.2. human. [Q9NZ43-1 ]
    uc010eal.1. human. [Q9NZ43-2 ]

    Organism-specific databases

    CTDi 55850.
    GeneCardsi GC19P017326.
    HGNCi HGNC:30882. USE1.
    HPAi HPA026851.
    MIMi 610675. gene.
    neXtProti NX_Q9NZ43.
    PharmGKBi PA162408692.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299387.
    HOGENOMi HOG000007677.
    HOVERGENi HBG079328.
    InParanoidi Q9NZ43.
    KOi K08507.
    PhylomeDBi Q9NZ43.
    TreeFami TF325006.

    Miscellaneous databases

    GeneWikii USE1.
    GenomeRNAii 55850.
    NextBioi 61111.
    PMAP-CutDB Q9NZ43.
    PROi Q9NZ43.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NZ43.
    Bgeei Q9NZ43.
    CleanExi HS_USE1.
    Genevestigatori Q9NZ43.

    Family and domain databases

    InterProi IPR019150. Vesicle_transport_protein_Use1.
    [Graphical view ]
    Pfami PF09753. Use1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
      Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
      Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-154.
      Tissue: Lung fibroblast.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Mammary gland.
    3. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
      Zhao M., Gu J., Li N., Peng Y., Han Z., Chen Z.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-154.
      Tissue: Hematopoietic stem cell.
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-154.
      Tissue: Brain and Skeletal muscle.
    6. "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi."
      Hirose H., Arasaki K., Dohmae N., Takio K., Hatsuzawa K., Nagahama M., Tani K., Yamamoto A., Tohyama M., Tagaya M.
      EMBO J. 23:1267-1278(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH STX18 AND SEC22B, INTERACTION WITH STX18.
    7. "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion."
      Nakajima K., Hirose H., Taniguchi M., Kurashina H., Arasaki K., Nagahama M., Tani K., Yamamoto A., Tagaya M.
      EMBO J. 23:3216-3226(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH STX18; BNIP1 AND SEC22B.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiUSE1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NZ43
    Secondary accession number(s): Q8NCK1, Q9BRT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3