Q9NZ09 (UBAP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-associated protein 1
Short name=UBAP-1

Alternative name(s):
Nasopharyngeal carcinoma-associated gene 20 protein

Gene names

Name:	UBAP1
ORF Names:	NAG20

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	502 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas. Ref.1
Sequence similarities	Contains 2 UBA domains. Contains 1 UMA domain.
Sequence caution	The sequence BAC11162.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: LIFEdb
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NZ09-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NZ09-2)

The sequence of this isoform differs from the canonical sequence as follows:
     362-422: Missing.

Note: Derived from EST data. No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 502

502

Ubiquitin-associated protein 1

PRO_0000211017

Regions

Domain

17 – 63

47

UMA

Domain

389 – 430

42

UBA 1

Domain

451 – 498

48

UBA 2

Natural variations

Alternative sequence

362 – 422

61

Missing in isoform 2.

VSP_013650

Natural variant

357

1

N → K. Ref.5
Corresponds to variant rs16935457 [ dbSNP | Ensembl ].

VAR_034577

Experimental info

Sequence conflict

81

1

C → R in CAG38582. Ref.4

Sequence conflict

331

1

E → D in BAC11176. Ref.3

Sequence conflict

403

1

G → C in BAC11323. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

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.

.

.

.

502

Helix Strand Turn

Details...

Helix

383 – 386

4

Helix

390 – 401

12

Helix

406 – 416

11

Helix

420 – 435

16

Helix

440 – 449

10

Helix

454 – 470

17

Helix

474 – 483

10

Turn

484 – 486

3

Helix

488 – 496

9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 548457B0B2ABC0F4	FASTA	502	55,084
	10 20 30 40 50 60 MASKKLGADF HGTFSYLDDV PFKTGDKFKT PAKVGLPIGF SLPDCLQVVR EVQYDFSLEK 70 80 90 100 110 120 KTIEWAEEIK KIEEAEREAE CKIAEAEAKV NSKSGPEGDS KMSFSKTHST ATMPPPINPI 130 140 150 160 170 180 LASLQHNSIL TPTRVSSSAT KQKVLSPPHI KADFNLADFE CEEDPFDNLE LKTIDEKEEL 190 200 210 220 230 240 RNILVGTTGP IMAQLLDNNL PRGGSGSVLQ DEEVLASLER ATLDFKPLHK PNGFITLPQL 250 260 270 280 290 300 GNCEKMSLSS KVSLPPIPAV SNIKSLSFPK LDSDDSNQKT AKLASTFHST SCLRNGTFQN 310 320 330 340 350 360 SLKPSTQSSA SELNGHHTLG LSALNLDSGT EMPALTSSQM PSLSVLSVCT EESSPPNTGP 370 380 390 400 410 420 TVTPPNFSVS QVPNMPSCPQ AYSELQMLSP SERQCVETVV NMGYSYECVL RAMKKKGENI 430 440 450 460 470 480 EQILDYLFAH GQLCEKGFDP LLVEEALEMH QCSEEKMMEF LQLMSKFKEM GFELKDIKEV 490 500 LLLHNNDQDN ALEDLMARAG AS
	Isoform 2 [UniParc]. Checksum: 001566AEC2898859	FASTA	441	48,247
	10 20 30 40 50 60 MASKKLGADF HGTFSYLDDV PFKTGDKFKT PAKVGLPIGF SLPDCLQVVR EVQYDFSLEK 70 80 90 100 110 120 KTIEWAEEIK KIEEAEREAE CKIAEAEAKV NSKSGPEGDS KMSFSKTHST ATMPPPINPI 130 140 150 160 170 180 LASLQHNSIL TPTRVSSSAT KQKVLSPPHI KADFNLADFE CEEDPFDNLE LKTIDEKEEL 190 200 210 220 230 240 RNILVGTTGP IMAQLLDNNL PRGGSGSVLQ DEEVLASLER ATLDFKPLHK PNGFITLPQL 250 260 270 280 290 300 GNCEKMSLSS KVSLPPIPAV SNIKSLSFPK LDSDDSNQKT AKLASTFHST SCLRNGTFQN 310 320 330 340 350 360 SLKPSTQSSA SELNGHHTLG LSALNLDSGT EMPALTSSQM PSLSVLSVCT EESSPPNTGP 370 380 390 400 410 420 TILDYLFAHG QLCEKGFDPL LVEEALEMHQ CSEEKMMEFL QLMSKFKEMG FELKDIKEVL 430 440 LLHNNDQDNA LEDLMARAGA S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a novel cDNA, UBAP1, derived from the tumor suppressor locus in human chromosome 9p21-22." Qian J., Yang J., Zhang X., Zhang B., Wang J., Zhou M., Tang K., Li W., Zeng Z., Zhao X., Shen S., Li G. J. Cancer Res. Clin. Oncol. 127:613-618(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-357. Tissue: Stomach.
[6]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 2).
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Colon.
[9]	"Solution structure of UBA domain of human ubiquitin associated protein 1 (UBAP1)." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 381-430.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF222043 mRNA. Translation: AAF37827.2.
AL136733 mRNA. Translation: CAB66667.1.
AK074724 mRNA. Translation: BAC11162.1. Different initiation.
AK074745 mRNA. Translation: BAC11176.1.
AK074812 mRNA. Translation: BAC11224.1.
AK074969 mRNA. Translation: BAC11323.1.
AK074995 mRNA. Translation: BAC11342.1.
CR533551 mRNA. Translation: CAG38582.1.
AK223235 mRNA. Translation: BAD96955.1.
AL353662 Genomic DNA. Translation: CAI15914.1.
AL353662 Genomic DNA. Translation: CAI15915.1.
CH471071 Genomic DNA. Translation: EAW58467.1.
CH471071 Genomic DNA. Translation: EAW58468.1.
CH471071 Genomic DNA. Translation: EAW58469.1.
CH471071 Genomic DNA. Translation: EAW58470.1.
BC020950 mRNA. Translation: AAH20950.1.
BC098141 mRNA. Translation: AAH98141.1.
BC098316 mRNA. Translation: AAH98316.1.
BC099726 mRNA. Translation: AAH99726.1.
BC100668 mRNA. Translation: AAI00669.1.

IPI

IPI00301305.
IPI00514788.

RefSeq

NP_001164672.1. NM_001171201.1.
NP_001164673.1. NM_001171202.1.
NP_001164674.1. NM_001171203.2.
NP_001164675.1. NM_001171204.2.
NP_057609.2. NM_016525.4.

UniGene

Hs.268963.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WGN	NMR	-	A	381-430	[»]
4AE4	X-ray	1.65	A/B	389-502	[»]

ProteinModelPortal

Q9NZ09.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-47291N.

STRING

9606.ENSP00000297661.

PTM databases

PhosphoSite

Q9NZ09.

Polymorphism databases

DMDM

67475018.

Proteomic databases

PaxDb

Q9NZ09.

PRIDE

Q9NZ09.

Protocols and materials databases

DNASU

51271.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000297661; ENSP00000297661; ENSG00000165006.
ENST00000359544; ENSP00000352541; ENSG00000165006.
ENST00000379186; ENSP00000368484; ENSG00000165006.
ENST00000536252; ENSP00000440456; ENSG00000165006.
ENST00000540348; ENSP00000439976; ENSG00000165006.

GeneID

51271.

KEGG

hsa:51271.

UCSC

uc003ztx.3. human.

Organism-specific databases

CTD

51271.

GeneCards

GC09P034179.

HGNC

HGNC:12461. UBAP1.

HPA

HPA019804.

MIM

609787. gene.

neXtProt

NX_Q9NZ09.

PharmGKB

PA37111.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG42214.

HOVERGEN

HBG060426.

InParanoid

Q9NZ09.

OrthoDB

EOG4J6RR9.

PhylomeDB

Q9NZ09.

Gene expression databases

ArrayExpress

Q9NZ09.

Bgee

Q9NZ09.

CleanEx

HS_UBAP1.

Genevestigator

Q9NZ09.

GermOnline

ENSG00000165006. Homo sapiens.

Family and domain databases

InterPro

IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR023340. UMA.
[Graphical view]

SUPFAM

SSF46934. UBA_like. 1 hit.

PROSITE

PS50030. UBA. 2 hits.
PS51497. UMA. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

UBAP1. human.

EvolutionaryTrace

Q9NZ09.

GenomeRNAi

51271.

NextBio

54471.

SOURCE

Search...

Entry information

Entry name

UBAP1_HUMAN

Accession

Primary (citable) accession number: Q9NZ09
Secondary accession number(s): D3DRL7 , Q4V759, Q53FP7, Q5T7B3, Q6FI75, Q8NC52, Q8NCG6, Q8NCH9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.