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Q9NZ43

- USE1_HUMAN

UniProt

Q9NZ43 - USE1_HUMAN

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Protein

Vesicle transport protein USE1

Gene
USE1, USE1L, MDS032
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. endoplasmic reticulum tubular network organization Source: Ensembl
  2. lysosomal transport Source: HGNC
  3. protein catabolic process Source: HGNC
  4. protein transport Source: UniProtKB-KW
  5. regulation of ER to Golgi vesicle-mediated transport Source: Ensembl
  6. secretion by cell Source: HGNC
  7. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport protein USE1
Alternative name(s):
Putative MAPK-activating protein PM26
USE1-like protein
p31
Gene namesi
Name:USE1
Synonyms:USE1L
ORF Names:MDS032
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:30882. USE1.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type IV membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 231231Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei232 – 25221Helical; Anchor for type IV membrane protein; Reviewed predictionAdd
BLAST
Topological domaini253 – 2597Lumenal Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum Source: HGNC
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162408692.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Vesicle transport protein USE1PRO_0000215579Add
BLAST

Proteomic databases

MaxQBiQ9NZ43.
PaxDbiQ9NZ43.
PRIDEiQ9NZ43.

PTM databases

PhosphoSiteiQ9NZ43.

Miscellaneous databases

PMAP-CutDBQ9NZ43.

Expressioni

Gene expression databases

ArrayExpressiQ9NZ43.
BgeeiQ9NZ43.
CleanExiHS_USE1.
GenevestigatoriQ9NZ43.

Organism-specific databases

HPAiHPA026851.

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18.2 Publications

Protein-protein interaction databases

BioGridi120952. 3 interactions.
IntActiQ9NZ43. 2 interactions.
MINTiMINT-1463844.
STRINGi9606.ENSP00000263897.

Structurei

3D structure databases

ProteinModelPortaliQ9NZ43.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili152 – 23180 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the USE1 family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299387.
HOGENOMiHOG000007677.
HOVERGENiHBG079328.
InParanoidiQ9NZ43.
KOiK08507.
PhylomeDBiQ9NZ43.
TreeFamiTF325006.

Family and domain databases

InterProiIPR019150. Vesicle_transport_protein_Use1.
[Graphical view]
PfamiPF09753. Use1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NZ43-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAASRLELNL VRLLSRCEAM AAEKRDPDEW RLEKYVGALE DMLQALKVHA    50
SKPASEVINE YSWKVDFLKG MLQAEKLTSS SEKALANQFL APGRVPTTAR 100
ERVPATKTVH LQSRARYTSE MRSELLGTDS AEPEMDVRKR TGVAGSQPVS 150
EKQLAAELDL VLQRHQNLQE KLAEEMLGLA RSLKTNTLAA QSVIKKDNQT 200
LSHSLKMADQ NLEKLKTESE RLEQHTQKSV NWLLWAMLII VCFIFISMIL 250
FIRIMPKLK 259
Length:259
Mass (Da):29,371
Last modified:May 18, 2010 - v2
Checksum:i6538ED0B231AEC05
GO
Isoform 2 (identifier: Q9NZ43-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-146: GVAGS → PCHTH
     147-259: Missing.

Note: No experimental confirmation available.

Show »
Length:146
Mass (Da):16,511
Checksum:i307946785B1BAC38
GO
Isoform 3 (identifier: Q9NZ43-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-135: EPEM → GESP
     136-259: Missing.

Note: No experimental confirmation available.

Show »
Length:135
Mass (Da):15,063
Checksum:i22DF3FEF395B8489
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti154 – 1541L → S.3 Publications
Corresponds to variant rs414528 [ dbSNP | Ensembl ].
VAR_021052

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei132 – 1354EPEM → GESP in isoform 3. VSP_012662
Alternative sequencei136 – 259124Missing in isoform 3. VSP_012663Add
BLAST
Alternative sequencei142 – 1465GVAGS → PCHTH in isoform 2. VSP_012664
Alternative sequencei147 – 259113Missing in isoform 2. VSP_012665Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381A → V in AAH06005. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB097050 mRNA. Translation: BAC77403.1.
AK074683 mRNA. Translation: BAC11136.1.
AF220052 mRNA. Translation: AAF67645.1.
AC020913 Genomic DNA. No translation available.
BC006005 mRNA. Translation: AAH06005.1.
BC008455 mRNA. Translation: AAH08455.1.
CCDSiCCDS46011.1. [Q9NZ43-1]
RefSeqiNP_060937.1. NM_018467.3.
UniGeneiHs.16187.

Genome annotation databases

EnsembliENST00000263897; ENSP00000263897; ENSG00000053501. [Q9NZ43-1]
ENST00000595101; ENSP00000472362; ENSG00000053501. [Q9NZ43-3]
ENST00000596136; ENSP00000473239; ENSG00000053501. [Q9NZ43-2]
GeneIDi55850.
KEGGihsa:55850.
UCSCiuc002nfn.2. human. [Q9NZ43-3]
uc002nfo.2. human. [Q9NZ43-1]
uc010eal.1. human. [Q9NZ43-2]

Polymorphism databases

DMDMi296452858.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB097050 mRNA. Translation: BAC77403.1 .
AK074683 mRNA. Translation: BAC11136.1 .
AF220052 mRNA. Translation: AAF67645.1 .
AC020913 Genomic DNA. No translation available.
BC006005 mRNA. Translation: AAH06005.1 .
BC008455 mRNA. Translation: AAH08455.1 .
CCDSi CCDS46011.1. [Q9NZ43-1 ]
RefSeqi NP_060937.1. NM_018467.3.
UniGenei Hs.16187.

3D structure databases

ProteinModelPortali Q9NZ43.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120952. 3 interactions.
IntActi Q9NZ43. 2 interactions.
MINTi MINT-1463844.
STRINGi 9606.ENSP00000263897.

PTM databases

PhosphoSitei Q9NZ43.

Polymorphism databases

DMDMi 296452858.

Proteomic databases

MaxQBi Q9NZ43.
PaxDbi Q9NZ43.
PRIDEi Q9NZ43.

Protocols and materials databases

DNASUi 55850.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263897 ; ENSP00000263897 ; ENSG00000053501 . [Q9NZ43-1 ]
ENST00000595101 ; ENSP00000472362 ; ENSG00000053501 . [Q9NZ43-3 ]
ENST00000596136 ; ENSP00000473239 ; ENSG00000053501 . [Q9NZ43-2 ]
GeneIDi 55850.
KEGGi hsa:55850.
UCSCi uc002nfn.2. human. [Q9NZ43-3 ]
uc002nfo.2. human. [Q9NZ43-1 ]
uc010eal.1. human. [Q9NZ43-2 ]

Organism-specific databases

CTDi 55850.
GeneCardsi GC19P017326.
HGNCi HGNC:30882. USE1.
HPAi HPA026851.
MIMi 610675. gene.
neXtProti NX_Q9NZ43.
PharmGKBi PA162408692.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG299387.
HOGENOMi HOG000007677.
HOVERGENi HBG079328.
InParanoidi Q9NZ43.
KOi K08507.
PhylomeDBi Q9NZ43.
TreeFami TF325006.

Miscellaneous databases

GeneWikii USE1.
GenomeRNAii 55850.
NextBioi 61111.
PMAP-CutDB Q9NZ43.
PROi Q9NZ43.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NZ43.
Bgeei Q9NZ43.
CleanExi HS_USE1.
Genevestigatori Q9NZ43.

Family and domain databases

InterProi IPR019150. Vesicle_transport_protein_Use1.
[Graphical view ]
Pfami PF09753. Use1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
    Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
    Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-154.
    Tissue: Lung fibroblast.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Mammary gland.
  3. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
    Zhao M., Gu J., Li N., Peng Y., Han Z., Chen Z.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-154.
    Tissue: Hematopoietic stem cell.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-154.
    Tissue: Brain and Skeletal muscle.
  6. "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi."
    Hirose H., Arasaki K., Dohmae N., Takio K., Hatsuzawa K., Nagahama M., Tani K., Yamamoto A., Tohyama M., Tagaya M.
    EMBO J. 23:1267-1278(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH STX18 AND SEC22B, INTERACTION WITH STX18.
  7. "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion."
    Nakajima K., Hirose H., Taniguchi M., Kurashina H., Arasaki K., Nagahama M., Tani K., Yamamoto A., Tagaya M.
    EMBO J. 23:3216-3226(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH STX18; BNIP1 AND SEC22B.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUSE1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZ43
Secondary accession number(s): Q8NCK1, Q9BRT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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