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Protein

Actin-related protein 10

Gene

ACTR10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. microtubule-based movement Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9NZ32.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 10
Alternative name(s):
Actin-related protein 11
Short name:
hARP11
Gene namesi
Name:ACTR10
Synonyms:ACTR11, ARP11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:17372. ACTR10.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. dynactin complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134899463.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Actin-related protein 10PRO_0000089131Add
BLAST

Proteomic databases

MaxQBiQ9NZ32.
PaxDbiQ9NZ32.
PRIDEiQ9NZ32.

PTM databases

PhosphoSiteiQ9NZ32.

Expressioni

Gene expression databases

BgeeiQ9NZ32.
CleanExiHS_ACTR10.
ExpressionAtlasiQ9NZ32. baseline and differential.
GenevestigatoriQ9NZ32.

Interactioni

Protein-protein interaction databases

BioGridi120962. 21 interactions.
IntActiQ9NZ32. 6 interactions.
STRINGi9606.ENSP00000254286.

Structurei

3D structure databases

ProteinModelPortaliQ9NZ32.
SMRiQ9NZ32. Positions 15-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiCOG5277.
GeneTreeiENSGT00760000119271.
HOGENOMiHOG000034069.
HOVERGENiHBG050578.
InParanoidiQ9NZ32.
KOiK16576.
OMAiKPIKVVQ.
PhylomeDBiQ9NZ32.
TreeFamiTF315151.

Family and domain databases

InterProiIPR004000. Actin.
IPR027127. Arp10.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF14. PTHR11937:SF14. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NZ32-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLYEGLGSG GEKTAVVIDL GEAFTKCGFA GETGPRCIIP SVIKRAGMPK
60 70 80 90 100
PVRVVQYNIN TEELYSYLKE FIHILYFRHL LVNPRDRRVV IIESVLCPSH
110 120 130 140 150
FRETLTRVLF KYFEVPSVLL APSHLMALLT LGINSAMVLD CGYRESLVLP
160 170 180 190 200
IYEGIPVLNC WGALPLGGKA LHKELETQLL EQCTVDTSVA KEQSLPSVMG
210 220 230 240 250
SVPEGVLEDI KARTCFVSDL KRGLKIQAAK FNIDGNNERP SPPPNVDYPL
260 270 280 290 300
DGEKILHILG SIRDSVVEIL FEQDNEEQSV ATLILDSLIQ CPIDTRKQLA
310 320 330 340 350
ENLVVIGGTS MLPGFLHRLL AEIRYLVEKP KYKKALGTKT FRIHTPPAKA
360 370 380 390 400
NCVAWLGGAI FGALQDILGS RSVSKEYYNQ TGRIPDWCSL NNPPLEMMFD
410
VGKTQPPLMK RAFSTEK
Length:417
Mass (Da):46,307
Last modified:October 1, 2000 - v1
Checksum:iDF351A7B299DB7C1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531R → K in BAA91243. (PubMed:14702039)Curated
Sequence conflicti93 – 931E → K in BAA91243. (PubMed:14702039)Curated
Sequence conflicti219 – 2191D → G in BAB14083. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220190 mRNA. Translation: AAF67655.1.
AK000544 mRNA. Translation: BAA91243.1.
AK022534 mRNA. Translation: BAB14083.1.
BC011997 mRNA. Translation: AAH11997.1.
CCDSiCCDS32090.1.
RefSeqiNP_060947.1. NM_018477.2.
UniGeneiHs.509451.

Genome annotation databases

EnsembliENST00000254286; ENSP00000254286; ENSG00000131966.
GeneIDi55860.
KEGGihsa:55860.
UCSCiuc001xdf.3. human.

Polymorphism databases

DMDMi27923739.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220190 mRNA. Translation: AAF67655.1.
AK000544 mRNA. Translation: BAA91243.1.
AK022534 mRNA. Translation: BAB14083.1.
BC011997 mRNA. Translation: AAH11997.1.
CCDSiCCDS32090.1.
RefSeqiNP_060947.1. NM_018477.2.
UniGeneiHs.509451.

3D structure databases

ProteinModelPortaliQ9NZ32.
SMRiQ9NZ32. Positions 15-382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120962. 21 interactions.
IntActiQ9NZ32. 6 interactions.
STRINGi9606.ENSP00000254286.

PTM databases

PhosphoSiteiQ9NZ32.

Polymorphism databases

DMDMi27923739.

Proteomic databases

MaxQBiQ9NZ32.
PaxDbiQ9NZ32.
PRIDEiQ9NZ32.

Protocols and materials databases

DNASUi55860.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254286; ENSP00000254286; ENSG00000131966.
GeneIDi55860.
KEGGihsa:55860.
UCSCiuc001xdf.3. human.

Organism-specific databases

CTDi55860.
GeneCardsiGC14P058666.
HGNCiHGNC:17372. ACTR10.
neXtProtiNX_Q9NZ32.
PharmGKBiPA134899463.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5277.
GeneTreeiENSGT00760000119271.
HOGENOMiHOG000034069.
HOVERGENiHBG050578.
InParanoidiQ9NZ32.
KOiK16576.
OMAiKPIKVVQ.
PhylomeDBiQ9NZ32.
TreeFamiTF315151.

Enzyme and pathway databases

SignaLinkiQ9NZ32.

Miscellaneous databases

GenomeRNAii55860.
NextBioi61151.
PROiQ9NZ32.

Gene expression databases

BgeeiQ9NZ32.
CleanExiHS_ACTR10.
ExpressionAtlasiQ9NZ32. baseline and differential.
GenevestigatoriQ9NZ32.

Family and domain databases

InterProiIPR004000. Actin.
IPR027127. Arp10.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF14. PTHR11937:SF14. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hypothalamus.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARP10_HUMAN
AccessioniPrimary (citable) accession number: Q9NZ32
Secondary accession number(s): Q9H9Y5, Q9NWY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.